1.What Is Tetrandrine? Purity, Specifications, Safety Profile & Global Suppliers Guide (2025)

Tetrandrine (C₃₈H₄₂N₂O₆) is a well-characterized bis-benzylisoquinoline alkaloid extracted from Stephania tetrandra roots. At AIHerba®, we supply high-purity Tetrandrine as a laboratory and R&D-grade botanical active used by research institutions, pharmaceutical developers, universities, and analytical labs worldwide. Our production is carried out in a GMP-aligned plant extract factory in China, where we apply modern purification technology and strict QC standards to ensure dependable batch-to-batch consistency.

Whether you’re sourcing a bulk herbal extract for analytical method development, reference testing, formulation R&D, or exploring new natural actives, our team supports you with verified purity data, full traceability, and COA / MSDS available upon request. AIHerba® is a trusted herbal extract supplier and botanical extract manufacturer with more than 28 years of extraction experience, offering reliable pricing, fast delivery, and professional technical support.

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2. Key Product Information

Product Name: Tetrandrine
Botanical Source: Stephania tetrandra (root)
Specification: ≥ 98% by HPLC
CAS No.: 518-34-3
Molecular Formula: C₃₈H₄₂N₂O₆
Appearance: Off-white to light yellow crystalline powder
Grade: Research / Laboratory / R&D Raw Material
Solubility: Soluble in ethanol, methanol, DMSO
MOQ: 1–5 g for lab use; 100 g / 1 kg for bulk orders
Samples: Free sample herbal extract available for qualified institutions
Certificates: ISO, HACCP, GMP-aligned production; third-party testing available

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3. Source & Botanical Origin

Tetrandrine is derived from the roots of Stephania tetrandra, a traditional botanical used across East Asia. AIHerba® sources raw materials from controlled farms with verified species ID, ensuring consistent alkaloid profiles and clean agricultural practices.

All incoming raw materials are processed under:

• ISO 9001 quality control

• HACCP-based safety management

• GMP-aligned extraction protocols

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4. Scientific Characteristics & Research Relevance

Tetrandrine has been widely studied for its:

• Chemical properties and structural characteristics

• Alkaloid class behavior

• Potential interactions with ion channels

• Use in pharmacology research models

• Application in analytical standard development

These statements reflect research interest only, not health or therapeutic applications.

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5. Traditional Background 

Stephania tetrandra has a long historical presence in East Asian botanical use. Modern research isolates Tetrandrine as one of its major alkaloids. This section is for cultural reference only and does not imply any health benefits.

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6. Suggested Use (R&D, Laboratory Only)

• Reference standard development

• Chromatographic method validation

• Natural compound screening projects

• Bioactive compound isolation research

• Analytical projects requiring high-purity alkaloids

Not for human consumption. Not a dietary ingredient.

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7. Recommended Handling (Laboratory Only)

• Dissolve in DMSO, ethanol, or methanol for analytical use

• Wear gloves, eye protection, and lab coat

• Store in a cool, dry, dark environment

• Use analytical equipment in compliance with local regulations

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8. Formulation & R&D Guidance

Tetrandrine is often used in:

• Compound libraries

• Natural product research

• Reference material preparations

• Alkaloid profile studies

Our technical team provides guidance on:

• Solubility optimization

• HPLC method parameters

• Purity verification

• Stability evaluation

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9. Specifications & COA Table 

A) Pesticide Residue Testing

B) Heavy Metals

C) Microbiological Tests

COA / MSDS available upon request.

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10. Production Process

1. Botanical raw material selection

2. Cleaning & drying

3. Water–ethanol extraction

4. Alkaloid enrichment

5. Filtration & solvent recovery

6. Column purification (HPLC-guided)

7. Crystallization & drying

8. Fine grinding & sieving

9. QC testing (HPLC / ICP-MS / Microbial)

10. Packaging in GMP-aligned cleanroom

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11. Storage & Shelf Life

• Store below 25°C

• Keep sealed and protected from light

• Shelf life: 24 months in original packaging

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12. Packaging Options

• 1–100 g aluminum foil bag

• 1 kg bottle / double-layered foil pouch

• 25 kg drum (bulk herbal extract orders)

• Customized packaging available

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13. Shipping, MOQ & Lead Time

• MOQ: 1–5 g for R&D; 100 g / 1 kg for bulk

• Lead Time: 3–7 working days

• Shipping: FedEx, DHL, UPS, air cargo, or sea for wholesale orders

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14. Industry Applications

• Academic research labs

• Pharmaceutical R&D

• Analytical testing laboratories

• Natural product research centers

• Universities and research institutions

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15. Application Methods (R&D Only)

• Dissolve to prepare research solutions

• Use in chromatographic method studies

• Add to compound screening assays

• Apply as a reference standard

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16. Scientific Source & Quality Assurance

• Raw material traceability system for every batch

• Production under ISO, HACCP, GMP-aligned standards

• Third-party testing: HPLC / UV / LC-MS / Microbial

• Full documentation support: COA, MSDS, process flowchart

• Over 28 years of extraction and purification expertise

• In-house R&D team and pilot facility for custom projects

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17. Why AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.)

AIHerba® is a China Natural Plant Extracts Supplier & Botanical Extract Manufacturer with a strong track record in bulk herbal ingredients. Our plant extract factory in China integrates supercritical CO₂ extraction, traditional water-ethanol extraction, microbial fermentation, and advanced purification systems.

We support global partners with:

• Customized herbal extract solutions

• Bulk supply and wholesale options

• OEM & ODM services

• Transparent pricing and traceable QC data

• Fast response and technical support

📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com

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18. Frequently Asked Questions (FAQ)

Q1: Is Tetrandrine suitable for human use or supplements?
No. This material is for R&D, laboratory, and reference use only.

Q2: Can you provide a COA or MSDS before ordering?
Yes, both documents are available upon request.

Q3: Do you offer customized herbal extract specifications?
Yes — as a botanical extract manufacturer, we support customized purity and analytical requirements.

Q4: Do you accept small-quantity test orders?
Yes. We provide small-quantity R&D packs and free samples for qualified institutions.

Q5: Is third-party testing available?
Yes, we can provide HPLC, LC-MS, heavy metals, and microbial test reports.

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19. References (Scientific, Non-Claim)

1. PubChem – Tetrandrine compound summary

2. NIH – Natural product alkaloid research resources

3. PubMed – Structural studies on bis-benzylisoquinoline alkaloids

4. FDA Guidance – Botanical product development framework

5. AOAC & USP standards for analytical testing