Silybin A
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Silybin A

Buy Silybin A in Bulk | Food-Grade & Cosmetic-Grade Extract for Professional Formulations

  1. English Name: Silybin A
  1. Specification
Silybin A has no relation to Cocoa Butter. It’s a flavonolignan compound. Usually, excessive – high quality Silybin A has a purity ≥ 98% (decided by HPLC). It has low water – solubility, however superior pharmaceutical strategies like nano – formulations or mixture with solubilizing brokers can enhance its dissolution, which is essential for its efficient utilization in numerous purposes.
  1. Appearance
Presents as a white to gentle yellow powder, odorless, making certain it will not intrude with the sensory qualities of merchandise through which it is integrated.
  1. CAS NO.
22888 – 70 – 6, an necessary identifier for regulatory compliance, product identification, and scientific analysis throughout completely different markets.
  1. Lead Time
3 – 7 working days, permitting for fast order success, which advantages companies by decreasing stock ready occasions and enabling immediate response to market calls for.
  1. Package
Packed in 25kg/drum, with 27 drums/tray. This packaging protects Silybin A from environmental elements corresponding to moisture and oxidation throughout transportation and storage, whereas additionally facilitating simple dealing with and distribution for giant – scale orders.
  1. Main Market
Broadly distributed in European, North American, Asian markets, and different areas. Its world reputation stems from its important well being – associated properties and in depth purposes within the pharmaceutical and nutraceutical sectors.
  1. Application Scenarios
    • Pharmaceutical Business: Silybin A is a key energetic ingredient in liver – protecting medicines. It reveals potent antioxidant and anti – inflammatory actions, successfully safeguarding liver cells from injury brought on by toxins, medication, and oxidative stress. It is used within the remedy of varied liver ailments together with hepatitis, cirrhosis, and fatty liver. Moreover, it could possibly support in liver perform restoration and is concerned in ongoing analysis for brand spanking new liver – associated drug improvement.
    • Nutraceutical Business: As a result of its liver – defending and well being – selling advantages, Silybin A is utilized in dietary dietary supplements. It helps keep general liver well being, making it widespread amongst people with excessive – threat elements for liver issues, corresponding to these with a poor weight loss plan, extreme alcohol consumption, or publicity to environmental pollution. Dietary supplements containing Silybin A may also help basic effectively – being and cleansing processes within the physique.
Silybin A, with its distinct chemical properties, necessary purposes, and environment friendly provide chain options, performs a major position within the fields of prescription drugs and nutraceuticals, constantly assembly the well being – associated wants of shoppers globally.
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SILYBIN A – High-Purity Extract for Nutraceutical, Pharmaceutical & Cosmetic Formulations

1. Product Overview: What Is Silybin A?

Silybin A—also known as Silibinin A, one of the primary active isomers of silymarin—is a high-value flavonolignan extracted from Silybum marianum (milk thistle). This compound is widely studied for its antioxidant, hepatoprotective, and cell-supportive biological activities.

AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) supplies GMP-certified plant extract for cosmetics, dietary supplements, functional foods, and pharmaceutical formulations. With 28+ years of manufacturing experience, our factory specializes in bulk production of high-purity Silybin A using supercritical CO₂ extraction and advanced purification technologies.

Applications: liver support supplements, detox formulas, anti-aging skincare, hepatoprotective pharmaceuticals, and functional beverages.

(Insert Image Placeholder: “High-purity Silybin A crystalline powder – factory lab photo”)

2. Natural Botanical Source

  • Botanical Name: Silybum marianum (L.) Gaertn.

  • Plant Part Used: Seeds

  • Extraction Method: Supercritical CO₂ + Low-temperature ethanol purification

  • Origin: Northwest China (traceable origin)

  • Active Component: Silybin A (≥98%)

Milk thistle has been used for over 2,000 years in European herbal medicine, particularly for liver, gallbladder, and detoxification support.

3. Key Benefits & Biological Functions of Silybin A

Below is a concise evidence-based review with expert citations:

3.1 Liver Protection & Detoxification

Silybin A is considered the most bioactive fraction of silymarin, shown to support:

  • Enhanced antioxidant activity in hepatic tissue

  • Promotion of hepatocyte regeneration

  • Support for liver enzyme normalization

  • Reduction of oxidative stress markers

Reference:
• NIH – LiverTox: Clinical and Research Information on Drug-Induced Liver Injury
• PubMed ID: 30710087, 33803703

3.2 Potent Antioxidant & Anti-Inflammatory Effects

Silybin A neutralizes free radicals and modulates inflammatory pathways (NF-κB, Nrf2), making it relevant for:

  • Anti-aging formulations

  • UV-protection cosmetic applications

  • Functional nutrition products

3.3 Metabolic & Cellular Support

Research suggests Silybin A may:

  • Support lipid metabolism

  • Promote healthy insulin activity

  • Aid normal cell division and DNA protection

Reference:
• PubMed: 28658887 – Silybin and metabolic syndrome

4. Traditional Use Summary

Milk thistle seeds have traditionally been used in European herbal pharmacopeias for:

  • General liver well-being

  • Gallbladder support

  • Detoxification after dietary excess or environmental exposure

5. Recommended Usage & Formulation Guide

5.1 Suggested Dosage (Raw Material Guidance)

For formulators (not final consumer dosage):

  • Dietary supplements: 50–200 mg per serving (depending on formulation potency)

  • Pharmaceutical-grade formulas: As per pharmacopeial guidelines

  • Cosmetics: 0.1–1% in emulsions, serums, gels

5.2 How to Use (Application Formulas)

  • Capsules/Tablets: Combine with phosphatidylcholine to enhance bioavailability

  • Powder blends: Combine with turmeric, berberine, N-acetyl-cysteine

  • Cosmetics: Dissolve in ethanol or propylene glycol, then add to emulsions below 45°C

  • Functional beverages: Stabilize with cyclodextrin complexes

5.3 Best-Pairing Ingredients

  • Phospholipids (for phytosome complexes)

  • Curcumin / Boswellia (inflammation-support formulas)

  • Alpha-lipoic acid (metabolic support)

6. Full Specifications & Technical Data

6.1 Product Specifications

Item Description
Product Name Silybin A
Specification 98% pure by HPLC
Appearance Light yellow to off-white powder
Odor/Taste Mild, characteristic
Solubility Soluble in ethanol and DMSO
CAS No. 29782-72-7
Source Silybum marianum seeds
Grade Food-grade & cosmetic-grade
Certifications GMP, ISO9001, ISO22000, HACCP
Shelf Life 24 months

7. COA-Style Quality Report (Residues, Heavy Metals, Microbiology)

7.1 Pesticide Residues

Pesticide Item Limit Test Method
Organophosphorus ≤0.05 ppm GC-MS/MS
Organochlorine ≤0.1 ppm GC-MS/MS
Carbamates ≤0.1 ppm LC-MS/MS
Pyrethroids ≤0.05 ppm GC-MS/MS
EU/USP Total Compliance Pass USP<561>

7.2 Heavy Metals

Heavy Metal Limit Test Method
Lead (Pb) ≤2.0 ppm ICP-MS
Arsenic (As) ≤1.0 ppm ICP-MS
Cadmium (Cd) ≤0.5 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm ICP-MS
Total Heavy Metals ≤10 ppm USP<231>

7.3 Microbiological Testing

Microbial Item Limit Test Method
Total Plate Count ≤1,000 cfu/g USP<2021>
Yeast & Mold ≤100 cfu/g USP<2021>
E. coli Negative USP<2022>
Salmonella Negative USP<2022>
Staphylococcus aureus Negative USP<2022>

8. Manufacturing Process & Workflow

8.1 Production Technology

AIHerba’s manufacturer facility uses:

  • Supercritical CO₂ extraction

  • Low-temperature ethanol refinement

  • Column chromatography isolation

  • High-precision crystallization

  • GMP-controlled drying & milling

8.2 Production Flowchart

  1. Raw material selection

  2. Seed cleaning & milling

  3. Supercritical CO₂ extraction

  4. Ethanol purification

  5. Column separation

  6. Concentration

  7. Crystallization of Silybin A

  8. Filtration

  9. Vacuum drying

  10. Milling & sieving

  11. Final QC testing

  12. Packaging & labeling

9. Storage & Packaging

9.1 Storage Conditions

  • Store in a cool, dry place (<25°C)

  • Protect from light and moisture

  • Keep sealed after opening

9.2 Packaging Specifications

  • 1 kg foil bags

  • 25 kg fiber drums

  • Customized packaging available (OEM/ODM)

9.3 Shelf Life

  • 24 months in original packaging

10. Sample Policy, MOQ & Logistics

  • Free sample herbal extract: 10–20 g available for qualified buyers

  • MOQ: 1 kg for R&D / 25 kg for bulk orders

  • Lead Time: 3–7 days

  • Shipping: DHL/FedEx/Air/Sea freight

  • Trade Terms: EXW, FOB, CIF, DDP available

11. Industries & Application Scenarios

Industries Served

  • Nutraceuticals & dietary supplements

  • Pharmaceuticals

  • Cosmetics & personal care

  • Functional foods & beverages

  • Veterinary health products

Application Scenarios

  • Liver detox formulas

  • Anti-aging skincare

  • Metabolic wellness products

  • Post-alcohol support blends

  • Antioxidant beverages

  • Immune & cellular health supplements

12. Why Choose AIHerba (Shaanxi Zhonghong Investment Technology Co., Ltd.)?

28+ years of extraction experience
GMP-certified manufacturer
Strict QA/QC, third-party testing
Traceable botanical raw materials
Fast delivery + stable supply
Accept OEM & customized herbal extract solutions

(Insert Image Placeholder: “Factory GMP cleanroom, QC lab equipment, raw material warehouse”)

13. Frequently Asked Questions (FAQ)

1. Is Silybin A the same as silymarin?

No. Silymarin is a complex mixture, while Silybin A is one isolated, highly bioactive isomer.

2. Can you provide a COA and MSDS?

Yes. Full documentation is provided for every batch.

3. Do you offer bulk and wholesale supply?

Yes—our supplier and factory support global bulk and wholesale shipments.

4. What is your typical price range?

Pricing depends on purity and order volume. Contact us for the latest price quotation.

5. Do you ship globally?

Yes. We export to 50+ countries.

14. Scientific References (PubMed / NIH / FDA)

  1. PubMed: Antioxidant activity of Silybin A (PMID: 30710087)

  2. PubMed: Hepatoprotective effects (PMID: 33803703)

  3. NIH LiverTox – Milk Thistle Monograph

  4. FDA GRAS Notice: Silymarin components (public database)

15. Contact Information (Verified)

AIHerba® – Shaanxi Zhonghong Investment Technology Co., Ltd.
📧 sales@aiherba.com
📧 info@aiherba.com
📧 liaodaohai@gmail.com
🌐 www.aiherba.com

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