Beverage addition, Cosmetics and Personal Care, Dietary supplements, Food additives, Functional food, Healthcare & Pharmaceutical Ingredients

Alpha-Ketoglutarate

Alpha-Ketoglutarate (AKG): Your Final Information from Premium Provider Aiherba

English Name: Alpha-Ketoglutarate, often abbreviated as AKG
Chemical Nature: It is a key intermediate in the Krebs cycle (also known as the citric acid cycle), which is central to cellular energy metabolism. AKG plays a crucial role in various biochemical processes within the body.
Specification：Purity: Alpha-Ketoglutarate ≥ 98% (HPLC – tested). Stringent production and purification methods are employed to achieve this high level of purity. Rigorous quality control ensures minimal contaminants, such as heavy metals and microbial impurities, conforming to international standards for dietary supplements, cosmetics, and food ingredients.
Appearance：It appears as a white crystalline powder. The powder is odorless or has a very faint, characteristic smell. It is free – flowing, facilitating its use in different formulations.
CAS NO.: 328 – 50 – 7. This unique identifier is essential for chemical identification, research, and regulatory compliance.
Lead Time: 3 – 7 Working Days. Minor adjustments may occur depending on order volume and production capacity. Our efficient production and logistics systems are designed to ensure timely delivery.
Package: 25kg/drum, with 27 drums/tray. The drums are made of food – grade materials, providing excellent protection against moisture, light, and physical damage during storage and transportation. Custom packaging options are available upon request.
Main Market: European, North America, Asia etc. It has a global market presence. In Europe and North America, it has gained significant popularity among fitness enthusiasts, athletes, and those interested in anti – aging and longevity research. In Asia, with a growing focus on health and wellness, it is also attracting attention.
Applications
- Health Supplements:
  - Energy Production: AKG is involved in the generation of adenosine triphosphate (ATP), the body\’s primary energy currency. Supplementing with AKG can potentially enhance athletic performance, reduce fatigue during exercise, and support overall physical endurance.
  - Muscle Building: It may contribute to muscle protein synthesis, helping to build and maintain lean muscle mass. This is beneficial for bodybuilders and those looking to improve their body composition.
  - Anti – aging: Some studies suggest that AKG can extend lifespan in certain organisms. In humans, it may help maintain cellular health by supporting mitochondrial function and protecting cells from oxidative stress, potentially slowing down the aging process.
- Cosmetics:
  - Skin Rejuvenation: The anti – aging effects on skin cells involve promoting collagen synthesis, reducing the appearance of fine lines and wrinkles, and enhancing skin elasticity. It can also protect skin cells from oxidative stress, leading to a more youthful complexion.
  - Skin Repair: Its antioxidant and anti – inflammatory properties make it effective in repairing damaged skin, soothing irritation, and promoting skin healing. This is useful for conditions like acne, eczema, and psoriasis.
- Food Industry:
  - Functional Foods: Incorporated into sports nutrition products, energy drinks, and fortified cereals to enhance their nutritional value. It offers consumers a natural way to boost their energy levels and support overall well – being.
  - Nutraceutical Beverages: Can be used in specialty drinks aimed at providing anti – aging and performance-enhancing benefits, making them more appealing to health – oriented consumers.

Categories: Beverage addition, Cosmetics and Personal Care, Dietary supplements, Food additives, Functional food, Healthcare & Pharmaceutical Ingredients Tags: anti-aging, Energy Production, Functional Foods, Muscle Building, Nutraceutical Beverages, Skin Rejuvenation, Skin Repair

描述

Alpha-Ketoglutarate (AKG) – High-Purity Nutraceutical Ingredient | AIHerba®
Bulk Supply | OEM & ODM Factory | GMP-Certified Manufacturer

(1) Product Overview

Alpha-Ketoglutarate (AKG) is a key intermediate in the Krebs (citric acid) cycle, essential for cellular energy metabolism and amino acid synthesis. AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) provides high-purity Alpha-Ketoglutarate powder produced under GMP-certified facilities. Our product is available in bulk for nutraceuticals, pharmaceuticals, sports nutrition, and anti-aging formulations.

CAS No.: 328-50-7
Molecular Formula: C5H6O5
Appearance: White crystalline powder
Purity: ≥ 99% (HPLC)
Solubility: Water soluble
Source: Fermentation-derived and refined through advanced purification technology

(2) Production Source & Manufacturing Process

AIHerba® uses microbial fermentation of glucose substrates, followed by enzymatic oxidation and crystallization to produce high-purity Alpha-Ketoglutarate.
Our process combines green chemistry principles and supercritical CO₂ extraction to ensure product stability and safety.

Manufacturing Flowchart

Selection of non-GMO fermentation strain
Controlled microbial fermentation
Enzymatic oxidation to AKG
Purification via membrane filtration
Crystallization and drying
Quality inspection (HPLC, GC, ICP-MS, Microbiological tests)
GMP packaging and warehouse storage

(3) Key Benefits & Health Applications

Core Functional Benefits

Enhances Energy Metabolism: Supports ATP production and reduces cellular fatigue.
Promotes Muscle Recovery: Ideal for sports and bodybuilding supplements.
Supports Longevity & Anti-Aging: Regulates mitochondrial function and combats oxidative stress.
Improves Nitrogen Balance: Enhances amino acid metabolism and detoxification of ammonia.
Boosts Gut & Immune Health: Promotes beneficial intestinal flora and supports immune response.

Alpha-Ketoglutarate Applications

Scientific Health Benefits

Supports mitochondrial energy production (PubMed ID: 28975987)
Reduces oxidative stress in aging tissues (NIH Reference: PMC6570582)
Improves muscle endurance and recovery post-exercise (PubMed: 29926454)

(4) Traditional & Modern Applications

Category	Common Applications
Dietary Supplements	Capsules, tablets, energy powders, and anti-aging formulas
Pharmaceuticals	Mitochondrial support, fatigue recovery, metabolic disorders
Sports Nutrition	Pre-workout or post-workout blends
Functional Foods	Fortified beverages, protein powders
Cosmetics	Anti-aging and energy-enhancing skincare formulations

(5) Recommended Dosage & Usage Guidelines

General Health Support: 200–500 mg/day
Sports Nutrition: 1–3 g/day (split dosage)
Formulation Suggestion: Combine with L-Arginine, L-Ornithine, L-Citrulline, or Magnesium for synergistic effects.
Use Form: Mix with water, capsule, or functional beverage base.

Consult your healthcare professional before use, especially for pregnant or lactating individuals or those with metabolic disorders.

(6) Product Specification & Quality Assurance (COA Summary)

Category	Item	Specification	Test Method
Appearance	White crystalline powder	Conforms	Visual
Purity (HPLC)	≥ 99%	HPLC
Loss on Drying	≤ 0.5%	USP<731>
Residue on Ignition	≤ 0.1%	USP<281>
pH (1% Solution)	2.2–2.8	USP<791>

Pesticide Residue

Name	Limit	Test Method
Organophosphates	≤ 0.1 ppm	GC-MS
Organochlorine pesticides	≤ 0.05 ppm	GC-MS
Pyrethroids	≤ 0.1 ppm	GC-MS

Heavy Metals

Name	Limit	Test Method
Lead (Pb)	≤ 2 ppm	ICP-MS
Arsenic (As)	≤ 1 ppm	ICP-MS
Cadmium (Cd)	≤ 1 ppm	ICP-MS
Mercury (Hg)	≤ 0.1 ppm	ICP-MS

Microbiological Tests

Name	Limit	Test Method
Total Plate Count	≤ 1,000 CFU/g	USP<61>
Yeast & Mold	≤ 100 CFU/g	USP<61>
E. coli	Negative	USP<62>
Salmonella	Negative	USP<62>
Staphylococcus aureus	Negative	USP<62>

(7) Storage & Shelf Life

Storage: Keep in a tightly sealed container, away from light, heat, and moisture.
Shelf Life: 24 months from manufacturing date when properly stored.
Packaging: 1 kg/aluminum foil bag; 25 kg/drum.
Samples: 50–100 g free sample available for quality testing.
MOQ: 1 kg (for pilot testing); bulk orders ≥ 25 kg preferred.
Shipping: Air/Sea/FedEx/DHL with export documentation support.

(8) Applicable Industries & Application Scenarios

Industry	Typical Use
Nutraceuticals	Energy & longevity formulas
Pharmaceuticals	Mitochondrial and metabolic regulation
Food & Beverage	Functional drinks, energy shots
Cosmetics	Anti-aging and revitalizing skin care
Sports Nutrition	Muscle recovery, endurance enhancement

(9) Certifications & Quality Standards

GMP / ISO 9001 / HACCP Certified
Complies with USP, EP, and GB standards
Third-Party Tested by SGS / Eurofins / Intertek
Traceable Batch Reports and COA with every shipment

(10) AIHerba® Factory Advantage

✅ 28+ Years of Extraction & Fermentation Expertise
✅ Full OEM & ODM Custom Formulation Service
✅ Global Export Experience (60+ Countries)
✅ In-House R&D Laboratory with Advanced HPLC, GC, ICP-MS Testing
✅ Professional Support for Regulatory & Documentation Needs (FDA, EFSA, CFDA)

(11) Frequently Asked Questions (FAQ)

Q1: What is Alpha-Ketoglutarate used for?
A1: AKG supports energy metabolism, muscle recovery, anti-aging, and immune system health.

Q2: Can Alpha-Ketoglutarate be combined with amino acids?
A2: Yes, combining with L-Arginine or L-Ornithine enhances nitric oxide synthesis and recovery benefits.

Q3: Is it safe for long-term use?
A3: Clinical studies indicate good tolerance at standard doses. Always follow professional guidance.

Q4: Can AIHerba provide OEM capsules or blends?
A4: Yes, our OEM/ODM team supports capsule, tablet, or powder formulation under private label.

(12) Reference Publications

Chinopoulos C. “Mitochondrial α-ketoglutarate metabolism in health and disease.” Biochim Biophys Acta Bioenerg. 2019. PubMed
De Sá et al. “Alpha-Ketoglutarate supplementation improves exercise performance.” Nutrients. 2018. NIH PMC6570582
FDA GRAS Notice No. GRN 000799: Alpha-Ketoglutaric Acid recognized as safe for food use.

(13) Contact & Ordering

AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd.
📍 GMP Certified Factory – Xi’an, China
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com

Your trusted Alpha-Ketoglutarate (AKG) bulk supplier and OEM factory partner for nutraceutical, pharmaceutical, and functional food applications.