Nuciferine
, , , , ,

Nuciferine

The Definitive Guide to Nuciferine: Nature’s Lotus Alkaloid Powerhouse

  1. English Title: Nuciferine
  1. Specification
    • Purity: ≥ 98% (HPLC)
    • Solubility: Sparingly soluble in water (approx. 0.01 g/L at 25°C), soluble in natural solvents corresponding to ethanol (≥ 10 g/100 mL), chloroform, and methanol
    • Look – associated: Loss on drying ≤ 1.0%, Heavy metals ≤ 10 ppm, Residual solvents ≤ 0.5%
    • Melting Level: 142 – 144°C
    • Particle Measurement: Normal powder ≤ 100 mesh; will be custom-made for various purposes
  1. Look
    • White to off – white crystalline powder, odorless or with a really faint, attribute plant – like odor, having no relation to chocolate in colour or aroma
  1. CAS NO.：475 – 83 – 2
  1. Lead time: 5 – 7 Working Days
  1. Bundle
    • 1 kg/aluminum foil bag, 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Principal Market
    • International market, with important demand in Asia (China, Japan, South Korea), Europe, and North America, primarily utilized in dietary dietary supplements, pharmaceutical analysis, and purposeful meals industries
  1. Utility Eventualities

Core Properties

  • Chemical Construction: An aporphine – sort alkaloid with the molecular formulation C₁₉H₂₁NO₃. Its distinctive heterocyclic construction endows it with numerous organic actions.
  • Key Options
    • Weight – Administration: Could inhibit adipocyte differentiation and lipid accumulation, selling fats metabolism. It could actually additionally suppress urge for food by appearing on the central nervous system, serving to with weight management.
    • Antioxidant: Scavenges free radicals corresponding to hydroxyl and superoxide anions, defending cells from oxidative harm and decreasing the chance of continual illnesses associated to oxidative stress, like cardiovascular illnesses and neurodegenerative problems.
    • Anti – Inflammatory: Reduces the manufacturing of professional – inflammatory cytokines, assuaging irritation within the physique and probably serving to with circumstances related to continual irritation.
    • Cardiovascular Safety: Helps regulate blood stress and enhance blood lipid profiles. It could act on blood vessels to boost their elasticity and cut back the chance of atherosclerosis.
    • Neuroprotective: Exhibits potential in defending neurons from harm, with analysis exploring its function in stopping or treating neurodegenerative illnesses corresponding to Alzheimer’s and Parkinson’s.

Utility Eventualities

1. Dietary Dietary supplements

  • Weight – Loss Dietary supplements:
    • Capsules or tablets containing nuciferine (50 – 200 mg per serving) are common amongst shoppers aiming to drop some weight. Typically mixed with different pure components like inexperienced tea extract, garcinia cambogia, or caffeine for enhanced efficacy.
  • Total Well being – Help Formulations:
    • Included in multi – ingredient dietary supplements that concentrate on general well being, offering antioxidant, anti – inflammatory, and metabolic – boosting advantages.

2. Pharmaceutical Analysis

  • Drug Growth:
    • Investigated as a possible lead compound for growing medicine to deal with weight problems, metabolic syndrome, and neurodegenerative illnesses. Researchers examine its mechanisms of motion on the mobile and molecular ranges to discover new therapeutic methods.
  • Medical Trials:
    • Participates in pre – scientific and scientific trials to judge its security and efficacy in human topics for numerous well being circumstances, contributing to the development of medical science.

3. Useful Meals & Drinks

  • Fortified Merchandise:
    • Added to vitality bars, shakes, and purposeful drinks (0.05 – 0.2% focus) to boost their well being – selling properties. For instance, in weight – administration – centered drinks, nuciferine supplies an additional edge in supporting fats loss and metabolism.
  • Nutraceutical Meals:
    • Integrated into yogurt, granola, and different meals merchandise to supply shoppers purposeful choices that transcend fundamental vitamin, offering potential well being advantages associated to metabolism and general nicely – being.

Detection Strategies

  • Excessive – Efficiency Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Cellular Part: Acetonitrile – 0.1% formic acid (45:55, v/v), Movement Price: 1.0 mL/min, Detection Wavelength: 282 nm. This technique permits correct quantification of nuciferine in numerous samples, making certain product high quality and consistency.
  • Liquid Chromatography – Mass Spectrometry (LC – MS):
    • Ultimate for analyzing nuciferine in advanced matrices, corresponding to organic samples or multi – ingredient formulations. It presents excessive sensitivity and specificity, permitting for the detection of hint quantities and identification of associated compounds.
  • Nuclear Magnetic Resonance (NMR) Spectroscopy:
    • Used to verify the chemical construction of nuciferine by analyzing its attribute nuclear magnetic resonance indicators. This supplies detailed details about the molecular construction, serving to to differentiate it from different alkaloids and impurities.

Supply & Benefits

  • Natural Supply: Extracted from the leaves, seeds, or stems of Nelumbo nucifera (lotus plant), which is extensively cultivated in Asia. Using plant components which may in any other case be underutilized promotes sustainable useful resource use.
  • Potent Bioactivity: Its a number of well being – selling properties make it extremely invaluable within the well being and wellness trade, presenting alternatives for growing revolutionary merchandise.
  • Rising Market Curiosity: With the rising shopper demand for pure and efficient components for well being administration, nuciferine is attracting extra consideration from producers and researchers alike.
  • Regulatory Concerns: Whereas typically acknowledged as a pure compound, its use in several merchandise is topic to regulatory necessities in numerous areas. Making certain compliance with laws concerning dosage, security, and labeling is crucial for market entry and product success.
Categories: , , , , ,

Nuciferine | Natural Lotus Leaf Alkaloid Extract

Botanical Source: Nelumbo nucifera (Lotus Leaf)
Active Ingredient: Nuciferine ≥98% (HPLC)
CAS No.: 475-83-2
Appearance: Light yellow to off-white powder
Supplier: AIHerba® – Shaanxi Zhonghong Investment Technology Co., Ltd.
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com

1. Product Overview

Nuciferine is a natural aporphine alkaloid derived from the leaves of Nelumbo nucifera, commonly known as the lotus plant. Recognized for its fat metabolism regulation, sedative, and anti-obesity properties, nuciferine has become a key functional ingredient in nutraceuticals, weight management supplements, and cosmetic formulations.

At AIHerba®, we produce high-purity nuciferine extract using advanced water-ethanol extraction and chromatographic purification under GMP-certified conditions. Our production integrates 28 years of herbal extraction experience and strict analytical testing (HPLC, GC-MS, ICP-MS) to ensure batch consistency, safety, and verified potency.

2. Source & Manufacturing Process

Our lotus leaves are sustainably harvested from pollution-free regions in Hunan and Jiangsu, China.
The production process follows these key steps:

  1. Raw Material Selection: Mature lotus leaves are handpicked and shade-dried.

  2. Extraction: Water-ethanol extraction under controlled temperature (≤60°C).

  3. Concentration & Filtration: Removal of impurities and concentration under reduced pressure.

  4. Purification: Column chromatography to isolate nuciferine.

  5. Drying: Low-temperature vacuum drying to preserve active components.

  6. Quality Control: HPLC verification for purity ≥98%.

  7. Final Packaging: Hygienically sealed in GMP-certified facilities.

3. Key Benefits & Applications

✅ Weight Management:
Promotes lipid metabolism and inhibits adipogenesis; studied for its ability to reduce body fat accumulation.
(Reference: PubMed ID 31042426)

✅ Metabolic Support:
Helps regulate glucose and lipid levels, making it ideal for metabolic health formulations.
(NIH Source: Nuciferine and Lipid Metabolism Study)

✅ Calming and Mood Balance:
Acts as a mild sedative and dopamine receptor modulator—used in natural relaxant formulations.

✅ Cosmetic Applications:
Nuciferine’s antioxidant and anti-inflammatory effects support skin detox, brightening, and anti-aging products.
(Cosmetic grade nuciferine – GMP certified plant extract for cosmetics)

✅ Pharmaceutical Potential:
Emerging research supports its potential in treating non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome.

4. Product Specifications (Typical COA)

Category Item Specification / Limit Test Method
Physical & Chemical Appearance Light yellow powder Visual
Purity (Nuciferine) ≥98.0% HPLC
Moisture ≤5.0% GB 5009.3
Ash ≤3.0% GB 5009.4
Pesticide Residues Organochlorine pesticides ≤0.1 mg/kg GC-MS
Organophosphorus pesticides ≤0.1 mg/kg GC-MS
Heavy Metals Lead (Pb) ≤2.0 ppm ICP-MS
Arsenic (As) ≤1.0 ppm ICP-MS
Cadmium (Cd) ≤1.0 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm ICP-MS
Microbiological Tests Total Plate Count ≤1,000 CFU/g GB 4789.2
Yeast & Mold ≤100 CFU/g GB 4789.15
E. coli Negative GB 4789.3
Salmonella Negative GB 4789.4

5. Recommended Usage & Dosage

  • Dietary Supplements: 10–100 mg/day (capsule, tablet, or powder blend)

  • Functional Foods: 0.1–0.5% inclusion in beverages, nutrition bars, or slimming teas

  • Cosmetics: 0.05–0.2% in essence, serum, or body lotion formulations

Formulation Tip:
Combines synergistically with Green Tea Extract, Caffeine, and L-Carnitine for enhanced weight management and fat oxidation.

6. Application Industries

  • Dietary Supplements – weight management, anti-stress formulas

  • Functional Foods & Beverages – slimming teas, detox drinks

  • Pharmaceuticals – metabolic and hepatoprotective formulations

  • Cosmetics & Personal Care – anti-aging, detoxifying, brightening skincare

7. Packaging, Storage & Shelf Life

  • Packaging: 1 kg/aluminum foil bag; 25 kg/drum

  • Storage: Store in a cool, dry place, away from light and moisture

  • Shelf Life: 24 months under sealed conditions

8. Logistics, MOQ & Sample Policy

  • MOQ: 1 kg (bulk supply available)

  • Samples: Free sample herbal extract available for lab testing and formulation trials

  • Shipping: DHL, FedEx, air, or sea freight (customs documents provided)

  • Lead Time: 3–5 business days for stock items; 10–15 days for customized orders

9. Certifications & Quality Assurance

  • GMP Certified Manufacturer

  • ISO 9001, ISO 22000, and HACCP compliant

  • COA, MSDS, and third-party testing reports available upon request

  • Traceable origin & batch records

All AIHerba® ingredients meet EU and US regulatory standards for food-grade botanical extract supplier and dietary supplement raw material manufacturer.

10. Why Choose AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.)

With 28+ years of R&D and manufacturing experience, AIHerba® has grown into a trusted China-based plant extract supplier offering customized herbal extract solutions for global B2B clients.
We integrate supercritical CO₂, fermentation, and water-ethanol extraction technologies to ensure stable purity and bioavailability.

Whether you’re looking to buy bulk nuciferine, request a custom formulation, or need OEM & ODM factory support, AIHerba delivers consistent quality, competitive price, and global shipment with verified documentation.

11. Frequently Asked Questions (FAQ)

Q1: Is Nuciferine safe for daily consumption?
Yes. Studies and toxicology assessments show nuciferine is safe within normal supplement dosages. Always follow local regulatory guidelines.

Q2: Can I order a small quantity before bulk purchase?
Absolutely — we offer free sample herbal extract for testing before wholesale orders.

Q3: Is the product suitable for cosmetic use?
Yes. AIHerba provides GMP certified plant extract for cosmetics with cosmetic-grade purity and documentation support.

Q4: Do you provide customized herbal extract solutions?
Yes. Our R&D team supports customized herbal extract formulations tailored to specific active content or solubility requirements.

Q5: How can I verify the quality?
Each batch includes a COA, third-party lab report, and full traceability from raw material to finished product.

12. References

  1. Zhang X. et al., “Nuciferine regulates lipid metabolism via AMPK signaling pathway,” PubMed ID: 31042426

  2. NIH Natural Products Database: Nuciferine Monograph

  3. FDA GRAS Database (Lotus Leaf Extract Related Entries)

  4. Liu, S., et al. (2019). Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozotocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. Journal of Agricultural and Food Chemistry, 67(42), 11637-11646. (Metabolic Effects)

  5. Sugimoto, Y., et al. (2010). Serotonin receptor subtypes involved in the discriminative stimulus effects of nuciferine in rats. Psychopharmacology, 208(1), 23-30. (Neuropharmacology)

  6. Kashiwada, Y., et al. (2005). Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure–activity correlations with related alkaloids. Bioorganic & Medicinal Chemistry, 13(2), 443-448. (Bioactivity)

  7. Yan, Z., et al. (2021). Nuciferine protects against LPS-induced acute lung injury via inhibiting MAPK/NF-κB activation and NLRP3 inflammasome signaling pathway. International Immunopharmacology, 100, 108137. (Anti-inflammatory)

  8. Wang, J., et al. (2022). Nuciferine: A review of its pharmacology, pharmacokinetics, toxicity and clinical application. Journal of Ethnopharmacology, 298, 115650. (Review)

  9. ICH Q7: Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients.

  10. USP-NF General Chapters: <561> Articles of Botanical Origin, <62> Microbiological Examination of Nonsterile Products, <232> Elemental Impurities—Limits, <467> Residual Solvents.

  11. European Pharmacopoeia (Ph. Eur.) Monographs on Herbal Drugs and Extracts.

📦 Contact & Orders

For bulk purchase, technical data sheets, or custom formulations:
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com
🏭 AIHerba® | GMP Certified Herbal Extract Factory, Xi’an, China

请在浏览器中启用JavaScript来完成此表单。

Related products

滚动至顶部

Get a Quote & Sample

请在浏览器中启用JavaScript来完成此表单。

Get a Quote & Sample

Call Chat Email