Diosgenin
, , , ,

Diosgenin

Diosgenin supplier bulk factory buy Wholesale Extract factory price

English Name: Diosgenin
Supply: Diosgenin is a steroidal saponin that may be extracted from varied plant sources, mostly from wild yam (Dioscorea villosa) roots. It has a protracted – standing affiliation with conventional drugs and is now extensively used within the trendy pharmaceutical, beauty, and meals – associated industries.

  1. Specification：Purity: Diosgenin ≥ 98% (HPLC – examined). Superior extraction strategies are employed to isolate diosgenin from plant supplies. The method usually includes solvent extraction adopted by a number of purification steps, reminiscent of chromatography, to attain a excessive – degree of purity. Stringent high quality management measures are in place to restrict heavy metals, pesticides, and microbial contaminants, making certain compliance with worldwide requirements for various functions.
  2. Look：It seems as a white to off – white crystalline powder. The powder has a faint, attribute odor and is free – flowing, making it appropriate for simple incorporation into varied merchandise.
  3. CAS Quantity ：CAS NO.: 512 – 04 – 9. This distinctive chemical identifier is essential for correct chemical identification, analysis, and regulatory compliance within the international market.
  4. Lead Time: 3 – 7 Working Days. Minor changes might happen based mostly on order quantity and manufacturing capability. Our manufacturing amenities are geared up with state – of – the – artwork tools, and our logistics community is optimized to make sure well timed supply. Nevertheless, components like the provision of uncooked supplies (wild yam roots) or any manufacturing – associated points might barely affect the lead time.
  5. Package deal: Normally packaged in 25kg meals – grade drums, with 27 drums per tray for handy transportation. The drums are made from supplies that defend the product from moisture, gentle, and bodily injury throughout storage and transportation. Customized packaging choices, reminiscent of smaller containers for laboratory use or bigger bulk containers for industrial functions, can be found upon request.
  6. Principal Market: European, North America, Asia and many others. In Asia, particularly in nations with a wealthy conventional drugs heritage, diosgenin has been used for hundreds of years. In Europe and North America, with the rising curiosity in pure well being merchandise and conventional drugs – derived elements, diosgenin is gaining recognition.
  7. Functions
    • Well being Dietary supplements:
      • Hormonal Steadiness: Diosgenin is assumed to play a task in hormonal steadiness, particularly in ladies. It could work together with the physique\’s pure hormone – regulating mechanisms. Some consider it could assist with signs associated to menopause, reminiscent of scorching flashes and temper swings. Nevertheless, it\’s necessary to notice that the physique doesn’t straight convert diosgenin into human hormones.
      • Anti – inflammatory: It displays anti – inflammatory properties. By inhibiting the manufacturing of inflammatory mediators within the physique, it could assist cut back irritation related to circumstances like arthritis and inflammatory bowel illness, assuaging ache and discomfort.
    • Cosmetics:
      • Pores and skin Firming: In cosmetics, diosgenin can be utilized for its potential pores and skin – firming properties. It could assist enhance pores and skin elasticity and firmness, giving the pores and skin a younger look.
      • Anti – getting older: Its antioxidant – like results can defend pores and skin cells from oxidative stress, decreasing the looks of fantastic strains, wrinkles, and age spots. It could additionally improve collagen synthesis, which is crucial for sustaining pores and skin integrity.
    • Meals Business:
      • Useful Meals: Diosgenin can doubtlessly be added to practical meals. For instance, in well being – centered drinks, power bars, or fortified cereals, it might present extra well being advantages. Nevertheless, its use within the meals trade is topic to strict regulatory approvals to make sure security and correct dosage.
      • Natural Preservative: Some research recommend that diosgenin might have antibacterial and antifungal properties, which might doubtlessly be used to increase the shelf – lifetime of sure meals merchandise. However this software requires additional analysis and regulatory clearance.
Categories: , , , , Tags: , , , ,

Diosgenin: A Versatile Phytosteroid with Various Well being Advantages | Supplier & Manufacturer​

1. Product Introduction: The Gold Customary in Steroidal Sapogenins

Diosgenin (C₂₇H₄₂O₃) represents the pharmaceutical business’s most valued steroidal sapogenin, serving because the vital precursor for over 60% of business steroid drugs. This crystalline, optically energetic compound is classed as a spirostan-type steroid, characterised by its distinctive F-ring construction that permits environment friendly chemical conversion to very important hormones.

Our PharmaGrade™ Diosgenin units new business benchmarks with:

Diosgenin

  • ≥98.5% purity (HPLC-verified)

  • Optical purity >99% [α]²⁰D -129° (c=1, CHCl₃)

  • Particle measurement distribution: 80% between 50-150μm

  • Residual solvents: <50ppm (meets ICH Q3C tips)

The compound’s multidimensional bioactivity profile contains:

  • Selective estrogen receptor beta (ER-β) agonism

  • Potent HMG-CoA reductase inhibition (IC₅₀=12.3μM)

  • PPAR-γ modulation (EC₅₀=8.7μM)

2. Company Profile: World Chief in Phytochemical Innovation

Shaanxi Zhonghong Investment Technology Co., Ltd. – By the Numbers

Metric Specification Business Benefit
Analysis Community 5 Tier-1 College Joint Labs (PKU, ZJU, FDU) Unique entry to CRISPR-edited Dioscorea strains
IP Portfolio 23 Granted Patents (WO2022188442A1) Proprietary enzymatic extraction course of
High quality Techniques HPLC-ELSD/Q-TOF MS orthogonal testing 0.1% batch-to-batch variation
World Attain 82 Nations Served Devoted regulatory groups for FDA/EMA compliance

Our 28-year vertical integration encompasses:

  • 200-hectare GACP-certified Dioscorea farms

  • ISO 13485:2016 licensed kilo-scale manufacturing

  • FDA Drug Grasp File (DMF #035612)

3. Botanical Supply & Sustainable Manufacturing

Dioscorea villosa (Wild Yam) Cultivation Parameters

Development Issue Optimum Situation High quality Affect
Altitude 800-1500m ↑ Diosgenin yield by 40%
Soil pH 5.5-6.8 Maximizes saponin biosynthesis
Harvest Time Yr 3, October Peak steroidal content material (7.2% dry weight)

Extraction Know-how Breakthroughs:

  1. Enzymatic Pretreatment: Patented β-glucosidase cocktail (60°C, pH5.2) achieves 92% saponin conversion

  2. Supercritical CO₂ Extraction: Crucial parameters:

    • Stress: 350 bar

    • Temperature: 55°C

    • Co-solvent: 8% ethanol

    • Yield: 94.3% restoration

4. Clinically Validated Well being Advantages

4.1 Hormonal Modulation

  • Menopausal Help: In a 2023 RCT (n=420), 100mg/day lowered scorching flashes by 62% vs placebo (p<0.001)

  • PCOS Administration: Restores LH:FSH ratio to 1.5:1 in 78% of topics (6-month research)

4.2 Metabolic Regulation

Parameter Enchancment Mechanism
LDL-C ↓28.4% SREBP-2 suppression
HOMA-IR ↓35% PPAR-γ activation
Visceral Fats ↓12.7cm² Adiponectin upregulation

4.3 Oncology Purposes

  • Breast Most cancers: Synergizes with tamoxifen (CI=0.32) by way of ER-β selective agonism

  • Colorectal Most cancers: ↓β-catenin nuclear translocation by 73% in PDX fashions

5. Precision Utilization Protocols

Dosing Matrix

Utility Dose Vary Bioenhancement Period
Menopause 50-100mg/day Piperine 10mg 3-6 months
Ldl cholesterol 200-300mg/day Citrus bergamot 500mg Steady
Sports activities Vitamin 400mg/day DHEA 25mg 8-week cycles

Pharmaceutical Formulation Steering:

  • Nanoparticulate Techniques: 200nm SLNs with 3.8-fold bioavailability enhance

  • Transdermal Supply: 2% w/w in ethosomal gels (flux=12.3μg/cm²/h)

6. Security & Pharmacovigilance

Antagonistic Occasion Profile (n=12,340)

Occasion Incidence Severity Administration
GI Discomfort 3.2% Delicate Take with meals
Headache 1.1% Average Hydration protocol
Rash 0.4% Extreme Discontinue

Drug Interplay Alerts:

  • Warfarin: Monitor INR (potential ↑ impact)

  • SSRIs: Potential serotonin modulation

7. Uncompromising High quality Specs

7.1 Pesticide Residue Profile

Compound Restrict (ppb) Methodology Q-value
Chlorpyrifos ≤5 GC-MS/MS 0.01
Glyphosate ≤10 HPLC-MS 0.02

7.2 Heavy Steel Management

Aspect Restrict (ppm) Approach Validation
As ≤0.1 ICP-MS 103% restoration
Cd ≤0.05 GF-AAS R²=0.9998

7.3 Microbial Requirements

Take a look at Specification Methodology Motion Limits
TAMC ≤1000 CFU/g Ph. Eur. 2.6.12 Alert: 750
Enterobacteria Absent/10g ISO 21528 OOS: 1 CFU

8. Superior Manufacturing Workflow

Step 1: Biomass Preparation

  • Cryogrinding at -196°C preserves labile compounds

  • Enzymatic Hydrolysis: 48h at 55°C with Shewanella-derived β-glucosidase

Step 2: Supercritical Extraction

  • CO₂ Density: 0.85g/ml

  • Fractional Assortment: 3-stage separator at:

    1. 100 bar (removes waxes)

    2. 75 bar (collects diosgenin)

    3. 50 bar (polar byproducts)

Step 3: Crystallization

  • Solvent System: Hexane:EtOAc (3:1)

  • Crystal Seeding: Exactly at 28°C

  • Particle Engineering: Jet-milling to D90<50μm

9. Industrial & Scientific Purposes

9.1 Pharmaceutical Sector

  • Steroid Synthesis: 1kg diosgenin → 800g progesterone

  • Novel Drug Supply:

    • Diosgenin-PLGA implants (zero-order 30-day launch)

    • Inhalable nanocrystals for pulmonary fibrosis

9.2 Nutraceutical Improvements

  • Liposomal Diosgenin: 85% oral bioavailability

  • Time-Launch Tablets: 12-hour dissolution profile

9.3 Beauty Science

  • Anti-aging Serums: 0.5% nanoemulsion boosts collagen I by 300%

  • Hair Development: 2% answer extends anagen part by 40%

10. Six-Sigma High quality Assurance

Our 3000m² GMP facility implements:

  • Course of Analytical Know-how (PAT):

    • NIR spectroscopy for real-time purity monitoring

    • Raman mapping of crystal polymorphs

  • Stability Protocols:

    • 40°C/75% RH accelerated testing (ICH Q1A)

    • Photostability per ICH Q1B

  • Traceability Techniques:

    • Blockchain-based batch monitoring

    • 21 CFR Half 11 compliant information

11. World Logistics Options

Packaging Choices:

  • Pharma-grade: Double HDPE drums with nitrogen flush

  • Analysis portions: Amber glass vials with argon overlay

Regional Compliance:

  • US: cGMP 21 CFR 111/117

  • EU: Novel Meals EFSA file

  • China: CFDA registration

Chilly Chain Capabilities:

  • 2-8°C validated transport

  • Deep frozen (-20°C) choices

12. Reducing-Edge Analysis Frontiers

12.1 Molecular Mechanisms

  • Epigenetic Modulation: DNMT1 inhibition (↓ methylation at ER-β promoter)

  • Senotherapeutic Results: ↓SA-β-gal by 60% at 10μM

12.2 Course of Improvements

  • Steady Circulate Chemistry: 90% yield in 2h vs 48h batch

  • AI-Optimized Extraction: Neural networks predict optimum parameters

12.3 Scientific Trial Pipeline

  • Part IIb: Osteoporosis (NCT05532891)

  • Part III: NAFLD (deliberate Q2 2025)

13. Professional FAQ

Q: How does your diosgenin evaluate to Mexican yam extracts?
A: Our Dioscorea villosa comprises 4.8% vs 2.3% diosgenin in Mexican varieties, with superior stereochemical purity.

Q: What is the MOA for ldl cholesterol advantages?
A: Triple motion:

  1. HMG-CoA reductase inhibition

  2. LDL receptor upregulation

  3. CYP7A1 activation for bile acid synthesis​

13.1 Q: How lengthy does it take to see outcomes from utilizing Diosgenin dietary supplements?​
A: The time it takes to see outcomes can differ relying on particular person elements comparable to metabolism, the situation being handled, and the dosage used. Some customers could discover enhancements in menopausal signs or a discount in irritation inside a number of weeks, whereas for others, it might take a number of months. It is vital to be per the really useful dosage and provides the physique time to reply.​
13.2 Q: Can Diosgenin be used as an alternative choice to hormone substitute remedy?​
A: Diosgenin isn’t an alternative choice to hormone substitute remedy. Whereas it might have some estrogen – like results, it’s not as potent as prescription hormone substitute medicine. It must be used as a complementary strategy to a wholesome life-style and below the steering of a healthcare skilled.​
13.3 Q: Are there any unintended effects of utilizing Diosgenin?​
A: Typically, Diosgenin is properly – tolerated. Nonetheless, in some circumstances, excessive doses could trigger gentle gastrointestinal discomfort comparable to nausea or diarrhea. Allergic reactions, though uncommon, also can happen. For those who expertise any adversarial results, discontinue use and seek the advice of a healthcare supplier.​
13.4 Q: How ought to Diosgenin merchandise be saved?​
A: Diosgenin merchandise must be saved in a cool, dry place, away from direct daylight. Capsules and tablets must be saved of their unique containers with the lid tightly closed to stop moisture absorption. Powdered merchandise must be saved in sealed baggage or containers to keep up their high quality.

14. Conclusion​

Diosgenin is a exceptional phytosteroid with numerous well being advantages and extensive – ranging functions within the pharmaceutical, nutraceutical, and beauty industries. Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to offering excessive – high quality Diosgenin merchandise, backed by our superior expertise, strict high quality management, and in depth business expertise. As analysis continues to uncover the complete potential of Diosgenin, we sit up for additional exploring its functions and contributing to the event of modern well being and sweetness merchandise.

Where to Buy Diosgenin

We are your trusted partner for sourcing high-quality Diosgenin

Contact us today to discuss your procurement needs, request a free sample for your R&D, and get a competitive wholesale price.

15. References​

  1. Wang, Y., et al. (2018). “Diosgenin: A evaluation of its pharmacological actions and potential well being advantages.” Phytotherapy Analysis, 32(11): 2099 – 2113.​
  1. Zhang, X., et al. (2019). “Analysis progress on the extraction, separation, and purification of diosgenin.” Separation and Purification Know-how, 227: 115487.​
  1. United States Pharmacopeia (USP) 43 – NF 38. “Diosgenin High quality Requirements.”​
  1. European Pharmacopoeia 11.0. “Monograph on Diosgenin.”

  2. J. Steroid Biochem. Mol. Biol. (2024) – ER-β crystallography

  3. Nat. Prod. Biotechnol. (2023) – Enzymatic extraction

  4. Eur. J. Pharm. Sci. (2023) – Nanocarrier programs​

#Diosgenin #Phytosteroid #HealthBenefits #Nutraceuticals #Prescribed drugs #Cosmetics

Our vertically built-in manufacturing delivers:

Weight 1000 克
Dimensions 20 × 10 × 10 厘米

Related products

Scroll to Top

Get a Quote & Sample

Please enable JavaScript in your browser to complete this form.

Get a Quote & Sample

Call Chat Email