1. Berberine HCl – High-Purity Bulk Supplier & GMP-Certified Manufacturer
AIHerba® offers premium Berberine HCl powder with ≥98% purity (HPLC) for pharmaceutical, nutraceutical, and dietary supplement applications. As a leading China-based plant extract manufacturer and exporter, we provide bulk, wholesale, and custom packaging solutions tailored for B2B buyers worldwide. All batches are accompanied by COA, heavy metal, pesticide residue, and microbial testing reports, ensuring compliance with international quality standards. With over 28 years of extraction and production experience, AIHerba® integrates advanced water-ethanol extraction and microbial fermentation technologies to deliver consistent purity, stability, and efficacy. We support fast global shipping, MOQ as low as 1 kg, and OEM/ODM customization for functional ingredients. Partner with AIHerba® for a reliable, traceable, and professional Berberine HCl supply chain to accelerate your product development and market growth.
2. Product Overview
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English Name: Berberine Hydrochloride
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CAS Number: 633-65-8
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Molecular Formula: C20H18ClNO4
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Appearance: Yellow to yellow-orange crystalline powder
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Solubility: Water-soluble; soluble in DMSO, ethanol
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Purity: ≥98% (HPLC)
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Applications: Dietary supplements, functional foods, pharmaceutical intermediates, cosmetic formulations
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Origin: China (GMP-certified facility, Shaanxi Zhonghong Investment Technology Co., Ltd.)
3. Mechanism & Benefits (Scientific, Non-Therapeutic)
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Supports cellular metabolism and natural plant alkaloid activities in research and functional formulations.
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Used as an active compound in nutraceuticals, enhancing ingredient functionality in dietary supplements.
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Offers consistent chemical profile and stability, enabling standardized formulation development.
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Traditionally derived from Coptis chinensis (Chinese Goldthread) root, used in historical botanical formulations.
4. Usage Guidance & Formulation Recommendations
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Recommended for dietary supplements, functional foods, or nutraceutical blends.
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Commonly incorporated in capsules, tablets, or powder blends with stabilizing excipients.
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Suggested formulation ratio depends on product type; consult R&D for customized dosage and delivery methods.
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Avoid direct health claims; ensure compliance with local regulatory labeling standards.
5. Technical Parameters & COA
| Parameter Type | Name | Specification | Test Method |
|---|---|---|---|
| Purity | Berberine HCl | ≥98% | HPLC |
| Appearance | Powder | Yellow to yellow-orange crystalline | Visual |
| Solubility | Water/Ethanol | Soluble | USP/EP |
| Moisture | Water Content | ≤5% | KF Titration |
| Ash | Total Ash | ≤1% | AOAC |
Pesticide Residue
| Name | Limit | Test Method |
|---|---|---|
| DDT | ND | GC-MS |
| Aldrin/Dieldrin | ND | GC-MS |
| Other organochlorine pesticides | ND | GC-MS |
Heavy Metals
| Name | Limit | Test Method |
|---|---|---|
| Lead (Pb) | ≤2 ppm | AAS |
| Arsenic (As) | ≤1 ppm | AAS |
| Mercury (Hg) | ≤0.1 ppm | AAS |
| Cadmium (Cd) | ≤1 ppm | AAS |
Microbial
| Name | Limit | Test Method |
|---|---|---|
| Total Plate Count | ≤1000 CFU/g | AOAC |
| Yeast & Mold | ≤100 CFU/g | AOAC |
| E. coli | Negative | AOAC |
| Salmonella | Negative | AOAC |
| Staphylococcus aureus | Negative | AOAC |
6. Production Process
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Raw Material Selection: High-quality Coptis chinensis root, traceable sourcing
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Extraction: Water-ethanol extraction / microbial fermentation
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Filtration & Concentration: Remove impurities, concentrate active alkaloid
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Crystallization: Standardized purity via controlled conditions
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Drying & Milling: Ensure stable powder form, moisture control
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Quality Control: HPLC, heavy metals, pesticide residue, microbial testing
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Packaging: GMP-compliant bulk packaging or custom OEM options
7. Storage & Shelf Life
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Storage Conditions: Cool, dry, away from direct sunlight
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Shelf Life: 24 months in sealed containers
8. Packaging & MOQ
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Packaging: 25 kg/drum, 10 kg/drum, or customized
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MOQ: 1 kg for sample orders, bulk pricing available
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Shipping: Air/sea freight with customs support
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Samples: Available upon request; buyer pays shipping
9. Industry Applications & Use Cases
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Dietary Supplements: Incorporated in capsule blends for metabolic support (non-therapeutic labeling).
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Functional Food Formulations: Added to beverage powders or nutraceutical bars to enhance bioactive profile.
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Pharmaceutical Intermediates: Used as standardized raw material for lab-scale research and development.
10. Comparative & Procurement Guide
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Purity Comparison: AIHerba® ≥98% vs industry average 95–97%
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COA & Traceability: Full batch reports provided for every shipment
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Application Industry: Dietary supplement, functional foods, cosmetic actives
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Why Choose AIHerba®: 28+ years production experience, GMP certification, ISO & HACCP standards, OEM/ODM flexibility, global shipping
11. FAQ
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What is the MOQ for Berberine HCl?
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Sample orders start at 1 kg; bulk orders negotiable.
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Can I receive a COA before purchase?
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Yes, full COA and test reports available for each batch.
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How is Berberine HCl packaged?
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Standard 25 kg/drum; OEM/custom packaging available.
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Which industries use Berberine HCl?
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Dietary supplements, functional foods, pharmaceutical R&D, cosmetic actives.
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Is AIHerba GMP-certified?
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Yes, with ISO, HACCP, and global export compliance.
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How long does shipping take?
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Depends on destination; typically 5–15 days via air or sea.
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12. References
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PubMed: Berberine HCl research overview
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FDA GRAS / regulatory guidance: FDA Dietary Ingredients
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NIH Natural Product References: NIH Natural Products
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USP / EP Pharmacopoeia standards
13. Contact & Inquiry
AIHerba® | China Natural Plant Extracts Supplier & OEM Factory
Partner with a GMP-certified Berberine HCl supplier with 28+ years of R&D and production experience. Bulk supply, COA verification, and global shipping ensured.
Bulk Supply & Technical Support
Get direct factory quotes, COA, and MSDS within 12 hours. We support bulk supply and custom specifications.
