Table of Contents
What is Chlorogenic Acid?
Chlorogenic Acid (CGA) is a potent polyphenol abundantly found in:
- ☕ Green coffee beans (primary source)
- 🌿 Artichokes, strawberries, apples
- 🍃 Eucommia ulmoides leaves
Chemically, it’s an ester of caffeic and quinic acid, functioning as a key antioxidant with clinically studied metabolic benefits.
Top 5 Science-Backed Benefits & Mechanisms
- Metabolic Health & Weight Management
- ⚡️ Boosts fat metabolism by modulating glucose-6-phosphatase (reduces liver glucose output)
- 📉 Lowers blood sugar spikes post-meal (Diabetes Care, 2019)
- Antioxidant Powerhouse
- 🛡️ Neutralizes free radicals 2x more effectively than green tea EGCG (Journal of Agricultural Food Chemistry)
- Cardiovascular Support
- ❤️ Reduces LDL oxidation and improves endothelial function (Hypertension Research, 2020)
- Neuroprotection
- 🧠 Crosses blood-brain barrier; reduces neuroinflammation markers
- Antimicrobial Activity
- 🦠 Effective against H. pylori, Candida, and oral pathogens
Chlorogenic Acid Applications
- 🦠 Effective against H. pylori, Candida, and oral pathogens
Chlorogenic Acid vs. Green Coffee Extract
| Factor | Chlorogenic Acid (Purified) | Green Coffee Extract |
|---|---|---|
| CGA Concentration | 20%-50%+ (Standardized) | 5%-20% (Variable) |
| Consistency | Batch-to-batch reliability | Fluctuates with crop |
| Applications | Pharma, supplements, functional foods | Basic supplements |
Dosing Protocol & Optimal Daily Intake
For End Products (Capsules/Tablets):
- Standard Dose: 120–300 mg/day (split into 2 doses)
- Weight Management: 200–400 mg/day pre-meals
- Functional Foods: 50–100 mg/serving (bars, shakes)
B2B Formulation Guidance:
1. Solubility: Use microencapsulated CGA for beverages (oil-soluble base)
2. Stability: Pair with antioxidants (e.g., rosemary extract) to prevent degradation
3. Synergies: Combine with chromium for glucose control
Best Practice: Start with 100 mg doses → clinically effective with minimal side effects.
Safety & Side Effects
- Generally Safe: EFSA/WHO-approved (ADI: ~5 mg/kg body weight)
- Rare Side Effects:
- Mild digestive upset (doses >400 mg)
- Jitteriness (when combined with caffeine)
- Contraindications:
- Pregnancy (limited data)
- Autoimmune disorders (theoretical immune modulation risk)
Critical Notes for Manufacturers
- Purity Matters:
- Demand ≥40% HPLC-verified CGA (avoid UV-spectrometry testing)
- Reject extracts with chlorogenic acid “equivalents”
- Extraction Method:
- ✅ Ethanol/water extraction (preserves bioactivity)
- ❌ Avoid chemical solvents (acetyl acetate)
- Certifications:
- Non-GMO, ISO 9001, FDA facility registration
Where to Buy Chlorogenic Acid (Bulk Quantities)
AIHerba Sourcing Advantages:
✅ Grade A Extracts: 20%/40%/50% CGA options
✅ Third-Party Testing: Heavy metals, pesticides, microbials (COA included)
✅ Customization: Powder/granules, organic/non-GMO, private labeling
✅ Global Compliance: FDA GRAS, EU Novel Food, Halal/Kosher
✅ MOQs: From 1kg (samples) to metric tons
Partner With Trust:
AIHerba supplies GMP-certified chlorogenic acid for supplement, food, and cosmetic industries.
✉️ Request quotes/custom specs: liaodaohai@gmail.com
Key Takeaways for Buyers
- CGA is a multifunctional nutraceutical with metabolic/antioxidant benefits
- Optimal dose: 200–300 mg/day for finished products
- B2B priority: ≥40% purity, ethanol extraction, full traceability
- AIHerba delivers:
- Lab-verified potency
- Competitive bulk pricing
- End-to-end regulatory support
References
- Tajik, N. et al. (2017). Chlorogenic Acid: A Comprehensive Review. Biomedicine & Pharmacotherapy.
- EFSA Panel. (2015). Safety of green coffee extracts. EFSA Journal.
- Onakpoya, I. et al. (2019). CGA for body weight loss. Diabetes Care.
- Mubarak, A. et al. (2012). Acute effects of CGA on glucose metabolism. Journal of Nutritional Science.
- FDA GRAS Notice No. GRN 000997 (2019).
Contact for Bulk Orders: liaodaohai@gmail.com
Disclaimer: Product specifications subject to technical datasheets. Not evaluated by the FDA for disease treatment.