Urolithin A (UA) has redefined the mitochondrial health category. However, standard Urolithin A faces significant industrial hurdles: low water solubility and poor oral bioavailability.
At AIHerba®, we have solved these bottlenecks through Cocrysta™ Technology—a proprietary hydrogen-bond cocrystal platform that pairs Urolithin A with L-Carnitine. This dossier provides the analytical evidence (HPLC, XRD, NMR) required for high-tier R&D and pharmaceutical-grade procurement.
01. Industrial Procurement Snapshot
30-Second Reference for Sourcing & Formulation Teams
| Parameter | Cocrysta™ Urolithin A (Co-crystal) | Standard Urolithin A (98% Pure) |
| Active Ingredient | Urolithin A + Levocarnitine | Urolithin A (CAS 1143-70-0) |
| Urolithin A Content | | |
| Bioavailability | 12.5x Cmax Increase | Standard |
| Identity Verification | ¹H NMR (400MHz) & XRD | COA Only |
| Solubility Profile | Enhanced Aqueous Dissolution | Lipophilic / Low Solubility |
| Synergy | Mitophagy + ATP Metabolism | Mitophagy only |
02. Cocrysta™ Technology: The Science of Molecular Embedding
Cocrysta™ is not a simple physical blend. It is a molecular co-crystal where Urolithin A and Levocarnitine are bonded via hydrogen bonds within a unique crystal lattice.
The 12.5x Bioavailability Advantage
The primary barrier to Urolithin A efficacy is its crystalline structure, which is difficult for the gut to break down. Cocrysta™ alters the crystal arrangement without changing the chemical identity of the UA molecule.
Enhanced Dissolution: Facilitates rapid dissociation in the intestinal environment.
Synergistic Delivery: Levocarnitine acts as a co-former that supports mitochondrial fatty acid transport, creating a dual-action energy formula.
03. Analytical Verification: The Proof is in the Peaks
At AIHerba®, we utilize the Agilent 1260 Infinity II platform to ensure every gram of Cocrysta™ meets the exact dosage required for premium synergistic formulations (e.g., UA + NMN).
HPLC Assay Performance (Batch U05520260721)
As shown in our Analytical Protocol (EX-UA-SOP-2026), our Cocrysta™ grade maintains:
Urolithin A Content: Verified
55.0% (on dry basis).Levocarnitine Content: Verified
40.0% (on dry basis).Chromatogram Integrity: Sharp, symmetrical peaks at approx. 8.1 min, with a clean baseline and zero significant unknown impurities.
04. Structural Characterization (XRD & NMR)
We provide the “Molecular Fingerprint” that commodity traders cannot match:
XRD (X-Ray Diffraction): Our characterization report shows distinct, high-intensity peaks at
2θ=19.59∘and 23.37∘. These peaks are the definitive signature of the Cocrysta™ lattice, proving the formation of a true co-crystal rather than a simple mixture.¹H NMR (400MHz): Confirms the absolute structural identity and ensures no isomerization occurred during the crystallization process.
05. Key Applications for Longevity Brands
Next-Gen Nootropics: Combining UA with Alpha-GPC for cognitive and mitochondrial support.
Mitochondrial “Power Stacks”: Using Cocrysta™ as the base for UA + NMN + Coenzyme Q10 formulas.
Sports Performance: Leveraging the 12.5x bioavailability boost for muscle recovery and endurance products.
Premium Capsules: Optimized bulk density (100% through 80 mesh) for high-speed encapsulation.
06. Strategic Sourcing: Why Global Brands Choose AIHerba®
GMP-Certified Manufacturing: Full control over synthesis and crystallization.
Zero Solvent Risk:
n-Hexane Not Used / Not Detected (GC-HS Verified).Heavy Metal Hardlines: Pb < 2.0 mg/kg, As < 1.0 mg/kg (ICP-MS).
Global Logistics: Validated DDP shipping to USA and EU hubs.
FAQ: Comprehensive Technical & Procurement Insights (PAA)
Q1: What is Urolithin A?
A: Urolithin A is a natural metabolite produced by gut bacteria from ellagitannins (found in pomegranates). It is the only known compound that clinically induces mitophagy (cellular housekeeping).
Q2: Is Urolithin A naturally found in pomegranate?
A: No. Pomegranate contains ellagitannins. You must have the specific gut microbiome (only 30-40% of people do) to convert them into Urolithin A. AIHerba provides the direct, pure metabolite to bypass this limitation.
Q3: What is Cocrysta™ Urolithin A?
A: It is a patented hydrogen-bond co-crystal of Urolithin A and L-Carnitine. It is designed to solve the solubility and bioavailability issues of standard UA powder.
Q4: Does cocrystal technology change the Urolithin A structure?
A: Absolutely not. The chemical structure of UA remains 100% intact. Only the physical arrangement (crystal lattice) is optimized to improve absorption.
Q5: How is Urolithin A purity tested?
A: We use a validated HPLC-DAD method at 305 nm. Standard COAs only show assay, but we provide the raw HPLC chromatograms and XRD data to prove structural integrity.
Q6: What is the difference between standard UA and advanced delivery UA?
A: Standard UA (98%) has very low oral absorption. Advanced delivery forms like Cocrysta™ provide a 12.5x increase in Cmax (peak blood concentration), meaning you need a lower dose for better results.
Q7: Can I use Cocrysta™ in a synergistic formula with NMN?
A: Yes. Cocrysta™ was specifically engineered for synergy. UA cleans the mitochondria (mitophagy), while NMN provides the fuel (NAD+), making them the “Gold Standard” stack for longevity.
Q8: What is the shelf life of AIHerba Urolithin A?
A: Our Cocrysta™ and 98% pure grades are stable for 24 months when stored in a cool, dry environment in their original vacuum-sealed packaging.
Q9: Does your material comply with California Prop 65?
A: Yes. Our heavy metal limits (Lead < 2.0ppm, Arsenic < 1.0ppm) are strictly controlled via ICP-MS to ensure global compliance.
Q10: Do you provide samples for R&D?
A: Yes, we provide 1kg Pilot Evaluation Kits which include the physical sample, HPLC data, NMR spectra, and XRD characterization.
07. Technical References & Authority
Nature Metabolism: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial health in humans.
FDA/GRAS: Safety evaluation of high-purity Urolithin A.
Bruker XRD Standards: Methodology for crystalline lattice characterization of HPAPIs.
In conclusion, Urolithin A is a strong compound with a variety of well being advantages. When selecting a Urolithin A complement, it is very important do thorough analysis and select dependable merchandise. As analysis on Urolithin A continues to progress, we will anticipate much more thrilling discoveries about its potential sooner or later.
Article Index
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[2] Chen, F., Lu, Ok., Bai, N., Hao, Y., Wang, H., Zhao, X., & Yue, F. (2024). Oral administration of ellagic acid mitigates perioperative neurocognitive issues, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling. Scientific Reviews, 14(1), 2509. doi:10.1038/s41598-024-53127-8
[3] Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., . . . Auwerx, J. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and will increase muscle perform in rodents. Nature Drugs, 22(8), 879-888. doi:10.1038/nm.4132
[4] D’Amico, D., Andreux, P. A., Valdés, P., Singh, A., Rinsch, C., & Auwerx, J. (2021). Affect of the Natural Compound Urolithin A on Well being, Illness, and Ageing. Traits in Molecular Drugs, 27(7), 687-699. doi:10.1016/j.molmed.2021.04.009
[5] Xia, B., Shi, X. C., Xie, B. C., Zhu, M. Q., Chen, Y., Chu, X. Y., . . . Wu, J. W. (2020). Urolithin A exerts antiobesity results by means of enhancing adipose tissue thermogenesis in mice. PLOS Biology, 18(3), e3000688. doi:10.1371/journal.pbio.3000688
[6] Ezzat-Zadeh, Z., Henning, S. M., Yang, J., Woo, S. L., Lee, R.-P., Huang, J., . . . Li, Z. (2021). California strawberry consumption elevated the abundance of intestine microorganisms associated to lean physique weight, well being and longevity in wholesome topics. Diet Analysis, 85, 60-70. doi:https://doi.org/10.1016/j.nutres.2020.12.006
[7] Singh, A., D’Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., . . . Rinsch, C. (2022). Urolithin A improves muscle energy, train efficiency, and biomarkers of mitochondrial well being in a randomized trial in middle-aged adults. Cell Reviews Drugs, 3(5), 100633. doi:https://doi.org/10.1016/j.xcrm.2022.100633
[8] D’Amico, D., Fouassier, A. M., Faitg, J., Hennighausen, N., Brandt, M., Konstantopoulos, D., . . . Singh, A. (2023). Topical software of Urolithin A slows intrinsic pores and skin growing old and protects from UVB-mediated photodamage: Findings from Randomized Medical Trials. medRxiv, 2023.2006.2016.23291378. doi:10.1101/2023.06.16.23291378
[9] D’Amico, D., Olmer, M., Fouassier, A. M., Valdés, P., Andreux, P. A., Rinsch, C., & Lotz, M. (2022). Urolithin A improves mitochondrial well being, reduces cartilage degeneration, and alleviates ache in osteoarthritis. Ageing Cell, 21(8), e13662. doi:https://doi.org/10.1111/acel.13662
[10] Singh, A., D’Amico, D., Andreux, P. A., Dunngalvin, G., Kern, T., Blanco-Bose, W., . . . Rinsch, C. (2022). Direct supplementation with Urolithin A overcomes limitations of dietary publicity and intestine microbiome variability in wholesome adults to realize constant ranges throughout the inhabitants. European Journal of Medical Diet, 76(2), 297-308. doi:10.1038/s41430-021-00950-1