Yohimbine Extract 98% Supplier

1. Yohimbine Extract ≥98% Supplier & Manufacturer (GMP) | Bulk / Wholesale Grade | COA & HPLC Assay | Factory Direct

AIHerba® supplies Yohimbine Extract ≥98% as a documentation-ready botanical active for qualified B2B buyers—brands, contract manufacturers, and ingredient distributors who require consistent release testing, traceable batches, and export-ready paperwork. Each lot is supported by a clear specification sheet, COA, and method-based testing (typically HPLC assay/identity, with contaminant controls available to match your target market). If your QA team needs chromatogram review, custom limits (heavy metals, pesticide panel, micro), or packaging alignment for production, we can prepare a spec pack for fast vendor qualification.
CTA: Request COA & Spec Sheet • Get Bulk Pricing & Lead Time

Quick Summary

• Ingredient name: Yohimbine (high-purity botanical extract) (sigmaaldrich.com)
• CAS No.: 146-48-5 (sigmaaldrich.com)
• Main applications: sports nutrition formulas, stimulant blends, men’s health formulations (where permitted), analytical reference/QC benchmarking (NCCIH)
• Typical purity: ≥98% (HPLC) (sigmaaldrich.com)
• Suitable industries: dietary supplements, functional formulations, cosmetic R&D, regulated-product R&D (documentation-led sourcing)

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2. What Is Yohimbine Extract ≥98%?

Yohimbine is an indole alkaloid associated with Pausinystalia yohimbe bark. In B2B supply chains, “Yohimbine Extract ≥98%” typically refers to a high-purity yohimbine material verified by HPLC and controlled under defined quality specifications for manufacturing use. (sigmaaldrich.com)

Benefits:

• High assay for predictable formulation math and blending control
• Documentation-ready for vendor onboarding (COA/SDS/TDS)
• Suitable for buyers requiring method-based QA review (HPLC/ICP-MS)

Applications:

• Supplement and functional formulations (market-dependent)
• R&D reference material benchmarking and method validation support (e.g., yohimbe/yohimbine quantification challenges in finished products) (NIST)

Dosage / Specification:
This page does not provide consumer dosage guidance. B2B use should be determined by your formulation team and market compliance review. We supply specification alignment, analytical support, and documents for your internal assessment.

Safety (compliance-first):
Yohimbe/yohimbine ingredients carry safety and labeling sensitivity in many markets; regulatory status varies and may be restricted. Procurement should be compliance-led, with traceable supply and verified assay to reduce mislabeling risk. (NCCIH)

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3. Detailed Technical Specifications

Item	Value / Range	Notes
Ingredient	Yohimbine (≥98% grade) (sigmaaldrich.com)	High-purity botanical active
CAS No.	146-48-5 (sigmaaldrich.com)	Yohimbine base
Molecular Formula	C21H26N2O3 (sigmaaldrich.com)	Reference chemistry
Molecular Weight	354.44 g/mol (sigmaaldrich.com)	For QA documentation
Assay Method	HPLC (sigmaaldrich.com)	Assay/identity
Typical Appearance	White to off-white powder	Spec-controlled
Mesh / Particle Size	80–120 mesh (or as specified)	Customizable by request
MOQ	1 kg	Bulk / wholesale available
Lead Time	3–7 days standard / 10–15 days custom	Production scheduling
Packaging	1 kg foil bag; 25 kg drum	Custom packaging available

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4. Product Source & Raw Material Origin

• Botanical source: Pausinystalia yohimbe (yohimbe) (NCCIH)
• Plant part: Bark
• Sourcing approach (B2B): audited supplier intake, incoming inspection, and batch mapping to ensure traceability in your procurement file.
• Origin statement: raw material origin and country-of-origin documentation are available as part of the export document set (as applicable).

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5. Mechanism of Action & Functional Properties (Non-medical)

From a functional ingredient perspective, yohimbine is widely described in scientific literature as an α2-adrenergic receptor antagonist. This functional profile is often used by R&D teams to categorize it within stimulant/alkaloid ingredient classes for formulation design and analytical method development.
Note: This statement is for technical classification and does not imply disease-related claims.

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6. Application-Relevant Benefits (Regulatory-Safe)

For professional formulators and QA teams, Yohimbine Extract ≥98% may support:

• Precision dosing math at the manufacturing stage (assay-defined raw material)
• Lower variability risk vs. low-assay bark extracts (assay verified by HPLC)
• Vendor qualification readiness through documentation and traceability
• Analytical clarity for finished-product testing and method validation (matrix effects and quantification challenges are well recognized) (NIST)

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7. Usage Guidelines & Formulation Recommendations (B2B)

• Use in controlled manufacturing environments with documented SOPs and lot-level release criteria.
• Align assay and contaminant limits to target market expectations and your internal spec (heavy metals, pesticides, micro).
• Request chromatogram/HPLC conditions if your lab needs cross-method comparability.
• For new launches, we recommend a staged approach: sample → pilot → first bulk lot with retained samples and COA matching.

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8. Traditional & Modern Industrial Applications

• Traditional context: yohimbe bark has a long history of use as a botanical preparation (context only).
• Modern industrial use: purified yohimbine materials appear in supplement supply chains and analytical workflows; however, market access varies and requires careful compliance review. (NCCIH)

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9. COA & Quality Control Specifications

9.1 Core COA Specification

Test Item	Specification	Method
Appearance	White to off-white powder	Visual
Assay (Yohimbine)	≥98.0%	HPLC (sigmaaldrich.com)
Identification	Positive	HPLC / IR
Loss on Drying	≤2.0%	USP
Residue on Ignition	≤0.3%	USP
Particle Size	80–120 mesh (or agreed)	Sieve

9.2 Pesticide Residue Panel

Pesticide Category	Limit (typical)	Method
Organochlorines	≤0.1 mg/kg	GC-MS
Organophosphates	≤0.1 mg/kg	GC-MS
Pyrethroids	≤0.1 mg/kg	GC-MS
Multi-residue screening	Complies (panel per request)	LC-MS/MS

9.3 Heavy Metals

Heavy Metal	Limit	Method
Lead (Pb)	≤2.0 ppm	ICP-MS
Arsenic (As)	≤1.0 ppm	ICP-MS
Cadmium (Cd)	≤1.0 ppm	ICP-MS
Mercury (Hg)	≤0.1 ppm	ICP-MS

9.4 Microbiology

Micro Test	Limit	Method
Total aerobic count (TAMC)	≤10,000 cfu/g	USP <61> enumeration (usp.org)
Yeast & mold (TYMC)	≤300 cfu/g	USP <61> enumeration (usp.org)
E. coli	Negative	USP specified microorganisms
Salmonella	Negative	USP specified microorganisms
Staphylococcus aureus	Negative	USP specified microorganisms

Residual solvents: controlled to agreed limits; testing available to align with buyer requirements (commonly ICH-aligned where requested).
Important QA note: final release scope and limits can be tailored to your target market and internal vendor standard.

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10. Manufacturing Process & Production Flow

Production overview (procurement-facing):

1. Supplier qualification & incoming inspection (identity, contamination screening as needed)
2. Pre-processing: cleaning → drying → milling
3. Extraction (controlled solvent system; process parameters documented)
4. Purification (chromatographic purification to concentrate yohimbine fraction)
5. Concentration & drying (validated conditions to protect quality attributes)
6. Milling/sieving (mesh control)
7. QC release testing (HPLC assay/ID; contaminants per agreed plan)
8. Packaging & labeling (lot code + traceability mapping)

Why this matters for buyers: this workflow supports repeatable lots and audit-ready records—critical in categories where labeling variability has been reported in market surveillance.

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11. Storage, Shelf Life & Packaging

• Storage: sealed, cool and dry; protect from light and moisture
• Shelf life: 24–36 months (unopened, per recommended storage)
• Packaging options:
  • 1 kg aluminum foil bag (inner)
  • 25 kg fiber drum (outer)
  • Custom packaging/labeling available for OEM supply chains

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12. MOQ, Sample Policy & Global Shipping

• MOQ: 1 kg (bulk supply available)
• Sample: free 10–20 g for qualified buyers (courier cost negotiable)
• Lead time: 3–7 business days standard; 10–15 business days for custom specs
• Shipping options: DHL / FedEx / UPS / air cargo / sea freight
• Export docs: commercial invoice, packing list, COA, SDS, COO (as applicable), labels, and forwarder-required paperwork

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13. Clinical Data & Scientific Research (Citation Only, No Medical Conclusions)

To support your R&D and QA documentation, the following sources are commonly referenced in technical and regulatory discussions:

• EFSA safety evaluation related to yohimbe/yohimbine context (regulatory review perspective). (efsa.onlinelibrary.wiley.com)
• NCCIH (NIH) safety and labeling considerations for yohimbe/yohimbine in supplements. (NCCIH)
• Analytical studies reporting variability/mislabeling issues in commercial supplement products (quality justification for assay-defined sourcing).
• NIST materials and guidance highlighting analytical challenges and standardization approaches for yohimbe/yohimbine quantification. (NIST)

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14. Applicable Industries

• Dietary supplement manufacturers (where permitted)
• Sports nutrition and functional formulation brands
• OEM/ODM contract manufacturing
• Ingredient distributors and trading partners (documentation-led procurement)
• Quality laboratories and R&D teams requiring assay-defined materials

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15. Industry Application Scenarios

1. Brand Launch with Strict Vendor Qualification (US/EU distributors)
   A brand requires a documentation-ready supplier: COA + SDS + TDS, plus chromatogram review and a defined pesticide plan. Yohimbine Extract ≥98% is sourced with lot-coded traceability and a release testing package to reduce labeling variability risk.
2. Contract Manufacturer Production Planning (pilot → scale-up)
   A CM runs a pilot blend using a sample lot, then locks the spec for bulk. They require consistent mesh, defined moisture/ash, and repeatable HPLC assay results to maintain finished-product uniformity across production runs.
3. Distributor Portfolio Standardization (multi-market requests)
   A distributor supports multiple destinations and needs flexible testing scope. They use a base spec (HPLC assay + micro) and add market-driven add-ons (ICP-MS metals, expanded pesticide panel, residual solvents) per customer request.

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16. Supplier Comparison & Procurement Guide

How procurement teams typically compare suppliers (quick checklist):

• Factory identity: real manufacturer vs. trading-only
• Assay credibility: HPLC assay method clarity; chromatogram availability (sigmaaldrich.com)
• Contaminant controls: ICP-MS metals + pesticide plan + micro methods (USP-aligned where requested) (usp.org)
• Traceability: lot-to-lot mapping, retention samples, CAPA readiness
• Documentation: COA/SDS/TDS + COO + statements (GMO/allergen/irradiation as applicable)
• Market awareness: compliance-first posture (status varies across countries) (NCCIH)

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17. FAQ

1. Can you provide a full COA for Yohimbine Extract ≥98%?
   Yes. COA includes assay and key quality parameters. Additional testing scope can be aligned to your internal spec.
2. Do you provide HPLC chromatograms and method details?
   Available upon request for QA review (chromatogram, method summary, and batch linkage).
3. Can you customize specifications (mesh, moisture, metals, pesticides)?
   Yes. Share your target market and internal limits; we confirm feasibility and lead time before order.
4. What are your MOQ and standard lead time for bulk supply?
   MOQ is 1 kg. Standard lead time is 3–7 business days; custom specs typically 10–15 business days.
5. What packaging and labeling options are supported for OEM supply chains?
   Standard 1 kg foil bag and 25 kg drum; custom packaging/labels are available for OEM/ODM workflows.
6. Which documents can you provide for import and vendor onboarding?
   COA, SDS, TDS/spec sheet, COO (as applicable), and traceability records; third-party test reports available on request.

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19. References & Regulatory Sources

NIH / NCCIH – Yohimbe: Usefulness and Safety
https://www.nccih.nih.gov/health/yohimbe

EFSA Journal (2013) – Scientific Opinion on the evaluation of the safety in use of Yohimbe (Pausinystalia yohimbe) – DOI:10.2903/j.efsa.2013.3302
https://efsa.onlinelibrary.wiley.com/doi/pdfdirect/10.2903/j.efsa.2013.3302
https://www.efsa.europa.eu/fi/efsajournal/pub/3302

FDA (PDF) – discussion of yohimbine quantities found in supplements (reference to mislabeling concerns)
https://www.fda.gov/media/108522/download

Peer-reviewed analytical study (Drug Testing and Analysis, 2015) – Pharmaceutical quantities of yohimbine found in dietary supplements in the USA
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dta.1849

NIST – Standard for quantifying yohimbe in dietary supplements (SRM 3383)
https://www.nist.gov/news-events/news/2024/04/standard-quantifying-yohimbe-dietary-supplements
https://www.nist.gov/publications/certification-standard-reference-materialr-3383-yohimbe-containing-solid-oral-dosage

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Manufacturer & Quality Assurance

Manufactured by AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.),
a GMP-certified manufacturer specializing in high-purity botanical extracts
for dietary supplements, cosmetics, and pharmaceutical applications.
✔ GMP-certified production facility
✔ Full COA & technical specifications available
✔ Batch traceability & strict quality control
✔ Bulk supply & OEM/ODM services for global B2B buyers
📧 sales@aiherba.com
| info@aiherba.com
| liaodaohai@gmail.com
🌐 www.aiherba.com

If you are looking for a bulk supplier / OEM manufacturer of Yohimbine Extract ≥98%, contact us for specifications, COA, and pricing.