1. Vitamin D2/D3 Bulk Supplier & GMP Manufacturer | Food/Pharma/Cosmetic Grade | Wholesale OEM/ODM
AIHerba® supplies Vitamin D2 (ergocalciferol) and Vitamin D3 (cholecalciferol) as bulk raw materials for supplement brands, contract manufacturers, food & beverage fortification plants, and distributors. As a GMP manufacturer and wholesale supplier, we support B2B procurement with clear specifications, batch traceability, and export-ready documentation (COA, MSDS, stability data).
Choose from oil concentrate (for softgels and premixes) or micro-encapsulated / spray-dried powder (for tablets, gummies, beverage premixes, and functional foods). Typical orders include pilot batches for formulation validation and scale-up supply for ongoing production.
Request a quotation for MOQ, lead time, available potency (IU/g), and packaging options—our team can provide an application-matched recommendation and a compliant technical pack for your QA review.
Quick Summary
- Ingredient name: Vitamin D (Vitamin D3 / Cholecalciferol; Vitamin D2 / Ergocalciferol)
- CAS No.: D3 67-97-0; D2 50-14-6 (eCFR)
- Main applications: Dietary supplements, food & beverage fortification, premixes, cosmetics (formulation active), veterinary nutrition
- Typical purity: ≥ 99% (HPLC) (active assay; form-dependent)
- Suitable industries: Supplement brands, OEM/ODM factories, dairy/plant-based beverage producers, cereal/nutrition bar manufacturers, cosmetics manufacturers, distributors
2. What Is Vitamin D (D2/D3)?
Vitamin D refers mainly to Vitamin D3 (cholecalciferol) and Vitamin D2 (ergocalciferol)—fat-soluble ingredients widely used in fortification and supplement manufacturing. In industrial supply, Vitamin D is typically delivered as (1) crystalline active for further processing, (2) oil concentrate for softgels and liquid drops, or (3) micro-encapsulated powder to improve handling, dispersion, and stability in dry blends.
Benefits
- Commonly used to support calcium and phosphorus utilization in nutritional formulations (a functional nutrition role widely described in professional references).
- Frequently selected for seasonal nutrition product positioning and daily wellness SKUs (label-compliant, non-medical language).
- In topical formulations, Vitamin D derivatives/actives are used in niche product concepts where formulators prioritize barrier-support narratives (country/region compliance dependent).
Applications
- Dietary supplements: softgels, capsules, tablets, gummies, drops, multivitamin blends
- Functional foods & beverages: fortified dairy, plant-based milks, cereals, nutrition bars, powdered beverage mixes (process choice depends on heat/light exposure)
- Cosmetics: selected emulsions/serums where permitted (regulatory review required per market)
- Veterinary nutrition: feed premixes and pet supplements
Dosage / Specification
- Ingredient supply is commonly quoted by potency (IU/g) and assay by HPLC. For finished products, dosage decisions are the brand’s responsibility and must align with local regulations and labeling rules. For background nutrient reference values and professional context, see NIH resources.
Safety
Vitamin D is a nutrient ingredient; however, over-fortification is not acceptable. Formulators should validate target potency, homogeneity, and stability, and confirm label claims per market rules. This page does not provide medical advice.
Supplier / Manufacturer
AIHerba® supports B2B buyers with COA/MSDS, batch traceability, compliant packaging, and application-oriented options (oil vs encapsulated powder). We can align documentation requirements for supplement, food fortification, or cosmetic supply chains.
3. Detailed Technical Specifications
| Item | Vitamin D3 (Cholecalciferol) | Vitamin D2 (Ergocalciferol) |
|---|---|---|
| CAS No. | 67-97-0 (eCFR) | 50-14-6 (law.cornell.edu) |
| Molecular Formula | C27H44O (merckmillipore.com) | C28H44O (law.cornell.edu) |
| Molecular Weight | 384.64 g/mol (merckmillipore.com) | 396.65 g/mol (sigmaaldrich.com) |
| Typical Assay (active) | ≥ 99.0% (HPLC) | ≥ 99.0% (HPLC) |
| Potency Options (examples) | 500,000–1,000,000 IU/g (custom) | 500,000–1,000,000 IU/g (custom) |
| Solubility | Fat-soluble (oil systems) | Fat-soluble (oil systems) |
| Common Supply Forms | Oil concentrate; micro-encapsulated powder; premix | Oil concentrate; micro-encapsulated powder; premix |
| Recommended Storage | Cool, dry, protected from light/oxygen | Cool, dry, protected from light/oxygen |
4. Product Source & Raw Material Origin
- Vitamin D3 is commonly produced from lanolin-derived precursors via controlled UV conversion and downstream purification—consistent with descriptions in U.S. regulatory references. (eCFR)
- Vitamin D2 is commonly produced from ergosterol (yeast/fungi-derived) precursors via UV conversion and purification. (law.cornell.edu)
AIHerba® can provide an origin statement and technical pack suitable for supplier qualification (raw material declaration + traceability statement where applicable).
5. Mechanism of Action & Functional Properties (Non-medical)
From a formulation standpoint, Vitamin D’s value is tied to its role as a fat-soluble nutrient used to support normal nutritional functions in fortified foods and supplements. It is:
- Light-sensitive and benefits from protective packaging and controlled processing
- Oxidation-sensitive in certain matrices, so antioxidants/carriers and headspace control may be used
- Better suited to oil systems or encapsulated powders for dry blends and beverage premixes
6. Application-Relevant Benefits (Regulatory-Safe)
These are industry-use statements (not medical claims):
- Fortification ingredient for dairy and plant-based beverages (process-adapted forms improve dispersion and stability)
- Potency-driven raw material for supplement dosage formats (softgels/capsules/tablets/gummies)
- Formulation flexibility: oil concentrate for lipophilic delivery; micro-encapsulation for improved handling in powders
- QA-friendly supply: COA, assay methods, and traceability to support audit requirements
For regulatory context on adding vitamins/minerals to foods in the EU, see Regulation (EC) No 1925/2006 and the European Commission overview page. (EUR-Lex)
7. Usage Guidelines & Formulation Recommendations
Select the form based on your process:
- Softgels / liquid drops: oil concentrate is typically preferred for uniformity and processing
- Tablets / capsules / gummies / drink powders: micro-encapsulated or carrier-based powders improve blending, flowability, and dosing accuracy
Typical formulation notes (B2B):
- Use light-protective packaging and minimize high-temperature exposure during mixing
- Validate blend uniformity (especially at high potency)
- Confirm claim stability through shelf-life and accelerated studies (matrix-dependent)
- If formulating bone-health positioning SKUs, brands often co-formulate with Vitamin K2 (MK-7), calcium, and magnesium (market compliance required)
8. Traditional & Modern Industrial Applications
- Traditional: dairy fortification, cod-liver-oil style nutritional products (ingredient evolution into standardized potency supply)
- Modern: high-potency softgel SKUs, gummy supplements, plant-based beverage fortification, ready-to-mix powdered nutrition, premix systems for contract manufacturing
9. COA & Quality Control Specifications
9.1 COA Summary
| Parameter | Specification | Method |
|---|---|---|
| Appearance | White to off-white powder / oil concentrate (form-dependent) | Visual |
| Identification | Positive | HPLC / UV |
| Assay (Active) | ≥ 99.0% | HPLC |
| Loss on Drying | ≤ 1.0% | Gravimetric / USP-style |
| Residual Solvent | ≤ 0.5% | GC |
| Particle Size (powder) | 95% pass 80 mesh (optional) | Sieving |
| Heavy Metals (total, optional) | Meets internal/contract specs | ICP-MS |
9.2 Pesticide Residues
| Item | Limit (mg/kg) | Test Method |
|---|---|---|
| Organochlorine pesticides | ≤ 0.1 | GC-MS |
| Organophosphorus pesticides | ≤ 0.2 | GC-MS |
| Pyrethroids | ≤ 0.2 | GC-MS |
9.3 Heavy Metals
| Item | Limit (ppm) | Test Method |
|---|---|---|
| Lead (Pb) | ≤ 1.0 | ICP-MS |
| Arsenic (As) | ≤ 1.0 | ICP-MS |
| Cadmium (Cd) | ≤ 0.5 | ICP-MS |
| Mercury (Hg) | ≤ 0.1 | ICP-MS |
9.4 Microbiological Tests (Non-sterile)
| Item | Specification | Test Method |
|---|---|---|
| Total Plate Count | ≤ 1000 CFU/g | USP microbiological enumeration (e.g., USP <61> framework) (uspnf.com) |
| Yeast & Mold | ≤ 100 CFU/g | USP microbiological enumeration (e.g., USP <61> framework) (uspnf.com) |
| E. coli | Negative | USP specified microorganisms approach (method aligned to pharmacopeial practice) |
| Salmonella | Negative | USP specified microorganisms approach (method aligned to pharmacopeial practice) |
| Staphylococcus aureus | Negative | USP specified microorganisms approach (method aligned to pharmacopeial practice) |
Note: Final microbial specifications should match your product category, destination market, and internal QA standards. We can align the COA panel to your incoming inspection SOP.
10. Manufacturing Process & Production Flow
AIHerba® uses controlled conversion and purification with QA checkpoints designed for repeatable potency and stability.
Production Flow (typical):
- Raw material preparation (lanolin-derived or ergosterol source)
- UV conversion under controlled parameters (eCFR)
- Solvent extraction (food-grade solvent systems as applicable)
- Purification and crystallization (active standardization)
- In-process controls + HPLC assay
- Optional micro-encapsulation / spray drying (improved handling + stability)
- Final QA release (COA, traceability pack)
Diagram Alt Text (recommended): “Vitamin D manufacturing process: UV conversion, purification, HPLC testing, micro-encapsulation, final QA release”
11. Storage, Shelf Life & Packaging
- Storage: Keep sealed, cool and dry, protected from light and oxygen; avoid high humidity.
- Shelf life: Typically 24 months under recommended storage (matrix and packaging dependent).
- Packaging options (B2B):
- 1 kg aluminum foil bag (powder)
- 25 kg fiber drum (powder)
- Food-grade drums for oil concentrate (light-protective handling; temperature-managed shipping available)
12. MOQ, Sample Policy & Global Shipping
- MOQ: 1 kg for trial orders; bulk pricing typically at 25 kg+
- Sample policy: Samples available for qualification (COA included)
- Lead time: commonly 3–7 working days (stock-dependent; contract manufacturing schedules vary)
- Shipping: air/sea/express (DHL/FedEx/UPS) with export documentation, MSDS, and labeling support
CTA (procurement-ready): Send your target market (EU/US/Asia), required form (oil/powder), potency (IU/g), and annual volume—our team will return pricing, lead time, and the COA/MSDS pack.
13. Clinical Data & Scientific Research (Reference-Only; No Medical Conclusions)
Vitamin D has been widely studied in nutrition science and physiology. The NIH fact sheet summarizes background, dietary reference concepts, and safety considerations for general professional context.
Research literature also discusses vitamin D in immune-related pathways and other areas; conclusions depend on study design, baseline status, and dosage. Examples of peer-reviewed reviews/meta-analyses include publications on vitamin D and immune regulation and on depressive symptom outcomes. (OUP Academic)
14. Applicable Industries
- Dietary supplement brands, importers, and distributors
- OEM/ODM supplement factories (softgel, capsule, tablet, gummy)
- Functional food & beverage producers (dairy, plant-based, cereal, bars)
- Cosmetic manufacturers (where permitted; compliance review required)
- Veterinary nutrition and feed premix operators
15. Industry Application Scenarios (Real B2B Use Cases)
- EU plant-based beverage fortification (powder form): A private-label oat milk producer selects micro-encapsulated Vitamin D to improve handling in dry premix and reduce potency loss during processing; supplier qualification includes COA + stability data aligned to their QA checklist.
- Softgel OEM (oil concentrate): A contract manufacturer producing high-volume softgels uses Vitamin D oil concentrate for accurate dosing and fast blending; procurement focuses on potency consistency (IU/g), lead time, and batch-to-batch traceability for audits.
- Gummy supplement brand scale-up (encapsulated powder): A brand moving from pilot to monthly production chooses encapsulated powder to improve dispersion and reduce “hot spots” in blending; incoming QC verifies HPLC assay and microbial specs before release to production.
16. Supplier Comparison & Procurement Guide
How procurement teams typically compare Vitamin D suppliers:
- Potency & assay transparency: IU/g definition, assay method, batch variance limits
- Form selection: oil vs encapsulated powder (process fit + stability profile)
- Quality system: GMP/ISO scope, traceability, deviation handling, retention samples
- Regulatory alignment: documentation readiness for destination market
- Commercial terms: MOQ, tiered pricing, lead time, and logistics capability
Practical procurement checklist (send to suppliers):
- Required form (oil / encapsulated powder), target potency (IU/g), annual demand forecast
- COA template requirements + test methods
- Packaging and labeling requirements (food-grade, light-protective, palletization)
- Country import requirements + preferred incoterms
- Confirmation of batch traceability and change-control policy
17. FAQ
- Do you supply Vitamin D2 and Vitamin D3?
Yes—both D2 (50-14-6) and D3 (67-97-0) are available, depending on your market needs and product positioning. (law.cornell.edu) - Which form is best for my factory: oil or powder?
Oil concentrate is often chosen for softgels/liquid drops; encapsulated powder is usually better for tablets, gummies, beverage premixes, and dry blending where handling and uniformity are critical. - What documents can you provide for supplier qualification?
Standard package includes COA, MSDS, specification sheet, and batch traceability details. Additional documents can be provided based on your QA audit checklist. - What is your MOQ and typical lead time?
MOQ typically starts at 1 kg for trials; standard lead time is often 3–7 working days (subject to stock and customization). - Can you support OEM/ODM finished products?
Yes—AIHerba supports OEM/ODM for supplement and functional food projects, including format selection guidance (softgel/capsule/tablet/gummy) and documentation support. - How do you manage stability for a light-sensitive ingredient?
We recommend light-protective packaging, controlled storage, and choosing encapsulation/carriers aligned to your process. Stability data can be shared for qualification.
19. References & Regulatory Sources
- NIH Office of Dietary Supplements – Vitamin D Fact Sheet (Health Professionals): https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/
- U.S. eCFR – 21 CFR §184.1950 Vitamin D (food additive regulation context): https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-184/subpart-B/section-184.1950 (eCFR)
- Cornell LII – 21 CFR §184.1950 (accessible mirror): https://www.law.cornell.edu/cfr/text/21/184.1950 (law.cornell.edu)
- EU EUR-Lex – Regulation (EC) No 1925/2006 (addition of vitamins/minerals to foods): https://eur-lex.europa.eu/eli/reg/2006/1925/oj/eng (EUR-Lex)
- European Commission – Addition of vitamins and minerals (overview): https://food.ec.europa.eu/food-safety/labelling-and-nutrition/addition-vitamins-and-minerals_en (Food Safety)
- EFSA – Dietary Reference Values for vitamin D (Scientific Opinion PDF): https://www.efsa.europa.eu/sites/default/files/consultation/160321.pdf (European Food Safety Authority)
- USP General Chapter <61> (Microbial Enumeration Tests, reference PDF): https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/generalChapter61.pdf (uspnf.com)
Manufacturer & Quality Assurance
Manufactured by AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.),
a GMP-certified manufacturer specializing in high-purity botanical extracts
for dietary supplements, cosmetics, and pharmaceutical applications.
✔ GMP-certified production facility
✔ Full COA & technical specifications available
✔ Batch traceability & strict quality control
✔ Bulk supply & OEM/ODM services for global B2B buyers
📧 sales@aiherba.com
| info@aiherba.com
| liaodaohai@gmail.com
🌐 www.aiherba.com
If you are looking for a bulk supplier / OEM manufacturer of Vitamin D, contact us for specifications, COA, and pricing.
Bulk Supply & Technical Support
Get direct factory quotes, COA, and MSDS within 12 hours. We support bulk supply and custom specifications.
