Vinblastine
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Vinblastine

Vinblastine – COA, Specs, Applications & Factory Supply from AIHerba®

  1. English Name: Vinblastine
  1. Specification
    • Purity: Vinblastine sulfate ≥ 98% (HPLC); high – purity grade: ≥ 99% (HPLC)
    • Solubility: Soluble in water (as sulfate salt, ~50 mg/mL), methanol, and ethanol; insoluble in non – polar solvents
    • Appearance – Related: Loss on drying ≤ 1.0%, heavy metals ≤ 10 ppm, residual solvents ≤ 0.5%
    • Particle Size: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better dissolution in formulations
  1. Appearance
    • White to off – white crystalline powder (sulfate salt form), odorless
  1. CAS NO.：143-67-9 (Vinblastine); 2068 – 78 – 2 (Vinblastine sulfate)
  1. Lead time: 7 – 10 Working Days
  1. Package
    • 10 mg/vial (sterile glass vial), sealed under nitrogen; 100 mg/aluminum foil – lined bag for research – grade products
  1. Main Market: Global pharmaceutical and research markets, with significant demand in North America, Europe, and Asia, mainly for oncology treatment and biomedical research
  1. Application Scenarios

Core Properties

  • Molecular Formula: C₄₆H₅₈N₄O₉ (Vinblastine); C₄₆H₅₈N₄O₉·2H₂SO₄ (Vinblastine sulfate)
  • Chemical Structure: An indole – alkaloid derived from Catharanthus roseus (Madagascar periwinkle), consisting of a complex dimeric structure with two linked indole rings.
  • Key Features
    • Antimitotic Agent: Binds to tubulin, inhibiting microtubule polymerization and disrupting the mitotic spindle during cell division, leading to cell cycle arrest at the metaphase – anaphase transition.
    • Broad – Spectrum Antitumor Activity: Effective against various cancers, including Hodgkin’s lymphoma, non – Hodgkin’s lymphoma, testicular cancer, breast cancer, and lung cancer.
    • Low Bioavailability: Oral absorption is poor; typically administered intravenously for therapeutic use.
    • High Potency: Requires careful dosage control due to significant toxicity to rapidly dividing normal cells (e.g., bone marrow, gastrointestinal tract).

Application Scenarios

1. Oncology Treatment

  • Chemotherapy Regimens:
    • Hodgkin’s Lymphoma: A key component of the ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) regimen, achieving high remission rates (up to 80 – 90% in early – stage cases).
    • Testicular Cancer: Used in combination with cisplatin and bleomycin (PVB regimen), contributing to the high cure rate of testicular germ cell tumors.
    • Breast and Lung Cancer: Employed as a second – line or palliative treatment option, either alone or in combination with other chemotherapeutic agents.
  • Adjuvant Therapy:
    • Given after surgery or radiation to reduce the risk of cancer recurrence by targeting remaining cancer cells.

2. Biomedical Research

  • Cell Biology Studies:
    • Used as a tool to study microtubule dynamics, cell division mechanisms, and the role of the cytoskeleton in cell function. By disrupting microtubule formation, researchers can observe cellular responses to mitotic stress.
  • Drug Development:
    • Serves as a reference compound for the development of novel antimitotic drugs. Its structure inspires the synthesis of analogs with improved efficacy, reduced toxicity, and enhanced selectivity for cancer cells.
  • Cancer Resistance Research:
    • Investigated to understand how cancer cells develop resistance to microtubule – targeting agents. This knowledge helps in designing strategies to overcome resistance, such as combination therapies or novel drug delivery systems.

3. Veterinary Oncology

  • Cancer Treatment in Animals:
    • Administered to dogs and cats with certain types of cancers (e.g., lymphoma, mast cell tumors) at adjusted dosages based on body weight and species – specific pharmacokinetics.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% trifluoroacetic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 262 nm for quantification.
  • Liquid Chromatography – Mass Spectrometry (LC – MS):
    • Used for identifying vinblastine and its metabolites in biological samples, providing high – sensitivity detection and confirmation of the compound’s structure.
  • UV – Visible Spectroscopy:
    • Quick – screening method to estimate vinblastine concentration based on its characteristic absorption peak at 262 nm, useful for initial quality control and batch analysis.

Source & Advantages

  • Natural Source: Originally isolated from the leaves and stems of Catharanthus roseus. However, due to the low natural content (0.002 – 0.005% dry weight) and environmental considerations, semi – synthetic and synthetic production methods are increasingly used.
  • Therapeutic Significance: A cornerstone in cancer chemotherapy, having significantly improved survival rates for several types of cancer since its discovery.
  • Research Value: A fundamental tool in biological research, facilitating the understanding of basic cellular processes and driving innovation in cancer treatment strategies.

Regulatory Compliance

  • US FDA: Approved as an antineoplastic drug, strictly regulated under the Federal Food, Drug, and Cosmetic Act. Stringent manufacturing, labeling, and safety standards must be met for clinical use.
  • EMA (European Medicines Agency): Licensed for use in oncology, with continuous pharmacovigilance to monitor adverse effects and ensure patient safety.
  • China NMPA: Registered for clinical use in cancer treatment, subject to Good Manufacturing Practice (GMP) requirements and regular quality inspections.
Categories: ,

Buy Vinblastine in Bulk: Pharmaceutical-Grade Vinca Alkaloid Extract for Oncology Formulations

1. Product Overview: What Is Vinblastine?

Vinblastine is a well-known vinca alkaloid originally isolated from Catharanthus roseus (Madagascar periwinkle). It is widely used as an oncology API for research, drug development, and pharmaceutical production.
AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) supplies high-purity Vinblastine supported by GMP manufacturing, strict quality controls, and more than 28 years of extraction and pharmaceutical ingredient production experience.

Our Vinblastine is produced using modern extraction, purification chromatography, and pharmaceutical-grade finishing to ensure stable potency, verified purity, and global regulatory compliance.

2. Botanical Source & Extraction Origin

  • Botanical name: Catharanthus roseus

  • Plant part used: Leaves

  • Active compound: Vinblastine (Vinca alkaloid)

  • Production type: Purified plant-derived API

  • Grade available: Pharmaceutical, research, injectable-grade (upon request)

3. Key Benefits & Functional Advantages

Although Vinblastine is an oncology drug and not a dietary supplement, professional buyers typically evaluate the following attributes:

(1) Mechanism of Action

Vinblastine binds to tubulin and inhibits microtubule formation, interfering with mitosis and inducing cell-cycle arrest (G2–M phase).

(2) Verified Biological Benefits

  • Strong anticancer activity against lymphoma, testicular cancer, Kaposi’s sarcoma, and others (PubMed).

  • Often used in combination therapy (e.g., ABVD regimen).

  • Highly consistent purity when sourced from GMP-certified factories.

(3) Health-Related Uses (Pharma Only)

  • Oncology drug formulations

  • Clinical research

  • Injectable drug manufacturing

  • Bioscience laboratories and R&D institutes

Note: Vinblastine is a prescription anticancer drug. It is not intended for dietary supplements or nutraceuticals.

4. Usage Guide (For Industry Professionals Only)

Typical Pharmaceutical Dosage Forms

  • Injection (IV)

  • Lyophilized powder

  • Combination therapy formulations

Reference Dosage (Medical References Only)

Clinical dosages must be prescribed by licensed oncologists.
General reference: 6 mg/m² IV every 2 weeks (source: FDA label, NIH monographs).

Handling Guidelines

  • For trained personnel only

  • Use PPE

  • Store in controlled environment per ICH guidelines

5. Traditional Applications (Botanical Background)

The plant Catharanthus roseus has a long history in traditional medicinal systems for:

  • Blood sugar management

  • Traditional wound care

  • Herbal metabolic support

Modern oncology applications emerged after discovery of vinca alkaloids in the 1950s.

6. Recommended Formulation Guidance (B2B R&D)

While Vinblastine is used only in pharmaceuticals, buyers generally integrate it into:

  • Oncology therapeutic combinations

  • Novel drug delivery systems

  • Liposomal injection formulations

  • Controlled-release oncology drugs

  • R&D pipelines for anti-mitotic agents

7. Specifications & COA Summary (Example Batch Data)

✔ Product Specifications

Item Specification
Product Name Vinblastine
CAS 865-21-4
Molecular Formula C46H58N4O9
Molecular Weight 810.99
Purity ≥98% (HPLC)
Appearance White to off-white powder
Solubility Soluble in methanol, DMSO
Grade Pharmaceutical / Research

8. COA Table with Pesticides, Heavy Metals & Microbiology

A. Pesticide Residues

Item Limit Test Method
Organochlorine pesticides ≤0.1 mg/kg GC-MS
Organophosphorus pesticides ≤0.5 mg/kg GC-MS
Pyrethroid pesticides ≤0.2 mg/kg GC-MS
Carbamates ≤0.5 mg/kg LC-MS/MS
PAHs (Benzo[a]pyrene) ≤10 ppb HPLC-FLD

B. Heavy Metals

Item Limit Test Method
Lead (Pb) ≤2.0 ppm ICP-MS
Arsenic (As) ≤1.0 ppm ICP-MS
Cadmium (Cd) ≤1.0 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm ICP-MS
Total Heavy Metals ≤10 ppm ICP-OES

C. Microbiological Tests

Item Limit Test Method
Total Plate Count ≤1,000 CFU/g USP <61>
Yeast & Mold ≤100 CFU/g USP <61>
E. coli Negative USP <62>
Salmonella Negative USP <62>
Staphylococcus aureus Negative USP <62>

9. Production Process & Technology

✔ Our GMP Production Technology

  1. Raw Material Identification (Catharanthus roseus leaves)

  2. Solvent Extraction (water–ethanol selection)

  3. Fractionation & Purification

  4. Chromatographic Isolation of Vinblastine

  5. Crystallization & Concentration

  6. Vacuum Drying

  7. HPLC Purity Testing

  8. Final Sterilization / Micronization (upon request)

  9. GMP Packaging & Lot Traceability

Factory Capabilities

  • 28+ Years manufacturing

  • Supercritical CO₂ extraction

  • HPLC/UPLC purification

  • ISO9001, HACCP, GMP

  • In-house R&D and pilot production line

10. Applications & Industry Use-Cases

Industries Served

  • Pharmaceuticals

  • Oncology API manufacturers

  • Research institutions

  • Biotechnology companies

  • University laboratories

Application Scenarios

  • Anti-cancer drug production

  • Combination therapy research

  • Oncology innovation pipelines

  • Preclinical & clinical studies

11. Storage & Shelf Life

  • Storage: 2–8°C, keep in sealed containers, protected from light

  • Shelf Life: 24–36 months

  • Packaging: 1g / 5g / 10g / 100g sterile bottles; custom packaging available

12. MOQ, Sample Policy, Shipping

  • MOQ: 1 g

  • Free sample: Available for qualified R&D buyers (supports free sample herbal extract policy)

  • Shipping: FedEx, DHL, air freight with cold-chain option

  • Lead time: 3–5 working days for stock; 10–20 days for custom batches

  • Customized orders: Supports customized herbal extract and special purity requests

13. Certifications & Compliance

  • GMP workshop

  • ISO9001

  • ISO22000 / HACCP

  • COA, MSDS, HPLC chromatogram

  • Traceable batch records

  • Third-party testing (SGS, Eurofins available on request)

14. Why Choose AIHerba® as Your Vinblastine Supplier?

Our Strengths

  • 28 years of factory production experience

  • Stable supply chain of Catharanthus roseus

  • Strict quality control (GMP + advanced chromatography)

  • Global project experience with pharma clients

  • Competitive price, fast delivery

  • Trusted manufacturer, verified by global buyers

We support:

  • bulk Vinblastine supply

  • OEM/ODM formulation solutions

  • food-grade botanical extract supplier services for other ingredients

  • dietary supplement raw material manufacturer cooperation (other products)

15. Frequently Asked Questions (FAQ)

1. Can I buy Vinblastine directly from your factory?

Yes. AIHerba® is a GMP-certified manufacturer and supplier, providing bulk API quantities with full documentation.

2. Do you provide MSDS and analytical data?

Absolutely. COA + MSDS + HPLC + stability data are included for each batch.

3. Do you offer a wholesale price for large orders?

Yes. Clients placing large-volume or long-term contracts receive wholesale pricing.

4. What purity grades do you supply?

Standard ≥98% HPLC; custom higher-purity batches available.

5. Can you provide supporting documents for registration?

Yes—DMF-related documents, validation data, and impurity profiles available upon request.

16. Scientific References (PubMed / FDA / NIH)

  1. NIH – Vinblastine Drug Information: https://pubchem.ncbi.nlm.nih.gov

  2. FDA Label – Vinblastine Sulfate Injection

  3. PubMed: “Vinca alkaloids in cancer therapy”

  4. NCI – Vinblastine mechanism of action

17. Contact & Verification Information

AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd.
GMP-Certified Herbal Extract & API Manufacturer
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com

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