Squalane
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Squalane

The Final Information to Pharmaceutical-Grade Squalane: Supply, Science & Superior High quality

  1. English Name: Squalane
  1. Specification
    • Purity: ≥ 99% (GC)
    • Acid Worth: ≤ 0.1 mg KOH/g
    • Iodine Worth: ≤ 1.0 g I₂/100g
    • Peroxide Worth: ≤ 5.0 meq/kg
    • Solubility: Insoluble in water; soluble in natural solvents like ethanol, hexane, and vegetable oils
  1. Look: Clear, colorless to pale yellow liquid, odorless or with a really faint attribute odor
  1. CAS NO.: 111 – 01 – 3
  1. Lead time: 3 – 7 Working Days
  1. Bundle: 5 kg, 25 kg, 200 kg drums (meals – grade or beauty – grade containers)
  1. Primary Market: Europe, North America, Asia, and so forth.
  1. Software Situations

Key Properties

  • Stability: Chemically inert, proof against oxidation and hydrolysis, appropriate for lengthy – time period storage
  • Pores and skin Compatibility: Much like the sebum naturally produced by human pores and skin, with wonderful biocompatibility and low irritation
  • Moisturizing: Varieties a protecting movie on the pores and skin floor, decreasing water loss and sustaining pores and skin hydration
  • Emollient: Improves the spreadability of formulations, leaving a clean and non – greasy really feel
  • Penetration: Simply penetrates the pores and skin with out clogging pores, enhancing the absorption of different lively components

Software Situations

  1. Cosmetics and Private Care
    • Facial skincare: Utilized in lotions, lotions, serums, and facial oils (5 – 20% addition) to moisturize, restore the pores and skin barrier, and scale back effective traces
    • Physique care: Added to physique lotions, lotions, and oils to melt pores and skin and relieve dryness
    • Hair care: Included in shampoos, conditioners, and hair oils to nourish hair, scale back frizz, and enhance shine
    • Solar care: Utilized in sunscreens to boost texture and enhance the soundness of UV filters
  1. Pharmaceutical Trade
    • Topical formulations: As a base or excipient in ointments, lotions for treating dry pores and skin circumstances, eczema, and dermatitis
    • Transdermal supply techniques: Enhances the absorption of lively pharmaceutical components by means of the pores and skin
  1. Meals Trade
    • Additive in some excessive – finish cosmetics – grade meals merchandise (restricted use) for its emollient properties
  1. Different Industries
    • Leather-based care: Utilized in leather-based conditioners to melt and defend leather-based
    • Lubricants: Utilized as a excessive – purity lubricant in precision devices

Detection Strategies

  • Fuel Chromatography (GC): Column: HP – 5 (30 m × 0.32 mm × 0.25 μm), Service fuel: Nitrogen, Stream price: 1.0 mL/min, Detector: FID, Temperature program: 80°C (maintain 2 min) → 280°C at 10°C/min (maintain 10 min)
  • FTIR Spectroscopy: Attribute peaks at 2920 cm⁻¹, 2850 cm⁻¹ (C – H stretching), 1460 cm⁻¹ (C – H bending) for identification
  • Refractive Index: Measured at 20°C, typical vary 1.453 – 1.457

Benefits

  • Natural and Artificial Sources: Will be derived from shark liver oil (conventional supply) or plant – primarily based sources like olives, sugarcane, and rice bran (sustainable alternate options)
  • Security: Typically acknowledged as protected for beauty and pharmaceutical use, with low toxicity and minimal pores and skin irritation
  • Versatility: Suitable with a variety of components, appropriate for numerous formulations
  • Sustainability: Plant – derived squalane meets the rising demand for eco – pleasant and cruelty – free merchandise
Categories: , ,

Squalane (Olive / Sugarcane Derived) – High-Purity Cosmetic Grade | AIHerba® Factory Supply

1. Product Overview

Squalane is a highly stable, saturated hydrocarbon derived from hydrogenated squalene, naturally found in olive oil, sugarcane, and amaranth seeds. It is widely used in cosmetics, skincare, and pharmaceutical formulations due to its excellent biocompatibility, emollient properties, and oxidative stability.

AIHerba® supplies high-purity squalane (≥99%) manufactured under GMP and ISO-certified facilities using supercritical CO₂ extraction and catalytic hydrogenation technology, ensuring low peroxide value, high purity, and eco-friendly sourcing.

2. Botanical & Technical Source

Parameter Description
Common Name Squalane
Source Hydrogenated Squalene from Olive / Sugarcane
CAS Number 111-01-3
INCI Name Squalane
Molecular Formula C₃₀H₆₂
Appearance Clear, colorless, odorless liquid
Purity ≥99%
Production Method Supercritical CO₂ extraction + catalytic hydrogenation
Origin Shaanxi, China
Certifications GMP, ISO9001, ISO22000, Halal, Kosher

3. Key Benefits & Functions

  1. Deep Moisturization: Mimics natural sebum; enhances skin barrier repair.

  2. Anti-oxidative Protection: Prevents lipid peroxidation and protects against environmental stressors.

  3. Non-comedogenic Emollient: Lightweight, non-greasy texture suitable for sensitive and acne-prone skin.

  4. Improves Spreadability: Enhances texture and absorption of creams and serums.

  5. Stabilizer in Formulations: Improves shelf life and oxidative stability of actives.

  6. Anti-aging Effects: Supports collagen integrity and reduces fine lines via improved hydration.

4. Health & Dermatological Benefits

  • Skin Health: Enhances elasticity and smoothness; reduces transepidermal water loss (TEWL).

  • Hair Care: Strengthens cuticles, enhances shine, and reduces breakage.

  • Cosmetic Dermatology: Used in post-treatment skin recovery for its soothing and barrier-restoring properties.

  • Pharmaceutical Use: Carrier oil for topical formulations, ointments, and lipid-based drug delivery.

5. Applications & Recommended Usage

Industry Application Examples Recommended Usage
Cosmetics & Personal Care Moisturizers, serums, sunscreens, lipsticks, hair oils 2–15%
Pharmaceuticals Ointments, topical creams, transdermal patches 5–30%
Food & Nutraceuticals Functional lipid component, antioxidant agent 0.1–1%
Industrial / Specialty Use Lubricants, eco-friendly emollient bases As required

6. Traditional & Modern Applications

Traditionally sourced from deep-sea shark liver oil, modern biotechnology and plant-based extraction have replaced it with sustainable olive and sugarcane squalane, ensuring vegan and cruelty-free production.
Modern R&D recognizes it as a biomimetic lipid essential in anti-aging skincare and wound healing formulations.

7. Recommended Formulation & Compatibility

Best Formulation Partners:

  • Ceramide NP

  • Vitamin E (Tocopherol)

  • Sodium Hyaluronate

  • Retinol

  • Botanical Extracts (Centella Asiatica, Green Tea, Licorice)

Formulation Tips:

  • Add in the oil phase, stable under high temperature (≤80°C).

  • Compatible with most esters, silicones, and surfactants.

  • Ideal for emulsions, anhydrous serums, and lipid-based formulations.

8. Production Process

  1. Raw Material Selection – Olive/sugarcane squalene sourced from certified organic suppliers.

  2. Supercritical CO₂ Extraction – To isolate squalene.

  3. Catalytic Hydrogenation – Conversion to stable squalane.

  4. Vacuum Refinement & Filtration – Removal of impurities and stabilization.

  5. Quality Testing (GC, HPLC, ICP-MS) – Ensures purity ≥99%.

  6. Filling & Packaging – Under GMP-controlled conditions.

9. Typical COA Specifications

Category Item Specification Testing Method
Physical & Chemical Appearance Clear, colorless liquid Visual
Odor Odorless Sensory
Purity (GC) ≥99% GC
Peroxide Value ≤1.0 meq/kg ISO 3960
Heavy Metals Lead (Pb) ≤1.0 mg/kg ICP-MS
Arsenic (As) ≤1.0 mg/kg ICP-MS
Cadmium (Cd) ≤0.5 mg/kg ICP-MS
Mercury (Hg) ≤0.1 mg/kg ICP-MS
Pesticide Residues Organochlorine Pesticides ≤0.01 mg/kg GC-MS
Organophosphorus Pesticides ≤0.01 mg/kg GC-MS
Microbiological Total Plate Count ≤1000 CFU/g GB 4789.2
Yeast & Mold ≤100 CFU/g GB 4789.15
E. coli Negative GB 4789.3
Salmonella Negative GB 4789.4

10. Packaging, Storage & Shelf Life

Parameter Description
Packaging 1 kg, 5 kg, 25 kg food-grade HDPE drums or aluminum bottles
Storage Store in cool, dry, dark place below 25°C
Shelf Life 24 months (sealed, unopened)
MOQ 1 kg
Sample Policy Free 20–50 ml sample available for quality evaluation
Shipping Express (FedEx/DHL/UPS) for samples; air or sea freight for bulk orders

11. Applicable Industries

  • Cosmetics & Skincare – Moisturizers, facial oils, sunscreens, anti-aging products

  • Hair Care – Shampoos, conditioners, hair serums

  • Pharmaceuticals – Topical ointments, drug delivery systems

  • Food & Nutraceuticals – Functional lipid formulations

  • Industrial Applications – Eco-friendly lubricants and biodegradable base oils

12. Quality & Certifications

  • ✅ GMP, ISO9001, ISO22000 Certified Factory

  • ✅ Halal & Kosher Approved

  • ✅ COA, MSDS, and Third-Party Test Reports Available

  • ✅ Traceable Supply Chain & Batch QC Documentation

13. Factory & Production Experience

With 28+ years of extraction and hydrogenation expertise, AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) serves global brands and OEM factories across Asia, Europe, and North America.
Our modern production base integrates CO₂ extraction, refinement, and automated filling lines, ensuring consistent bulk quality for B2B supply and custom formulation projects.

14. FAQs

Q1: Is AIHerba’s squalane vegan and cruelty-free?
A: Yes, it is 100% plant-based, derived from olive or sugarcane, with no animal sources.

Q2: Can it be used in both oil-based and emulsion systems?
A: Absolutely. Squalane is compatible with both oil phases and emulsifiers.

Q3: What makes your squalane different from competitors?
A: AIHerba’s squalane is refined under GMP control, ensuring peroxide value ≤1 meq/kg and transparency suitable for premium skincare.

Q4: Do you support OEM/ODM bulk formulation?
A: Yes, AIHerba offers full OEM & ODM services for cosmetic and nutraceutical formulations.

15. References

  1. PubMed: Squalane as a Natural Emollient in Skincare Formulations

  2. NIH: Squalane’s Role in Skin Barrier Function and Lipid Metabolism

  3. FDA: GRAS Notice for Squalane (GRN 725)

16. Contact & Verification

📧 Email: sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 Website: www.aiherba.com
🏭 Factory: Shaanxi Zhonghong Investment Technology Co., Ltd. – GMP Certified Natural Extract Manufacturer
📍 Address: Xi’an, Shaanxi, China

 

  1. Huang, Z. R., et al. (2009). Biochemical Pharmacology, 78(11), 1462-1469. (Squalene/Squalane organic exercise).

  2. Kim, S. Okay., & Karadeniz, F. (2012). Advances in Meals and Vitamin Analysis, 65, 223-233. (Organic significance of squalene).

  3. Ottaviani, M., et al. (2010). Worldwide Journal of Beauty Science, 32(5), 347-353. (Squalane pores and skin absorption/barrier).

  4. US Pharmacopeia Nationwide Formulary (USP-NF). (Present Version). Monograph.

  5. European Pharmacopoeia (Ph. Eur.). (Present Version). Monograph.

  6. ICH Q3C (R8): Impurities: Guideline for Residual Solvents. (2023).

  7. ICH Q1A(R2): Stability Testing of New Drug Substances and Merchandise. (2003).

  8. Assessment articles on lipid nanoparticles (LNPs) and excipients in drug supply (e.g., in journals like Superior Drug Supply Evaluations, Worldwide Journal of Pharmaceutics).

  9. *Current research (2020+) on enzymatic synthesis or novel plant sources of squalene/squalane (e.g., in Inexperienced Chemistry, Journal of Agricultural and Meals Chemistry).*

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