Spermidine Bulk Supplier & Extract Guide for B2B Buyers

AIHerba® | China Natural Plant Extracts Supplier & OEM Factory
AIHerba (Shaanxi Zhonghong Investment Technology Co., Ltd.) is a GMP-certified manufacturer and exporter specializing in high-purity natural plant extracts. We provide bulk and wholesale botanical ingredients for cosmetics, pharmaceutical health products, functional foods, and dietary supplements. With over 28 years of R&D and production experience, we integrate modern extraction technologies—including supercritical CO₂ extraction, water-ethanol extraction, and microbial fermentation—to ensure high potency, stability, and purity. Our OEM & ODM services offer complete solutions for customized herbal formulations, natural flavors, and food & beverage additives, helping global partners accelerate product innovation and market expansion. Contact: 📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com 🌐 www.aiherba.com.

---

1. What is Spermidine? Overview & Science

Spermidine is a naturally occurring polyamine that plays a key role in cellular renewal by inducing autophagy, a process where cells remove damaged proteins and organelles to maintain optimal function. This compound is found naturally in foods such as wheat germ, aged cheese, soy products, mushrooms, legumes, nuts, and whole grains, and is also produced endogenously by the human body[^1].

For B2B buyers, spermidine extract represents a standardized, high-purity ingredient for functional foods, supplements, and cosmetic formulations, ensuring reproducible effects and regulatory compliance.

---

2. Scientific Evidence & Market Trends

Research indicates that spermidine may support:

1. Cellular Health & Longevity: Autophagy helps maintain healthy cells and may slow aging processes[^2].
2. Cardiovascular Health: Epidemiological studies show that higher spermidine intake correlates with reduced blood pressure and improved heart function[^3].
3. Neuroprotection: Spermidine may support cognitive function by clearing toxic proteins associated with neurodegenerative disorders[^4].

Market Insights:
Global demand for spermidine is growing in the nutraceutical and functional food markets, driven by consumer interest in longevity and cellular health. B2B buyers targeting supplement brands, functional beverage companies, and cosmetic formulations can leverage bulk, high-purity spermidine to meet this demand.

References:

• PubMed: Madeo et al., 2018
• Nature Cell Biology: Eisenberg et al., 2009
• Current Pharmaceutical Design: Soda et al., 2013
• NIH Neuroprotective Research

---

3. Dietary Sources vs. Industrial Extracts

Source	Spermidine Content	Notes for B2B Use
Wheat Germ	High	Raw material or extract for supplements
Aged Cheese	Moderate	Use in functional food products
Soy Products (Natto, Tofu, Miso)	Moderate	Fermented extracts available
Mushrooms (Shiitake, Maitake)	Low-Moderate	Extractable for powders/capsules
Legumes (Chickpeas, Lentils)	Low	Plant-based ingredient options
Whole Grains (Corn, Wheat, Rice Bran)	Low	Food-grade extract source
Nuts & Seeds	Low	Snack or powder formulations

B2B Insight: Industrial spermidine extract ensures consistent potency, HPLC certification, and easier integration into capsules, beverages, and functional foods compared to variable food sources.

---

4. Spermidine Raw Material Specifications

AIHerba® Spermidine Extract (Example Specs):

Parameter	Specification
Appearance	Yellowish-white crystalline powder
Purity (HPLC)	≥98%
Water Solubility	Soluble
Microbial Limits	<1000 CFU/g
Heavy Metals	<10 ppm
COA/MSDS	Provided per batch

B2B Advantage: Each batch includes full documentation, ensuring traceability, regulatory compliance, and quality assurance for supplement and functional food manufacturers.

---

5. Manufacturing Process & Quality Control

AIHerba uses advanced extraction technologies to maintain spermidine purity and stability:

• Supercritical CO₂ Extraction – for maximum bioactive retention
• Water-Ethanol Extraction – for standardized concentration
• Microbial Fermentation – for scalable production

Quality control measures include HPLC testing, microbial limit verification, heavy metal screening, and batch traceability.

---

6. Applications in Supplements & Functional Foods

• Capsules/Tablets: Stable powder form for daily supplements
• Functional Beverages: Soluble extracts for drinks and shakes
• Cosmetic Formulations: Anti-aging skin serums or creams

B2B buyers can choose customized formulations, leveraging AIHerba’s OEM/ODM services for private labeling, dosage optimization, and product innovation.

---

7. Regulatory & Compliance Overview

• US: Generally Recognized As Safe (GRAS) for food applications; dietary supplement compliance under FDA
• EU: Novel Food approval required for concentrated spermidine extracts
• Asia: Local supplement regulations vary; AIHerba ensures documentation and certifications for export

B2B Tip: Always verify local regulatory requirements before importing or using spermidine in functional foods or supplements.

References:

• FDA Dietary Supplements Guidelines
• EFSA Novel Food Guidance

---

8. How to Choose a Reliable Spermidine Supplier

B2B Checklist:

1. GMP/ISO-certified manufacturing
2. Batch-specific COA and MSDS
3. Bulk supply with MOQ flexibility
4. OEM/ODM service availability
5. Transparent production and traceable supply chain

AIHerba® provides all of the above, making it a trusted spermidine bulk supplier for global partners.

---

9. Bulk Pricing, MOQ & Lead Times

• MOQ: Typically 5–10kg per batch
• Lead Time: 3–7 business days for standard orders
• Pricing: Competitive wholesale rates, dependent on batch size and purity
• B2B Insight: Early engagement with suppliers ensures faster delivery and custom formulation support.

---

10. FAQ for B2B Buyers

Q1: Can I request a sample?
A1: Yes, AIHerba provides free sample testing (shipping costs apply) to verify quality and HPLC purity.

Q2: What documentation is provided?
A2: COA, MSDS, and batch-specific HPLC results are available for every shipment.

Q3: Is OEM/ODM service available?
A3: Yes, including private label formulation, dosage customization, and packaging solutions.

Q4: Are there any storage or stability considerations?
A4: Store in a cool, dry environment; stable for 24 months in sealed packaging.

Q5: Which regulatory certifications are supported?
A5: GMP, ISO, HACCP; documentation supports compliance with US, EU, and Asian regulations.

Q6: Can spermidine be used in beverages and capsules?
A6: Yes, AIHerba’s HPLC-tested extract is stable in dry powders, capsules, and water-based formulations.

---

11. Call to Action

• Request a Free Sample: Verify purity and potency
• Download COA/MSDS: For regulatory and QA documentation
• Consult Our OEM Experts: Custom formulations and private label solutions

Contact AIHerba® today to secure high-purity spermidine extract for your functional foods, supplements, or cosmetic products.
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com

---

References

1. Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018). Spermidine in health and disease. Science, 359(6374), eaan2788. PubMed
2. Eisenberg, T., Knauer, H., Schauer, A., et al. (2009). Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 11(11), 1305–1314. Nature
3. Soda, K., Kano, Y., & Chiba, F. (2013). Food polyamine and cardiovascular disease. Current Pharmaceutical Design, 19(4), 747–753. PubMed
4. Ramot, Y., & Paus, R. (2015). Spermidine boosts human hair growth. Journal of Investigative Dermatology, 135(4), 1152–1154. PubMed
5. FDA Dietary Supplement Guidelines
6. EFSA Novel Food Guidance