Silybin B
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Silybin B

Silybin B (High-Purity) – Premium Milk Thistle Active for Advanced Formulations | Bulk Supply & GMP Factory Source

  1. English Name: Silybin B
  1. Specification
    • Purity: ≥ 98% (HPLC)
    • Solubility: Slightly soluble in water; dissolves well in ethanol and acetone
    • Melting Point: Around 164-166°C
    • Loss on Drying: ≤ 0.5%
    • Heavy Metals: ≤ 10 ppm
  1. Appearance: Pale yellow crystalline powder with a mild, earthy smell – no chocolate vibes at all
  1. CAS NO.: 72581-71-6
  1. Lead time: 3-7 Working Days
  1. Package: 1g, 10g, 100g glass vials; 1kg aluminum containers; 25kg sealed drums (kept away from light)
  1. Main Market: Europe, North America, Asia, etc.
  1. Application Scenarios

Key Features

  • Liver Support: Known for helping protect liver cells and promoting healthy liver function
  • Antioxidant Power: Fights off harmful free radicals that can damage cells
  • Natural Origin: Comes from milk thistle (Silybum marianum) seeds
  • Bioactive: One of the main active components in milk thistle extract
  • Stability: Stays potent when stored in cool, dry places away from light

Industry Applications

  1. Dietary Supplements
    • Liver Health Formulas: Used in capsules (typically 50-200mg per serving) to support liver wellness
    • Antioxidant Blends: Added to supplements that focus on fighting oxidative stress
    • Wellness Supplements: Included in mixes aimed at overall health maintenance
  1. Pharmaceutical Research
    • Liver Support Studies: Being looked into for potential use in liver health medications
    • Antioxidant Therapies: Investigated for roles in treatments involving oxidative damage
  1. Nutraceuticals
    • Functional Drinks: Sometimes added to health drinks (in small amounts) for its benefits
    • Specialty Foods: Included in certain wellness-focused food products
Categories: , , , ,

Silybin B Ingredient Supplier – Pharmaceutical-Grade Extract for Liver Support & Antioxidant Applications

Silybin B – High-Purity Active from Milk Thistle Extract

GMP-Certified Manufacturer | Bulk Supply | COA Provided | Global Shipping

Silybin B is one of the major bioactive flavonolignans isolated from Silybum marianum (milk thistle). Recognized for its potent antioxidant, hepatoprotective, and anti-inflammatory activities, Silybin B is a preferred raw material in pharmaceutical formulations, liver support supplements, skincare products, and functional beverages.

AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) delivers high-purity Silybin B produced in our GMP-certified factory, supported by 28+ years of extraction experience and validated through stringent QC/QA systems, third-party tests, and traceable raw material sourcing.

1. Product Overview

Botanical Source: Silybum marianum (Milk Thistle)
Active Ingredient: Silybin B (one of the primary components of silymarin)
Appearance: Light yellow to off-white powder
Purity: 80% – 98% (HPLC)
Production Method: Supercritical CO₂ + Water–Ethanol Extraction + Crystallization
Supply Forms: Powder (custom specifications available)

2. Origin & Extraction

Our Silybin B is extracted from premium-grade milk thistle seeds cultivated in Northwestern China under traceable GAP programs.
Extraction combines:

  • Cold-press degreasing

  • Water–ethanol extraction

  • Supercritical CO₂ purification

  • Fine crystallization & micronization
    This ensures high purity, stable potency, and low solvent residue, consistent with pharmaceutical-grade requirements.

3. Key Benefits & Functions

3.1 Scientific Benefits

(1) Liver Protection
Supports detoxification pathways, reduces oxidative stress in hepatic cells, and assists liver regeneration (Referenced: NIH, PubMed 19700054).

(2) Antioxidant Power
Neutralizes free radicals and protects lipids and proteins from oxidative damage.

(3) Anti-inflammatory Support
Modulates inflammatory cytokines, contributing to joint, metabolic, and liver health.

(4) Skin Health
Helps reduce oxidative aging, supports cell repair, and is widely used in cosmeceuticals.

(5) Metabolic Support
Preclinical studies suggest benefits related to glucose metabolism and fatigue recovery.

3.2 Traditional Use

Milk thistle has been used for centuries in Mediterranean herbal medicine for liver support, antioxidant protection, and digestive health.

4. Health Applications

  • Dietary Supplements: Liver detox formulas, antioxidant blends, metabolic support

  • Pharmaceutical Enhancers: Herbal-based liver protection products

  • Cosmetics: Anti-aging creams, antioxidant serums, skin barrier support

  • Functional Foods & Beverages: Ready-to-drink tonics, herbal beverages

  • Sports Nutrition: Recovery formulas

5. Recommended Dosage

  • Dietary Supplements: 80–200 mg/day (depending on formulation)

  • Pharmaceutical Uses: According to medical guidelines

  • Cosmetics: 0.1–1% in finished formulations

Note: Usage should follow regional regulations.

6. Best Formulation Practices

  • Combine with phospholipids (enhanced bioavailability)

  • Use with NAC, curcumin, quercetin for liver and antioxidant synergy

  • Natural emulsifiers recommended for beverage applications

  • Consider microencapsulation for stability in sports powders and functional drinks

7. Product Specifications & COA Example

7.1 General Specifications

Item Specification Method
Appearance Light yellow to off-white fine powder Visual
Purity (Silybin B) ≥ 80–98% HPLC
Loss on Drying ≤ 2.0% USP
Residue on Ignition ≤ 0.5% USP
Solubility Soluble in ethanol —

7.2 Pesticide Residues

Category Name Limit Test Method
Organochlorines DDT, BHC < 0.1 ppm GC-MS
Organophosphates Chlorpyrifos < 0.1 ppm GC-MS
Pyrethroids Cypermethrin < 0.2 ppm GC-MS
Carbamates Carbaryl < 0.1 ppm HPLC

7.3 Heavy Metals

Name Limit Method
Lead (Pb) < 2 ppm ICP-MS
Cadmium (Cd) < 1 ppm ICP-MS
Mercury (Hg) < 0.1 ppm ICP-MS
Arsenic (As) < 1 ppm ICP-MS
Total Heavy Metals < 10 ppm ICP-OES

7.4 Microbiology

Item Limit Method
Total Plate Count < 1,000 cfu/g USP
Yeast & Mold < 100 cfu/g USP
E. coli Negative USP
Salmonella Negative USP
Staphylococcus aureus Negative USP
Coliforms Negative USP

8. Production Process

  1. Raw material cleaning & quality screening

  2. Cold-press degreasing

  3. Water–ethanol extraction

  4. Filtration & concentration

  5. Supercritical CO₂ purification

  6. Fine crystallization

  7. Vacuum drying

  8. Micronization

  9. Packaging in GMP-certified workshop

9. Storage & Shelf Life

Storage:
Store in a cool, dry, well-ventilated place away from direct sunlight.

Shelf Life:
24–36 months (unopened, under recommended storage conditions).

10. Packaging Options

  • 1 kg aluminum foil bag

  • 25 kg fiber drum

  • Customized packaging available (OEM/ODM)

11. Sample Policy

  • Free sample herbal extract (10–30 g) available for R&D teams

  • Freight collected or charged at cost

  • COA and technical documents available upon request

12. Transportation & MOQ

  • MOQ: 1 kg for lab testing / 25 kg bulk orders

  • Shipping Options: Air freight, sea freight, DHL/UPS/FedEx

  • Export documents: COA, MSDS, invoice, packing list, Origin certificate, etc.

  • Stable supply for large-scale bulk and wholesale orders

13. Suitable Industries & Application Scenarios

  • Nutraceutical & Dietary Supplement manufacturers

  • Pharmaceutical companies

  • Cosmetics & personal care product developers

  • Functional foods & beverages

  • Sports nutrition brands

  • OEM/ODM health product manufacturer networks

14. Why Work With AIHerba® (Shaanxi Zhonghong)

Expertise

28+ years of professional extraction, formulation, and OEM/ODM development.

Authoritativeness

  • GMP-certified production

  • ISO, HACCP, and third-party laboratory testing

  • Traceable supply chain & batch-level documentation

Trustworthiness

  • Real factory photos and manufacturing videos available

  • Strict QC from raw material to finished products

  • Transparent price, COA, and sample support

15. Frequently Asked Questions (FAQ)

Q1: Can I buy Silybin B in small test quantities?
Yes. MOQ starts at 1 kg, with free sample herbal extract for testing.

Q2: Do you provide customized herbal extract solutions?
Yes, including customized purity levels, particle sizes, and OEM formulations.

Q3: Are you a manufacturer or a trading company?
We are a GMP-certified manufacturer and direct factory supplier.

Q4: How stable is Silybin B in beverages or liquid formulas?
Stable under pH 5–7 with proper emulsifiers or microencapsulation.

Q5: Can you support documentation for regulatory review?
Yes—COA, MSDS, allergen statement, heavy metal test, microbial test, etc.

16. Scientific References

  • PubMed: “Silibinin and hepatoprotection” (PMID: 19700054)

  • NIH Natural Medicines Database

  • FDA Botanical Drug Development Guidance

17. Contact & Verification

AIHerba® – Shaanxi Zhonghong Investment Technology Co., Ltd.
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com

GMP certified plant extract for cosmetics, functional foods, and dietary supplements.

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