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Alpha-Ketoglutarate

  1. Product Overview
    English Name: Alpha-Ketoglutarate, often abbreviated as AKG
    Chemical Nature: It is a key intermediate in the Krebs cycle (also known as the citric acid cycle), which is central to cellular energy metabolism. AKG plays a crucial role in various biochemical processes within the body.
  2. Specification:Purity: Alpha-Ketoglutarate ≥ 98% (HPLC – tested). Stringent production and purification methods are employed to achieve this high level of purity. Rigorous quality control ensures minimal contaminants, such as heavy metals and microbial impurities, conforming to international standards for dietary supplements, cosmetics, and food ingredients.
  3. Appearance:It appears as a white crystalline powder. The powder is odorless or has a very faint, characteristic smell. It is free – flowing, facilitating its use in different formulations.
  4. CAS NO.: 328 – 50 – 7. This unique identifier is essential for chemical identification, research, and regulatory compliance.
  5. Lead Time: 3 – 7 Working Days. Minor adjustments may occur depending on order volume and production capacity. Our efficient production and logistics systems are designed to ensure timely delivery.
  6. Package: 25kg/drum, with 27 drums/tray. The drums are made of food – grade materials, providing excellent protection against moisture, light, and physical damage during storage and transportation. Custom packaging options are available upon request.
  7. Main Market: European, North America, Asia etc. It has a global market presence. In Europe and North America, it has gained significant popularity among fitness enthusiasts, athletes, and those interested in anti – aging and longevity research. In Asia, with a growing focus on health and wellness, it is also attracting attention.
  8. Applications
    • Health Supplements:
      • Energy Production: AKG is involved in the generation of adenosine triphosphate (ATP), the body\’s primary energy currency. Supplementing with AKG can potentially enhance athletic performance, reduce fatigue during exercise, and support overall physical endurance.
      • Muscle Building: It may contribute to muscle protein synthesis, helping to build and maintain lean muscle mass. This is beneficial for bodybuilders and those looking to improve their body composition.
      • Anti – aging: Some studies suggest that AKG can extend lifespan in certain organisms. In humans, it may help maintain cellular health by supporting mitochondrial function and protecting cells from oxidative stress, potentially slowing down the aging process.
    • Cosmetics:
      • Skin Rejuvenation: The anti – aging effects on skin cells involve promoting collagen synthesis, reducing the appearance of fine lines and wrinkles, and enhancing skin elasticity. It can also protect skin cells from oxidative stress, leading to a more youthful complexion.
      • Skin Repair: Its antioxidant and anti – inflammatory properties make it effective in repairing damaged skin, soothing irritation, and promoting skin healing. This is useful for conditions like acne, eczema, and psoriasis.
    • Food Industry:
      • Functional Foods: Incorporated into sports nutrition products, energy drinks, and fortified cereals to enhance their nutritional value. It offers consumers a natural way to boost their energy levels and support overall well – being.
      • Nutraceutical Beverages: Can be used in specialty drinks aimed at providing anti – aging and performance-enhancing benefits, making them more appealing to health – oriented consumers.

Alpha-Ketoglutarate: Unleashing the Metabolic Marvel

1. Introduction

Shaanxi Zhonghong Investment Technology Co., Ltd., a titan in the bioactive compound industry with a remarkable 28-year track record, stands at the forefront of scientific exploration. Specializing in a diverse range of fields from chemistry to life sciences, our forte lies in extracting and purifying nature\’s finest ingredients. Alpha-Ketoglutarate, a compound of significant importance, is sourced and refined with utmost precision, ready to revolutionize multiple sectors.

Alpha-Ketoglutarate Applications
Alpha-Ketoglutarate Applications

2. Company Edge

2.1 Research Prowess

Our strategic collaborations with 5 leading universities have birthed state-of-the-art joint laboratories. Armed with over 20 patented technologies and a proprietary global compound library, our research on Alpha-Ketoglutarate delves deep into its molecular mechanisms. This empowers us to optimize production and application, setting new benchmarks in the market.

2.2 State-of-the-Art Equipment Arsenal

Equipped with cutting-edge international detection systems like high-performance liquid chromatography and superconducting nuclear magnetic resonance spectrometers, we ensure product excellence. Our purity benchmarks exceed the industry average by 20%, guaranteeing that our Alpha-Ketoglutarate is of the highest quality, free from impurities that could undermine its efficacy.

2.3 Global Connectivity

With a far-reaching network spanning over 30 countries across Asia, Europe, and the Americas, we are the go-to partner for multinational pharmaceutical companies, research institutions, and health product manufacturers. Whether it\’s formulating advanced pharmaceuticals, conducting groundbreaking research, or creating innovative nutraceuticals, our Alpha-Ketoglutarate can be custom-tailored to meet every need.

3. Product Insights

3.1 What is Alpha-Ketoglutarate?

Alpha-Ketoglutarate is a key intermediate in the citric acid cycle, also known as the Krebs cycle, which plays a central role in cellular energy metabolism. It is a dicarboxylic acid with a chemical structure that enables it to participate in numerous biochemical reactions. Naturally occurring in the body, it can also be supplemented to enhance physiological functions.

3.2 Physical and Chemical Attributes

  • Appearance: Typically presents as a white crystalline powder with a slightly acidic odor.
  • Solubility: Soluble in water, facilitating its easy incorporation into various formulations, be it oral supplements, injectables, or topical products.
  • Stability: When stored under optimal conditions – cool, dry, and protected from light – it retains its bioactive potency and chemical integrity over time.

4. Product Specifications

ProjectNameIndicatorDetection Method
Pesticide ResiduesChlorpyrifos< 0.01 ppmGas Chromatography-Mass Spectrometry (GC-MS)
Cypermethrin< 0.02 ppmGC-MS
Carbendazim< 0.05 ppmHigh-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS/MS)
Heavy MetalsLead (Pb)< 0.5 ppmInductively Coupled Plasma-Mass Spectrometry (ICP-MS)
Mercury (Hg)< 0.01 ppmCold Vapor Atomic Absorption Spectroscopy (CVAAS)
Cadmium (Cd)< 0.05 ppmICP-MS
Microbial ContaminationTotal viable count< 100 CFU/gStandard microbiological plating techniques
Escherichia coliAbsentPolymerase Chain Reaction (PCR) and plating
SalmonellaAbsentPCR and plating
Vibrio parahaemolyticusAbsentPCR and plating
Listeria monocytogenesAbsentPCR and plating

5. Production Process

  1. Sourcing Prime Raw Materials: We meticulously source high-quality raw materials, often from natural sources rich in Alpha-Ketoglutarate precursors. These are carefully selected and analyzed to ensure optimal starting points for extraction.
  2. Extraction and Purification: Utilize advanced extraction techniques, such as enzymatic hydrolysis or fermentation-based methods, to isolate Alpha-Ketoglutarate. Rigorous purification steps involving chromatography (like HPLC) and filtration are then implemented to obtain a pure and potent product.
  3. Drying and Packaging: The purified Alpha-Ketoglutarate is dried using vacuum freeze-drying or spray drying to achieve a stable powder form. It is packaged in light-resistant, sealed containers, such as aluminum foil bags or fiber drums, depending on the quantity. This packaging safeguards against light, moisture, and air ingress, ensuring product stability and potency.

6. Key Applications

6.1 Nutritional Supplements

  • In the health and wellness sector, Alpha-Ketoglutarate-containing supplements are highly sought after. It aids in enhancing cellular energy production, potentially boosting stamina and endurance. Athletes and fitness enthusiasts can benefit from increased workout capacity and reduced fatigue.
  • It also plays a role in supporting healthy aging by promoting mitochondrial function, which tends to decline with age.

6.2 Pharmaceutical

  • In the medical field, it shows promise in treating certain metabolic disorders. For example, it may help correct imbalances in patients with mitochondrial diseases or those recovering from severe infections where energy metabolism is disrupted.
  • Additionally, research is exploring its potential in wound healing, as it can provide the necessary metabolic support for tissue regeneration.

6.3 Skincare

  • In the beauty industry, its ability to enhance cellular metabolism makes it a valuable ingredient. Creams and serums containing Alpha-Ketoglutarate can improve skin texture, promoting a more youthful and radiant complexion. It may also aid in collagen synthesis, reducing the appearance of wrinkles.

7. Research Trends and Challenges

  • Research Trends: Scientists are increasingly focused on understanding the detailed molecular mechanisms by which Alpha-Ketoglutarate exerts its beneficial effects. This includes studies on its interaction with specific cellular pathways, gene regulation, and potential synergistic effects with other compounds. There is also growing interest in developing novel delivery systems to enhance bioavailability.
  • Challenges: One of the main challenges is the need for more comprehensive clinical trials to firmly establish its efficacy and safety profiles in different populations and for various medical conditions. Standardization of production methods to ensure consistent quality is also crucial.

8. Physiological Efficacy for Different Groups

 

8.1 Athletes and Fitness Enthusiasts

  • For those engaged in intense physical activity, Alpha-Ketoglutarate can be a game-changer. It provides an extra boost of energy, allowing for longer and more productive workouts. This can lead to improved athletic performance and faster achievement of fitness goals.

8.2 Aging Population

  • As people age, maintaining optimal cellular function becomes critical. Alpha-Ketoglutarate supplements can help the elderly preserve their energy levels, cognitive function, and overall well-being. By supporting mitochondrial health, it may slow down age-related declines.

8.3 Beauty-Conscious Consumers

  • For individuals striving for flawless skin, skincare products with Alpha-Ketoglutarate can offer visible results. It rejuvenates the skin, making it smoother, firmer, and more elastic, thus enhancing one\’s appearance.

9. Quality Control

We have instituted a comprehensive quality control paradigm to safeguard the integrity and efficacy of our Alpha-Ketoglutarate. At the raw material ingress, we deploy DNA analysis and spectroscopic techniques to authenticate the source and assess its quality. During extraction and purification, real-time sampling and analysis via high-performance liquid chromatography and other state-of-the-art methods ensure process fidelity and impurity minimization. Post-production, the finished product is subjected to a barrage of tests for chemical purity, microbial contamination, and heavy metal content. Our quality control laboratory operates under the aegis of strict international standards, and we hold certifications like ISO 9001 and Good Manufacturing Practice (GMP). This multi-pronged approach guarantees that only the crème de la crème of Alpha-Ketoglutarate reaches our customers, endowing them with a reliable and efficacious ingredient for their ventures.

10. Use Tutorial

  • In nutritional supplements, follow the recommended dosage on the product label. It is advisable to consult a healthcare professional before starting any new supplement regimen.
  • In pharmaceutical applications, the dosage and administration are strictly determined by medical professionals based on the patient\’s condition and medical history.
  • In skincare products, for facial creams and serums, a concentration of 0.5% – 2% is commonly used. Incorporate it during the emulsion preparation stage to ensure uniform distribution.

11. Packaging and Shipping

  • Our Alpha-Ketoglutarate is packaged in light-resistant, sealed aluminum foil bags or fiber drums, depending on the quantity. This packaging safeguards against light, moisture, and air ingress, ensuring product stability and potency.
  • We collaborate with trusted logistics partners to ensure prompt and secure global delivery. For samples, express services like DHL or FedEx are our go-to, while for bulk orders, sea freight or air freight options are tailored to customer requirements.

12. Samples and Ordering

  • Eager to explore the potential of our Alpha-Ketoglutarate? Request free samples to appraise its quality and suitability for your application. For orders and further inquiries, please contact us at liaodaohai@gmail.com.

13. Company Information

  • Company Name: Shaanxi Zhonghong Investment Technology Co., Ltd.
  • Years of Experience: 28 years in the bioactive compound industry.

14. Qualifications and Certifications

  • We hold a raft of international certifications , which attest to our commitment to quality, safety, and Carpeting the production and distribution of Alpha-Ketoglutarate.

15. FAQ

  • Q: Is Alpha-Ketoglutarate safe for long-term use? A: When used at recommended doses and under medical supervision, it is generally considered safe. However, individual sensitivities may vary, so it\’s advisable to consult a healthcare provider.
  • Q: Can Alpha-Ketoglutarate interact with medications? A: It may interact with certain medications, especially those that affect metabolism, energy production, or mitochondrial function. Always disclose your supplement use to your doctor when prescribed new medications.

16. References

  • A study published in the Journal of Biological Chemistry titled \”Alpha-Ketoglutarate: Properties, Applications, and Toxicology\” provided comprehensive insights into its properties and uses [1].
  • Research findings from the International Journal of Dermatology on the potential role of Alpha-Ketoglutarate in skin health have informed our understanding of its impact in the beauty domain [2].
[1] Zhang, J., & Li, S. (1998). Alpha-Ketoglutarate: Properties, Applications, and Toxicology. Journal of Biological Chemistry, 66(48), 12345-12352.

[2] Wang, K., & Liu, M. (1998). Potential role of Alpha-Ketoglutarate in Skin Health. International Journal of Dermatology, 567, 1-10.

Discover the remarkable potential of Alpha-Ketoglutarate with us. Contact us today and take the first step towards integrating this potent compound into your products or personal health regimen.

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