Pachymic Acid
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Pachymic Acid

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Pachymic Acid factory supplier bulk Wholesale Extract factory

  1. English Name: Pachymic Acid (it’s a triterpenoid—fancy term for a beneficial compound—from Poria cocos, the “poria mushroom” used in TCM for ages!)
  2. Specification
    • Purity: ≥ 98% (HPLC tested—super pure, no random mushroom bits or fillers)
    • Solubility: Slightly soluble in water; dissolves well in ethanol, methanol, and oils (perfect for supplement capsules or topical formulas)
    • Melting Point: Around 198–202°C (stays stable in most formulation processes—no easy breakdown)
    • Loss on Drying: ≤ 0.5% (keeps it dry, no clumping or losing potency over time)
    • Heavy Metals: ≤ 10 ppm (totally safe for oral/topical use—meets strict wellness standards)
  3. Appearance: White to off-white crystalline powder with a mild, earthy mushroom smell—definitely no chocolate aroma! It’s subtle, so it doesn’t overpower whatever it’s mixed into.
  4. CAS NO.: 29070-92-6 (this is the real CAS for Pachymic Acid, not that cocoa butter one—huge difference!)
  5. Lead time: 3-7 Working Days (we keep it in stock regular, so you won’t wait long to get it)
  6. Package: Small sizes: 1g/10g/100g light-resistant glass vials (protects its crystalline structure); bulk: 1kg aluminum tins or 25kg sealed drums (locks in freshness—no moisture damage)
  7. Main Market: Europe, North America, Asia—anywhere people trust mushroom-based wellness or TCM-inspired ingredients
  8. Application Scenarios

Key Features

  • Poria Mushroom’s Star Compound: The main reason poria’s been a staple in TCM for centuries—known for supporting calmness and overall balance
  • Natural & Mushroom-Derived: Sourced straight from high-quality Poria cocos (no synthetic copies)—fits “clean label” products perfectly
  • Gentle for Daily Use: Most people take it with no side effects—great for long-term wellness routines
  • Versatile in Blends: Mixes smoothly into capsules, powders, or skincare—no fussy handling needed
  • Stable Storage: Stays potent for months if kept cool and dry—no fancy storage setup required

Industry Applications

    1. Dietary Supplements
      • Wellness Capsules/Powders: 20-50mg per serving for daily balance support (popular with folks into TCM or mushroom wellness)
      • Calm & Sleep Blends: Mixed with adaptogens like ashwagandha or magnolia bark (helps with occasional stress or restlessness)
      • Mushroom Complexes: Added to “super mushroom” supplements (alongside reishi or lion’s mane) for rounded benefits
    2. Pharmaceutical Research
      • Lab Studies: Used in research to explore its potential benefits for things like inflammation or digestive health
      • Herbal Drug Development: Investigated for use in plant-based meds—thanks to its well-documented properties in traditional use
    3. Cosmetics & Skincare
      • Topical Creams/Serums: Added in small amounts (0.1-1% concentration) to products for skin wellness—its properties help support a smooth, healthy look
      • Natural Skincare Lines: Perfect for brands focusing on “herbal-mushroom” ingredients—no harsh chemicals
    4. Traditional Wellness Products
      • TCM Formulations: A key ingredient in modern poria tinctures, teas, or herbal soups—stays true to its TCM roots
      • Eastern Wellness Blends: Popular in products for “qi balance” (a TCM concept)—great for folks seeking holistic health
      • Nutraceuticals: Included in premium wellness products that mix science with traditional mushroom wisdom
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Pores and skin Soothing Pachymic Acid: Premium Bioactive Triterpenoid for Pharmaceutical & Nutraceutical Functions | Supplier & Manufacturer

1. Product Introduction

Pachymic Acid (C33H52O5) is a pharmacologically lively lanostane-type triterpenoid predominantly remoted from the sclerotium of Poria cocos (茯苓), a revered medicinal fungus in Conventional Chinese language Medication (TCM). As a high-purity (>98%) standardized extract, it demonstrates exceptional:

Pachymic Acid Extract Ingredient Aiherba Pachymic Acid

  • Anti-inflammatory exercise through COX-2 and TNF-α suppression

  • Neuroprotective results by way of Nrf2/ARE pathway activation

  • Antitumor potential by inducing caspase-dependent apoptosis

  • Hepatorenal protecting properties in opposition to oxidative injury

Our pharmaceutical-grade Pachymic Acid is produced underneath cGMP circumstances, validated by HPLC-ELSD and qNMR to make sure batch-to-batch consistency for medical analysis and industrial formulations.

2. Firm Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

As a ISO 9001:2015 & ISO 13485 licensed producer, we combine:

Core Competencies

Differentiator Technical Specification
Educational Collaboration Joint labs with Peking College, ETH Zurich
IP Portfolio 23 patents (together with 5 PCT worldwide patents)
Analytical Functionality UHPLC-QTOF-MS, 600MHz NMR with cryoprobe
World Distribution FDA/DMF filed for US/EU markets

Our 28-year experience in plant extraction delivers 20% increased bioavailability in comparison with business averages by way of proprietary subcritical water extraction (SWE) expertise.

3. Botanical Supply & Extraction Methodology

  • Supply Materials: Wild-harvested Poria cocos from GAP-certified forests in Yunnan Province

  • Extraction Course of:

    1. Decoction optimization: 8:1 water-to-material ratio at 95°C

    2. Macroporous resin purification: AB-8 resin, 75% ethanol elution

    3. Crystallization: Gradient cooling to acquire >98% purity crystals

  • Identification Affirmation:

    • FTIR (KBr pellet): 3420 cm⁻¹ (OH), 1695 cm⁻¹ (C=O)

    • ¹³C-NMR: 38 attribute peaks matching USP reference customary

4. Scientific-Grade Well being Benefits

Mechanistic Pharmacodynamics

Profit Mode of Motion Efficient Dose
Anti-arthritic Downregulates MMP-13 through JNK/AP-1 pathway 50 mg/kg/day
Nootropic Enhances BDNF expression in hippocampal neurons 100 mg/kg/day
Chemopreventive Inhibits STAT3 phosphorylation in TNBC cells IC50 = 12.7 μM

Dosing Protocols

  • Nutraceutical use: 50-150 mg/day enteric-coated capsules

  • Topical formulations: 0.5-2% w/w in anti-aging serums

  • Contraindications: Not advisable throughout immunosuppressive remedy

5. Rigorous High quality Specs Triple-Verification Testing Protocol

Desk 1: Complete QC Parameters

Class Check Merchandise Specification Methodology
Pesticides Chlorpyrifos ≤0.01 mg/kg GC-MS/MS (EU 396/2005)
Hexachlorobenzene ND EPA 8081B
Heavy Metals As (Arsenic) ≤0.5 ppm ICP-OES (USP <232>)
Hg (Mercury) ≤0.1 ppm Chilly vapor AAS
Microbiology E. coli Absent in 10g USP <62>
Aflatoxins (B1+B2+G1+G2) ≤5 ppb whole HPLC-FLD

6. Industrial-Scale Manufacturing Workflow

  1. Uncooked Materials Qualification: DNA barcoding (ITS2 area sequencing)

  2. Steady Extraction: Dynamic countercurrent extraction at 85°C

  3. Chromatographic Purification:

    • Preparative HPLC (C18 column, MeOH:H₂O = 85:15)

    • Chiral separation for enantiomeric purity (>99% ee)

  4. Lyophilization: 48h freeze-drying to protect thermolabile compounds

7. Chopping-Edge Functions

Rising Sector Utilization

  • Oncology Adjuvants: Synergizes with paclitaxel (1.8-fold ↑ apoptosis in MDA-MB-231)

  • Cosmeceuticals: Inhibits melanogenesis by 63% vs. arbutin (at 50 μM)

  • Veterinary Medication: Canine cognitive dysfunction syndrome administration

8. High quality Assurance Ecosystem

Our 360° high quality management implements:

  • Stability Research: 24-month accelerated testing per ICH Q1A pointers

  • Elemental Impurities: Full compliance with USP <232>/<233>

  • Residual Solvents: Class 1 solvents <1 ppm by HS-GC

  • Pressured Degradation: Acid/alkali/oxidative stress testing for impurity profiling

9. Good Packaging Options

  • Major: Nitrogen-flushed amber glass vials with PTFE-lined caps

  • Bulk: Double-layer aluminized luggage with oxygen scavengers

  • Chilly Chain: 2-8°C transport with real-time TempTale® monitoring

10. Analysis Frontiers & Challenges

Innovation Pipeline

  • Nanoemulsion Supply: Bettering oral bioavailability from 12% to 38%

  • Artificial Biology: Heterologous manufacturing in Yarrowia lipolytica

Technical Hurdles

  • Crystalline Polymorphism: Kind I vs. Kind II stability points

  • Metabolite Identification: Section II glucuronidation pathways

11. Professional FAQ

Q: How does your Pachymic Acid evaluate with opponents?
*A: Our UHPLC-ELSD quantification exhibits 102.3% efficiency vs. 89-95% in market samples.*

Q: Shelf life underneath completely different storage circumstances?
*A: 36 months at -20°C with <0.5% degradation yearly (HPLC monitoring).*

12. Conclusion

This GMP-certified Pachymic Acid represents the next-generation triterpenoid customary, combining ethnopharmacological validation with cutting-edge analytical verification for premium therapeutic purposes.

Where to Buy Pachymic Acid

We are your trusted partner for sourcing high-quality Pachymic Acid

Contact us today to discuss your procurement needs, request a free sample for your R&D, and get a competitive wholesale price.

13. Authoritative References

  1. Journal of Natural Merchandise (2023) – Structural modification research

  2. EDQM Certification No. CERT-03872-2024

  3. WHO Pointers on Natural Medication High quality (2022)

#Pharmaceutical-grade Pachymic Acid, #GMP-certified triterpenoid, #Poria cocos extract 98%,# anti-inflammatory pure compound, bioactive mushroom extract supplier*

Weight 1000 克
Dimensions 20 × 10 × 10 厘米

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