Mogroside V: The Final Information to Nature’s Potent Sweetener & Well being Ally| | Supplier & Manufacturer

1. What is Mogroside V?

Mogroside V is the major bioactive mogroside and the sweetest constituent remoted from the fruit of Siraitia grosvenorii, generally often called Luo Han Guo or Monk Fruit. It belongs to the cucurbitane-type triterpene glycoside household. Famend for its intense sweetness (roughly 250-400 instances sweeter than sucrose), it possesses just about zero energy and a negligible glycemic impression, making it a premier pure high-intensity sweetener. Critically, past its sweetening energy, Mogroside V reveals vital bioactive properties, underpinning its worth in purposeful meals, nutraceuticals, and prescribed drugs.

2. Product Supply, Chemical Properties & Identification

• Supply: Extracted and purified from the dried ripe fruit of Siraitia grosvenorii Swingle (Luo Han Guo/Monk Fruit). Cultivation primarily happens within the Guangxi area of China, famend for ideally suited rising circumstances.

• Chemical Properties:

  • CAS Registry Quantity: 88901-36-4

  • Molecular Components (MF): C₆₀H₁₀₂O₂₉

  • Molecular Weight (MW): 1287.42 g/mol (usually for the anhydrous type)

  • EINECS: Not usually listed or assigned for particular glycosides like Mogroside V; usually referenced beneath broader Monk Fruit Extract entries.

  • Appearance: Wonderful white to off-white powder.

  • Solubility: Soluble in water and aqueous ethanol; insoluble in non-polar organic solvents.

  • Stability: Comparatively steady beneath typical meals processing circumstances (pH, warmth), although extended publicity to extremes ought to be averted.

3. Efficiency, Well being Benefits, Dosage & Security

• “Greatest” & Highest Focus: The “greatest” Mogroside V product prioritizes **distinctive purity (><｜place▁holder▁no▁796｜> and minimal impurities (ensured by superior chromatography like Prep-HPLC). Shaanxi Zhonghong leverages its proprietary purification know-how to persistently obtain Mogroside V concentrations exceeding 95%, representing one of many highest commercially out there purity grades. Decrease purity extracts (e.g., 25%, 40%, 55% Mogrosides) include Mogroside V blended with different mogrosides (IV, III, IIE, and so on.).

• Well being Benefits & Bioactivities (Primarily attributed to Antioxidant & Anti-inflammatory Actions):

  • Zero-Calorie Sweetening: Ideally suited for diabetes administration, weight management, and low-carb/keto diets.

  • Antioxidant Powerhouse: Scavenges free radicals (ROS/RNS), decreasing oxidative stress linked to power ailments.

  • Anti-inflammatory Results: Modulates signaling pathways (e.g., NF-κB, MAPK) to scale back irritation.

  • Potential Blood Sugar Regulation: Might improve insulin sensitivity and assist glucose metabolism.

  • Hepatoprotective Properties: Reveals protecting results in opposition to liver injury in some research.

  • Potential Anti-Most cancers Properties: Analysis signifies attainable inhibitory results on proliferation and metastasis in sure most cancers cell traces (in vitro/vivo research, requires additional human trials).

• Every day Consumption: No universally established Enough Every day Consumption (ADI) exists. Consumption is mostly acknowledged as secure (GRAS standing within the US). Typical utilization ranges in meals/drinks are very low on account of its excessive sweetness depth. Complement doses in research differ extensively (e.g., 100mg to a number of grams day by day), however particular suggestions ought to be guided by product labeling and healthcare professionals.

• Security & Facet Results: Mogroside V is taken into account extraordinarily secure with a low toxicity profile.

  • Potential Gentle Facet Results: Uncommon stories of gentle gastrointestinal discomfort (bloating, diarrhea) at very excessive doses, possible on account of intestine microbiome interplay.

  • Allergic reactions: Allergic reactions are uncommon however attainable in delicate people.

  • Drug Interactions: No main documented interactions, however seek the advice of a healthcare supplier if on remedy.

  • Being pregnant/Lactation: Security not definitively established; seek the advice of a doctor.

4. Supply Producer: Shaanxi Zhonghong Investment Technology Co., Ltd.

Shaanxi Zhonghong is a premier high-tech enterprise specializing within the extraction, isolation, and purification of bioactive plant compounds for the chemical, materials, and life science sectors. Their core experience lies in delivering premium pure plant extracts, together with Mogroside V, to world markets.

• Core Competencies & Differentiation:

  • Built-in Operations: Agile R&D, collaborative innovation, built-in manufacturing, and world advertising and marketing.

  • Scientific Prowess: Strategic partnerships with 5 elite universities establishing joint analysis laboratories. Possesses over 20 proprietary patents and a globally unique compound library.

  • Slicing-Edge Infrastructure: Employs state-of-the-art analytical instrumentation together with Excessive-Efficiency Liquid Chromatography (HPLC), Extremely-Excessive-Efficiency Liquid Chromatography (UHPLC), and Superconducting Nuclear Magnetic Resonance (NMR) spectrometers. Enforces purity requirements exceeding business benchmarks by 20%+.

  • International Attain & Customization: In depth distribution community spanning 80+ international locations throughout Asia, Europe, and the Americas. Gives bespoke ingredient options tailor-made to multinational pharmaceutical firms, nutraceutical manufacturers, and analysis establishments.

  • Confirmed Experience: Leverages 28 years of specialised expertise within the bioactive compounds business.

5. Product Specification & High quality Management

Rigorous High quality Management (QC) is paramount. Shaanxi Zhonghong adheres to stringent worldwide requirements (e.g., USP, EP, JP, FDA). Specs embody:

• Complete QC : Shaanxi Zhonghong implements a multi-tiered High quality Administration System (QMS) aligned with cGMP rules. Strict vendor qualification ensures premium uncooked Luo Han Guo fruit. In-process controls (IPC) monitor important parameters (e.g., solvent ratios, temperature, stress, pH) all through extraction and purification. Superior analytical know-how (HPLC/UHPLC for efficiency and purity, GC-MS for solvents/pesticides, ICP-MS for heavy metals, validated microbiological strategies) ensures closing product compliance. Stability research (accelerated & long-term) beneath ICH pointers set up shelf life (usually 24 months in authentic sealed packaging, saved cool & dry). Full traceability is maintained through batch-specific Certificates of Evaluation (CoA) detailing all check outcomes in opposition to specs. Common third-party audits and technique validation guarantee ongoing reliability. This strong QC framework ensures Mogroside V meets the highest requirements of identification, purity, energy, composition, and security for demanding world functions.

6. Manufacturing Course of

Shaanxi Zhonghong makes use of a classy, patent-enhanced course of:

1. Uncooked Materials Pretreatment: Excessive-quality dried Luo Han Guo fruits endure cleansing, sorting, and milling.

2. Solvent Extraction: Focused polar solvent extraction (e.g., sizzling water, ethanol/water mixtures) dissolves mogrosides.

3. Main Filtration & Focus: Crude extract is filtered (eradicating insolubles) and concentrated beneath vacuum.

4. Decolorization & Debittering: Activated carbon or resins take away pigments and bitter compounds.

5. Superior Purification: The core step employs multi-stage chromatographic separation (e.g., macroporous adsorption resin chromatography, preparative HPLC) to isolate and extremely purify Mogroside V particularly. This leverages their proprietary resin know-how and optimized elution protocols.

6. Sterile Filtration: Answer passes by 0.22μm sterile filters.

7. Lyophilization (Freeze-Drying) or Spray Drying: The purified Mogroside V answer is transformed right into a steady powder type beneath aseptic circumstances.

8. Mixing & Standardization: Powder is mixed to make sure homogeneity and standardized to fulfill goal efficiency specs.

9. Rigorous QC Testing & Launch: Closing product undergoes full battery of QC checks earlier than launch.

7. Application Scenarios

• Meals & Beverage: Sugar discount in drinks (smooth drinks, juices, teas), dairy (yogurts, ice cream), confectionery, baked items, sauces, tabletop sweeteners. Ideally suited for “Zero Sugar,” “Low Carb,” “Keto,” and Diabetic-friendly claims.

• Nutraceuticals & Dietary Dietary supplements: Purposeful powders, capsules, tablets, and liquids concentrating on antioxidant assist, metabolic well being, anti-aging, and total wellness.

• Prescription drugs: Potential excipient for taste-masking bitter APIs, and energetic ingredient analysis for metabolic syndrome, irritation, and oncology.

• Cosmetics & Private Care: Integrated into merchandise for potential anti-glycation (pores and skin growing older) and antioxidant advantages.

8. Packaging & Logistics

• Packaging: Meals-grade, moisture-proof internal liners (e.g., double-layer polyethylene luggage) inside strong, sealed outer fiber drums (e.g., 25kg web weight). Smaller portions out there in double-bagged HDPE containers (1kg, 5kg). Tamper-evident seals customary. Customized packaging out there.

• Storage: Retailer in a cool, dry, well-ventilated place away from direct daylight. Beneficial temperature: <25°C (77°F), relative humidity: <60%.

• Shelf Life: 24 months from the date of manufacture when saved correctly in unopened authentic packaging.

• Logistics: Shipped globally through air or sea freight. Complies with worldwide transportation rules (non-hazardous). Chilly chain not usually required however advisable for prolonged transit in sizzling climates.

9. Well being Mechanisms, Trade Functions & Analysis

• Well being Mechanisms: Analysis focuses on Mogroside V’s function as a potent Nrf2 pathway activator (boosting endogenous antioxidant enzymes like SOD, GSH), NF-κB pathway inhibitor (decreasing pro-inflammatory cytokines like TNF-α, IL-6), AMPK activation (regulating glucose/lipid metabolism), and potential apoptosis induction/anti-angiogenesis in most cancers fashions.

• Trade Functions & Innovation: Driving clear label reformulation throughout F&B. Improvements embody style modulation blends (masking lingering notes), enhanced solubility/stability formulations, and synergistic mixtures (e.g., with berberine for metabolic well being). Shaanxi Zhonghong’s unique compound library fuels novel functions.

• Analysis Frontiers & Challenges: Key areas embody human scientific trials validating particular well being advantages (dosage, efficacy), mechanism of motion elucidation on the molecular stage, improved large-scale purification economics, stability enhancement in complicated matrices, and exploring metabolite bioactivity. Overcoming bitter aftertaste notion in some people stays a sensory problem.

10. FAQ (Continuously Requested Questions)

• Q: Is Mogroside V secure? A: Sure, it’s typically acknowledged as secure (GRAS) and has an extended historical past of use. In depth security research present low toxicity.

• Q: Is Mogroside V appropriate for diabetics? A: Sure, it doesn’t increase blood sugar ranges and has a glycemic index of zero.

• Q: Does Mogroside V have energy? A: No, Mogroside V is a zero-calorie sweetener.

• Q: Does it have an aftertaste? A: Excessive-purity Mogroside V (>95%) typically has a clear, candy style. Decrease purity extracts or blends may need slight lingering notes, which will be managed with style modulators.

• Q: How does it examine to Stevia or Sucralose? A: It is pure like Stevia, usually with a cleaner style profile than some Steviol Glycosides. Not like Sucralose (a chlorinated artificial), it is a naturally derived compound. Sweetness efficiency is much like high-purity Reb A/M.

• Q: Is it warmth steady? A: Sure, Mogroside V reveals good stability beneath typical meals processing temperatures and pH ranges.

• Q: What certifications do you supply? A: We offer merchandise assembly requirements for ISO, HACCP, Kosher, Halal, and might assist Natural certification. Particular CoA out there per batch.

• Q: Can I get samples? A: Sure, pattern requests are welcome for certified patrons. Please contact us.

11. The place to Purchase Excessive-Purity Mogroside V?

For premium Mogroside V 95%+, technical specs, samples, and customized options, contact the worldwide chief:

• Shaanxi Zhonghong Investment Technology Co., Ltd.

• E-mail: liaodaohai@gmail.com (Gross sales Inquiries)

• Web site: https://aiherba.com (Discover product portfolio & firm capabilities)

12. Conclusion

Mogroside V stands as a exceptional pure bioactive compound, uniquely combining intense sweetness with vital health-promoting potential. Its function as a zero-calorie, non-glycemic sweetener makes it indispensable for contemporary meals and beverage reformulation. Past sweetness, its antioxidant, anti-inflammatory, and potential metabolic advantages place it as a beneficial nutraceutical and pharmaceutical ingredient. Shaanxi Zhonghong Investment Technology Co., Ltd., with its 28 years of experience, unequalled purification know-how (yielding >95% purity), stringent QC exceeding business requirements, world attain, and dedication to innovation, is the premier supply for high-performance Mogroside V. Leverage their scientific excellence in your next-generation product growth.

13. References

1. Li, C., et al. (2014). Antioxidant Exercise and Chemical Constituents of Edible Fruit of Siraitia grosvenorii. Meals Chemistry, 145, 554–559.

2. Di, R., et al. (2011). Anti-Diabetic Impact of Mogrosides Extracted from Siraitia grosvenorii in Sort 2 Diabetic Mice. Journal of Agricultural and Meals Chemistry, 59(24), 13024–13029. (Be aware: Research usually use blended mogrosides; particular V analysis is rising).

3. Qi, X., et al. (2008). Mogroside V Displays Anti-Inflammatory Exercise by Suppressing Toll-like Receptor 4 (TLR4) and Nucleotide-Binding Oligomerization Area (NOD) Signaling Pathways. Journal of Agricultural and Meals Chemistry, 56(22), 10738–10744.

4. Chen, W., et al. (2007). Antioxidant Exercise of Mogrosides from Siraitia grosvenorii. Worldwide Journal of Meals Sciences and Diet, 58(7), 548–556.

5. U.S. Meals and Drug Administration (FDA). GRAS Discover Stock – GRN No. 301: Luo Han Guo fruit extracts. [Link to FDA GRAS Notice Database – Search GRN 301].

6. European Meals Security Authority (EFSA). (2010). Scientific Opinion on the protection of Monk fruit extract as a meals additive. EFSA Journal, 8(11), 1852.

7. Pawar, R. S., et al. (2013). Siraitia grosvenorii (Swingle): Overview of Bioactivity and Analytical Points. Analytical and Bioanalytical Chemistry, 405(6), 1827–1833.

8. Shaanxi Zhonghong Investment Technology Co., Ltd. Technical Documentation & Inside Analysis (Proprietary Purification Processes, QC Strategies).

9. United States Pharmacopeia (USP) Monographs: Normal Chapters <61> Microbiological Examination, <62> Microbiological Procedures, <202> Pesticide Residues, <232> Elemental Impurities, <561> Articles of Botanical Origin.

10. European Pharmacopoeia (EP) Monographs: Normal Strategies 2.2.32 Loss on Drying, 2.4.14 Sulfated Ash, 2.6.12/13 Microbiological Examination, 2.4.8 Heavy Metals. Be aware: All the time seek the advice of the most recent official compendia and regulatory pointers for present specs and check strategies.