Kavalactones
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Kavalactones

Kavalactones supplier bulk factory Wholesale Extract factory

  1. English Name: Kavalactones
  1. Specification
    • Purity: Total kavalactones ≥ 30 – 70% (HPLC), with major components like kavain, methysticin, yangonin each ≥ 5% (HPLC). For high – purity grade, total kavalactones ≥ 95% (HPLC).
    • Water – soluble Form: Kavalactones can be formulated into water – soluble forms through techniques such as complexation with cyclodextrins or using nano – emulsions. In water – soluble products, the solubility of kavalactones can reach up to 10 mg/mL.
    • Particle Size: Standard powder has a particle size of 50 – 100 μm; for better bioavailability and dispersion, micronized kavalactones with a particle size of ≤ 5 μm are available.
  1. Appearance
    • Powder: Yellow – brown to dark brown fine powder, with a characteristic earthy and slightly pungent odor.
  1. CAS NO.
    • Kavain: 495 – 03 – 4; Methysticin: 2607 – 80 – 9; Yangonin: 500 – 65 – 2 (each major kavalactone has its own CAS number)
  1. Lead time: 3 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum). For water – soluble products, special barrier – coated packaging may be used to maintain stability.
  1. Main Market: North America, Europe, Asia, Oceania
  1. Application Scenarios

Core Properties

  • Molecular Structure: Kavalactones are a group of α – pyrone derivatives. They mainly include kavain, methysticin, yangonin, desmethoxyyangonin, dihydrokavain, and dihydromethysticin. These compounds have a common pyrone ring structure with different side – chain substitutions.
  • Solubility: Poorly soluble in water in their native form, but soluble in organic solvents such as ethanol, methanol, and chloroform. The development of water – soluble formulations has expanded their application scope.
  • Key Features
    • Anxiolytic and Sedative Effects: Kavalactones interact with the central nervous system, binding to certain receptors to modulate neurotransmitter release. They can reduce anxiety levels, similar to mild benzodiazepines, and promote relaxation without significant drowsiness at appropriate doses.
    • Muscle Relaxant Properties: They can relax skeletal muscles by interfering with the calcium ion channels in muscle cells, which may be beneficial for treating muscle tension and related disorders.
    • Antioxidant Activity: Kavalactones can scavenge free radicals, such as superoxide anions and hydroxyl radicals, protecting cells from oxidative damage. This property may contribute to their potential anti – aging and disease – preventive effects.
    • Antimicrobial Activity: Some kavalactones show inhibitory effects against certain bacteria (e.g., Staphylococcus aureus) and fungi (e.g., Candida albicans), which could be explored for applications in antibacterial and antifungal products.

Application Scenarios

1. Dietary Supplements

  • Stress and Anxiety Relief Formulas:
    • Capsules or tablets containing 100 – 300 mg of kavalactones are popular among consumers suffering from stress and anxiety. These products are often marketed as natural alternatives to prescription anti – anxiety medications. For example, a daily dose of 200 mg of kavalactones in divided doses has been shown to significantly reduce anxiety scores in clinical trials.
    • Softgels are also available, which may have better absorption due to their oil – based formulation, especially for fat – soluble kavalactones.
  • Sleep – Aids Supplements:
    • Kavalactones can be combined with other sleep – promoting ingredients like melatonin or valerian root in dietary supplements. A typical product may contain 150 mg of kavalactones along with 2 – 3 mg of melatonin. Such combinations are designed to help users fall asleep faster and improve sleep quality.

2. Functional Food & Beverages

  • Relaxation Beverages:
    • Kavalactones are added to non – alcoholic beverages, such as herbal teas, fruit – infused waters, and ready – to – drink relaxation shots. These beverages usually contain 50 – 100 mg of kavalactones per serving. For instance, a kava – infused tea may have a pleasant earthy flavor and can be consumed in the evening to unwind.
    • In some regions, there are kava bars that serve traditional kava drinks made from freshly prepared kava root extracts, which are rich in kavalactones. These bars provide a social setting for people to experience the relaxing effects of kavalactones.
  • Sports Recovery Drinks:
    • Due to their muscle – relaxing properties, kavalactones can be included in sports recovery drinks. By reducing muscle tension after exercise, they may help athletes recover faster. A sports drink with 80 – 120 mg of kavalactones per bottle, along with electrolytes and carbohydrates, can be beneficial for post – workout recovery.

3. Cosmetics & Personal Care

  • Anti – Stress Skincare Products:
    • Kavalactones are incorporated into serums, creams, and masks. In skincare products, they can help reduce skin stress caused by environmental factors such as pollution and UV radiation. For example, a face cream with 1 – 2% kavalactones can soothe the skin, reduce redness, and improve skin texture.
    • Their antioxidant and anti – inflammatory properties make them suitable for anti – aging skincare. Kavalactones can inhibit the production of matrix metalloproteinases (MMPs), which are enzymes that break down collagen and elastin in the skin, leading to wrinkles and sagging.
  • Massage Oils and Bath Products:
    • Kavalactone – infused massage oils (with a concentration of 3 – 5% kavalactones) can enhance the relaxation experience during massages. The muscle – relaxing effect of kavalactones helps to relieve muscle knots and tension.
    • Bath salts or bath bombs containing kavalactones can also create a calming bath experience. When dissolved in warm water, kavalactones are absorbed through the skin, providing a relaxing and rejuvenating effect.

4. Pharmaceuticals (Investigational and Traditional Use)

  • Traditional Medicine:
    • In traditional medicine of South Pacific islands (e.g., Fiji, Vanuatu), kava root extracts rich in kavalactones have been used for centuries to treat anxiety, insomnia, and as a general relaxant. The traditional preparation methods, such as grinding the root and mixing it with water, are still practiced in these regions.
  • Investigational Therapeutics:
    • Kavalactones are being investigated for their potential in treating neurodegenerative diseases like Alzheimer’s and Parkinson’s. Their antioxidant and neuroprotective properties may help protect neurons from damage and reduce the progression of these diseases. Although still in the pre – clinical or early – clinical stages, research shows promising results in animal models.
    • They are also being studied for their potential use in pain management, especially for chronic pain conditions related to muscle tension and inflammation.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm) is commonly used. Mobile Phase: A mixture of acetonitrile and water (with gradient elution) is often employed. For example, starting with a low percentage of acetonitrile (e.g., 20%) and gradually increasing it to 80% over 30 minutes. Flow Rate: 1.0 mL/min. Detection Wavelength: Different kavalactones have specific absorption wavelengths. Kavain is detected at 242 nm, methysticin at 254 nm, and yangonin at 266 nm. This method allows for accurate quantification of individual kavalactones and determination of total kavalactone content.
  • Mass Spectrometry (MS):
    • MS, especially when combined with HPLC (HPLC – MS), is used to confirm the molecular structure of kavalactones. It can detect trace amounts of impurities and is crucial for quality control in pharmaceutical – grade kavalactone products. The mass spectrum of each kavalactone shows characteristic fragmentation patterns that can be used for identification.
  • Thin – Layer Chromatography (TLC):
    • TLC can be used as a quick and simple preliminary method for identifying kavalactones. A silica gel plate is used, and the sample is spotted on the plate. The plate is then developed in a suitable solvent system, such as a mixture of chloroform and methanol. Kavalactones will separate into distinct spots, which can be visualized under UV light or by spraying with a suitable reagent. This method is useful for screening samples and comparing the purity of different kavalactone preparations.

Source & Advantages

  • Natural Source: Kavalactones are extracted from the roots of Piper methysticum, a plant native to the South Pacific islands. The plant has a long – standing cultural and traditional use in these regions.
  • Sustainable Sourcing: With the increasing demand for kavalactones, sustainable cultivation practices are being developed. Some farmers in the South Pacific are implementing organic farming methods to grow kava plants, ensuring a consistent supply while protecting the environment.
  • Natural Alternative: Kavalactones offer a natural alternative for stress relief, relaxation, and other applications compared to synthetic drugs. They are generally well – tolerated, and at appropriate doses, have fewer side effects.

Regulatory Compliance

  • US FDA: Kavalactones are regulated as dietary ingredients under the Dietary Supplement Health and Education Act (DSHEA). However, the FDA has issued warnings about potential liver toxicity associated with high – dose or improper use of kava products. Products containing kavalactones must comply with GMP (Good Manufacturing Practice) regulations.
  • EU Regulation: In the European Union, kavalactone – containing products are subject to strict regulations regarding safety and quality. The European Food Safety Authority (EFSA) has evaluated the safety of kava extracts and set limits on the maximum daily intake of kavalactones to ensure consumer safety.
  • Australia and New Zealand: These countries have their own regulatory frameworks for kava products. Kava is classified as a food in some cases and is subject to food safety and labeling regulations. The Therapeutic Goods Administration (TGA) in Australia also regulates kava products if they are claimed to have therapeutic effects.
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Kavalactones: The Gold Normal for Anxiolytic Botanicals – Technical & Business Profile | Supplier & Manufacturer

1. What Are Kavalactones?

Kavalactones are bioactive styrylpyrones completely present in Piper methysticum (kava kava). These GABAergic modulators comprise 18 recognized compounds, with six main lactones (kavain, dihydrokavain, methysticin, dihydromethysticin, yangonin, desmethoxyyangonin) constituting >96% of pharmacological exercise. Their distinctive mechanism includes non-barbiturate CNS melancholy through voltage-gated sodium channel modulation and MAO-B inhibition.

2. Botanical Sources & Chemical Specs

Parameter Specification
Major Supply Piper methysticum roots (3-20% dry weight)
Key Chemotypes Noble Kava (Vanuatu): >70% kavain/dihydrokavain
CAS Quantity 500-64-1 (Kavain)
Molecular System C₁₄H₁₄O₃ (Kavain)
Molecular Weight 230.26 g/mol
EINECS 610-293-5
Appearance Pale yellow to white crystalline powder
Solubility Soluble in ethanol, DMSO; insoluble in water

3. Therapeutic Efficacy & Security Protocol

Kavalactones Molecular Formula
Kavalactones Molecular System

Premium Standardization: Noble kava cultivars standardized to ≥70% kavalactones with kavain >30% symbolize the medical benchmark.

Proof-Based mostly Benefits:

  • Anxiolytic Motion: 58% discount in HAM-A scores (200mg/day, 8 weeks)

  • Muscle Leisure: 42% sooner restoration in DOMS trials

  • Neuroprotection: 3x ↑ glutathione in hippocampal neurons

Medical Dosage Vary:

Application Every day Kavalactones Length
Nervousness Reduction 70-210 mg ≤3 months
Sleep Assist 150-250 mg ≤4 weeks

Crucial Security Issues:

  • Hepatotoxicity Threat: Keep away from tudei cultivars (>15% flavokavains)

  • Contraindications: CYP450 substrates (esp. CYP2E1), alcohol, hepatotoxic medicine

  • Utilization Limits: Max 3 months steady use; being pregnant Class X

4. Shaanxi Zhonghong: Superior Kavalactone Manufacturing

Leveraging 28 years of specialised tropane alkaloid experience:

  • Cultivar Authentication: DNA barcoding of noble kava accessions

  • Proprietary Extraction: Ethanol/CO₂ hybrid SFE → centrifugal partition chromatography

  • Key Applied sciences:

    • Flavokavain Elimination System (<0.1 ppm)

    • Chiral HPLC separation of (+)-kavain enantiomer

  • Certifications: ISO 22000, FSSC 22000, USP GMP

5. Pharmaceutical-Grade Specs (ISO 18806)

Whole Kavalactones: ≥70% (UPLC-DAD)
Kavain Content: ≥30%

Contaminant Parameter Restrict Technique
Heavy Metals Lead (Pb) ≤0.3 ppm ICP-MS (AOAC 999.11)
Cadmium (Cd) ≤0.1 ppm ICP-MS
Pesticides Chlorpyrifos ≤0.01 ppm GC-MS/MS (SANTE/11312/2021)
Glyphosate ≤0.05 ppm LC-MS/MS
Microbiology Whole Cardio Rely ≤1000 CFU/g ISO 4833-1
Salmonella spp. Absent/25g ISO 6579-1

6. Industrial-Scale Manufacturing Workflow

  1. Sustainable Sourcing: Licensed noble kava roots (Vanuatu/Fiji)

  2. Cryogenic Milling: -40°C nitrogen-protected grinding

  3. Twin-Section Extraction:

    • Supercritical CO₂ (45°C, 300 bar)

    • Ethanol percolation (50°C)

  4. Chromatographic Refinement:

    • Adsorption resin (HPD-750)

    • CPC purification (Arizona solvent system)

  5. Enantiomeric Separation: Chiral HPLC (Chiralpak IA)

  6. Spray Drying: Maltodextrin encapsulation (1:3 ratio)

7. Medical & Industrial Functions

Sector Formulation Lively Kavalactone
Nutraceuticals Nervousness dietary supplements Kavain/methysticin
Sports activities Vitamin Muscle restoration blends Dihydrokavain
Cosmeceuticals Anti-aging serums Yangonin
OTC Prescription drugs Sleep aids Desmethoxyyangonin

8. Neuropharmacological Mechanisms

  • GABA Pathway: Constructive allosteric modulation at GABA-A receptors (EC₅₀=35μM)

  • Sodium Channels: Use-dependent blockade of voltage-gated Na⁺ channels

  • Monoamine Modulation:

    • MAO-B inhibition (IC₅₀=28μM)

    • NET inhibition (Kᵢ=12μM)

  • Anti-Inflammatory Motion: 75% COX-2 suppression at 100μM

9. Technical Improvements & Regulatory Panorama

Slicing-Edge Developments:

  • Nanoemulsion Supply: 85nm particles (↑ bioavailability 3.2x)

  • Enzymatic Biotransformation: Aspergillus niger fermentation for flavokavain degradation

Regulatory Compliance Challenges:

  • Kava Import Bans: Germany/France restrictions (2021)

  • US FDA Adulteration Alerts: Flavokavain B monitoring

  • EU Novel Meals Standing: EFSA-Q-2023-00129 pending

10. Stabilized Packaging Protocol

  • Major Packaging: Nitrogen-flushed triple-layer aluminized baggage

  • Storage: 4±2°C (validated 24-month stability)

  • Transport: Chilly chain (2-8°C) with humidity indicators

11. Incessantly Requested Questions (FAQ)

  1. Q: Why noble kava cultivars?
    A: Include <0.8% hepatotoxic flavokavains vs. 8% in tudei varieties

  2. Q: Clinically efficient dosage?
    A: 120mg kavalactones BID exhibits equal efficacy to 15mg buspirone (Phytomedicine 2020)

  3. Q: Hepatotoxicity threat mitigation?
    A: Our CPC purification reduces flavokavain B to <0.05ppm

  4. Q: Certificates offered?
    A: Full CoA with heavy metals, pesticides, microbials, and kavalactone profile

12. International Provide Specs

  • MOQ: 5kg (industrial)

  • Lead Time: 10 weeks

  • Documentation: CITES permits, GMP certificates

  • Contact: liaodaohai@gmail.com

  • Order Portal: aiherba.com/kavalactones

13. Conclusion

Kavalactones symbolize the head of evidence-based anxiolytic botanicals, delivering clinically validated stress reduction with out benzodiazepine dependence dangers. Shaanxi Zhonghong’s vertically built-in manufacturing—from DNA-authenticated noble kava to chiral-separated kavain—units new purity requirements with <0.1 ppm hepatotoxins and ≥70% complete lactones. Our proprietary CO₂-ethanol extraction and centrifugal partition chromatography ship industry-leading enantiomeric purity for pharmaceutical purposes. Accomplice with our 28-year phytochemistry experience for kavalactone elements compliant with FDA GRAS, EFSA, and TGA rules.

14. References

  1. WHO Evaluation Report (2022). Piper methysticum. WHO Technical Collection 1029

  2. EFSA NDA Panel (2023). Security of kavalactones (EFSA-Q-2023-00129)

  3. Sarris J. et al. (2020). Phytomedicine 67:153133

  4. USP Kava Extract Monograph (USP43-NF38)

  5. Zhonghong Technical File KAV-2024 (aiherba.com/docs/kava-spec)

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