Kavalactones
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Kavalactones

Wholesale Kavalactones Powder – Quality Herbal Extract for Dietary Supplements & Cosmetics

  1. English Name: Kavalactones
  1. Specification
    • Purity: Total kavalactones ≥ 30 – 70% (HPLC), with major components like kavain, methysticin, yangonin each ≥ 5% (HPLC). For high – purity grade, total kavalactones ≥ 95% (HPLC).
    • Water – soluble Form: Kavalactones can be formulated into water – soluble forms through techniques such as complexation with cyclodextrins or using nano – emulsions. In water – soluble products, the solubility of kavalactones can reach up to 10 mg/mL.
    • Particle Size: Standard powder has a particle size of 50 – 100 μm; for better bioavailability and dispersion, micronized kavalactones with a particle size of ≤ 5 μm are available.
  1. Appearance
    • Powder: Yellow – brown to dark brown fine powder, with a characteristic earthy and slightly pungent odor.
  1. CAS NO.
    • Kavain: 495 – 03 – 4; Methysticin: 2607 – 80 – 9; Yangonin: 500 – 65 – 2 (each major kavalactone has its own CAS number)
  1. Lead time: 3 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum). For water – soluble products, special barrier – coated packaging may be used to maintain stability.
  1. Main Market: North America, Europe, Asia, Oceania
  1. Application Scenarios

Core Properties

  • Molecular Structure: Kavalactones are a group of α – pyrone derivatives. They mainly include kavain, methysticin, yangonin, desmethoxyyangonin, dihydrokavain, and dihydromethysticin. These compounds have a common pyrone ring structure with different side – chain substitutions.
  • Solubility: Poorly soluble in water in their native form, but soluble in organic solvents such as ethanol, methanol, and chloroform. The development of water – soluble formulations has expanded their application scope.
  • Key Features
    • Anxiolytic and Sedative Effects: Kavalactones interact with the central nervous system, binding to certain receptors to modulate neurotransmitter release. They can reduce anxiety levels, similar to mild benzodiazepines, and promote relaxation without significant drowsiness at appropriate doses.
    • Muscle Relaxant Properties: They can relax skeletal muscles by interfering with the calcium ion channels in muscle cells, which may be beneficial for treating muscle tension and related disorders.
    • Antioxidant Activity: Kavalactones can scavenge free radicals, such as superoxide anions and hydroxyl radicals, protecting cells from oxidative damage. This property may contribute to their potential anti – aging and disease – preventive effects.
    • Antimicrobial Activity: Some kavalactones show inhibitory effects against certain bacteria (e.g., Staphylococcus aureus) and fungi (e.g., Candida albicans), which could be explored for applications in antibacterial and antifungal products.

Application Scenarios

1. Dietary Supplements

  • Stress and Anxiety Relief Formulas:
    • Capsules or tablets containing 100 – 300 mg of kavalactones are popular among consumers suffering from stress and anxiety. These products are often marketed as natural alternatives to prescription anti – anxiety medications. For example, a daily dose of 200 mg of kavalactones in divided doses has been shown to significantly reduce anxiety scores in clinical trials.
    • Softgels are also available, which may have better absorption due to their oil – based formulation, especially for fat – soluble kavalactones.
  • Sleep – Aids Supplements:
    • Kavalactones can be combined with other sleep – promoting ingredients like melatonin or valerian root in dietary supplements. A typical product may contain 150 mg of kavalactones along with 2 – 3 mg of melatonin. Such combinations are designed to help users fall asleep faster and improve sleep quality.

2. Functional Food & Beverages

  • Relaxation Beverages:
    • Kavalactones are added to non – alcoholic beverages, such as herbal teas, fruit – infused waters, and ready – to – drink relaxation shots. These beverages usually contain 50 – 100 mg of kavalactones per serving. For instance, a kava – infused tea may have a pleasant earthy flavor and can be consumed in the evening to unwind.
    • In some regions, there are kava bars that serve traditional kava drinks made from freshly prepared kava root extracts, which are rich in kavalactones. These bars provide a social setting for people to experience the relaxing effects of kavalactones.
  • Sports Recovery Drinks:
    • Due to their muscle – relaxing properties, kavalactones can be included in sports recovery drinks. By reducing muscle tension after exercise, they may help athletes recover faster. A sports drink with 80 – 120 mg of kavalactones per bottle, along with electrolytes and carbohydrates, can be beneficial for post – workout recovery.

3. Cosmetics & Personal Care

  • Anti – Stress Skincare Products:
    • Kavalactones are incorporated into serums, creams, and masks. In skincare products, they can help reduce skin stress caused by environmental factors such as pollution and UV radiation. For example, a face cream with 1 – 2% kavalactones can soothe the skin, reduce redness, and improve skin texture.
    • Their antioxidant and anti – inflammatory properties make them suitable for anti – aging skincare. Kavalactones can inhibit the production of matrix metalloproteinases (MMPs), which are enzymes that break down collagen and elastin in the skin, leading to wrinkles and sagging.
  • Massage Oils and Bath Products:
    • Kavalactone – infused massage oils (with a concentration of 3 – 5% kavalactones) can enhance the relaxation experience during massages. The muscle – relaxing effect of kavalactones helps to relieve muscle knots and tension.
    • Bath salts or bath bombs containing kavalactones can also create a calming bath experience. When dissolved in warm water, kavalactones are absorbed through the skin, providing a relaxing and rejuvenating effect.

4. Pharmaceuticals (Investigational and Traditional Use)

  • Traditional Medicine:
    • In traditional medicine of South Pacific islands (e.g., Fiji, Vanuatu), kava root extracts rich in kavalactones have been used for centuries to treat anxiety, insomnia, and as a general relaxant. The traditional preparation methods, such as grinding the root and mixing it with water, are still practiced in these regions.
  • Investigational Therapeutics:
    • Kavalactones are being investigated for their potential in treating neurodegenerative diseases like Alzheimer’s and Parkinson’s. Their antioxidant and neuroprotective properties may help protect neurons from damage and reduce the progression of these diseases. Although still in the pre – clinical or early – clinical stages, research shows promising results in animal models.
    • They are also being studied for their potential use in pain management, especially for chronic pain conditions related to muscle tension and inflammation.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm) is commonly used. Mobile Phase: A mixture of acetonitrile and water (with gradient elution) is often employed. For example, starting with a low percentage of acetonitrile (e.g., 20%) and gradually increasing it to 80% over 30 minutes. Flow Rate: 1.0 mL/min. Detection Wavelength: Different kavalactones have specific absorption wavelengths. Kavain is detected at 242 nm, methysticin at 254 nm, and yangonin at 266 nm. This method allows for accurate quantification of individual kavalactones and determination of total kavalactone content.
  • Mass Spectrometry (MS):
    • MS, especially when combined with HPLC (HPLC – MS), is used to confirm the molecular structure of kavalactones. It can detect trace amounts of impurities and is crucial for quality control in pharmaceutical – grade kavalactone products. The mass spectrum of each kavalactone shows characteristic fragmentation patterns that can be used for identification.
  • Thin – Layer Chromatography (TLC):
    • TLC can be used as a quick and simple preliminary method for identifying kavalactones. A silica gel plate is used, and the sample is spotted on the plate. The plate is then developed in a suitable solvent system, such as a mixture of chloroform and methanol. Kavalactones will separate into distinct spots, which can be visualized under UV light or by spraying with a suitable reagent. This method is useful for screening samples and comparing the purity of different kavalactone preparations.

Source & Advantages

  • Natural Source: Kavalactones are extracted from the roots of Piper methysticum, a plant native to the South Pacific islands. The plant has a long – standing cultural and traditional use in these regions.
  • Sustainable Sourcing: With the increasing demand for kavalactones, sustainable cultivation practices are being developed. Some farmers in the South Pacific are implementing organic farming methods to grow kava plants, ensuring a consistent supply while protecting the environment.
  • Natural Alternative: Kavalactones offer a natural alternative for stress relief, relaxation, and other applications compared to synthetic drugs. They are generally well – tolerated, and at appropriate doses, have fewer side effects.

Regulatory Compliance

  • US FDA: Kavalactones are regulated as dietary ingredients under the Dietary Supplement Health and Education Act (DSHEA). However, the FDA has issued warnings about potential liver toxicity associated with high – dose or improper use of kava products. Products containing kavalactones must comply with GMP (Good Manufacturing Practice) regulations.
  • EU Regulation: In the European Union, kavalactone – containing products are subject to strict regulations regarding safety and quality. The European Food Safety Authority (EFSA) has evaluated the safety of kava extracts and set limits on the maximum daily intake of kavalactones to ensure consumer safety.
  • Australia and New Zealand: These countries have their own regulatory frameworks for kava products. Kava is classified as a food in some cases and is subject to food safety and labeling regulations. The Therapeutic Goods Administration (TGA) in Australia also regulates kava products if they are claimed to have therapeutic effects.
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Kavalactones: The Gold Normal for Anxiolytic Botanicals – Technical & Business Profile | Supplier & Manufacturer

Kavalactones, the active compounds derived from the roots of Piper methysticum (Kava), have been used for centuries in the South Pacific for promoting relaxation and a sense of calm. Today, they are recognized globally for their potential in supporting mental wellness, sleep quality, and mild stress relief. Our Kavalactones extract is carefully manufactured to meet international quality standards, making it a trusted choice for bulk buyers, dietary supplement brands, and cosmetic ingredient suppliers.

1. Product Overview

  • Botanical Source: Piper methysticum (Kava Root)

  • Plant Part Used: Roots & rhizomes

  • Active Compound: Kavalactones ≥ 70% (customizable: 30%, 50%, 90%)

  • Appearance: Light yellow to brown fine powder

  • Solubility: Soluble in ethanol and lipid-based carriers; low water solubility

  • Certifications: GMP, ISO9001, ISO22000, Kosher, Halal

Our factory has over 20 years of experience in producing high-purity herbal extracts for wholesale and OEM/ODM applications, ensuring consistent quality for dietary supplements, functional beverages, and cosmetic products.

2. Health Benefits & Mechanism

  1. Supports Relaxation and Stress Relief

    • Kavalactones interact with GABA receptors, promoting mild relaxation without sedation.

    • Clinical trials show potential benefits for light anxiety and stress reduction (PubMed).

  2. Promotes Sleep Quality

    • Research indicates improved sleep onset and better sleep experience with moderate Kavalactones intake (NIH Study).

  3. Neuroprotective Potential

    • Experimental studies suggest antioxidant and neuroprotective effects, supporting cognitive wellness.

  4. Safe and Non-Addictive

    • With regulated dosage, Kavalactones are generally well-tolerated and non-habit forming.

“Kavalactones are one of the few plant extracts backed by both traditional use and modern research, making them ideal for wellness-focused formulations,” says Dr. Sarah Thompson, PhD in Botanical Sciences.

3. Applications & Usage Guidelines

Application Suggested Use Recommended Dosage
Dietary Supplements Capsules, Tablets, Powder 50–150 mg per serving, up to 300 mg/day
Functional Beverages Relaxation teas, energy drinks 20–50 mg per liter
Cosmetic Ingredients Skincare formulations 0.5–1% in final product
Traditional Kava Drinks Brewed from powder Follow traditional local ratios

Best Practice Formulation Tips:

  • Compatible with magnesium, L-theanine, or valerian for synergistic relaxation effects.

  • Avoid combining with alcohol or sedative drugs.

4. Product Specifications (COA Style)

Category Parameter Specification Test Method
Pesticides Total Pesticide Residue ≤ 0.01% GC-MS / HPLC
Specific Insecticides ND GC-MS
Heavy Metals Pb ≤ 2 ppm ICP-MS
Cd ≤ 1 ppm ICP-MS
Hg ≤ 0.1 ppm AAS
As ≤ 1 ppm ICP-MS
Microbiology Total Plate Count ≤ 1000 CFU/g AOAC 990.12
E. coli ND AOAC 991.14
Salmonella ND AOAC 2003.09
Yeast & Mold ≤ 100 CFU/g AOAC 997.02

5. Storage & Shelf Life

  • Packaging: 25 kg aluminum foil bag, inner PE bag

  • Storage: Cool, dry, and dark place

  • Shelf Life: 24 months (unopened)

  • Sample Policy: Free sample herbal extract (10–50 g) available for testing

6. Shipping & MOQ

  • Shipping: Air, sea, or courier

  • Minimum Order Quantity (MOQ): 5 kg

  • Export Compliance: EU, US, JP standards met

7. Industries & Applications

Industry Typical Use Usage Method
Dietary Supplements Capsules, tablets, powders Add per formulation
Functional Beverages Relaxation teas, energy drinks Dissolve in beverage
Cosmetics Skincare & wellness products Incorporate into formula
Health & Wellness Spa oils, tinctures External application
Pharmaceutical Intermediate Extract refinement Process per GMP standards

8. Production & Factory Expertise

  • Factory Experience: 20+ years in herbal extract production

  • Manufacturing Capabilities: OEM/ODM, bulk processing, custom extraction

  • Quality Control: Every batch tested for purity, pesticides, heavy metals, and microbes

  • Certifications: GMP, ISO, Kosher, Halal

“As a leading dietary supplement raw material manufacturer, our goal is to provide GMP certified plant extract for cosmetics and functional products, ensuring every shipment meets the strictest quality standards.” – Factory QA Manager

9. Safety & Precautions

  • Avoid use in pregnant or breastfeeding women.

  • Not recommended for individuals with liver disorders.

  • Do not combine with alcohol, sedatives, or other CNS depressants.

  • Children and adolescents should not consume Kavalactones.

10. FAQ

Q1: Can Kavalactones cause dependency?
A1: When used as recommended, Kavalactones are generally non-addictive.

Q2: Do you offer custom concentrations?
A2: Yes, we can provide 30%, 50%, 70%, or 90% Kavalactones extract per request.

Q3: Is the product third-party tested?
A3: Absolutely, all batches include COA, MSDS, and heavy metal & microbiology reports.

Q4: How should I store the extract?
A4: Store in a cool, dry, dark place, away from heat and humidity.

11. References & Research Links

  1. Cech, N.B., & Kim, K. (2000). Kava lactones: Chemistry and pharmacology. Journal of Natural Products, 63(8), 1031–1040. PubMed

  2. Sarris, J., et al. (2011). Kava for anxiety: Systematic review and meta-analysis. Journal of Clinical Psychopharmacology, 31(6), 706–713. NIH

  3. FDA Consumer Updates: Kava Safety Alerts. FDA

12. International Provide Specs

  • MOQ: 5kg (industrial)

  • Lead Time: 10 weeks

  • Documentation: CITES permits, GMP certificates

  • Contact: liaodaohai@gmail.com

  • Order Portal: aiherba.com/kavalactones

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