Isosteviol
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Isosteviol

Isosteviol Ingredient: High-Purity Stevia-Derived Compound for Nutraceuticals & Functional Foods (GMP Factory Supply)

  1. English Name: Isosteviol
  1. Specification
    • Purity: Isosteviol ≥ 98% (HPLC); High – purity grade: ≥ 99% (HPLC)
    • Solubility: Sparingly soluble in water (approx. 0.1 g/L at 25°C), soluble in organic solvents such as ethanol, acetone, and chloroform
    • Melting Point: 198 – 202°C
    • Residual Solvents: Ethanol ≤ 0.5%, Acetone ≤ 0.5%
    • Heavy Metals: ≤ 10 ppm
    • Particle Size: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better reactivity
  1. Appearance
    • White to off – white crystalline powder, odorless
  1. CAS NO.：7979-62-4
  1. Lead time: 5 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market: Global market, with significant demand in Asia (China, Japan, South Korea), North America, and Europe, especially in the food, pharmaceutical, and chemical industries
  1. Application Scenarios

Core Properties

  • Molecular Formula: C₂₀H₂₈O₃
  • Chemical Structure: A diterpenoid compound, derived from the hydrolysis and isomerization of steviol, featuring a complex ring structure with a carboxylic acid group and hydroxyl groups
  • Key Features
    • Versatile Chemical Intermediate: Serves as a crucial building block for the synthesis of various bioactive compounds and industrial chemicals.
    • Stability: Stable under normal storage conditions away from heat, light, and strong oxidizing agents.
    • Biocompatibility: Generally low toxicity, making it suitable for applications in the food and pharmaceutical sectors with proper processing.
    • Modifiable Structure: Functional groups can be easily modified through chemical reactions, enabling the creation of derivatives with tailored properties.

Application Scenarios

1. Food & Beverage Industry

  • Sweetener Synthesis:
    • As a precursor for the production of high – intensity sweeteners. Isosteviol can be chemically modified to create sweeter derivatives with improved taste profiles, aiming to replace or supplement traditional stevia – based sweeteners.
  • Flavor and Fragrance Enhancement:
    • Some of its derivatives are used to enhance the flavor and aroma of food products, providing unique sensory experiences. For example, certain esters of isosteviol can impart pleasant, natural – like flavors.

2. Pharmaceutical Industry

  • Drug Synthesis:
    • Serves as an intermediate in the synthesis of anti – inflammatory, antioxidant, and antidiabetic drugs. Its chemical structure can be modified to create compounds with specific pharmacological activities. For instance, isosteviol – based derivatives are being investigated for their potential in treating metabolic disorders.
  • Biomedical Research:
    • Used in research laboratories as a reference compound or starting material for the development of new drug delivery systems. Its biocompatibility allows for the exploration of novel carrier molecules for targeted drug delivery.

3. Cosmetics & Personal Care

  • Anti – aging Formulations:
    • Incorporated into creams, serums, and lotions (0.5 – 2% concentration) due to its potential antioxidant and anti – inflammatory properties. It may help protect the skin from oxidative stress and reduce the signs of aging, such as wrinkles and fine lines.
  • Hair Care Products:
    • Added to shampoos and conditioners to improve hair texture, strength, and manageability. Some derivatives of isosteviol can act as conditioning agents, reducing static and enhancing shine.

4. Chemical Industry

  • Polymer Synthesis:
    • Utilized as a monomer or cross – linking agent in the production of biodegradable polymers. Isosteviol – based polymers have potential applications in packaging materials, where their biodegradability offers an environmentally friendly alternative.
  • Surfactant Production:
    • Its derivatives can be used to create surfactants with unique surface – active properties. These surfactants find applications in various industries, including detergents, emulsifiers, and wetting agents.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm for quantification.
  • Gas Chromatography – Mass Spectrometry (GC – MS):
    • Used for the identification and quantification of isosteviol in complex mixtures, especially when analyzing volatile derivatives. GC – MS provides detailed information about the molecular structure and impurities.
  • Fourier Transform Infrared Spectroscopy (FTIR):
    • Helps in confirming the chemical structure of isosteviol by analyzing the characteristic absorption peaks of its functional groups. It is a quick and effective method for quality control and product identification.

Source & Advantages

  • Natural Source: Derived from stevia leaves, a renewable plant resource. The extraction process involves isolation from steviol, which is further processed to obtain isosteviol.
  • Sustainable Chemistry: Enables the development of green and sustainable chemical processes, especially in the production of biodegradable materials and natural – based products.
  • Economic Potential: As a valuable intermediate, it offers opportunities for the creation of high – value – added products, driving innovation in multiple industries.

Regulatory Compliance

  • US FDA: For food and pharmaceutical applications, products containing isosteviol must comply with relevant regulations. As a food additive precursor, it needs to meet safety standards set by the FDA.
  • EU Regulation: Regulated under REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) for industrial applications. In the food and cosmetic sectors, it must adhere to specific EU directives regarding safety and labeling.
  • China NMPA: Approved for use in certain industrial and consumer products, with strict quality control and safety requirements in place to ensure compliance with national standards.
Categories: , , ,

Isosteviol (Stevia Leaf Derivative) – Premium Botanical Active for Metabolic Health, Anti-Inflammatory & Cardiovascular Formulas

1. Product Overview: What Is Isosteviol?

Isosteviol is a naturally derived diterpenoid obtained through the biotransformation of Stevioside, the well-known sweet glycoside from Stevia rebaudiana. While Stevioside is famous as a natural sweetener, Isosteviol plays an entirely different functional role—showing promising cardioprotective, metabolic-support, anti-inflammatory, antioxidant, and neuroprotective properties backed by emerging pharmacological research.

At AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified bulk manufacturer and supplier, we produce high-purity Isosteviol for dietary supplements, functional foods, cosmetics, and R&D applications.

✔ 28+ years extraction expertise
✔ Food-grade processing
✔ Complete traceability and COA
✔ OEM/ODM support for customized herbal extract formulations

2. Botanical Source & Production Origin

  • Plant Source: Stevia rebaudiana (Stevia leaf)

  • Active Component: Isosteviol (a diterpenoid metabolite of Stevioside)

  • Plant Part: Leaf

  • Geographical Origin: Shaanxi, China

  • Manufacturing Standard: GMP, ISO9001, HACCP, Halal, Kosher

  • Processing Certifications: GMP certified plant extract for cosmetics, food-grade quality system

  • Factory Advantage: In-house supercritical CO₂ extraction + controlled hydrolysis + purification

3. Key Benefits & Functional Properties of Isosteviol

Research suggests Isosteviol exhibits several physiological effects relevant to dietary supplements and functional formulations:

(1) Cardiovascular Support

  • Helps regulate vascular tone

  • Demonstrates cardioprotective properties in preclinical models

  • May support healthy blood pressure levels (NIH reference below)

(2) Metabolic & Glucose Balance

  • Supports insulin sensitivity pathways

  • May help maintain balanced blood glucose levels

  • Potential adjunct ingredient for metabolic wellness formulas

(3) Anti-Inflammatory & Antioxidant Effects

  • Scavenges free radicals

  • Helps regulate inflammatory cytokines

  • Suitable for anti-inflammatory supplement categories

(4) Neuroprotective Potential

  • Shows protective effects in cerebral ischemia models

  • Investigated for its role in mitochondrial protection and oxidative stress reduction

(5) Digestive & Hepatic Support

  • May assist liver function and protect against toxin-mediated stress

  • Supports gastrointestinal comfort

Expert Note:
“Isosteviol is substantially more bioactive than Stevioside in non-sweetener applications, and its pharmacological diversity makes it attractive for next-generation nutraceutical formulations.”
— Dr. Lin H., PhD Pharmacognosy, 2024

4. Specifications (Typical COA Reference)

4.1 General Specifications

Item Specification Method
Appearance White to off-white crystalline powder Visual
Purity (HPLC) ≥ 98% HPLC
Odor/Taste Characteristic, mild Sensory
Molecular Formula C<sub>20</sub>H<sub>30</sub>O<sub>3</sub> —
Molecular Weight 318.45 —
Loss on Drying ≤ 1.0% USP
Residue on Ignition ≤ 0.2% USP

4.2 Pesticide Residues Testing

Category Test Item Limit Method
Organochlorine Pesticides DDT, BHC ≤ 0.1 mg/kg each GC-MS
Organophosphorus Pesticides Parathion, Malathion ≤ 0.2 mg/kg each GC-MS
Pyrethroids Cypermethrin ≤ 0.5 mg/kg LC-MS/MS
Multi-Residue Screen 300+ pesticides Complies LC-MS/MS

4.3 Heavy Metals Testing

Test Item Limit Method
Lead (Pb) ≤ 2 ppm ICP-MS
Arsenic (As) ≤ 1 ppm ICP-MS
Cadmium (Cd) ≤ 1 ppm ICP-MS
Mercury (Hg) ≤ 0.1 ppm ICP-MS
Total Heavy Metals ≤ 10 ppm USP <231>

4.4 Microbiological Standards

Test Item Limit Method
Total Plate Count ≤ 1,000 CFU/g USP
Yeast & Mold ≤ 100 CFU/g USP
Escherichia coli Negative USP
Salmonella Negative USP
Staphylococcus aureus Negative USP
Coliforms ≤ 10 CFU/g GB Standard

5. Recommended Use, Dosage & Application Guide

Recommended Dosage (B2B Reference Only)

  • Dietary supplements: 5–50 mg/day (formulation dependent)

  • Functional foods: 10–80 mg per serving

  • Cosmetic formulations: 0.1–1% as antioxidant/anti-inflammatory active

Dosage refinements should be supported by clinical strategy and regulatory compliance in each market.

6. Best Formulation Strategies

  1. Combine with metabolic-support actives
    – Berberine, alpha-lipoic acid, chromium picolinate

  2. Synergize with cardiovascular botanicals
    – Hawthorn extract, resveratrol

  3. Brain & stress formulas
    – GABA, L-theanine, Bacopa

  4. Liver health blends
    – Milk thistle, turmeric curcumin

Our R&D team supports customized herbal extract formulas for OEM/ODM projects.

7. Production Process & Flow

Process Flowchart

  1. Raw Material Sourcing (Stevia Leaves)

  2. Supercritical CO₂ Extraction

  3. Stevioside Isolation

  4. Controlled Acid Hydrolysis → Formation of Isosteviol

  5. Crystal Purification (recrystallization)

  6. Filtration & Concentration

  7. Drying (Vacuum / Spray Drying)

  8. Milling & Sieving (80–100 mesh)

  9. Final QC Testing (HPLC, ICP-MS, Microbial)

  10. Packaging & Traceable Labeling

8. Storage, Shelf Life & Packaging

  • Storage: Keep in sealed container, stored in a cool, dry environment away from light

  • Shelf Life: 24–36 months when properly stored

  • Standard Packaging:

    • 1 kg aluminum foil bags

    • 25 kg fiber drums

    • OEM custom packaging available

  • Sample Policy:
    ✔ Free sample herbal extract (10–30 g) available for formulation testing

  • MOQ: 1 kg for R&D; 25 kg for wholesale production

  • Shipping: FedEx/DHL for samples; air/sea freight for bulk orders

9. Industries & Application Scenarios

Primary Industries

  • Dietary supplement brands

  • Functional food & beverage

  • Sports nutrition

  • Cosmetic & personal care

  • Pharmaceutical intermediates

  • R&D laboratories

Application Scenarios

  • Capsules, tablets

  • Gummies & functional confections

  • Nutraceutical powder blends

  • Beverages, shots, energy drinks

  • Skincare anti-inflammatory formulas

  • Prototype research projects

10. Why Work With AIHerba® (Supplier & Manufacturer Advantage)

AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd.

  • 28+ years extraction expertise

  • GMP, ISO, HACCP, Halal, Kosher

  • Fast global delivery from a China-based factory manufacturer

  • Competitive price for bulk orders

  • Strict quality control (HPLC, GC-MS, LC-MS/MS)

  • Responsive technical support

  • Stable yearly supply capacity

We support:

  • Bulk supply

  • Wholesale distribution

  • OEM/ODM formulation

  • Food-grade botanical extract supplier services

📧 sales@aiherba.com
📧 info@aiherba.com
📧 liaodaohai@gmail.com
🌐 www.aiherba.com

11. Frequently Asked Questions (FAQ)

1. Is Isosteviol the same as Stevia sweeteners?

No. Although derived from Stevioside, Isosteviol is not a sweetener. It is a bioactive compound used for metabolic, cardiovascular, and wellness applications.

2. Can I buy Isosteviol in bulk directly from the factory?

Yes. AIHerba® is a direct bulk supplier and manufacturer with GMP-certified facilities.

3. Do you offer COA and third-party test reports?

Yes. Each batch includes HPLC assay, heavy metals, pesticide residue, and microbial testing.

4. Can you support customized formulations?

Absolutely — we support customized herbal extract development for OEM/ODM clients.

5. Do you provide free samples?

Yes, we offer a free sample herbal extract (10–30 g) for qualified business customers.

12. Scientific References (PubMed, NIH, FDA)

  1. Chen J., et al. Pharmacological effects of Isosteviol on cardiovascular function. PubMed: https://pubmed.ncbi.nlm.nih.gov/

  2. Geuns J.M. Stevia and steviol metabolites: safety and bioactivity. NIH: https://www.nih.gov/

  3. FDA GRAS Notice for Stevia-related compounds & safety assessments: https://www.fda.gov/

  4. Wong K.L., et al. Isosteviol as a potential neuroprotective agent in ischemia models. PubMed.

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