Flavonol Glycosides
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Flavonol Glycosides

Flavonol Extract: Benefits, Specifications, Applications & How to Source from a Trusted Manufacturer

  1. English Name: Flavonol Glycosides
  1. Specification
    • Total Flavonol Glycosides Content: ≥ 90% (HPLC); high – purity grade: ≥ 95% (HPLC)
    • Solubility: Varies by structure; some are water – soluble (due to glycosylation), while others are soluble in ethanol, methanol, and DMSO
    • Moisture Content: ≤ 5%
    • Heavy Metals: ≤ 10 ppm
    • Residual Solvents: ≤ 0.5%
    • Particle Size: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for enhanced dissolution
  1. Appearance
    • Yellow to pale yellow fine powder, odorless or with a faint plant – like smell
  1. CAS NO.
    • As a class, no single CAS number; individual compounds have specific numbers (e.g., Quercetin – 3 – O – glucoside: 522 – 12 – 3)
  1. Lead Time: 5 – 7 Working Days
  1. Package
    • 1 kg/aluminum foil bag, 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market: Global market, with significant demand in Europe, North America, Asia, particularly in nutraceutical, pharmaceutical, and cosmetic industries
  1. Application Scenarios

Core Properties

  • Chemical Structure:
    • Composed of a flavonol aglycone (e.g., quercetin, kaempferol, myricetin) bonded to one or more sugar moieties (glucose, rhamnose, galactose)
  • Antioxidant Activity:
    • Scavenges free radicals (e.g., hydroxyl, superoxide), with ORAC values ranging from 5000 – 20,000 μmol Trolox Equivalents/g
  • Key Features:
    • Anti – inflammatory: Inhibits COX – 2 enzyme and NF – κB pathway, reducing pro – inflammatory cytokine production
    • Cardioprotective: Improves endothelial function, reduces LDL oxidation, and lowers blood pressure
    • Cancer Preventive: Induces apoptosis in cancer cells, blocks angiogenesis, and inhibits tumor cell migration
    • UV Protection: Absorbs UV radiation, protecting cells from photoaging and DNA damage
    • Bioavailability: Glycosylation can enhance water solubility and intestinal absorption

Application Scenarios

1. Dietary Supplements

  • General Health Formulas:
    • Capsules/tablets (50 – 200 mg/serving) for antioxidant support, often combined with other polyphenols like resveratrol or green tea extract
  • Cardiovascular Health:
    • Formulations targeting high cholesterol or hypertension, leveraging their ability to reduce oxidative stress and inflammation in blood vessels
  • Anti – Aging Supplements:
    • Products claiming to boost skin health and reduce age – related diseases by neutralizing free radicals

2. Functional Food & Beverages

  • Antioxidant Fortification:
    • Added to juices, teas, and sports drinks (0.05 – 0.5% concentration) to enhance nutritional value
    • Used in baked goods, snacks, and dairy products to extend shelf life through antioxidant properties
  • Clean Label Ingredients:
    • Meets consumer demand for natural additives; popular in “superfood” products

3. Pharmaceuticals

  • Clinical Research:
    • Investigated for treating chronic diseases:
      • Diabetes: Improves insulin sensitivity and reduces oxidative stress in diabetic patients
      • Neurodegenerative Disorders: Protects neurons from oxidative damage in Alzheimer’s and Parkinson’s disease models
  • Herbal Medicines:
    • Active ingredients in traditional herbal remedies, standardized for consistent efficacy

4. Cosmetics & Personal Care

  • Anti – Aging Skincare:
    • Serums, creams (1 – 3% concentration) to stimulate collagen production, reduce wrinkles, and protect against UV damage
  • Hair Care:
    • Shampoos and conditioners to strengthen hair follicles, prevent hair loss, and improve scalp health by reducing inflammation

5. Animal Health

  • Livestock Feed Additives:
    • Poultry and swine feed (50 – 200 ppm) to enhance growth performance, improve meat quality, and boost immune function
  • Pet Supplements:
    • Chewables or powders for dogs and cats, supporting joint health and reducing oxidative stress

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% formic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 254 – 360 nm (varies by flavonol type)
  • Liquid Chromatography – Mass Spectrometry (LC – MS):
    • Identifies individual flavonol glycosides and quantifies them in complex matrices (e.g., biological samples)
  • UV – Visible Spectroscopy:
    • Quick – screening method for total flavonoid content using the aluminum chloride colorimetric assay

Source & Advantages

  • Natural Sourcing:
    • Extracted from plants such as Ginkgo biloba, Sophora japonica, and grape seeds
  • Sustainable Production:
    • By – products of food processing (e.g., grape seed extract from winemaking) can be utilized, reducing waste
  • Regulatory Acceptance:
    • Recognized as safe in food and supplements in major markets:
      • US FDA: Generally Recognized As Safe (GRAS) for many sources
        • EU: Permitted as natural food additives and dietary ingredients
Categories: , , , , ,

Flavonol – High-Purity Botanical Antioxidant for Premium Formulations

From AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd. – GMP-Certified Plant Extract Manufacturer

Flavonols are a class of polyphenolic compounds naturally found in fruits, vegetables, and medicinal herbs. Known for their strong antioxidant activity, immune-supportive potential, and broad functionality across health supplements, skincare, and functional foods, Flavonols have become one of the most in-demand botanical actives in global nutraceutical markets.

AIHerba® produces high-purity Flavonol extract using GMP-certified facilities and advanced extraction technologies to ensure stable potency, clean profiles, and reliable batch-to-batch consistency. With over 28 years of manufacturing experience, we support brands, distributors, and R&D formulators with bulk supply, custom specifications, and OEM/ODM solutions.

1. Product Overview

  • Product Name: Flavonol / Flavonols (Botanical Polyphenols)

  • Source: Natural fruits, leaves, and plant materials rich in quercetin-type flavonols

  • Appearance: Fine yellow to light brown powder

  • Assay: 10%–98% Flavonols (UV or HPLC, depending on request)

  • Grade: Food-grade / Cosmetic grade

  • Available Forms: Water-soluble, ethanol-soluble, high-purity crystalline options

  • Status: Non-GMO, Allergen-free, Vegan, Halal & Kosher available

2. Key Benefits & Biological Functions (Evidence-Based)

[1] Antioxidant Protection
Flavonols help neutralize reactive oxygen species and reduce oxidative stress — a critical mechanism for skin health, cellular protection, and aging support.

[2] Immune & Inflammatory Balance
Research (NIH; PubMed 30112314) suggests flavonols help modulate inflammatory pathways, supporting immune resilience.

[3] Cardiovascular Health Support
Some flavonols, including quercetin derivatives, may support endothelial function and healthy blood pressure regulation.

[4] Skin & Anti-Aging Applications
Their antioxidant capacity makes flavonols an attractive ingredient for serums, creams, anti-aging products, and functional beauty supplements.

[5] Gut & Metabolic Benefits
Emerging studies show potential roles in supporting a balanced gut environment and metabolic wellness.

3. Traditional Uses

Plants rich in flavonols have been used in:

  • Herbal medicine for inflammation and immune support

  • Traditional teas and decoctions

  • Antioxidant tonics

  • Natural skincare formulations

4. Recommended Dosage (B2B Guidance Only)

Not medical advice. Final dosage depends on finished-product claims and regulatory requirements.

  • Dietary supplements: 50–500 mg/day

  • Functional beverages: 20–100 mg/serving

  • Cosmetics: 0.1–2% in emulsions, gels, serums

  • Food fortification: 10–200 mg/kg depending on matrix

5. Formulation Guide (Best Practices)

✔ Combine with Vitamin C, resveratrol, or green tea catechins for synergistic antioxidant effects.
✔ Use water-soluble grade for beverages and gummies.
✔ Use high-purity grade for capsules, tablets, and premium skincare.
✔ Encapsulation (liposomal / microencapsulated) improves stability and bioavailability.

6. COA Specification Table (Testing Standards)

A. Pesticide Residue Panel

Item Limit Test Method
Organophosphates (e.g., Diazinon) ≤ 0.01 mg/kg GC-MS
Carbamates ≤ 0.01 mg/kg LC-MS/MS
Organochlorines (DDT, HCH) ≤ 0.01 mg/kg GC-MS
Pyrethroids ≤ 0.01 mg/kg LC-MS/MS
EU/US 500+ pesticide screen Compliant LC-MS/MS

B. Heavy Metals

Heavy Metal Limit Test Method
Lead (Pb) ≤ 3.0 mg/kg ICP-MS
Arsenic (As) ≤ 2.0 mg/kg ICP-MS
Cadmium (Cd) ≤ 1.0 mg/kg ICP-MS
Mercury (Hg) ≤ 0.1 mg/kg AAS
Total Heavy Metals ≤ 10 mg/kg ICP-MS

C. Microbiological Testing

Item Limit Test Method
Total Plate Count ≤ 10,000 cfu/g GB/T 4789.2
Yeast & Mold ≤ 300 cfu/g GB/T 4789.15
Coliforms ≤ 10 cfu/g GB/T 4789.3
Salmonella Negative GB/T 4789.4
E. coli Negative GB/T 4789.38
Staphylococcus aureus Negative GB/T 4789.10

7. Production Process (High-Level Description)

AIHerba uses modern, controlled extraction systems to maintain bioactive integrity and ensure clean, stable ingredients.

Production Steps

  1. Raw Material Pre-Screening
    Selection of high-flavonol plant sources; pesticide & heavy metal testing.

  2. Grinding & Pretreatment
    Particle reduction for consistent extraction.

  3. Solvent Extraction
    Water-ethanol extraction or supercritical CO₂ (depending on plant source).

  4. Filtration & Purification
    Advanced adsorption resins or membrane separation.

  5. Concentration
    Low-temperature vacuum concentration to preserve activity.

  6. Drying
    Spray-drying or freeze-drying based on desired grade.

  7. Final Milling & Standardization
    Powder homogenization and assay adjustment.

  8. Quality Control
    Batch-to-batch HPLC fingerprinting, safety tests, COA release.

8. Applications & Industries

Industries

  • Dietary supplements

  • Functional foods & beverages

  • Cosmetics / personal care

  • Pharmaceutical health products

  • Sports nutrition

  • Beauty-from-within formulas

Application Examples

  • Capsules, tablets, softgels

  • Anti-aging serums and creams

  • Fortified beverages and superfood powders

  • Gummies and effervescent tablets

  • Food antioxidants and natural color stabilizers

9. Storage, Packaging & Logistics

Storage

  • Store in a cool, dry environment below 25°C

  • Keep sealed away from direct sunlight and moisture

Shelf Life

  • 24 months in original packaging

Packaging Options

  • 1 kg aluminum foil bags

  • 25 kg food-grade fiber drums

  • Customized packaging available for OEM buyers

Sample Policy

  • Free sample herbal extract (20–50 g) available for quality evaluation

  • Freight may be covered by the buyer depending on region

MOQ

  • Standard MOQ: 1 kg

  • Discount pricing offered for bulk orders and long-term partnerships

Transportation

  • Air freight, DHL/UPS/FedEx express, sea shipping for pallet quantities

10. Why Choose AIHerba® as Your Flavonol Supplier

✔ GMP-certified manufacturer with 28+ years of experience
✔ Fully traceable supply chain from raw material to finished ingredient
✔ Advanced extraction technology (water-ethanol, CO₂, membrane purification)
✔ Stable, repeatable, and internationally compliant specifications
✔ Strong R&D team, custom specifications available (customized herbal extract)
✔ Competitive price, global exports, reliable lead times
✔ Already supplying ingredients to brands in 60+ countries

11. Frequently Asked Questions (FAQ)

1. Is your Flavonol extract suitable for dietary supplements?
Yes — our material is food-grade and widely used in capsules, tablets, powders, and functional beverages.

2. Can I request a customized specification?
Absolutely. As a GMP-certified manufacturer, we can adjust purity, solubility, color, and particle size.

3. Do you offer wholesale or bulk volumes?
Yes — we supply bulk quantities globally, and offer competitive wholesale programs.

4. How can I verify product quality?
Every batch is supported by COA, HPLC fingerprint, microbial tests, and heavy metal reports.

5. Can your Flavonol be used in skincare?
Yes — we provide cosmetic-grade material with excellent stability.

6. How do I buy Flavonol extract from your factory?
Send your requirements to sales@aiherba.com and our technical sales team will respond within 24 hours.

12. Scientific References (PubMed / NIH / FDA Links)

  1. https://pubmed.ncbi.nlm.nih.gov/30112314/

  2. https://pubmed.ncbi.nlm.nih.gov/34245549/

  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465813/

  4. https://www.fda.gov/food/dietary-supplements

  5. https://ods.od.nih.gov/

13. Contact & Verification

AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd.
GMP-Certified Botanical Extract Factory & Exporter
🌐 www.aiherba.com
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com

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