Ergothioneine Benefits, Uses, and Supplier Guide – High-Purity Botanical Extracts for Supplements & Cosmetics

AIHerba® | Leading Herbal Extract Supplier & Botanical Extract Manufacturer in China

What Is Ergothioneine?

Ergothioneine (EGT) is a naturally occurring sulfur – containing amino acid with potent antioxidant and anti – inflammatory properties. Discovered in 1909, it acts as a cellular protectant by scavenging reactive oxygen species (ROS) and regulating mitochondrial function. Found in mushrooms, certain grains, and animal tissues, EGT is unique for its ability to cross the blood – brain barrier and accumulate in metabolically active tissues, making it a key ingredient in advanced nutraceuticals and pharmaceuticals.

AIHerba (Shaanxi Zhonghong Investment Technology Co., Ltd.) is a GMP-certified plant extract factory specializing in high-purity herbal extracts. With over 28 years of R&D and production experience, we provide global partners with bulk herbal extracts, customized herbal extract solutions, and OEM/ODM services for cosmetics, dietary supplements, functional foods, and pharmaceutical applications.

Our Ergothioneine is produced using advanced extraction technologies—supercritical CO₂, water-ethanol extraction, and microbial fermentation—ensuring stable, potent, and traceable ingredients for your formulations. Whether you want to buy herbal extracts wholesale or explore food-grade botanical extract options, AIHerba delivers consistent quality, fast delivery, and verified supply chains.

Contact us: 📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com

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1. Product Overview

Botanical Name: Ergothioneine
CAS Number: 497-30-3
Appearance: White to off-white crystalline powder
Solubility: Water-soluble, stable in neutral pH solutions
Purity: ≥ 99.99% (HPLC)
Form: Powder

As a naturally occurring antioxidant amino acid, Ergothioneine has gained attention for its

cell-protective properties, anti-aging potential, and neuroprotective benefits. Derived from microbial fermentation, it offers a high-quality, GMP-certified source suitable for dietary supplements, cosmetics, and functional foods.

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2. Key Benefits & Health Applications

1. Antioxidant & Cellular Protection – Supports oxidative stress defense and helps reduce cellular damage.

2. Anti-Aging Support – May protect skin cells and improve resilience to environmental stressors.

3. Neuroprotection & Cognitive Support – Research indicates Ergothioneine contributes to brain health.

4. Liver & Kidney Support – Helps maintain organ health by reducing oxidative stress.

5. Cosmetic & Skincare Benefits – Reduces free radicals, enhances product stability, and promotes skin vitality.

Reference:

• Cheah IK, Halliwell B. “Ergothioneine, recent developments.” Biochem Biophys Res Commun. 2012; 423(4): 647–651. PubMed

• FDA GRAS: GRAS Notice No. 652

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3. Recommended Usage & Formulation Guidelines

• Dietary Supplements: 1–5 mg/day in capsules or functional powders

• Functional Foods & Beverages: 0.01–0.1% w/w as an antioxidant additive

• Cosmetics & Skincare: 0.1–0.5% in creams, serums, or masks

Tips: Ergothioneine is stable under neutral pH; avoid strong oxidizers or acidic environments for prolonged periods. Works well in combination with vitamin C, vitamin E, CoQ10, and plant polyphenols.

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4. Traditional & Modern Applications

• Traditional Use: Sourced from mushrooms like Pleurotus eryngii and fermented natural plant extracts.

• Modern Use: Widely applied in anti-aging cosmetics, nutraceuticals, and functional beverages.

Example Application:

• Skincare serums with 0.2% Ergothioneine + 0.5% hyaluronic acid for anti-aging formulations.

• Functional beverage with 0.05% Ergothioneine + vitamin C for antioxidant support.

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5. Product Specifications (COA)

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6. Production & Manufacturing Process

1. Raw Material Selection: High-quality microbial fermentation strains and natural substrates.

2. Fermentation: Controlled microbial fermentation under sterile, GMP-compliant conditions.

3. Extraction & Purification: Water-ethanol extraction, filtration, and crystallization.

4. Drying & Milling: Spray drying or vacuum drying to obtain fine, stable powder.

5. Quality Control: Full COA testing including purity, heavy metals, pesticides, and microbiology.

6. Packaging: GMP-approved containers under controlled environment.

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7. Storage & Shelf Life

• Storage Conditions: Cool, dry, dark place (≤25°C, 60% RH).

• Shelf Life: 24 months in original, unopened packaging.

Packaging Options:

• 1 kg, 5 kg, 10 kg foil bags

• Customized packaging available upon request

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8. Sample & MOQ

• Free Sample: Available for testing & formulation validation.

• MOQ: 1 kg for bulk orders, scalable according to client needs.

• Shipping: DHL, FedEx, UPS, or sea freight for bulk shipments.

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9. Applicable Industries & Usage Scenarios

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10. Certifications & Quality Assurance

• GMP-certified manufacturer

• ISO 9001 & ISO 22000 standards

• COA & batch testing for each production lot

• Traceable supply chain from China’s leading plant extract factory

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11. Frequently Asked Questions (FAQ)

Q1: Is Ergothioneine safe for daily consumption?
A: Yes, research supports its safety at recommended doses. For dietary supplements, 1–5 mg/day is typical.

Q2: Can I request a custom formulation?
A: Absolutely! AIHerba provides OEM/ODM services for customized herbal extract solutions.

Q3: Do you provide COA and lab reports?
A: Yes, every batch comes with full COA including purity, heavy metals, pesticides, and microbial tests.

Q4: How can I buy in bulk?
A: Contact us at sales@aiherba.com or info@aiherba.com to discuss pricing, MOQ, and shipping.

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12. References & Regulatory Sources

1. Cheah IK, Halliwell B. Biochem Biophys Res Commun. 2012; 423(4):647–651. PubMed

2. FDA GRAS Notice No. 652 – Ergothioneine FDA Link

3. NIH Dietary Supplement Fact Sheet: NIH Link