At current, there are 15,000 species of huge fungi on this planet, of which greater than 2,000 are edible fungi, and greater than 1,000 species of edible fungi have been clearly recorded in China [1]. Mushrooms are wealthy in vitamins and useful energetic substances, together with polysaccharides, energetic proteins and peptides, phenols, ketones, terpenes and steroid compounds [2]. Amongst them, polysaccharides are one of many essential energetic components of edible fungi. Trendy analysis exhibits that edible fungi polysaccharides have a wide range of organic actions, together with antioxidant, anti-tumor, anti-inflammatory, immunomodulatory, hypoglycemic, intestinal flora regulation, antiviral and different actions [3]. Edible fungi polysaccharides are used as useful energetic components to stop and deal with varied power ailments and are very useful to human well being. The creator systematically evaluations the efficacy of assorted typical edible fungi polysaccharides and the analysis progress of their software in useful meals, biomedicine and cosmetics, to be able to present reference and scientific foundation for the additional improvement and utilization of edible fungi and their polysaccharides.
Typical edible fungus polysaccharides and their results
Ganoderma lucidum polysaccharides
Ganoderma lucidum is a well-known edible and medicinal fungus with a historical past of hundreds of years of software. The Pharmacopoeia of the Folks’s Republic of China [4] data that Ganoderma lucidum is “candy and impartial. It enters the center, lung, liver and kidney meridians” and has the consequences of “tonifying qi and calming the thoughts, relieving cough and relieving bronchial asthma”. Polysaccharides are one of many essential parts of Ganoderma lucidum to exert organic exercise. At current, Ganoderma lucidum polysaccharides are primarily derived from spore powder, fruiting our bodies, mycelium and Ganoderma lucidum fermentation liquid. Ganoderma lucidum polysaccharides have antioxidant, anti-tumor, hypoglycemic, anti-inflammatory, liver safety, immunomodulatory and neuroprotective results. Ganoderma lucidum polysaccharides present good antioxidant exercise by scavenging extra free radicals, rising antioxidant enzyme exercise and lowering peroxides [5]. Liu Yang et al. [6] discovered that Ganoderma lucidum polysaccharides can considerably promote the mobile immune response of 4T1 tumor-bearing mice to HER2/neu plasmid DNA vaccine and have a big immune-promoting impact on mice. As well as, Wu Ruiting et al. [7] discovered that black Ganoderma lucidum polysaccharide can considerably regulate blood glucose, blood lipids and insulin in diabetic rats induced by streptozotocin (STZ), and its mechanism could also be via altering the structural composition of microorganis Ganoderma lucidumms within the rat gut. Dilisoyer Yalekunmu et al. [8] identified that Ganoderma lucidum polysaccharide might play a radiation safety position by enhancing the expression of related potential biomarkers and their associated metabolic pathways within the thymus of radiation mannequin mice.
Cordyceps polysaccharide
Cordyceps polysaccharide is a extremely branched galactomannan. Research have discovered that Cordyceps polysaccharide performs an vital position in enhancing immune operate, anti-cancer, sterilization, lung safety, and kidney profit. Jiang Yuzhen et al. [9] optimized the enzyme-assisted sizzling water extraction of Cordyceps militaris polysaccharide by response floor methodology and located that the DPPH free radical scavenging charge of Cordyceps militaris polysaccharide reached 88.06%, and the hydroxyl free radical scavenging charge was 78.80%, each of which have been dose-dependent, proving that Cordyceps militaris polysaccharide has good antioxidant exercise. Yao Yanting et al. [10] obtained Cordyceps militaris polysaccharide fraction (SeCMP0.2) by water extraction and alcohol precipitation mixed with anion change chromatography column separation and purification. The outcomes confirmed that SeCMP0.2 can activate mitogen-activated protein kinase and nuclear factor-κB signaling pathways, upregulate the expression of inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-6, and interleukin-1β mRNA, and exert its immunomodulatory impact. Liu Guangqing et al. [11] extracted Cordyceps flower polysaccharide by water extraction and alcohol precipitation mixed with Sevag technique and located that Cordyceps flower polysaccharide can considerably scale back the expression ranges of tumor necrosis issue α, nuclear issue κB, and so forth. in CCl4-induced mouse liver, considerably downregulate serum ALT and AST ranges, alleviate CCl4-induced liver injury, inhibit hepatocyte apoptosis, and supply a reference for the remedy of liver fibrosis.
Phellinus igniarius polysaccharide
Phellinus igniarius can promote diuresis and cease bleeding, enhance inner organs. “Compendium of Materia Medica” [12] data that “Mulberry parasite advantages the 5 inner organs, promotes intestinal and abdomen qi, and removes poisonous qi.” As one of many essential bioactive parts of Phellinus igniarius, polysaccharides have been verified to have a number of organic actions akin to anti-tumor, immunomodulatory, anti-inflammatory, and antioxidant. Zhang Kunlin et al. [13] discovered that Phellinus igniarius polysaccharides can improve the exercise of embryonic alkaline phosphatase secreted by RAW-BlueTM cells and their macrophage phagocytosis, proving that Phellinus igniarius polysaccharides have immune exercise. Miao Yunping et al. [14] used Phellinus igniarius polysaccharides to deal with rat ulcerative colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). The outcomes confirmed that Phellinus igniarius polysaccharides might considerably scale back the expression ranges of NF-κB p65 protein and IL-6 and TNF-α mRNA within the rat colon. The therapeutic impact on rat ulcerative colitis was apparent, which can be associated to regulating the secretion of inflammatory cytokines, anti-oxidation and inhibiting the expression of NF-κB. Li Yuanyuan et al. [15] ready crude polysaccharide from mycelium of Phellinus igniarius by water extraction and alcohol precipitation, obtained fractions (IPS45-W) by distilled water elution, and located that it might inhibit the expansion of HepG2 cells (the inhibition charge was 57% at a focus of fifty μg/mL) via in vitro cytotoxicity and cell viability exams, proving the anti-tumor exercise of crude polysaccharide from mycelium of Phellinus igniarius. Yu Qiuju et al. [16] discovered that mulberry linterus polysaccharide has good antioxidant and tumor inhibition exercise via in vitro exercise exams.
Grifola frondosa polysaccharide
The polysaccharide parts extracted from Grifola frondosa fruiting our bodies have organic actions akin to antioxidant, anti-tumor, radiation safety and immunomodulatory. Xu Yingying [17] discovered that Grifola frondosa polysaccharide part (GFP1) has a big inhibitory impact on the proliferation of lung most cancers cells H1975, and GFP1 might obtain anti-tumor results by inhibiting the Ras/Raf/MEK/ERK signaling pathway. Tang Mengting [18] used the Illumina system to investigate the construction and composition of the intestinal flora after fermentation of the tradition medium and located that the parts of Grifola frondosa polysaccharide (GFP-H, GFP-L) can considerably promote the proliferation of Bifidobacterium and Bacteroides within the gut, and have a useful impact on the well being of the intestinal flora. Quan Shulin et al. [19] discovered that Grifola frondosa polysaccharide GFP-A1 can considerably enhance the train endurance of train mice and has an anti-fatigue impact. Liu Yonghua et al. [20] discovered that Grifola frondosa polysaccharide can considerably enhance the content material of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in rats with gastric ulcer mannequin, and scale back the degrees of gastrin (GAS), motilin (MTL), somatostatin (SS), and malondialdehyde (MDA), additional proving the position of Grifola frondosa polysaccharide in lowering gastrointestinal hormone secretion and enhancing antioxidant ranges.
Agaricus blazei polysaccharide
Research have discovered that Agaricus blazei polysaccharide has organic actions akin to anti-cancer, antioxidant, hypoglycemic, diabetes enchancment, and ldl cholesterol discount. Pu Chao et al. [21] handled CHON-001 cells with 10 ng/mL IL-1β to determine a chondrocyte irritation mannequin and explored the protecting impact of Agaricus blazei polysaccharide on interleukin 1β (IL-1β)-induced chondrocyte CHON-001 damage. The outcomes confirmed that Agaricus blazei polysaccharide might considerably scale back the apoptosis charge and Bax protein degree of the chondrocyte irritation mannequin, and identified that IL-1β-induced chondrocyte irritation and apoptosis have been inhibited by upregulating the expression degree of miR-382-3p. As well as, Zhong Pupeng et al. [22] discovered that Agaricus blazei polysaccharide additionally has a sure impact on intestinal barrier safety. They identified that Agaricus blazei polysaccharide can considerably enhance the relative expression of Faecalibacterium prausnitzii, Lactobacillus and Bifidobacterium 16SrRNA genes in rats with ulcerative colitis induced by sodium dextran sulfate (DSS), and considerably scale back the relative expression of Escherichia coli 16SrRNA genes, indicating its vital position in stopping acute colitis.
Hericium erinaceus polysaccharide
Hericium erinaceus is flat in nature, candy in style, wealthy in vitamin, helps digestion and advantages the 5 inner organs. Hericium erinaceus is generally used to enhance peptic ulcers, power gastroenteritis, lack of urge for food and different ailments, and likewise has a sure inhibitory impact on most cancers. Hericium erinaceus incorporates polysaccharide, which known as “hericium erinaceus polysaccharide”, which has a number of organic actions akin to antioxidant, immunomodulatory, regulating intestinal microbiota, decreasing blood sugar, anti-tumor, and gastric safety. Ma Zheng et al. [23] studied the consequences of Hericium erinaceus polysaccharide on the restoration of bodily activity-induced fatigue and antioxidant capability within the aged and located that supplementing Hericium erinaceus polysaccharide within the aged can considerably enhance their cardio capability and blood rheology, promote fatigue restoration, and enhance antioxidant capability. Niu Meilan et al. [24] confirmed that Hericium erinaceus polysaccharide can considerably scale back the degrees of TNF-α, IL-6, and IFN-r within the serum of rats with power non-bacterial prostatitis, scale back the degrees of immunoglobulins IgA and IgG within the serum, additional alleviate power non-bacterial prostatitis in rats, and delay the event of the illness. Li Xinghai et al. [25] explored the anti-tumor exercise and mechanism of Hericium erinaceus polysaccharide, primarily by culturing gastric adenocarcinoma cells and organising a Hericium erinaceus polysaccharide addition group. It was discovered that Hericium erinaceus polysaccharide mixed with reworking development factor-β1 can successfully inhibit the proliferation of gastric adenocarcinoma cells BGC-823 and SGC7901 by negatively regulating p-AKT and p-PI3K, thereby additional inhibiting the variety of most cancers cell clones.
Poria cocos polysaccharide
Poria cocos is the dried sclerotium of the fungus Poria cocos of the Polyporaceae household. It’s “impartial in nature, candy and lightweight in style, and enters the center, spleen, and kidney meridians. It’s diuretic and dehumidifying, strengthens the spleen, and calms the thoughts. It’s used for edema, oliguria, phlegm and fluid, palpitations, spleen deficiency, poor urge for food, unfastened stools, restlessness, palpitations, and insomnia.” Numerous research have confirmed that Poria cocos polysaccharide has antiviral and anti-tumor results, and reduces the unintended effects of radiotherapy and chemotherapy. Liu Jiali et al. [26] discovered that Poria cocos polysaccharide can considerably scale back the discharge of NO and the speed of apoptosis in lipopolysaccharide-induced cat kidney cells, and believed that it could obtain the impact of cell irritation safety by inhibiting the TLR4-NF-κB signaling pathway. This analysis consequence gives a brand new goal and experimental foundation for the verification of Poria cocos polysaccharide within the remedy of cat kidney cells. Zheng et al. [27] used sizzling water extraction to acquire Poria cocos polysaccharide (PCPP-1A) and located that PCPP-1A has wonderful potential in stimulating the immune response of RAW264.7 cells and defending AML-12 cells from radiation.
Tremella polysaccharide
Tremella is good in style, impartial in nature, and belongs to the lung meridian. It has the consequences of nourishing yin and moistening the lungs, replenishing qi and selling fluid, and beautifying the pores and skin. The tremella polysaccharide it incorporates has the consequences of enhancing immunity, decreasing blood sugar, and stopping and treating cardiovascular ailments. Xing Youzhe et al. [28] discovered that tremella polysaccharide can considerably promote the proliferation of mouse spleen lymphocytes, promote the secretion of IL-6, IL-10, IL-12 and IFN-γ, and exert its immunomodulatory impact by activating the PI3K/Akt and NF-κB signaling pathways of mouse spleen lymphocytes. Huang Xiaolan et al. [29] discovered that tremella polysaccharide can considerably scale back the degrees of TNF-α and Il-6 within the serum of mice present process exhaustive train by regulating the Nrf2/HO-1 signaling pathway, considerably enhance the degrees of SOD and GSH-Px, and extend the exhaustive swimming time of mice, proving that tremella polysaccharide improves oxidative injury brought on by train by inhibiting oxidative stress. Tan Minying et al. [30] discovered that Tremella polysaccharide has the impact of inhibiting osteoarthritis, defending cartilage tissue to a sure extent, and resisting cell apoptosis.
Black fungus polysaccharide
Black fungus is “impartial, candy, clean, and enters the abdomen and enormous gut meridians”. It is called the “intestinal scavenger”. It primarily depends on its cleansing, lipid-lowering, intestinal motility promotion, and metabolism enhancement. Black fungus is wealthy in antioxidants and has wealthy organic actions. Black fungus polysaccharide has a number of organic actions akin to antioxidant, lipid-lowering, immune enhancement and anti-tumor. Liu Nannan [31] extracted and purified two black fungus polysaccharide parts (AAP-1 and AAP-2) by sizzling water extraction-ethanol precipitation technique, and used C57BL/6J male mice to assemble a sort 2 diabetes mannequin for in vivo hypoglycemic exercise analysis. It was discovered that each black fungus polysaccharide parts can activate the PI3K/AKT signaling pathway, scale back insulin resistance, scale back oxidative stress injury, and enhance glucose and lipid metabolism to attain the impact of decreasing blood sugar. Li Xue et al. [32] ready phosphorylated black fungus polysaccharide liposomes by phosphorylation modification of black fungus polysaccharide, which considerably improved its scavenging charge of DPPH free radicals, proving its antioxidant capability in vitro. It was additionally discovered that the encapsulation of liposomes might successfully forestall the oxidation of phosphorylated black fungus polysaccharide. Zhang Tingting et al. [33] discovered that black fungus polysaccharide might considerably enhance the abundance of Rhodococcus or non-digestive saccharobacterium within the fecal flora of SD rats, considerably scale back the abundance of pro-inflammatory micro organism Prevotella, and alleviate hepatitis and different ailments brought on by a high-fat food plan. As well as, black fungus polysaccharide might considerably enhance the content material of short-chain fatty acids within the cecum of SD rats. This examine gives concepts for black fungus polysaccharide to enhance blood lipid metabolism.
Application Standing of Typical Edible Fungi Polysaccharides
Application in Practical Meals
Edible fungi have distinctive texture and taste. By including edible fungi or edible fungi polysaccharides, the flavour and style of meals will be improved. On the identical time, as a result of a number of organic actions of edible fungi and their polysaccharides, they can be utilized as meals uncooked supplies to develop new meals, which cannot solely have an effect on the feel and vitamin of meals, but additionally give new useful traits to new merchandise. my nation’s nationwide customary GB 16740-2014 Normal Commonplace for Well being (Practical) Meals factors out that polysaccharides can be utilized because the efficient components of useful well being meals. Among the many well being meals with polysaccharides as the principle components which were launched in my nation, solely 14 varieties are recorded by the Nationwide Particular Meals Data Question Platform, together with three dosage varieties: capsules, tablets, and oral liquids, overlaying a wide range of Chinese language natural polysaccharides akin to astragalus polysaccharides and ganoderma lucidum polysaccharides. For instance, Qingfu Ning capsule, Yangpeptide Lingzhi capsule, Tangzhi capsule, and Propolis Lingzhi capsule are developed with Lingzhi polysaccharide because the energetic ingredient, Seabuckthorn Tianbao gentle capsule is developed with Poria polysaccharide as the principle biologically energetic ingredient, and Cordyceps militaris Lingzhi Milk thistle capsule is developed with Cordyceps militaris polysaccharide as the principle energetic ingredient. In 2001, the Nationwide Well being Fee (previously the Ministry of Well being) launched a listing of 11 fungal species that can be utilized in well being meals [34]. It may be seen that the potential efficacy of edible fungi polysaccharides and useful meals constituted of edible fungi polysaccharides must be additional developed.
Meals with a excessive glycemic index (GI) could cause a pointy enhance in blood sugar ranges and result in the incidence of acute metabolic ailments. The digestion traits of starch are intently associated to the postprandial blood sugar response. Subsequently, controlling the absorption charge of starch to regulate the blood sugar degree of the human physique has develop into an efficient medical vitamin strategy. It’s reported that edible fungi polysaccharides can enhance insulin resistance and successfully scale back starch content material [35-36]. Su Jing[37] used Tremella fuciformis polysaccharide as an energetic ingredient (added at 0.4%), maltitol and isomalt as uncooked supplies, and gelatin as a gelling agent to develop a gel gentle sweet. Liu et al.[38] studied the consequences of Pleurotus eryngii and lemongrass powder on the bodily and chemical properties, sensory high quality and digestibility of bread. The outcomes confirmed that Pleurotus eryngii powder, as a high-value ingredient, can enhance the dietary high quality of bread and scale back its GI. Solar Fan[39] developed Pleurotus eryngii immune yogurt with the exercise of enhancing human immunity based mostly on the immune-enhancing exercise of Pleurotus eryngii polysaccharide. The system is 0.1% Lactobacillus bulgaricus and Streptococcus thermophilus, 0.7% Pleurotus eryngii polysaccharide, 7% white sugar, and 0.2% pectin. This product has the inherent taste of yogurt and the suitable Pleurotus eryngii taste, and the feel and look meet the product high quality requirements. Li Guangfu[40] added ganoderma lucidum polysaccharide, ganoderma acid, tea mushroom polysaccharide and enoki mushroom polysaccharide to yogurt to develop edible fungus polysaccharide yogurt, and located that the in vitro antioxidant and anti-aging results of edible fungus polysaccharide yogurt have been important. As well as, edible fungus polysaccharides are additionally used to supply useful meals akin to well being bread[41], noodles[42], and drinks[43], taking part in an vital position in enhancing product taste and vitamin.
Application within the discipline of biomedicine
Because of the potential organic exercise of edible fungus polysaccharides, they’re usually used to develop anti-cancer medicine, anti-diabetic medicine, antiviral medicine, prebiotics, immunosuppressive (regulatory) brokers, and so forth.[44].
Atpresent, many edible fungus polysaccharides have been developed into injections, tablets, granules, oral liquids, decoction items, syrups, and so forth. appropriate for medical software. The edible fungus polysaccharide medical merchandise permitted by the Nationwide Drugs Requirements contain a variety of varieties. The drug merchandise developed with edible fungus polysaccharides which were utilized in medical observe embrace Ganoderma lucidum injection, carboxymethyl Poria cocos polysaccharide injection, Polyporus umbellatus polysaccharide injection, Lentinula edodes polysaccharide tablets, Hericium erinaceus tablets, polysaccharide protein decoction items, Ganoderma lucidum dew, compound Ganoderma lucidum dry syrup, Yunzhi Gantai granules, Liangjun tablets, Ganbi Fu, Cordyceps essence, and so forth.
Along with getting used alone, edible fungus polysaccharides will be compounded with different energetic components. Chen Shuping et al. [45] compounded Tremella fuciformis, Poria cocos, Hericium erinaceus, Lentinula edodes and Dictyophora indica polysaccharides and located that the compound polysaccharides can regulate the immune exercise of macrophage RAW264.7, which gives concepts for the event of compound polysaccharide merchandise. Yang Yingge et al. [46] produced polysaccharides by strong bidirectional fermentation of Ganoderma lucidum and Astragalus membranaceus residues and located that when the polysaccharide dose was 25 mL/kg, the tumor inhibition charge of human colon most cancers HCT116 transplanted into nude mice was 55.99%.
Application within the discipline of cosmetics
Based on the traditional medical ebook “Imperial Drugs Prescriptions” [47], edible fungus polysaccharides play an vital position in magnificence. It’s recorded within the historic Chinese language drugs ebook “Taiping Jing Hui Fang” [48] that Tremella fuciformis was used for tub remedy within the Tang Dynasty. Numerous research have confirmed that edible fungi are widespread uncooked supplies that can be utilized in each cosmetics and oral magnificence merchandise. Taking Ganoderma lucidum for example, trendy scientific exams have proved that Ganoderma lucidum incorporates components akin to glucosamine and polysaccharides, is wealthy in antioxidants, and may play a very good position in skincare merchandise [49].
Tremella fuciformis polysaccharides have the distinctive impact of eradicating freckles, enhancing pores and skin and rising moisture, and are broadly utilized in cosmetics. The natural skincare merchandise (Jungwang Cream, Essence Oil) launched by the East Beast in 2021 primarily include Ganoderma lucidum triterpenes and Ganoderma lucidum polysaccharides, which play their anti-inflammatory and antioxidant results. The medicinal lamellae collection developed by Ximuyuan for greasy and delicate pores and skin is added with medicinal lamellae skincare extracts. The polysaccharides contained in it primarily play their antioxidant, soothing and repairing results, and are extra appropriate for delicate pores and skin. The pine mushroom collection skincare merchandise first beneficial by the Xiwuji model are added with pine mushroom extracts. The polysaccharides contained in them primarily play antioxidant and restore results.
Outlook
At the moment, a lot of the analysis on edible fungus polysaccharides focuses on organic exercise. The information concerning the structure-activity relationship and molecular mechanism of various edible fungus polysaccharides continues to be restricted. Subsequently, it’s nonetheless essential to broaden the analysis on the organic exercise of several types of edible fungi and their polysaccharides, and to discover the molecular construction and potential organic exercise of edible fungus polysaccharides in depth. On the identical time, via chemical modification of edible fungus polysaccharides, akin to carboxylation and methylation, its scope of use will be broadened and its organic exercise will be enhanced.
Totally different edible fungus polysaccharides have completely different organic actions. Subsequently, in line with the mechanism of motion of their organic actions, polysaccharides will be compounded in several proportions, combined into mixtures, or mixed with medicine to exert synergistic results and double their efficacy. With a purpose to make edible fungus polysaccharides extra environment friendly in medicinal remedy, their dosage varieties will be enriched, and the solubility and bioavailability of polysaccharides will be considerably improved.
Combining completely different applied sciences and disciplines, akin to computational biology, bioinformatics, and omics, to discover the potential worth of various edible fungus polysaccharides, present reference and steering for understanding and broadening the organic exercise of edible fungus polysaccharides. In particular purposes, optimize and improve extraction and purification applied sciences to transform vitamins and polysaccharides contained in edible fungi into energetic components that can be utilized in cosmetics, drugs and meals, and actually develop into high-efficiency energetic uncooked supplies.
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