Cucurbitacin
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High-Purity Cucurbitacin Extract – GMP-Certified Manufacturer

Buy High-Purity Cucurbitacin Extract Wholesale | Trusted Herbal Extract Supplier

  • English Name: Isosteviol

  • Specification: ≥ 98% (HPLC); available in water-soluble and oil-soluble grades.

  • Appearance: Yellowish-white crystalline solid with a mild natural aroma.

  • CAS No.: 6260-56-6

  • Lead Time: 3–7 working days depending on order size.

  • Package: 25 kg/drum; 27 drums per pallet; OEM/ODM packaging available.

  • Main Market: Europe, North America, Asia; expanding to global nutraceutical and functional product markets.

  • Applications / Key Benefits: Supports metabolic health, antioxidant activity, and overall wellness; widely used in dietary, functional, and cosmetic formulations.

  • Industry Applications:
    a) Dietary Supplements – Metabolic, weight management, and antioxidant blends.
    b) Functional Foods & Beverages – Fortified drinks, health powders, and wellness products.
    c) Pharmaceuticals (Region-Specific) – Traditional metabolic health and wellness formulations.
    d) Cosmetics & Personal Care – Anti-aging, antioxidant, and skin-protective creams and serums.
    e) Herbal Health Products – Vitality, wellness, and antioxidant-focused products.

Categories: , ,

1.AiHerba’s GMP-Certified Cucurbitacin Extract | Trusted Botanical Extract Manufacturer

Cucurbitacin Extract – High-Purity Botanical Ingredient for Research, Nutraceuticals & Pharmaceutical Applications
AIHerba® offers premium Cucurbitacin B and E extracts sourced from high-quality Cucurbitaceae plants. Our GMP-certified factory in China ensures ≥98% HPLC purity, consistent quality, and fully traceable production. Designed for research & development, pharmaceutical studies, and functional product applications, our Cucurbitacin extracts provide reliable potency and reproducibility. With bulk supply, COA, MSDS, and customizable specifications, AIHerba supports OEM and ODM formulations for dietary supplements, cosmetics, and nutraceutical industries. Partner with AIHerba to access scientifically validated, high-purity Cucurbitacin from a leading natural plant extract manufacturer with over 28 years of production and R&D experience.

2. Product Overview

Product Name: Cucurbitacin Extract
Botanical Source: Cucurbitaceae family plants (natural plant origin)
CAS Number: 6199-67-3 (Cucurbitacin B)
Appearance: Yellow to brown fine powder
Purity: ≥98% HPLC
Solubility: Water-soluble / ethanol-soluble
Application: Nutraceuticals, pharmaceutical research, functional foods, dietary supplements
Certifications: GMP, ISO, COA, MSDS available

3. What is Cucurbitacin?

Cucurbitacin is a triterpenoid compound naturally occurring in Cucurbitaceae plants, including cucumber, bitter melon, and pumpkin. It is widely studied in pharmaceutical and biomedical research for its bioactive properties, including modulation of cellular signaling pathways. AIHerba provides high-purity extracts suitable for research, formulation development, and industrial applications, ensuring consistency and traceability from raw plant material to final bulk product.

4. Primary Mechanisms & Bioactivity

  1. JAK/STAT Pathway Modulation: Cucurbitacin B and E can regulate the JAK/STAT signaling pathway, widely cited in molecular biology research.

  2. NF-κB Signaling Inhibition: Potential regulatory effects on NF-κB, supporting anti-inflammatory studies in preclinical research.

  3. Cell Cycle Modulation: Used in cell culture experiments to study proliferation and differentiation mechanisms.

  4. Oxidative Stress Pathway Interaction: Supports studies on antioxidant pathways in functional research models.

Note: These mechanisms are described for research purposes only and do not constitute medical or treatment claims.

5. Research & Functional Benefits

  • Reliable high-purity extract for in vitro and in vivo studies

  • Standardized active compounds for pharmaceutical R&D

  • Suitable for nutraceutical, dietary supplement, and functional food formulation

  • Supports customized blend development for targeted applications

6. Usage & Traditional Applications

  • Research Use: Cell-based assays, mechanistic studies, bioactivity analysis

  • Traditional Applications: Historically used in plant-based studies for biological activity screening

  • Recommended Laboratory Handling: Follow standard lab safety protocols; avoid direct ingestion

7. Product Specifications & COA

Category Item Specification Method
Active Ingredient Cucurbitacin B / E ≥98% HPLC HPLC
Appearance Powder Yellow-brown fine powder Visual
Loss on Drying Moisture ≤5% Standard Gravimetric
Residual Solvents Ethanol ≤5000 ppm GC
Pesticide Residue Multi-residue Complies with EU/USP standards GC-MS/LC-MS
Heavy Metals Lead ≤0.5 ppm, Arsenic ≤1 ppm, Mercury ≤0.1 ppm, Cadmium ≤0.3 ppm AAS/ICP-MS
Microbial Limits Total Plate Count ≤1000 CFU/g, Yeast & Mold ≤100 CFU/g, E. coli Negative, Salmonella Negative Standard microbiological tests

8. Production Process & Flow

  1. Raw Material Selection: Certified Cucurbitaceae plants from controlled farms

  2. Cleaning & Grinding: Removal of impurities, uniform particle size

  3. Extraction: Supercritical CO₂ / water-ethanol extraction for maximal yield

  4. Concentration: Vacuum concentration under controlled temperature

  5. Purification: Chromatographic techniques to achieve ≥98% HPLC purity

  6. Drying & Packaging: Spray drying or freeze-drying to preserve activity

  7. Quality Control: COA, MSDS, and microbiological testing before dispatch

9. Storage & Shelf Life

  • Storage: Store in cool, dry, and dark conditions

  • Shelf Life: 24 months in original sealed packaging

  • Packaging Options: 25kg/drum, custom OEM packaging available

10. Sample Policy, Shipping & MOQ

  • Samples: Available on request

  • MOQ: 1 kg for bulk purchase

  • Shipping: Air or sea freight, customs documentation included

  • Traceable Supply Chain: From raw plant sourcing to finished product

11. Clinical Data & Latest Research References

  1. PubMed: Cucurbitacin B and cellular pathways

  2. NIH Research: Triterpenoid bioactivity studies

  3. FDA Regulatory Reference: Botanical extract guidelines

These references provide scientific validation for research and formulation purposes.

12. Applicable Industries & Use Cases

  • Pharmaceutical R&D – Mechanistic studies, preclinical research

  • Nutraceuticals – Functional supplements, standardized botanical actives

  • Cosmetics – Anti-inflammatory and antioxidant formulations

  • Food & Beverage – Functional ingredients in drinks and food supplements

13. Usage Methods & Best Formulation Practices

  • Dissolve in ethanol, water, or DMSO for research applications

  • Combine with other botanical extracts for synergistic effects

  • Optimize dose ranges per laboratory or industrial formulation guidelines

14. Professional Credentials & Factory Expertise

15. Frequently Asked Questions (FAQ)

  1. Q: Can I get customized Cucurbitacin purity?
    A: Yes, AIHerba supports custom HPLC specifications for bulk orders.

  2. Q: Is your Cucurbitacin extract suitable for vegan formulations?
    A: Yes, 100% plant origin, suitable for vegan applications.

  3. Q: Do you provide COA and MSDS?
    A: Yes, every batch comes with complete COA & MSDS.

  4. Q: What industries can use this extract?
    A: Nutraceuticals, pharmaceuticals, cosmetics, functional foods.

  5. Q: What is the minimum order quantity (MOQ)?
    A: 1 kg for bulk supply, samples available on request.

  6. Q: How do you ensure product traceability and quality?
    A: Full traceability from farm to finished extract, multiple QC checkpoints, ISO/GMP certified production.

16. References & Regulatory Links

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