Chlorogenic Acid Supplier Guide (2026): 98% CGA (HPLC), Low-Caffeine Option, COA & Bulk Sourcing
Chlorogenic acid (CGA) is a naturally occurring polyphenol best known as a caffeoylquinic acid found in coffee and certain plants. For manufacturers, the key sourcing questions are rarely “what is it?”—they are how CGA is tested (HPLC), how batch consistency is controlled, how caffeine is handled, and what documentation is available for qualification.
This page is a procurement-focused guide for bulk buyers looking for purified Chlorogenic Acid ≥98% (HPLC) with a low-caffeine requirement.
Quick request (recommended for procurement):
Request a documentation pack: COA + Specification Sheet (TDS) + SDS + Allergen/Non-GMO statements + caffeine test (if required).
1) What Is Chlorogenic Acid (Procurement Summary)
Chlorogenic acid refers to a group of compounds commonly called caffeoylquinic acids. A standardized chemical identity reference is available via PubChem, which procurement and QA teams often use for nomenclature and identity checks.
2) Why Choose Purified 98% CGA (vs. Botanical Extracts)
Purified CGA (≥98% by HPLC) is typically selected when you need:
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Precise dosing in capsules/tablets or functional ingredients
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Cleaner impurity profile and tighter specifications
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Higher batch-to-batch consistency compared with agricultural extracts
Low-caffeine requirement:
Low-caffeine should be defined as a measurable target and verified with a caffeine test reported on the COA or a supporting 3rd-party report.
3) Evidence Snapshot (Compliance-Safe)
CGA has been studied for antioxidant activity and for effects on metabolic markers. Evidence varies by product form, dose, and study design.
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Post-meal glucose response: some human studies using CGA-rich materials report changes in post-prandial glucose measures, depending on dose and population.
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Cardiovascular markers (research context): reviews discuss mechanisms related to oxidative stress and endothelial function in the context of blood pressure research.
Regulatory note: For US dietary supplements, structure/function claim framing is governed by DSHEA and FDA guidance; avoid disease claims.
For EU/UK, health claims must be checked against the EU Register and relevant rules.
4) Formulation & Usage Reference (For R&D Teams)
Usage ranges depend on formulation goals, local regulations, and whether CGA is used as a single ingredient or as part of a blend. When building finished products, many brands start conservatively and validate stability and sensory properties.
R&D considerations (practical)
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Stability: protect from heat, light, and moisture; consider protective packaging and stability testing.
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Beverages: if solubility or taste is challenging, consider formulation techniques (e.g., encapsulation) and validate in pilot batches.
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Synergy claims: avoid specific disease/therapeutic implications; validate compatibility and regulatory compliance for any co-ingredients.
(This section is for formulation reference only; it is not medical advice.)
5) Purchase Specification Checklist (Copy/Paste for Your PO)
To reduce quality disputes, your PO/spec should clearly include:
Identity & assay
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Product name: Chlorogenic Acid (CGA)
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Purity: ≥98%
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Assay method: HPLC (method reference and acceptance criteria)
Low-caffeine requirement (if applicable)
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Caffeine limit: specify target (e.g., “≤X%” or “≤X ppm”)
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Caffeine test: required on COA / supporting report
Safety & contaminants (market-dependent)
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Heavy metals (Pb/As/Cd/Hg)
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Microbiology (TPC, yeast & mold; pathogens if applicable)
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Residual solvents (if used) and reporting requirements
Residual solvent control is often aligned with ICH Q3C where relevant.
Physical
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Appearance, particle size, bulk density (if needed for tableting/capsules)
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Packaging requirements and storage conditions
6) How to Read a COA (What QA Should Verify)
A procurement-ready COA should show:
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Batch/lot number, manufacturing date, retest/expiry date
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Purity result (≥98%) + method (HPLC)
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Contaminant panel results (as required)
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Caffeine test result (for low-caffeine projects)
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QA approval signature or release authorization
7) Documentation Pack (Typical for B2B Qualification)
Common documents available for supplier qualification:
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COA
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Specification Sheet / TDS
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SDS/MSDS
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Allergen Statement
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Non-GMO Statement
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TSE/BSE Statement
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Residual Solvents Statement
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Country of Origin (COO)
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Additional test reports upon request (heavy metals, micro, pesticides, caffeine)
8) Typical MOQ, Lead Time & Packaging
MOQ (typical)
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Samples: 100 g–1 kg
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Bulk: 1–25 kg for standard lots; larger volumes for long-term programs
Lead time (typical)
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Standard lots: 7–15 business days
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Customized (e.g., strict caffeine limit + expanded testing): 2–4 weeks
Packaging
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1 kg foil bag + carton
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25 kg fiber drum with inner liners (export-ready)
9) Compliance Notes (How to Avoid Claim Risks)
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US: FDA structure/function guidance and 21 CFR 101.93 help define compliant vs disease claims.
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EU: check claim status and conditions in the EU Register.
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EU market access may require evaluating Novel Food considerations depending on the ingredient history and intended use.
10) Request a Quote (RFQ Checklist)
To receive an accurate quote quickly, include:
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Spec: Chlorogenic Acid ≥98% (HPLC)
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Low-caffeine target (yes/no; include limit if you have it)
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Application: capsules/tablets/beverage/functional ingredient
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Target market: US/EU/UK/Other
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Required documents (COA/SDS/Allergen/Non-GMO/COO…)
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Order quantity + annual forecast
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Shipping terms & destination port
References & Regulatory Sources
Chemical identity
– PubChem – Chlorogenic acid (CID 1794427)
https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/1794427/XML/?response_type=display
Clinical/research context (examples)
– Postprandial glucose study (CGA-rich material; dose-dependent outcomes)
https://www.jstage.jst.go.jp/article/fstr/18/6/18_849/_article
– Antihypertensive mechanisms review (Hypertension Research PDF)
https://www.nature.com/articles/hr2011195.pdf
– Postprandial glucose trial (catechins + coffee chlorogenic acids; RCT context)
https://www.mdpi.com/2072-6643/14/23/5063
US claims compliance
– FDA – Structure/Function Claims
https://www.fda.gov/food/nutrition-food-labeling-and-critical-foods/structurefunction-claims
– eCFR – 21 CFR 101.93
https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-101/subpart-F/section-101.93
EU claims & market screening
– EU Register of Nutrition and Health Claims
https://food.ec.europa.eu/food-safety/labelling-and-nutrition/nutrition-and-health-claims/eu-register-health-claims_en
– Regulation (EU) 2015/2283 – Novel Foods
https://eur-lex.europa.eu/eli/reg/2015/2283/oj/eng
Quality (residual solvents reference framework)
– ICH Q3C(R9) – Residual Solvents Guideline (PDF)
https://database.ich.org/sites/default/files/ICH_Q3C%28R9%29_Guideline_MinorRevision_2024_2024_Approved.pdf
Regulatory example (not 98% CGA; coffee fruit extract standardized as chlorogenic acids)
– FDA GRAS Notice GRN 868 – Coffee fruit extract (standardized as chlorogenic acids)
https://cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?id=868&set=GRASNotices
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