Chlorogenic Acid: Bulk Buyer’s Guide to Benefits, Dosing & Sourcing Premium Extracts

What is Chlorogenic Acid?

Chlorogenic Acid (CGA) is a potent polyphenol abundantly found in:

☕ Green coffee beans (primary source)
🌿 Artichokes, strawberries, apples
🍃 Eucommia ulmoides leaves

Chemically, it’s an ester of caffeic and quinic acid, functioning as a key antioxidant with clinically studied metabolic benefits.

Top 5 Science-Backed Benefits & Mechanisms

Metabolic Health & Weight Management
- ⚡️ Boosts fat metabolism by modulating glucose-6-phosphatase (reduces liver glucose output)
- 📉 Lowers blood sugar spikes post-meal (Diabetes Care, 2019)
Antioxidant Powerhouse
- 🛡️ Neutralizes free radicals 2x more effectively than green tea EGCG (Journal of Agricultural Food Chemistry)
Cardiovascular Support
- ❤️ Reduces LDL oxidation and improves endothelial function (Hypertension Research, 2020)
Neuroprotection
- 🧠 Crosses blood-brain barrier; reduces neuroinflammation markers
Antimicrobial Activity
- 🦠 Effective against H. pylori, Candida, and oral pathogens
  Chlorogenic Acid Applications

Chlorogenic Acid vs. Green Coffee Extract

Factor	Chlorogenic Acid (Purified)	Green Coffee Extract
CGA Concentration	20%-50%+ (Standardized)	5%-20% (Variable)
Consistency	Batch-to-batch reliability	Fluctuates with crop
Applications	Pharma, supplements, functional foods	Basic supplements

Dosing Protocol & Optimal Daily Intake

For End Products (Capsules/Tablets):

Standard Dose: 120–300 mg/day (split into 2 doses)
Weight Management: 200–400 mg/day pre-meals
Functional Foods: 50–100 mg/serving (bars, shakes)

B2B Formulation Guidance:

1.  Solubility: Use microencapsulated CGA for beverages (oil-soluble base)  
2.  Stability: Pair with antioxidants (e.g., rosemary extract) to prevent degradation  
3.  Synergies: Combine with chromium for glucose control

Best Practice: Start with 100 mg doses → clinically effective with minimal side effects.

Safety & Side Effects

Generally Safe: EFSA/WHO-approved (ADI: ~5 mg/kg body weight)
Rare Side Effects:
- Mild digestive upset (doses >400 mg)
- Jitteriness (when combined with caffeine)
Contraindications:
- Pregnancy (limited data)
- Autoimmune disorders (theoretical immune modulation risk)

Critical Notes for Manufacturers

Purity Matters:
- Demand ≥40% HPLC-verified CGA (avoid UV-spectrometry testing)
- Reject extracts with chlorogenic acid “equivalents”
Extraction Method:
- ✅ Ethanol/water extraction (preserves bioactivity)
- ❌ Avoid chemical solvents (acetyl acetate)
Certifications:
- Non-GMO, ISO 9001, FDA facility registration

Where to Buy Chlorogenic Acid (Bulk Quantities)

AIHerba Sourcing Advantages:

✅ Grade A Extracts: 20%/40%/50% CGA options  
✅ Third-Party Testing: Heavy metals, pesticides, microbials (COA included)  
✅ Customization: Powder/granules, organic/non-GMO, private labeling  
✅ Global Compliance: FDA GRAS, EU Novel Food, Halal/Kosher  
✅ MOQs: From 1kg (samples) to metric tons

Partner With Trust:

AIHerba supplies GMP-certified chlorogenic acid for supplement, food, and cosmetic industries.
✉️ Request quotes/custom specs: liaodaohai@gmail.com

Key Takeaways for Buyers

CGA is a multifunctional nutraceutical with metabolic/antioxidant benefits
Optimal dose: 200–300 mg/day for finished products
B2B priority: ≥40% purity, ethanol extraction, full traceability
AIHerba delivers:
- Lab-verified potency
- Competitive bulk pricing
- End-to-end regulatory support

References

Tajik, N. et al. (2017). Chlorogenic Acid: A Comprehensive Review. Biomedicine & Pharmacotherapy.
EFSA Panel. (2015). Safety of green coffee extracts. EFSA Journal.
Onakpoya, I. et al. (2019). CGA for body weight loss. Diabetes Care.
Mubarak, A. et al. (2012). Acute effects of CGA on glucose metabolism. Journal of Nutritional Science.
FDA GRAS Notice No. GRN 000997 (2019).

Contact for Bulk Orders: liaodaohai@gmail.com
Disclaimer: Product specifications subject to technical datasheets. Not evaluated by the FDA for disease treatment.

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