Ceramide Np
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Ceramide NP

Ceramide NP: The Ultimate Guide to Premium Skin Barrier Restoration

1.English Name: Ceramide NP (also known as N-Palmitoyl Sphingosine)

  1. Specification
    • Purity: ≥ 95% (HPLC)
    • Solubility: Insoluble in water; soluble in organic solvents like ethanol, chloroform, and vegetable oils
    • Acid Value: ≤ 1.0 mg KOH/g
    • Loss on Drying: ≤ 0.5%
    • Heavy Metals: ≤ 5 ppm
  1. Appearance: White to off-white waxy solid or powder, odorless, with no chocolate-related properties
  1. CAS NO.: 100403-19-8
  1. Lead time: 3-7 Working Days
  1. Package: 100 g, 500 g, 1 kg aluminum foil bags; 25 kg drum (sealed container with nitrogen protection)
  1. Main Market: Europe, North America, Asia, etc.
  1. Application Scenarios

Key Properties

  • Skin Barrier Repair: Mimics the natural ceramide in the stratum corneum, replenishing lipid levels and strengthening the skin’s protective barrier
  • Moisture Retention: Reduces transepidermal water loss (TEWL) by sealing in moisture, keeping skin hydrated
  • Sensitivity Relief: Soothes dry, irritated skin by restoring barrier function, suitable for atopic or sensitive skin
  • Compatibility: Works synergistically with other lipids (cholesterol, fatty acids) in “ceramide trio” formulations
  • Stability: Stable under cool, dry conditions; requires protection from light and oxidation

Application Scenarios

  1. Skincare Products
    • Moisturizers and Creams: Added at 0.1-1% concentration in facial and body creams for dry/sensitive skin
    • Barrier Repair Formulations: Key ingredient in products targeting eczema, psoriasis, or post-sun damage
    • Anti-aging Serums: Included to maintain barrier integrity, reducing the appearance of fine lines from dryness
    • Baby Care: Used in gentle lotions for infants’ delicate skin to prevent dryness and irritation
    • Cleansers: Added to mild cleansers to counteract stripping effects and preserve barrier lipids
  1. Hair Care
    • Scalp Treatments: Used in serums to soothe dry, flaky scalps by restoring scalp barrier function
    • Conditioners: Added to nourish hair follicles and improve hair texture from root to tip
  1. Cosmetics
    • Makeup Primers: Included to create a smooth, hydrated base and enhance makeup adherence
    • Lip Balms: Added to repair and protect dry, chapped lips

Detection Methods

  • HPLC: Column C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – methanol (80:20, v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm
  • FTIR Spectroscopy: Characteristic peaks at 3300 cm⁻¹ (N-H stretching), 2920 cm⁻¹ (C-H stretching), 1640 cm⁻¹ (amide I)
  • Mass Spectrometry (MS): Used for structural confirmation and impurity analysis

Advantages

  • Biocompatibility: Naturally present in skin, minimizing irritation risk
  • Proven Efficacy: Supported by clinical data on barrier repair and hydration
  • Formulation Flexibility: Works in both water-in-oil and oil-in-water emulsions
  • Consumer Appeal: Meets demand for “skin-identical” ingredients in clean beauty products
Categories: ,

Ceramide NP – Premium Skin Barrier Lipid | AIHerba® Natural Cosmetic Ingredient Supplier
High-Purity Ceramide NP for Cosmetics, Functional Skincare & Dermatological Formulations

(1) Product Overview

Ceramide NP (also known as Ceramide 3) is a bioidentical skin lipid naturally found in the stratum corneum of human skin. It plays a critical role in maintaining the skin barrier, preventing transepidermal water loss (TEWL), and protecting against environmental damage. AIHerba® offers high-purity, cosmetic-grade Ceramide NP produced through advanced biotechnology fermentation and molecular purification, ensuring excellent stability, biocompatibility, and efficacy.

Supplier: Shaanxi Zhonghong Investment Technology Co., Ltd.
Brand: AIHerba®
Email: sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
Website: www.aiherba.com

(2) Botanical Source & Production

Although ceramides are naturally present in plant oils and human skin, AIHerba® Ceramide NP is synthesized through microbial fermentation and enzymatic conversion of plant-derived sphingolipids, ensuring vegan, non-GMO, and eco-friendly purity.

Production Process:

  1. Raw Material Preparation – Plant sphingolipids derived from wheat, rice bran, or soybeans.

  2. Fermentation – Controlled microbial process to generate sphingoid bases.

  3. Purification – Molecular distillation and chromatography for high-purity ceramide isolation.

  4. Stabilization – Encapsulation or micronization for enhanced bioavailability and cosmetic compatibility.

  5. Quality Testing – Each batch undergoes full-spectrum quality evaluation and COA verification.

(3) Key Benefits & Functions

Category Benefit Description
Skin Barrier Repair Strengthens the lipid matrix, restoring damaged or sensitive skin barriers.
Moisture Retention Reduces TEWL, enhances hydration, and maintains long-lasting moisture.
Anti-Aging Action Improves elasticity and smoothness by replenishing lost ceramides.
Protection Shields skin from pollutants, UV damage, and external irritants.
Enhanced Delivery Improves penetration of active ingredients in emulsions and serums.

(4) Health & Cosmetic Benefits

  • Promotes smooth, hydrated, and resilient skin.

  • Ideal for eczema, psoriasis, dry skin, and atopic dermatitis formulations.

  • Supports anti-aging, whitening, and post-treatment skincare (laser, chemical peel recovery).

  • Safe for daily use in sensitive skin applications.

(5) Recommended Applications & Usage

Industry Application Recommended Usage
Cosmetics & Skincare Lotions, serums, creams, facial masks, cleansers 0.1–2.0%
Personal Care Hair conditioners, scalp care, lip care 0.1–0.5%
Pharmaceutical Formulations Dermatological creams, ointments 0.5–2.0%
Functional Foods (Encapsulated Form) Skin-nourishing supplements As per formula design

Formulation Tips:

  • Dissolve in ethanol or warm emulsifiers before incorporation.

  • Ideal pH range: 4.5–6.5.

  • Compatible with hyaluronic acid, niacinamide, squalane, and phytosterols.

(6) Traditional & Scientific Background

Ceramides were first identified as key lipids in the skin’s stratum corneum, representing nearly 50% of the intercellular lipid matrix. Modern research confirms their essential role in maintaining the epidermal barrier and moisture balance (PubMed: PMID 11534942).

Studies published by the NIH and FDA-reviewed literature support ceramide supplementation for improving skin hydration and barrier recovery.

(7) Product Specifications & COA Summary

Parameter Specification Testing Method
Appearance White to off-white powder Visual
Purity (HPLC) ≥98% HPLC
Ceramide NP Content ≥98% HPLC
Loss on Drying ≤1.0% USP 731
Heavy Metals (Pb, As, Cd, Hg) ≤10 ppm ICP-MS
Residue on Ignition ≤0.1% USP 281
Odor Characteristic, neutral Sensory
Solubility Soluble in ethanol, insoluble in water —

(8) Pesticide Residue, Heavy Metals & Microbial Testing

Pesticide Residues

Item Specification (mg/kg) Testing Method
Organochlorine pesticides ≤0.1 GC-MS
Organophosphorus pesticides ≤0.05 GC-MS
Pyrethroid residues ≤0.05 GC-MS

Heavy Metals

Item Limit (ppm) Testing Method
Lead (Pb) ≤2.0 ICP-MS
Arsenic (As) ≤1.0 ICP-MS
Cadmium (Cd) ≤1.0 ICP-MS
Mercury (Hg) ≤0.1 ICP-MS

Microbiological Parameters

Item Specification (cfu/g) Testing Method
Total Plate Count ≤1,000 USP <2021>
Yeast & Mold ≤100 USP <2021>
E. coli Negative USP <2022>
Salmonella Negative USP <2022>
Staphylococcus aureus Negative USP <2022>

(9) Packaging, Storage & Shelf Life

Item Details
Packaging 1kg/foil bag; 10kg/carton drum; OEM bulk available
Storage Store in a cool, dry, and dark place (<25°C), avoid direct sunlight
Shelf Life 24 months under recommended conditions
MOQ 1kg (sample), 25kg (bulk)
Sample Policy Free samples available (≤50g); courier cost borne by buyer
Shipping Express (DHL/FedEx), air freight, or sea shipping with export documentation

(10) Certifications & Quality Assurance

  • GMP-certified production facility

  • ISO9001:2015, ISO22000, Halal, Kosher certified

  • REACH-compliant and IFRA-safe for cosmetic formulations

  • Full COA, MSDS, and TDS available upon request

(11) Application Industries

  • Cosmetics & Personal Care: Moisturizing and anti-aging formulations

  • Pharmaceutical & Dermatology: Skin barrier repair products

  • Functional Foods & Nutraceuticals: Oral ceramide supplements

  • OEM/ODM Custom Formulations: Skincare brands, functional beauty drinks

(12) Factory Strength & Experience

With 28+ years of plant extract manufacturing experience, AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) integrates biotechnology and modern extraction to produce stable, traceable, and high-purity bioactive ingredients. Trusted by over 1,000+ global brands across cosmetics, nutrition, and pharmaceuticals.

(13) FAQs

Q1: What is the difference between Ceramide NP and Ceramide EOP or AP?
A1: Ceramide NP has a neutral head group and superior skin compatibility, ideal for moisturizing products.

Q2: Can Ceramide NP be used in water-based formulations?
A2: It is oil-soluble and best used in emulsions or encapsulated systems.

Q3: Does AIHerba provide customized formulations (OEM/ODM)?
A3: Yes, AIHerba offers full-service customization for skincare and functional food formulations.

Q4: What is the lead time for bulk orders?
A4: Typically 7–15 days after order confirmation.

(14) References

  1. Bouwstra, J.A. et al. “Structure and function of the skin barrier.” Progress in Lipid Research, 2003. PubMed PMID: 11534942

  2. Elias, P.M. “The role of ceramides in barrier function and hydration.” Journal of Clinical Dermatology, 2010.

  3. FDA Database – GRAS Notice for Ceramides

  4. NIH: Ceramide and Skin Health Studies

  5. Coderch, L., et al. (2003). “Ceramides and skin function.” American Journal of Clinical Dermatology.

  6. van Smeden, J., & Bouwstra, J. A. (2016). “Stratum Corneum Lipids: Their Role for the Skin Barrier Function.” Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids.

  7. Imokawa, G. (2009). “Ceramides as natural moisturizing factors and their efficacy in dry skin.” International Journal of Cosmetic Science.

  8. U.S. Pharmacopeia (USP) General Chapters: <197>, <232>, <731>, <61>, <62>.

  9. European Pharmacopoeia (Ph. Eur.) Monographs & General Chapters: 2.2.24, 2.2.33, 2.6.12, 2.6.13.

  10. ICH Guidelines: Q1A(R2) Stability Testing, Q3C Residual Solvents, Q3D Elemental Impurities.

  11. EU Cosmetic Regulation (EC) No 1223/2009.

  12. Zhonghong Technical Dossier & Internal Efficacy Data (Available on Request).

(15) Contact Us

📧 Email: sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 Website: www.aiherba.com
🏭 Factory: Shaanxi Zhonghong Investment Technology Co., Ltd.
Your Trusted GMP-Certified Ceramide NP Supplier from China

Ceramide NP is the cornerstone of a functional skin barrier. Its efficacy is critically dependent on uncompromising purity (>99.5%), bio-identical structure, and pharmaceutical-grade manufacturing. Shaanxi Zhonghong Investment Technology Co., Ltd. sets the global benchmark, leveraging 28 years of lipid expertise, patented purification technology, and world-class analytics to deliver Ceramide NP trusted by leading cosmetic and pharmaceutical innovators worldwide. For formulations demanding proven barrier restoration and anti-aging efficacy, Zhonghong’s Ceramide NP is the definitive choice.

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