Beta Arbutin
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Beta arbutin

β-Arbutin supplier bulk factory Wholesale Extract factory

  1. English Name: β-Arbutin,Beta arbutin
  1. Specification
    • Basic Powder: β-Arbutin ≥ 98% (HPLC)
    • Water-soluble Powder: β-Arbutin ≥ 95% (HPLC), enhanced water solubility by means of microencapsulation or complexing brokers; solubility as much as 20 g/L at 25°C
  1. Appearance
    • Basic Powder: White to off-white crystalline powder, odorless
    • Water-soluble Powder: Superb, white, free-flowing powder
  1. CAS NO.：497-76-7
  1. Lead time: 3 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double-layer PE bag inside cardboard drum)
  1. Main Market: Asia (China, Japan, South Korea), North America, Europe
  1. Application Scenarios

Core Properties

  • Molecular Formulation: C₁₂H₁₆O₇
  • Solubility: Sparingly soluble in water; soluble in sizzling water, ethanol, and propylene glycol. Water-soluble formulations provide higher dispersion in aqueous programs.
  • Key Options
    • Pores and skin Lightening: Inhibits tyrosinase, an enzyme essential for melanin synthesis, lowering the looks of darkish spots, freckles, and hyperpigmentation.
    • Antioxidant Exercise: Scavenges free radicals, defending pores and skin cells from oxidative harm attributable to UV radiation and environmental pollution.
    • Stability: Steady beneath acidic circumstances (optimum pH 4 – 6); could degrade in alkaline environments or at excessive temperatures (above 60°C).

Application Scenarios

1. Cosmetics & Private Care

  • Pores and skin Whitening Merchandise
    • Serums and Lotions: Generally formulated at 3 – 7% focus, used to lighten pores and skin tone, fade age spots, and even out pores and skin complexion.
    • Sunscreens: Added to offer extra safety towards UV-induced pigmentation, usually mixed with different solar – filtering brokers.
    • Facial Masks: Infused in sheet masks or clay masks for intensive brightening therapies.
  • Anti – Getting old Formulations
    • Reduces the formation of age – associated darkish spots and helps preserve collagen integrity, minimizing the looks of high quality strains and wrinkles.

2. Prescribed drugs

  • Dermatological Remedies
    • Utilized in topical drugs for the remedy of melasma, submit – inflammatory hyperpigmentation, and different pigmentation problems.
    • In some instances, included into mixture therapies with different pores and skin – lightening brokers for enhanced efficacy.

3. Practical Meals & Drinks

  • Oral Dietary supplements
    • Capsules or tablets containing β-Arbutin are marketed for inner pores and skin – brightening advantages, usually mixed with nutritional vitamins C and E for synergistic antioxidant results.
  • Drinks
    • Added to magnificence – centered drinks at low concentrations (0.1 – 0.5%) to advertise general pores and skin well being from inside.

4. Industrial Purposes

  • Textile Business
    • Can be utilized as a pure dyeing assist or mordant, serving to to repair pure dyes on materials and imparting shade stability.
  • Biopesticides
    • Some research recommend β-Arbutin could have gentle antifungal properties, making it a possible ingredient in eco – pleasant agricultural pest management merchandise.

Detection Strategies

  • Excessive – Efficiency Liquid Chromatography (HPLC)
    • Column: C18 (250 × 4.6 mm, 5 μm); Cell Section: Acetonitrile – water (15:85, v/v); Stream Charge: 1.0 mL/min; Detection Wavelength: 280 nm. Used to precisely quantify β-Arbutin content material and guarantee product purity.
  • Skinny – Layer Chromatography (TLC)
    • A fast screening methodology for figuring out β-Arbutin in samples, utilizing silica gel plates and an acceptable cellular part for separation.
  • Mass Spectrometry (MS)
    • Gives detailed details about the molecular construction of β-Arbutin, helpful for confirming product id and detecting impurities.

Supply & Benefits

  • Natural Supply: β-Arbutin could be extracted from numerous vegetation reminiscent of bearberry (Arctostaphylos uva – ursi), blueberries, and cranberries, giving it a pure and clear – label attraction.
  • Delicate Efficacy: Affords a gentler strategy to pores and skin lightening in comparison with some stronger chemical brokers, making it appropriate for delicate pores and skin varieties.
  • Versatility: Could be simply included into a variety of formulations, from cosmetics to purposeful meals.

Regulatory Compliance

  • China NMPA: Allowed as a beauty ingredient with a most focus of seven% (requires security evaluation).
  • EU Beauty Regulation (EC 1223/2009): Authorised to be used in cosmetics, with a focus restrict of seven% in depart – on merchandise.
  • US FDA: No particular restrictions to be used in cosmetics, however is topic to basic security rules for beauty elements.
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Beta Arbutin: Premium Skin Brightening Agent for Cosmetic & Pharmaceutical Applications – Manufacturer & Exporter Guide

1. What is Beta Arbutin?
For cosmetic chemists and product developers seeking a superior skin brightening solution, Beta Arbutin represents the gold standard in tyrosinase inhibition. This pure, single-isomer compound (4-Hydroxyphenyl-β-D-glucopyranoside) is the most effective and stable form of arbutin, specifically designed for high-performance skincare formulations. Unlike mixed alpha/beta extracts, our Beta Arbutin offers predictable results and exceptional formulation stability, making it the preferred choice for professional skincare brands and pharmaceutical applications.

Beta Arbutin
Beta Arbutin

2. Source, Chemistry & Specifications

  • Source: Synthesized through enzymatic biotransformation of hydroquinone and glucose

  • Chemical Identity: Pure β-anomer of arbutin

  • Chemical Profile:

    • CAS No.: 497-76-7

    • MF: C₁₂H₁₆O₇

    • MW: 272.25 g/mol

    • EINECS: 207-850-3

  • Appearance: White to off-white crystalline powder

  • Solubility: Highly soluble in water (≥50 g/100mL), slightly soluble in ethanol

  • Purity: ≥99% (HPLC)

3. The Formulator’s Choice: Why Pure Beta Arbutin Outperforms
For B2B clients in cosmetic and pharmaceutical manufacturing, ingredient selection impacts final product efficacy and market success:

  • Key Advantage: Pure β-anomer configuration ensures optimal tyrosinase inhibition and formulation stability

  • Clinical Efficacy:

    • Superior Skin Brightening: 3x more effective than alpha-arbutin in melanin reduction

    • Hyperpigmentation Control: Significantly reduces dark spots and age spots

    • Even Skin Tone: Promotes uniform pigmentation and radiant complexion

  • Recommended Usage: 1-3% in leave-on products, 3-5% in rinse-off formulations

  • Compliance Status: Complies with EU Cosmetics Regulation, FDA guidelines, and ASEAN cosmetic standards

  • Optimal Applications: Serums, creams, lotions, spot treatments, and pharmaceutical depigmenting products

  • Safety Profile: Non-irritating, non-sensitizing, and photostable with excellent consumer tolerance

4. Zhonghong Biotech: Your Technical Partner in Skin Brightening Solutions
Sourcing reliable Beta Arbutin requires a partner with pharmaceutical-grade capabilities. 陕西中宏投资科技有限公司 (Shaanxi Zhonghong Investment Technology Co., Ltd.) combines 28 years of biochemical expertise with state-of-the-art manufacturing to deliver premium active ingredients for global markets.

  • Technical Capabilities:

    • Enzymatic Synthesis: Proprietary biotransformation process ensures highest purity

    • Advanced Analytics: HPLC-ELSD, NMR, and mass spectrometry for precise characterization

    • University Collaborations: Joint research with 5 leading institutions for continuous innovation

  • Global Compliance: Full documentation package including COA, MSDS, and regulatory support

5. Scientific Mechanism: Precision Tyrosinase Inhibition
Beta Arbutin’s efficacy stems from its specific molecular interaction with tyrosinase:

  • Competitive inhibition of tyrosine hydroxylase and DOPA oxidase activities

  • Structural similarity to tyrosine enables targeted enzyme binding

  • Glucosidic bond prevents spontaneous hydroquinone release

  • pH-stable performance across formulation matrices (pH 3.5-7.0)

6. Pharmaceutical-Grade Quality Assurance
Our rigorous quality control ensures every batch meets the highest standards:

Certificate of Analysis (COA) Summary – Beta Arbutin (≥99%)

Category Parameter Specification Test Method
Identity HPLC Retention Time Matches Reference HPLC-ELSD
Purity Beta Arbutin ≥ 99.0% HPLC-UV
Alpha Arbutin ≤ 0.5% HPLC-UV
Hydroquinone ≤ 1 ppm HPLC-UV
Safety Heavy Metals ≤ 10 ppm ICP-MS
Arsenic ≤ 2 ppm ICP-MS
Microbiology Total Plate Count ≤ 100 CFU/g USP <61>
Yeast/Mold ≤ 50 CFU/g USP <61>
Pathogens Absent USP <62>

7. Advanced Manufacturing Process
Our cGMP-compliant synthesis ensures superior quality:

  1. Enzyme Selection: Proprietary β-glucosidase optimization

  2. Biotransformation: Controlled enzymatic reaction under optimized conditions

  3. Purification: Multi-stage crystallization and chromatography

  4. Crystallization: Precision crystallization for consistent particle size

  5. Drying: Vacuum drying at controlled temperatures

  6. Quality Control: Comprehensive analytical testing

8. Professional Applications

  • Cosmeceuticals: Brightening serums, age spot correctors, evening treatments

  • Pharmaceuticals: Melasma and hyperpigmentation treatments

  • Professional Products: Clinical skincare and aesthetic formulations

  • Personal Care: Whitening toothpaste and body care products

9. Global Supply Chain Excellence

  • Packaging: 1kg double-bagged with oxygen scavengers, 25kg fiber drums

  • Storage: Cool, dry conditions (15-25°C) in original packaging

  • Stability: 24 months when stored properly

  • Logistics: Global express shipping with full documentation support

10. Technical Partnership Opportunities
We offer:

  • Custom purity grades (97%, 99%, 99.5%)

  • Formulation technical support

  • Regulatory documentation package

  • Stability and compatibility studies

Contact Our Technical Team:

  • Web: www.aiherba.com

  • Email: sales@aiherba.com; liaodaohai@gmail.com

  • Keywords: Beta Arbutin supplier, skin whitening ingredient manufacturer, bulk arbutin, cosmetic active ingredients, pharmaceutical raw materials, cGMP manufacturer, cosmetic ingredient exporter

11. Technical FAQ

  • Q: What’s the difference between alpha and beta arbutin?
    A: Beta arbutin is the natural, more stable form with proven efficacy, while alpha is synthetic and less stable

  • Q: Can you provide hydroquinone-free certification?
    A: Yes, we guarantee ≤1 ppm hydroquinone in all batches

  • Q: What documentation do you provide?
    A: Full COA, MSDS, stability data, and regulatory support documents

  • Q: Do you offer formulation support?
    A: Our technical team provides comprehensive application support

  • Q: What’s your typical lead time for large orders?
    A: 2-3 weeks for standard orders, 4-5 weeks for custom requirements

12. Professional Conclusion
Beta Arbutin remains the gold standard for safe and effective skin brightening in professional formulations. Zhonghong’s pharmaceutical-grade manufacturing and technical expertise ensure consistent quality and performance for demanding cosmetic and pharmaceutical applications.

Contact us today for technical documentation and samples.

References:

  1. Maeda, K., & Fukuda, M. (1996). Arbutin: mechanism of its depigmenting action in human melanocyte culture. Journal of Pharmacology and Experimental Therapeutics

  2. Sugimoto, K., et al. (2005). Synthesis of α-arbutin and its comparison with β-arbutin. Bioscience, Biotechnology, and Biochemistry

  3. JECFA (2008). Safety evaluation of arbutin. WHO Food Additives Series

  4. SCCS (2015). Opinion on arbutin. Scientific Committee on Consumer Safety

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