Berberine

Berberine Extract | High-Purity Botanical Ingredient Supplier | AIHerba® 

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1. Product Overview

English Name: Berberine Extract
Botanical Source: Berberis aristata, Coptis chinensis (Coptis root), or Phellodendron amurense bark
Active Ingredient: Berberine Hydrochloride / Berberine Sulfate
Specification: 97% Berberine (HPLC)
Appearance: Yellow crystalline powder
CAS No.: 633-65-8
Molecular Formula: C₂₀H₁₈NO₄⁺
Manufacturer: Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba®)
Certificates: GMP, ISO9001, ISO22000, HACCP, HALAL, KOSHER

Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis and other Berberis plants. With potent bioactivity and a long history in traditional Chinese medicine, it is widely used in pharmaceuticals, dietary supplements, and functional food formulations for its glucose-regulating, antimicrobial, and metabolic benefits.

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2. Source & Production

AIHerba® sources premium Coptis chinensis roots and Berberis aristata barks from pollution-free mountain regions in China.
Production utilizes modern water-ethanol extraction, supercritical CO₂ purification, and membrane separation to ensure:

• ≥97% purity (HPLC verified)
• Low heavy metal and pesticide residue levels
• Consistent batch-to-batch quality
• Full traceability from raw herb to final extract

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3. Health Benefits & Functions

(1) Key Bioactive Benefits

• Blood Sugar Regulation: Supports insulin sensitivity and lowers fasting glucose levels.
• Lipid Metabolism: Reduces LDL cholesterol and triglycerides while increasing HDL.
• Gut Microbiome Support: Balances intestinal flora and improves digestive function.
• Anti-Inflammatory & Antioxidant: Reduces systemic inflammation and oxidative stress.
• Cardiovascular Health: Promotes endothelial function and circulation.

(2) Scientifically Supported Health Effects

Clinical studies (NIH, PubMed) have shown berberine’s comparable effects to metformin in managing Type 2 diabetes and metabolic syndrome.

• NIH Study on Berberine & Glucose Control
• FDA Reference on Herbal Alkaloids

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4. Traditional Applications

Used for centuries in Traditional Chinese Medicine (TCM) as “Huang Lian,” berberine was prescribed to treat gastrointestinal infections, fever, and inflammation. In Ayurveda, Berberis aristata (Tree Turmeric) was known for its cleansing and antimicrobial effects.

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5. Recommended Dosage & Usage

Application	Typical Dosage	Usage Form
Dietary Supplements	500–1500 mg/day	Capsules, Tablets, Powders
Functional Beverages	100–300 mg/serving	Dissolved or mixed in drink bases
Pharmaceutical Formulations	Customized	Per regulatory and formulation requirements

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6. Best Formulation Combinations

Berberine is often combined with:

• Milk Thistle Extract (Silymarin): Enhances liver detoxification.
• Alpha Lipoic Acid: Boosts glucose metabolism.
• Cinnamon Extract: Improves insulin sensitivity.
• Probiotics: Supports microbiota balance and absorption efficiency.

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7. Safety & Precautions

• Avoid during pregnancy or lactation without medical supervision.
• May interact with diabetic medications—consult a physician before use.
• Store in a cool, dry place away from direct light and moisture.

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8. Technical Specifications (COA Summary)

Category	Item	Specification	Test Method
Appearance	Yellow crystalline powder	Conforms	Visual
Assay (Berberine)	≥97.0%	HPLC
Loss on Drying	≤5.0%	105°C, 2h
Ash Content	≤2.0%	Gravimetric
Solvent Residue	≤5000 ppm	GC

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Pesticide Residue Testing

Item	Limit (ppm)	Method
DDT	<0.05	GC-ECD
BHC	<0.05	GC-ECD
Parathion	<0.05	GC-MS
Carbofuran	<0.05	LC-MS/MS
Chlorpyrifos	<0.05	GC-MS

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Heavy Metal Testing

Metal	Limit	Method
Lead (Pb)	≤3.0 mg/kg	ICP-MS
Arsenic (As)	≤2.0 mg/kg	ICP-MS
Mercury (Hg)	≤0.1 mg/kg	ICP-MS
Cadmium (Cd)	≤1.0 mg/kg	ICP-MS

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Microbiological Testing

Parameter	Limit	Method
Total Plate Count	≤1000 CFU/g	USP <61>
Yeast & Mold	≤100 CFU/g	USP <61>
E. coli	Negative	USP <62>
Salmonella	Negative	USP <62>
Staphylococcus aureus	Negative	USP <62>

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9. Manufacturing Process

1. Raw Material Selection →
2. Crushing & Pre-treatment →
3. Water-Ethanol Extraction →
4. Filtration & Concentration →
5. Purification (Membrane & Chromatography) →
6. Drying (Spray or Vacuum Drying) →
7. Grinding & Sieving →
8. Quality Inspection & Packaging

All steps follow GMP, ISO, and HACCP standards with full traceability.

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10. Storage, Shelf Life & Packaging

• Storage: Store below 25°C, in a tightly sealed container, protected from light and humidity.
• Shelf Life: 24 months from production date.
• Packaging: 25 kg/drum (inner double PE bag + outer fiber drum).
• Samples: Free 20–50 g samples available upon request.
• MOQ: 1 kg (for trial order).

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11. Logistics & Delivery

• Lead Time: 3–7 working days for standard specifications.
• Shipping Methods: DHL, FedEx, UPS, or air/sea freight.
• Customs Documentation: COA, MSDS, TDS, Non-GMO statement, and Origin Certificate available.

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12. Application Industries

Industry	Applications
Nutraceuticals	Blood sugar control, lipid management supplements
Pharmaceuticals	Metabolic and anti-inflammatory formulations
Functional Foods	Metabolic health beverages, herbal tonics
Cosmetics	Antibacterial and anti-inflammatory skin formulations
Veterinary & Feed Additives	Natural antimicrobial ingredient

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13. Why Choose AIHerba®?

✅ Professional Factory: Over 28 years of production experience in botanical extracts.
✅ Certifications: GMP, ISO9001, ISO22000, HALAL, KOSHER.
✅ OEM/ODM Solutions: Custom formulations for global brands.
✅ Global Clients: Trusted by 1,000+ health and cosmetic companies.
✅ Full Traceability: Raw material to final batch with transparent quality control.

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14. Frequently Asked Questions (FAQ)

Q1: Is berberine water-soluble?
A1: Berberine hydrochloride is slightly soluble in water but dissolves better in ethanol and methanol.

Q2: Can I get customized specifications (e.g., 85% Berberine)?
A2: Yes. We provide tailored purity levels and formulation bases according to client needs.

Q3: What is the lead time for bulk orders?
A3: Typically 5–10 days depending on quantity and specification.

Q4: Can AIHerba provide third-party testing reports?
A4: Yes. We can provide SGS, Eurofins, or Intertek reports upon request.

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15. References

1. Yin, J. et al. “Efficacy of Berberine in Type 2 Diabetes Mellitus: A Meta-analysis.” Metabolism (2008). PubMed Link
2. NIH: Berberine — Herbal Supplement Information. NIH.gov
3. FDA Botanical Drug Development Guidance. FDA.gov

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Contact Us
📧 Email: sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 Website: www.aiherba.com
🏭 Factory: Shaanxi Zhonghong Investment Technology Co., Ltd.
AIHerba® – Your Trusted GMP-Certified Natural Plant Extract Supplier in China