Alpha GPC Specification
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Ingredient Name: L-Alpha Glycerylphosphorylcholine (Alpha GPC / Choline Alfoscerate)
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CAS No: 28319-77-9
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Typical Purity: 99% (Hygroscopic Powder) / 50% (Non-Hygroscopic Granule)
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Main Applications: Cognitive Formulations, Pre-workout Supplements, Functional Beverages
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Suitable Industries: Dietary Supplements, Pharma Intermediates, Sports Nutrition
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Solubility: Highly soluble in water and ethanol (99% grade)
1. Bulk Alpha GPC Powder Supplier | GMP Certified 99% & 50% Grade
Procurement Overview (For Buyers):
AiHerba is a specialized manufacturer and global supplier of high-purity L-Alpha Glycerylphosphorylcholine (Alpha GPC). We address the primary manufacturing challenge of Alpha GPC—hygroscopicity—by offering two distinct specifications: 99% pure powder for liquid formulations and 50% granular powder (blended with anti-caking agents like Dicalcium Phosphate or Silicon Dioxide) optimized for stable encapsulation and tableting.
Produced in our GMP-compliant facility, our Alpha GPC undergoes rigorous HPLC testing to ensure assay integrity and strictly controlled moisture levels (<1.0%). We support global B2B buyers, supplement brands, and contract manufacturers with flexible MOQ, commercial bulk pricing, and traceable batch documentation.
[ Request a Quote ] [ Download TDS/COA ]
2. What Is Alpha GPC? (Industrial Definition)
Alpha GPC (Choline Alfoscerate) is a phospholipid building block and a highly bioavailable choline donor. Unlike Choline Bitartrate, Alpha GPC rapidly crosses the blood-brain barrier. In the industrial raw material market, it is categorized as a premium nootropic ingredient and a precursor to acetylcholine.
From a supply chain perspective, Alpha GPC is synthesized or derived from soy lecithin fatty acids. It is critical for buyers to note that pure Alpha GPC is deliquescent (turns to liquid upon air exposure); therefore, selecting the correct grade (99% vs. 50%) is vital for your specific production machinery and end-product stability.
3. Detailed Technical Specifications
| Parameter | Specification (99% Grade) | Specification (50% Grade) |
| Appearance | White to off-white waxy powder/crystal | White free-flowing powder |
| Assay (Dry Basis) | ≥ 99.0% | 50.0% – 52.0% |
| Identification | Matches Standard Retention Time (HPLC) | Matches Standard Retention Time (HPLC) |
| Loss on Drying | ≤ 1.0% | ≤ 2.0% |
| pH (1% Solution) | 5.0 – 7.0 | 5.0 – 7.0 |
| Specific Rotation | -2.4° to -2.8° | N/A (Carrier dependent) |
| Residue on Ignition | ≤ 0.1% | ≤ 40% (Carrier dependent) |
| Hygroscopicity | Very Strong (Requires Vacuum Pack) | Low / Stable |
4. Product Source & Raw Material Origin
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Source Type: Semi-synthetic / Enzymatic conversion.
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Starting Material: Derived from highly purified Soy Lecithin (non-GMO options available) or synthetic phospholipid precursors.
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Solvent Control: Manufactured using Green Chemistry principles to minimize residual solvents, ensuring compliance with USP/EP limits for residual organic solvents.
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Allergen Status: Soy-derived variants are standard; Synthetic variants (Soy-Free) available upon request for specific hypoallergenic formulations.
5. Mechanism of Action & Functional Properties
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Cholinergic Precursor: Serves as a direct precursor to acetylcholine, a neurotransmitter essential for synaptic transmission.
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Phospholipid Synthesis: Provides glycerophosphate to support the synthesis of phosphatidylcholine within cell membranes.
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Growth Hormone Modulation: Research suggests Alpha GPC acts as a secretagogue, potentially supporting the secretion of Growth Hormone (GH) in conjunction with physical exercise.
(Note: These statements describe the ingredient’s biological function and do not claim to treat diseases.)
6. Application-Relevant Benefits (Regulatory-Safe)
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High Bioavailability: Recognized as one of the most efficient choline sources for industrial formulations due to its lipid-bound structure.
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Water Solubility: The 99% grade dissolves completely in water, making it ideal for RTD (Ready-to-Drink) functional beverages and liquid shots.
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Cognitive Positioning: Marketable in formulations targeting focus, memory recall, and mental clarity.
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Athletic Performance: Widely adopted in “Pump” products and non-stimulant pre-workout powders.
7. Usage Guidelines & Formulation Recommendations
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Handling 99% Pure Powder:
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Challenge: Extreme moisture sensitivity.
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Solution: Must be handled in a dehumidified environment (RH < 40%). Once opened, use immediately or reseal under nitrogen/vacuum. Ideal for liquid drops or soft gels.
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Handling 50% Powder:
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Benefit: Excellent flowability.
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Usage: Recommended for hard capsules and tablet compression. The excipients prevent the powder from clumping in hopper feeds.
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Recommended Dosage: Typically 300mg – 600mg per serving in finished dietary supplements (subject to local regulations).
8. Traditional & Modern Industrial Applications
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Dietary Supplements: Standalone brain health capsules or “Nootropic Stacks” combined with Huperzine A and Bacopa Monnieri.
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Sports Nutrition: Powder blends for e-gamers (focus) and bodybuilders (GH support).
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Pharmaceutical Intermediates: Used in the synthesis of specific neurological drugs (depending on grade and regulatory compliance).
9. COA & Quality Control Specifications
At AiHerba, we implement a strict testing protocol. Every batch is tested for contaminants.
Pesticide Residue Analysis (USP <561> / EP 2.8.13)
| Test Item | Specification Limit | Test Method |
| Total Pesticides | Complies with USP/EP | GC-MS / LC-MS-MS |
| DDT | < 0.05 mg/kg | GC-MS |
| Quintozene | < 0.05 mg/kg | GC-MS |
| Procymidone | < 0.05 mg/kg | GC-MS |
| Chlorpyrifos | < 0.05 mg/kg | GC-MS |
Heavy Metals Control (ICP-MS)
| Test Item | Specification Limit | Test Method |
| Total Heavy Metals | ≤ 10 ppm | USP <233> |
| Lead (Pb) | ≤ 3.0 ppm | ICP-MS |
| Arsenic (As) | ≤ 1.0 ppm | ICP-MS |
| Cadmium (Cd) | ≤ 1.0 ppm | ICP-MS |
| Mercury (Hg) | ≤ 0.1 ppm | ICP-MS |
Microbiological Control
| Test Item | Specification Limit | Test Method |
| Total Plate Count | ≤ 1,000 CFU/g | USP <61> |
| Yeast & Mold | ≤ 100 CFU/g | USP <61> |
| E. Coli | Negative / 10g | USP <62> |
| Salmonella | Negative / 25g | USP <62> |
| Staphylococcus Aureus | Negative / 10g | USP <62> |
10. Manufacturing Process & Production Flow
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Raw Material Inspection: Verification of Soy Lecithin or precursor purity.
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Deacylation/Reaction: Enzymatic or chemical hydrolysis to isolate the GPC molecule.
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Purification: Ion-exchange chromatography to remove fatty acids and impurities.
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Concentration: Vacuum concentration at low temperatures to prevent degradation.
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Crystallization (for 99%): Refined crystallization process.
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Blending (for 50%): Mixing with pharmaceutical-grade carriers (e.g., Silicon Dioxide).
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Drying & Packaging: Critical Step. Dried in a sterile environment and immediately vacuum-packed to prevent moisture absorption.
11. Storage, Shelf Life & Packaging
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Packaging Strategy:
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Inner Layer: Sterile Low-density polyethylene (LDPE) bag.
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Middle Layer: Vacuum-sealed composite aluminum foil bag (Essential for Alpha GPC).
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Outer Layer: 25kg fiber drum.
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Storage Conditions: Store in a cool, dry place regardless of packaging. Keep strictly away from moisture.
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Shelf Life: 24 months when stored in the original unopened vacuum-sealed package.
12. MOQ, Sample Policy & Global Shipping
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MOQ: 1 kg (for R&D/Pilot) / 25 kg (Commercial Bulk).
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Sample Policy: 10g-20g Free Samples available for business verification (Shipping cost covered by buyer or waived for qualified accounts).
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Shipping Class: General Cargo (Non-Hazardous).
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Incoterms: FOB, CIF, DDP (to select regions).
13. Clinical Data & Scientific Research
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Study on Cognitive Function: A study published in Clinical Therapeutics evaluated the efficacy of Alpha GPC in cognitive recovery protocols, noting improved Mini-Mental State Examination (MMSE) scores.
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Study on Power Output: Research in the Journal of the International Society of Sports Nutrition observed that Alpha GPC supplementation might increase lower body force production in athletes.
(Disclaimer: Data provided for R&D reference only. Not intended as consumer medical advice.)
14. Applicable Industries
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Nutraceuticals: Brain health, memory support, and geriatric nutrition.
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Sports Nutrition: Pre-workout blends, intra-workout recovery.
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Functional Foods: Fortified drinks and energy bars (using 50% grade).
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Cosmetics: Used in skin conditioning formulations (rare but applicable for hydration properties).
15. Industry Application Scenarios (B2B Case Studies)
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Scenario A: The Nootropic Startup
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Need: Creating a “Focus Capsule” for students.
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Solution: We supply Alpha GPC 50% combined with Silicon Dioxide. This allows the client’s encapsulation machine to run at high speed without the powder sticking to the tooling, reducing downtime by 40%.
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Scenario B: The Energy Drink Manufacturer
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Need: Adding a cognitive kick to a clear energy drink without affecting texture.
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Solution: We supply Alpha GPC 99%. Its high water solubility ensures a clear solution with no sedimentation, providing a premium “Brain Fuel” claim on the label.
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Scenario C: The OEM Contract Manufacturer
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Need: Bulk purchasing with long-term stability storage.
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Solution: AiHerba provides 25kg drums with reinforced aluminum liners. We schedule quarterly shipments to ensure the factory receives fresh batches, minimizing warehouse spoilage risks.
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16. Supplier Comparison & Procurement Guide
| Feature | AiHerba (Factory Direct) | Standard Traders |
| Moisture Control | Vacuum Foil + Drum | Standard PE Bag (High Risk) |
| Specifications | 99% Pure & 50% Stable | Often only 99% available |
| Traceability | Full Batch Record | Limited |
| Customization | Specific Carrier selection available | Fixed specification |
17. FAQ for B2B Buyers
Q1: Why is my Alpha GPC 99% turning into a liquid?
A: Alpha GPC is extremely hygroscopic. If the package is left open to air, it absorbs moisture rapidly. We recommend using 50% grade for solid dosage forms or handling 99% grade in humidity-controlled rooms.
Q2: Is your Alpha GPC synthetic or natural?
A: We offer both semi-synthetic grades (from Soy Lecithin) and fully synthetic grades depending on your “Natural” labeling requirements.
Q3: Can you provide a stable version for capsules?
A: Yes, our Alpha GPC 50% Granular is specifically designed for capsules. It flows well and does not clump.
Q4: Do you test for residual solvents?
A: Yes, we strictly monitor ethanol and other solvent residues to ensure they are well below USP limits.
Q5: What certifications does your facility hold?
A: Our manufacturing partners operate under ISO9001 and GMP standards. Kosher and Halal certifications are available for specific batches.
Q6: What is the HS Code for Alpha GPC?
A: Typically 2923900090 (Other quaternary ammonium salts and hydroxides).
19. References & Regulatory Sources
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PubChem CID 1069: Compound Summary for Alpha-GPC. [Link to PubChem]
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FDA GRAS Notices: Search for Choline sources in the GRAS database. [Link to FDA]
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European Food Safety Authority (EFSA): Opinions on Choline usage in food supplements. [Link to EFSA]
Manufacturer & Quality Assurance
Manufactured by AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified manufacturer specializing in high-purity botanical extracts and nutritional ingredients for dietary supplements, cosmetics, and pharmaceutical applications.
✔ GMP-certified production facility
✔ Full COA & technical specifications available
✔ Batch traceability & strict quality control
✔ Bulk supply & OEM/ODM services for global B2B buyers
📧 sales@aiherba.com
| info@aiherba.com
| liaodaohai@gmail.com
🌐 www.aiherba.com
If you are looking for a bulk supplier or OEM manufacturer of Alpha GPC Powder, contact us today for detailed specifications, current COA, and wholesale pricing.
