Rhamnose

 Rhamnose: Premium Manufacturer & Global Supplier for Cosmetic, Pharmaceutical and Food Applications | Aiherba

Source high-purity Rhamnose from Zhonghong, a leading manufacturer and bulk supplier. Natural deoxy sugar for skincare, flavors & pharmaceuticals. Request a free sample and get a competitive price quote.

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1. What is Rhamnose?

Rhamnose (or L-Rhamnose) is a naturally occurring deoxy sugar, specifically a 6-deoxyhexose. It is commonly found in nature as a component of plant glycosides, bacterial polysaccharides, and various bioflavonoids like quercetin and rutin. Unlike many common sugars, its unique structure makes it metabolically stable in many applications, serving as an excellent building block for various compounds. For B2B clients across the cosmetic, flavor & fragrance, pharmaceutical, and food industries, a reliable Rhamnose manufacturer provides a versatile, multifunctional ingredient with diverse applications.

2. Source, Chemical Properties, and Identifiers

• Product Source: Primarily produced through the acid hydrolysis of natural plant-derived glycosides (like rutin from Sophora japonica or quercitrin from quercus species), followed by purification. It can also be produced via microbial fermentation.

• Chemical Classification: Deoxy sugar (Methylpentose).

• CAS Number: 3615-41-6 (for L-Rhamnose monohydrate)

• Molecular Formula (MF): C6H12O5

• Molecular Weight (MW): 164.16 g/mol (Anhydrous); 182.17 g/mol (Monohydrate)

• EINECS: 222-793-4

3. What Defines the Best Rhamnose? A B2B Buyer’s Guide

For international brands and exporters, the “best” Rhamnose is defined by its high purity (anhydrous or monohydrate form), optical purity (L-enantiomer), low color, low residual mineral content, and the supplier’s ability to ensure batch-to-batch consistency.

• Key Ingredient & Efficacy: Premium Rhamnose is a high-purity compound (e.g., ≥98% or USP grade). Its value is derived from its function as a precursor and building block:

  • Skin Rejuvenation & Anti-Aging (Cosmetics): Research indicates it can stimulate aquaporin channels in skin cells, improving cellular hydration and potentially promoting the synthesis of collagen and elastin, leading to firmer, more youthful-looking skin.

  • Flavor & Fragrance Precursor: Serves as a key starting material for the synthesis of certain high-value flavor compounds.

  • Pharmaceutical Intermediate: Used in the synthesis of certain antibiotics, vitamins (like B2), and other bioactive molecules.

  • Sweetness Modifier: Can be used to modify the sweetness profile and mouthfeel in food and beverage applications.

  • (Compliant for use in cosmetics, as a food additive (where approved), and as a pharmaceutical intermediate. Regulatory status varies by application and region.)

• Origin & Quality: Our Rhamnose is derived from hydrolyzing high-quality plant glycosides, ensuring a natural origin and a product free from allergens common in other sources.

• Usage & Dosage:

  • Typical Use: Incorporated into anti-aging serums, creams, lotions, functional food formulations, and as a raw material for chemical synthesis.

  • Recommended Dosage: In cosmetic formulations, effective concentrations typically range from 1% to 5%. Usage levels in other applications are highly specific to the desired outcome.

• Applicable Audience: Formulators developing high-end anti-aging cosmetics, flavor & fragrance houses, pharmaceutical synthesis departments, and functional food developers.

• Notes & Side Effects:

  • Precautions: Generally recognized as safe for topical use and as a food component in moderate amounts. It is poorly absorbed in the human intestine.

  • Side Effects: None known for topical use. Excessive oral consumption may have a laxative effect, similar to other sugars.

4. Why Partner with Zhonghong (Aiherba) as Your Rhamnose Manufacturer?

Shaanxi Zhonghong Investment Technology Co., Ltd. (Global Marketing: Aiherba) is a certified high-tech enterprise and a trusted exporter specializing in the hydrolysis, fermentation, and purification of premium, plant-based ingredients for the global B2B market.

• Scientific Excellence: Our joint laboratories with 5 leading universities and portfolio of 20+ patents allow us to optimize hydrolysis and purification processes for maximum Rhamnose yield and purity from plant sources.

• Unmatched Quality Control: Our investment in advanced equipment like HPLC and chiral chromatography ensures our product meets high purity specifications and confirms the correct L-enantiomeric form, which is critical for biological activity.

• Global B2B Network: With 28 years of experience in bioactive compounds, we supply customized ingredients and wholesale quantities to multinational cosmetic brands, wholesale distributors, and pharmaceutical companies across 80+ countries.

• Technical Support: We provide comprehensive technical dossiers, application guidance, and stability data, making us more than just a supplier but a true innovation partner for your customized herbal extract and chemical needs.

5. Detailed Product Specifications (COA)

Every batch is accompanied by a comprehensive Certificate of Analysis (COA) to guarantee it meets the stringent standards of your industry.

6. Production Process & Quality Control

Our production of L-Rhamnose typically begins with the extraction of flavonoid glycosides (like rutin) from selected plant sources. The extracted glycosides then undergo a controlled acid hydrolysis process, which selectively cleaves the sugar moieties, releasing Rhamnose. The resulting hydrolysate is then subjected to a meticulous multi-stage purification process. This involves steps like neutralization, filtration, decolorization (using activated carbon), and crystallization to isolate the pure L-Rhamnose, which is then dried and milled to the desired particle size.

Our Quality Control is integrated into every step of the manufacturing process. It starts with the authentication and assay of the raw plant material. In-process testing during hydrolysis monitors the reaction completion and helps minimize the formation of degradation products. The final product is rigorously analyzed. High-Performance Liquid Chromatography (HPLC) with a refractive index (RI) or evaporative light scattering (ELSD) detector is the primary method for quantifying the Rhamnose content and assessing purity. Polarimetry is essential to confirm the specific optical rotation, ensuring the product is the biologically relevant L-enantiomer and not a racemic mixture. FT-IR Spectroscopy confirms the identity of the compound. We also employ ICP-MS for sensitive heavy metal detection and standard microbiological testing. This multi-tiered QC protocol guarantees a product that is pure, safe, and consistent for our global clients.

7. Application Scenarios

Rhamnose is a versatile ingredient for multiple high-value industries:

• Cosmeceuticals & Skincare: The primary application is in high-end anti-aging products, moisturizers, and serums for its purported skin rejuvenation and hydrating properties.

• Flavor & Fragrance Industry: Used as a starting material for the synthesis of certain furanone flavors and fragrance components.

• Pharmaceuticals: Employed as a chiral building block and intermediate in the synthesis of various antibiotics, vitamins, and other active pharmaceutical ingredients (APIs).

• Food & Beverage: Used as a mild sweetener and texturizer in some specialized food products.

8. Technical Role, Research, and Innovation

Rhamnose’s value lies in its role as a stable, natural chiral building block. Its proposed mechanism in skincare involves the upregulation of aquaporin-3 (AQP3) water channels in the skin, enhancing moisture transport and potentially influencing gene expression for collagen production. Current research frontiers are exploring its use in synthesizing novel glycoconjugates for targeted drug delivery and its prebiotic potential. The main challenge and area of innovation is improving the cost-efficiency of its production from sustainable sources and developing new, high-value derivatives. At Zhonghong, our R&D focuses on optimizing our hydrolysis and purification technology to provide our B2B partners with a high-purity, competitively priced product that meets the evolving needs of the market.

9. FAQ – Frequently Asked Questions

Q: What is the difference between L-Rhamnose and D-Rhamnose?
A: They are enantiomers (mirror-image isomers). L-Rhamnose is the naturally occurring and biologically active form used in cosmetics and nutrition. Our product is specifically L-Rhamnose.

Q: Can you provide Rhamnose derived from non-plant sources?
A: Our primary production is plant-based hydrolysis. We also offer Rhamnose produced via microbial fermentation for specific customer requirements. Please inquire for details.

Q: Is your Rhamnose suitable for organic certification?
A: We offer both conventional and organically certified versions (e.g., from organically grown plant sources). Please inquire for specific certification documentation.

Q: Do you offer samples for our product development and testing?
A: Absolutely. We provide free sample herbal extract and chemical materials to qualified businesses for evaluation and application testing in their labs.

Q: What packaging do you use for international export?
A: We use sealed, double-layer plastic bags with desiccant inside foil-lined cardboard drums or fiber drums to protect the product from moisture during transit.

10. Where to Buy and Request Free Samples

As a leading manufacturer and global supplier of premium sugars and plant actives, we are your trusted partner for sourcing high-quality L-Rhamnose.

Contact us today to discuss your procurement needs, request a free sample for your R&D, and get a competitive wholesale price.

• Email: sales@aiherba.com / liaodaohai@gmail.com

• Website: www.aiherba.com

11. Conclusion

For B2B clients in the cosmetic, pharmaceutical, and food industries, L-Rhamnose offers a unique, multifunctional natural building block. Choosing a supplier with robust production technology, rigorous QC that includes chiral purity confirmation, and global export capabilities is crucial for product quality and supply chain reliability. Zhonghong (Aiherba) provides not just a product, but a reliable partnership, offering a premium, well-documented ingredient that will empower your innovative formulations, backed by nearly three decades of experience.

12. References

• Carbohydrate Research: Studies on the properties, synthesis, and occurrence of L-Rhamnose.

• International Journal of Cosmetic Science: Research on the effects of Rhamnose on skin hydration and gene expression.

• USP/EP/JP Monographs for analytical standards (where applicable).

• ICH Guidelines for impurities in new drug substances (Q3A) when used as a pharmaceutical intermediate.