Bioperine® (Black Pepper Extract) | High-Purity Piperine Supplier & Manufacturer
INCI Name: Piper nigrum Extract
Active Ingredient: Piperine ≥ 95% (HPLC)
CAS No.: 94-62-2
Molecular Formula: C₁₇H₁₉NO₃
Appearance: Light yellow to off-white powder
Source: Derived from the dried fruits of Piper nigrum L. (Black Pepper)
1. Product Overview
Bioperine® is a standardized extract obtained from black pepper fruits, containing ≥95% piperine as the active compound. Recognized globally as a bioavailability enhancer, Bioperine improves the absorption of various nutrients, herbal extracts, and pharmaceutical compounds.
Produced by AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified herbal extract factory, this ingredient is available in bulk, wholesale, and OEM formulations for dietary supplements, pharmaceuticals, cosmetics, and functional foods.
2. Product Origin & Extraction Technology
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Botanical Source: Piper nigrum L. (Black Pepper), native to India and Southeast Asia.
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Extraction Process: Water–ethanol extraction followed by supercritical CO₂ refinement to achieve high purity.
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Purity Assurance: ≥95% Piperine verified by HPLC.
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Certifications: GMP, ISO, HACCP, HALAL, KOSHER.
3. Health Benefits & Mechanism of Action
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Enhances Nutrient Absorption – Boosts bioavailability of vitamins, minerals, and plant actives (e.g., curcumin, resveratrol, CoQ10).
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Improves Metabolism – Supports thermogenesis and fat metabolism, aiding weight management.
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Supports Digestive Health – Stimulates digestive enzymes and promotes gastrointestinal comfort.
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Antioxidant & Anti-inflammatory – Neutralizes free radicals and reduces oxidative stress.
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Synergistic in Formulations – Widely used as a bioenhancer in nutraceutical and pharmaceutical formulations.
References:
4. Traditional & Modern Applications
| Traditional Use | Modern Application |
|---|---|
| Ayurvedic medicine as digestive stimulant | Dietary supplements for nutrient absorption |
| Used in Unani & TCM for metabolism | Functional foods & beverages |
| Topical applications for circulation | Cosmetics & personal care actives |
5. Recommended Dosage & Usage Guidelines
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Dietary Supplements: 5–10 mg per serving.
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Cosmetics: 0.01–0.1% in formulations for circulation-enhancing or anti-aging effects.
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Food & Beverage: As per regional regulatory compliance (typically <20 mg/day).
⚠️ Note: High doses may cause gastric irritation; use standardized extract under recommended limits.
6. Ideal Formulation Partners
Bioperine® works synergistically with:
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Curcumin Extract (Turmeric)
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Resveratrol
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Coenzyme Q10 (CoQ10)
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Green Tea Extract (EGCG)
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Vitamin B Complex & Minerals
7. Specifications & Quality Control (COA Overview)
Main Specifications
| Item | Specification | Test Method |
|---|---|---|
| Appearance | Light yellow to off-white powder | Visual |
| Assay (Piperine) | ≥95% | HPLC |
| Loss on Drying | ≤5.0% | USP <731> |
| Ash | ≤1.0% | USP <281> |
| Solvent Residue | ≤5000 ppm | GC |
Pesticide Residue Testing
| Pesticide | Limit (mg/kg) | Test Method |
|---|---|---|
| DDT | ≤0.05 | GC-MS |
| BHC | ≤0.05 | GC-MS |
| Chlorpyrifos | ≤0.1 | GC-MS |
| Total Pesticide Residues | ≤0.5 | GC-MS |
Heavy Metals Testing
| Element | Limit (ppm) | Test Method |
|---|---|---|
| Lead (Pb) | ≤2.0 | ICP-MS |
| Arsenic (As) | ≤1.0 | ICP-MS |
| Cadmium (Cd) | ≤1.0 | ICP-MS |
| Mercury (Hg) | ≤0.1 | ICP-MS |
Microbiological Tests
| Parameter | Limit | Test Method |
|---|---|---|
| Total Plate Count | ≤1,000 cfu/g | USP <61> |
| Yeast & Mold | ≤100 cfu/g | USP <61> |
| E. coli | Negative | USP <62> |
| Salmonella | Negative | USP <62> |
| Staphylococcus aureus | Negative | USP <62> |
8. Manufacturing Process Flow
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Raw Material Selection (Black Pepper Fruits)
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Cleaning & Drying
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Water–Ethanol Extraction
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Concentration under Vacuum
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Crystallization & Purification
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Supercritical CO₂ Refinement
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Filtration & Drying
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Milling & Sieving
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Quality Testing (HPLC, ICP-MS, Microbial)
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Packaging & Labeling
9. Storage, Shelf Life & Packaging
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Storage: Store in a cool, dry place below 25°C, away from direct sunlight.
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Shelf Life: 24 months from production date.
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Packaging: 25 kg/drum (food-grade fiber drum with double PE inner bag).
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Sample Policy: Free 10–20 g sample available for quality evaluation.
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MOQ: 1 kg for trial order; 25 kg for bulk.
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Delivery Time: 3–7 working days after order confirmation.
10. Applications by Industry
| Industry | Application Examples |
|---|---|
| Nutraceuticals | Capsules, tablets, powders, bioenhanced blends |
| Pharmaceuticals | Bioavailability enhancer in APIs |
| Functional Foods & Beverages | Fortified drinks, energy bars, supplements |
| Cosmetics & Skincare | Circulation-boosting, detox, and anti-aging formulations |
11. Why Choose AIHerba® Bioperine
✅ 28+ Years of Manufacturing Experience – Expertise in natural bioactives and standardized herbal extracts.
✅ GMP, ISO, HALAL, KOSHER Certified – International compliance and traceable supply chain.
✅ Advanced Extraction Technologies – Supercritical CO₂, membrane filtration, and vacuum drying ensure purity and potency.
✅ OEM/ODM Customization – Custom extract ratios, blends, and formulations for global clients.
✅ Full Technical Documentation – COA, MSDS, HPLC reports, safety data, and regulatory support.
12. Contact & Ordering Information
AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd.
📍 No. 38, Gaoxin Avenue, Xi’an, Shaanxi, China
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com
📦 Bulk supply | OEM/ODM | Free sample available | Fast global delivery
13. References
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Shoba G. et al., “Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers,” Planta Medica, 1998.
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Srinivasan K., “Black pepper and its pungent principle-piperine: a review,” Crit Rev Food Sci Nutr., 2007.
