Provitamin B5
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Provitamin B5

Provitamin B5 (D-Panthenol) Final Information | Excessive-Purity Provider

  1. English Name: Panthenol (Provitamin B5)
  1. Specification
    • Purity: ≥ 99% (HPLC)
    • Solubility: Highly soluble in water; soluble in ethanol and propylene glycol
    • pH Value: 6.0 – 7.5 (5% aqueous solution)
    • Heavy Metals: ≤ 10 ppm
    • Loss on Drying: ≤ 0.5%
  1. Appearance: Clear, viscous liquid or white crystalline powder; odorless, no chocolate-related properties
  1. CAS NO.: 16485-10-2 (D-Panthenol)
  1. Lead time: 3 – 7 Working Days
  1. Package: 1 kg/bottle, 5 kg/barrel, 25 kg/drum (plastic or aluminum containers)
  1. Main Market: Europe, North America, Asia, etc.
  1. Application Scenarios

Key Features

  • Moisture Retention: Attracts and retains water in skin and hair, enhancing hydration
  • Skin Repair: Promotes epithelial cell regeneration, accelerating wound healing and soothing irritation
  • Compatibility: Stable in most formulations; works with acids, alcohols, and preservatives
  • Mildness: Non-irritating, suitable for sensitive skin, baby care, and ophthalmic products

Industry Applications

  1. Skincare
    • Moisturizers & Creams: Added at 0.5 – 5% concentration to boost hydration in facial and body products
    • Sensitive Skin Formulations: Key ingredient in products for eczema, rosacea, or post-sunburn care
    • After-sun Products: Soothes UV-damaged skin and restores moisture balance
    • Baby Care: Used in lotions and wipes to protect infants’ delicate skin
  1. Hair Care
    • Conditioners & Masks: Included at 1 – 3% to improve hair elasticity, reduce split ends, and add shine
    • Shampoos: Added to gentle formulas to prevent dryness and soothe scalps
    • Styling Products: Enhances hair manageability and reduces frizz
  1. Cosmetics
    • Foundations & Concealers: Improves spreadability and reduces cakey texture
    • Lipsticks & Balms: Moisturizes lips and prevents chapping
    • Eye Makeup: Used in eyeliners and mascaras to minimize irritation
  1. Pharmaceuticals
    • Topical Ointments: Used in wound-healing creams and diaper rash treatments
    • Ophthalmic Solutions: Added to eye drops as a lubricant for dry eyes
    • Oral Care: Included in toothpaste and mouthwash to soothe oral mucosa
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Provitamin B5 (D-Panthenol) – High-Purity Cosmetic & Nutraceutical Ingredient | AIHerba®
Professional-Grade Panthenol Supplier & OEM Factory from China

1. Product Overview

Provitamin B5 (D-Panthenol), also known as Pantothenol, is a biologically active alcohol form of Vitamin B5 (Pantothenic Acid). When applied to the skin or ingested, it converts into pantothenic acid—an essential component of Coenzyme A (CoA) that supports cell metabolism, tissue regeneration, and hydration.

AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) produces high-purity Provitamin B5 using advanced fermentation and purification technologies under GMP-certified facilities, ensuring stability, bioavailability, and compliance with global cosmetic and nutraceutical standards (USP/EP/CP).

2. Source & Production Process

Our Provitamin B5 is synthesized through a biotechnological fermentation process using plant-derived precursors.
Production Flowchart:

  1. Raw material fermentation (plant glucose base)

  2. Enzymatic bioconversion

  3. Purification & crystallization

  4. Concentration & drying

  5. Quality inspection (HPLC, GC, ICP-MS, Microbial tests)

  6. Packaging under nitrogen protection

This process guarantees >99% purity, excellent solubility, and high stability suitable for cosmetic formulations and dietary supplements.

3. Key Benefits & Mechanisms of Action

(1) Skin & Hair Care Benefits

  • Deeply moisturizes by increasing stratum corneum hydration

  • Promotes wound healing and epithelial regeneration

  • Strengthens the skin barrier and reduces transepidermal water loss (TEWL)

  • Improves hair elasticity and sheen in shampoos and conditioners

(2) Health & Nutritional Benefits

  • Converts to Vitamin B5 to support energy metabolism

  • Aids adrenal function and nervous system balance

  • Supports tissue repair and mucosal health

(3) Functional Properties

  • Water-soluble, non-irritant, stable in a wide pH range (4.0–7.0)

  • Compatible with most cosmetic and food-grade emulsions

4. Traditional & Modern Applications

Traditional Use:
Vitamin B5 analogs have been used since the 1940s for treating skin burns, inflammation, and wounds.

Modern Applications:

  • Cosmetics: Moisturizing creams, serums, hair conditioners, after-sun care, wound-repair products

  • Dietary Supplements: Energy support, metabolic health, anti-fatigue formulas

  • Pharmaceuticals: Dermatological ointments, mucosal healing formulations

  • Functional Foods & Beverages: Fortified drinks, vitamin complexes

5. Recommended Dosage & Usage

  • Cosmetics: 0.5–5% in creams, lotions, shampoos, serums

  • Dietary Supplements: 10–100 mg/day (converted to Vitamin B5 equivalent)

  • Pharmaceuticals: As per pharmacopeia or clinician guidelines

Formulation Compatibility: Excellent stability in aqueous and oil-based systems; pH range 4–7 preferred.

6. Specifications & Quality Standards

Parameter Specification Testing Method
Appearance Colorless to pale-yellow viscous liquid Visual
Assay (D-Panthenol) ≥99.0% HPLC
Specific Rotation +29° to +31° USP/EP
pH (10% solution) 8.0–9.0 pH meter
Heavy Metals (Pb, As, Hg, Cd) ≤10 ppm total ICP-MS
Loss on Drying ≤0.5% USP <731>
Residual Solvents ≤0.5% GC
Microbial Limits <100 CFU/g USP <61>

7. COA – Quality Control Table

(A) Pesticide Residues

Item Limit (ppm) Method
Organochlorine pesticides ≤0.01 GC-MS
Organophosphorus pesticides ≤0.01 GC-MS
Pyrethroids ≤0.02 LC-MS/MS

(B) Heavy Metals

Item Limit Method
Lead (Pb) ≤2 ppm ICP-MS
Arsenic (As) ≤1 ppm ICP-MS
Cadmium (Cd) ≤1 ppm ICP-MS
Mercury (Hg) ≤0.1 ppm ICP-MS

(C) Microbiological Analysis

Item Limit Method
Total Plate Count <1000 CFU/g USP <61>
Yeast & Mold <100 CFU/g USP <61>
E. coli Negative USP <62>
Salmonella Negative USP <62>
Staphylococcus aureus Negative USP <62>

8. Packaging, Storage & Shelf Life

  • Packaging: 25 kg fiber drum / 1 kg aluminum foil bag (customizable OEM packaging available)

  • Storage: Store in a cool, dry, well-ventilated area; avoid direct sunlight.

  • Shelf Life: 24 months unopened under recommended conditions.

9. Sampling Policy, Shipping & MOQ

  • Free Samples: ≤50 g sample available for testing

  • Shipping: By air, sea, or express (FedEx, DHL, UPS); global export supported

  • MOQ: 1 kg (trial order) | bulk price for ≥25 kg

10. Applicable Industries & Use Cases

  • Cosmetics & Personal Care: Skin repair creams, serums, after-sun, anti-aging formulations

  • Health Supplements: Metabolism boosters, energy tonics, immune support formulas

  • Pharmaceuticals: Dermatological, mucosal, and wound-healing applications

  • Functional Foods: Fortified beverages and dietary blends

11. Certifications & Compliance

  • GMP, ISO 9001, ISO 22000, HALAL, KOSHER certified

  • Complies with USP, EP, and CP standards

  • Full COA, MSDS, and Technical Data Sheet available upon request

12. Why Choose AIHerba®

✅ 28+ Years of Extraction & Fermentation Expertise
✅ GMP & ISO-Certified Production Facilities
✅ Global OEM/ODM Formulation Support
✅ Traceable Supply Chain & COA for Every Batch
✅ Clients in 60+ Countries Across Cosmetics, Nutraceuticals & Pharma Industries

13. FAQs

Q1: Is Provitamin B5 suitable for sensitive skin?
Yes, D-Panthenol is non-irritating and clinically proven to soothe sensitive or damaged skin.

Q2: Can it be used in both water- and oil-based formulas?
Yes, it is water-soluble and easily blends with most emulsions.

Q3: What’s the shelf life of Provitamin B5?
24 months under sealed, cool, and dry storage.

Q4: Do you offer OEM formulations or custom blends?
Yes, AIHerba® provides complete OEM & ODM services for customized formulations.

14. References

  1. NIH PubChem – Pantothenol (CID 8767)

  2. PubMed: Topical D-Panthenol and Skin Regeneration

  3. FDA Cosmetic Ingredient Review (CIR): Panthenol Safety Assessment

15. Contact & Verification

📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com
🏭 Shaanxi Zhonghong Investment Technology Co., Ltd.
China’s GMP-certified Natural Plant Extract & Functional Ingredient Manufacturer

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