Anthocyanin Manufacturer | Bulk 25% HPLC Powder | Wholesale Standardized Extract
Eliminate supply delays with 12,000kg ready-stock. Global lead time: 3-5 days. Standardized 25kg drums optimized for high-volume automated lines.
Advanced HPLC Isomer Fingerprinting. pH-Stability profiles and thermal stress data (121°C). Zero methanol residue verified via Headspace GC.
Formulation Guide
Regulatory Guide
Comparison Guide
Stability Data
≥ 25.0% Anthocyanosides
Instant / Crystal Clear
pH 2.0 – 4.5 Opt.
Ethanol/Water Only
Quick Expert Summary
Anthocyanin Extract (CAS 11029-12-2) is a high-intensity phytochemical pigment and antioxidant isolate derived from Vaccinium myrtillus.
Manufacturers utilize it for eye health (rhodopsin support) and vascular integrity.
Key formulation risks include pH-dependent color shifting and thermal oxidation.
Sourcing giants evaluate suppliers based on HPLC isomer fingerprint consistency and methanol-free extraction protocols. AIHerba® provides a 25% isolate optimized for functional beverage clarity and supplemental potency.
1. What is Anthocyanin Extract?
Anthocyanins are water-soluble vacuolar flavonoids that provide the vibrant red, purple, and blue hues in berry matrices. In industrial applications, they serve as both bioactive pharmaceutical ingredients and natural color additives (E163). AIHerba® isolates these bio-polymers using low-temperature membrane concentration, ensuring the flavylium cation remains biologically active for antioxidant property support.
2. Technical Specifications
| Property | Specification | Method |
|---|---|---|
| Assay | ≥ 25.0% Anthocyanosides | HPLC |
| pH (1% Sol.) | 2.5 — 4.5 | Potentiometric |
| Bulk Density | 0.45 — 0.65 g/ml | USP <616> |
3. Source & Origin
AIHerba® sources authentic Vaccinium myrtillus (Bilberry) and Ribes nigrum (Blackcurrant) from GAP-compliant high-latitude forests. Every lot is subjected to DNA barcoding to verify species authenticity, eliminating the “Blueberry-Mulberry substitution” risk common in the commodity market.
4. Mechanism of Action
Anthocyanins function by neutralizing reactive oxygen species (ROS) through hydrogen atom transfer. Specifically, they support the functional property of rhodopsin regeneration in the retina, enhancing night-vision markers. In the vascular system, they inhibit the activity of elastase and collagenase, supporting capillary structural integrity.
5. Application Benefits
- Visual Integrity: Functional property for supporting retinal adaptation to dark environments.
- Microvascular Support: May support healthy vascular endothelial functional properties.
- Anti-Pollution: Formulation advantage: High ORAC value for “Beauty-from-Within” complexes.
Industrial Benchmarking Analysis
| Metric | Standard Industry Grade | Competitor Generic Isolate | AIHerba Phyto-Pure |
|---|---|---|---|
| Analytical Method | UV-Vis Only | Basic HPLC | Full Isomer Fingerprint |
| Solvent Residue | Variable Methanol | < 3000ppm Ethanol | Verified ND / < 500ppm |
| Solubility Clarity | Partial Sediment | Cloudy at high conc. | Instant Aqueous Clarity |
Common Formulation Challenges
Root Cause: pH drift above 5.0 destabilizing the cation.
Recommendation: Buffer system (Citric Acid/Sodium Citrate) to maintain pH 3.0-3.5.
Root Cause: Aggregation with high-iron mineral salts.
Recommendation: Utilize chelating agents (EDTA) or add anthocyanin after mineral dispersion.
6. Usage & Formulation Guide
Baking & Thermal Processing: Allulose browns faster than sucrose. R&D should reduce oven temperatures by 10°C to optimize Maillard results. Dissolution: 100% Water Soluble. pH Range: Stable from pH 2.0 – 9.0.
7. Industrial Evolution
From simple fruit colorants to standardized pharmaceutical-grade isolates. AIHerba represents the 3rd generation of anthocyanin extraction, moving beyond bulk berry powders to precision-titrated isolates that satisfy the most rigorous clinical transparency audits.
8. Pharma-Grade Analytical COA Matrix
8.1 Identity & Assay Profile
| Testing Item | Industrial Specification | Method | Standard |
|---|---|---|---|
| Assay (Anthocyanins) | ≥ 25.0% | HPLC-DAD | USP / EP |
| Identification | Match Reference | HPTLC / IR | USP <197K> |
8.2 Physical & Flowability Analysis
| Testing Item | Specification | Method |
|---|---|---|
| Bulk Density | 0.45 – 0.65 g/ml | USP <616> |
| Carr Index | ≤ 15% | Calculation |
8.3 Safety & Residue Control
| Item | Spec | Method | |
|---|---|---|---|
| Pesticides (400+) | Negative | GC-MS/MS | USP <561> |
| Lead (Pb) | < 0.5 ppm | ICP-MS | EU 1881/2006 |
Analytical Evidence & Batch Consistency
HPLC Isomer Mapping
[Illustrative Engineering Simulation] Documenting monomodal distribution of five primary anthocyanoside peaks for identity authentication.
40°C Retention Data
Assay retention ≥ 98.2% after 180-day accelerated stress testing in AIHerba nitrogen-sealed drums.
9. Manufacturing Flow
Harvest → Cryogenic Milling → Low-Temp Aqueous Extraction → Membrane Fractionation → Column Chromatography → Spray Drying → Packaging.
10. Storage & Packaging
25kg standard fiber drum. Store at <20°C, humidity <60%. Use Nitrogen-sealed liners to prevent auto-oxidation of flavylium cations.
11. MOQ, Sample, Global Shipping
MOQ: 25kg bulk. 100g trial samples available. Global Air/Sea dispatch within 3-5 days. DDP available for US/EU.
12. Scientific Research & Regulatory
Research published in Nutrients confirm that 500mg daily berry anthocyanins support healthy microvascular elasticity. Regulatory Guide: In the US, classified under Title 21 CFR 73. European manufacturers comply with E163 standards.
Regulatory Decision Tree
FDA / DSHEA
↓
GRAS / NDI Status
Novel Food
↓
EFSA / E163
USP / EP
↓
ICH Q3C Solvent
13. Applicable Industries
Eye Health OEM
Nutricosmetics
14. B2B Application Scenarios
Used by contract manufacturers for vision-support capsules, anti-aging fruit seltzers, and clinical-grade antioxidant complexes requiring crystal-clear dissolution.
15. Industrial Market Trends
Target the Clean Label Functional Food segment with natural berry-derived colorants that meet E163 requirements while providing pharmaceutical-grade bioactive claims.
16. Supplier Comparison & Procurement Guide
| Metric | Generic Standard Grade | AIHerba® Phyto-Pure Isolate |
|---|---|---|
| Isomer Fingerprint | UV-Vis only (Fakeable) | HPLC Fingerprint Verified |
| Solvent Residue | Methanol Traces common | 100% Ethanol/Aqueous Only |
| Batch Uniformity | Manual blending | Membrane-Purified Precision |
17. Technical FAQ for Bulk Buyers
Q: How does the fatty acid ratio of your CO2 oil compare to the USP monograph?
(Note: Anthocyanin is a water-soluble isolate). Our isomer profile strictly adheres to the USP Bilberry monograph, providing ≥95% trans-anthocyanoside identity compared to official reference standards.
Q: Is your material stable in carbonated beverages?
Yes, provided the pH remains < 4.2. Anthocyanins are exceptionally stable in pressurized CO2 environments which naturally support an acidic matrix.
Q: What analytical method verifies its botanical identity?
We utilize HPTLC for botanical identification and HPLC with UV-DAD detection at 520nm for specific glycoside fingerprinting.
18. References & Regulatory Sources
PubMed: Anthocyanin Stability and Bioavailability (2024 review). | FDA: Color Additive Status List. | USP: Official Bilberry Monograph. | EFSA: Panel on Food Additives and Nutrient Sources.
AIHerba® Quality Assurance
Manufactured by AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.),
a GMP-certified manufacturer specializing in high-purity botanical extracts
for dietary supplements, cosmetics, and pharmaceutical applications.
✔ GMP-certified production facility
✔ Full COA & technical specifications available
✔ Batch traceability & strict quality control
✔ Bulk supply & OEM/ODM services for global B2B buyers
✔ HPLC Fingerprint Verified
✔ 15,000kg Bulk Stock
