Schisandrin
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Schisandra Extract

Schisandra Extract: Nature’s Adaptogenic Powerhouse | Premium Supplier Guide

  1. English Name:Schisandra Extract
  1. Specification
    • Total Lignans Content: ≥ 2% (HPLC, mainly schisandrin, schisandrol A)
    • Solubility: Partially soluble in water; soluble in ethanol and methanol
    • Moisture Content: ≤ 5%
    • Heavy Metals: ≤ 10 ppm
  1. Appearance: Brown to dark brown fine powder, with a characteristic sour – sweet aroma, no chocolate – related smell
  1. CAS NO.: N/A (mixture); Key component schisandrin: 58546 – 54 – 7
  1. Lead time: 3 – 7 Working Days
  1. Package: 1 kg/aluminum foil bag, 25 kg/drum (double – layer PE bag inside)
  1. Main Market: Europe, North America, Asia, etc.
  1. Application Scenarios

Key Properties

  • Adaptogenic: Helps the body adapt to physical and mental stress, supporting overall resilience
  • Antioxidant: Rich in lignans that scavenge free radicals, protecting cells from oxidative damage
  • Liver – protective: Promotes liver function and helps in detoxification processes
  • Neuroprotective: May support cognitive function and nervous system health
  • Immunomodulatory: Enhances immune system activity, aiding in disease resistance

Application Scenarios

  1. Dietary Supplements
    • Stress Relief: Included in formulations to combat fatigue and improve stress tolerance
    • Liver Support: Used in supplements targeting liver health and detoxification
    • Cognitive Health: Added to blends for supporting memory and mental clarity
  1. Functional Food and Beverages
    • Functional Drinks: Added to herbal teas, energy drinks for its adaptogenic properties
    • Nutraceuticals: Incorporated into health bars and powders to boost nutritional value
  1. Cosmetics
    • Anti – aging Products: Used in creams and serums (0.5 – 2% concentration) for its antioxidant effects, helping reduce signs of aging
    • Skin Care: Added to formulations to support skin barrier function
  1. Traditional Medicine
    • Used in traditional Chinese medicine for treating coughs, night sweats, and to tonify qi
  1. Pharmaceutical Research
    • Investigated for its potential in treating liver diseases and neurological disorders

Detection Methods

  • HPLC: Column C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 254 nm (for lignans)
  • UV – Vis Spectroscopy: For total phenolic content determination at 280 nm
  • Thin – Layer Chromatography (TLC): Used for qualitative identification of key components

Advantages

  • Natural Source: Derived from the fruits of Schisandra chinensis, a plant with a long history of medicinal use
  • Multi – functional: Offers various health benefits due to its diverse active components
  • Well – tolerated: Generally safe with low toxicity when used as directed
  • Regulatory Acceptance: Approved for use in dietary supplements and traditional medicine products in major markets
Categories: , , , , , ,

Schisandra Extract (Schisandra chinensis) – High-Purity Botanical Extract for Nutraceuticals, Cosmetics & Functional Foods
GMP-Certified | OEM & ODM Factory | AIHerba® – Shaanxi Zhonghong Investment Technology Co., Ltd.

(1) Product Overview

Schisandra Extract is derived from the fruit of Schisandra chinensis, a traditional adaptogenic herb known in Chinese medicine as “Wu Wei Zi,” meaning “five-flavor berry.” It is standardized to contain bioactive lignans such as Schisandrin A, Schisandrin B, and Schisandrol A, known for their potent antioxidant, hepatoprotective, and anti-stress properties.

AIHerba® supplies high-purity Schisandra Extract produced under GMP, ISO9001, and HACCP systems, ensuring safety, traceability, and consistent quality for use in dietary supplements, functional beverages, pharmaceuticals, and skincare formulations.

(2) Botanical Source & Production Process

  • Botanical Name: Schisandra chinensis (Turcz.) Baill.

  • Plant Part Used: Fruit

  • Extraction Method: Water-ethanol extraction → Concentration → Filtration → Spray drying

  • Active Ingredients: Schisandrins, Schisandrols, Schisantherins

  • Appearance: Fine brown-yellow powder

  • Assay: Schisandrins ≥ 2.0% (HPLC)

(3) Production Process Flow

  1. Raw Material Selection – Premium-grade Schisandra berries sourced from Northern China.

  2. Cleaning & Drying – Removal of impurities and moisture adjustment.

  3. Solvent Extraction – Gentle ethanol-water extraction to retain bioactives.

  4. Filtration & Concentration – Low-temperature vacuum concentration.

  5. Purification & Standardization – Ensures consistent lignan content.

  6. Spray Drying & Sieving – Converts extract into stable, free-flowing powder.

  7. Quality Control & Packaging – Each batch tested for purity, safety, and potency.

(4) Key Benefits & Health Effects

  • Liver Protection: Supports hepatic detoxification and helps regenerate liver cells.

  • Stress & Fatigue Reduction: Acts as an adaptogen, improving resistance to stress.

  • Cognitive Support: Enhances focus, concentration, and mental clarity.

  • Antioxidant Power: Neutralizes free radicals and reduces oxidative stress.

  • Anti-Aging & Skin Benefits: Promotes cell renewal and protects skin from UV damage.

  • Immune System Modulation: Balances immune response and supports vitality.

(5) Traditional Applications

In Traditional Chinese Medicine (TCM), Schisandra chinensis has been used for over 2,000 years to:

  • Nourish the liver and kidneys

  • Improve endurance and physical strength

  • Soothe coughing and support respiratory health

  • Restore balance and enhance longevity

(6) Recommended Dosage & Usage

  • Dietary Supplements: 250–500 mg/day (standardized extract, 2% schisandrins)

  • Functional Foods & Beverages: 0.1–0.5% in powder blends or tonics

  • Cosmetics & Skincare: 0.5–2% as an antioxidant or anti-aging active

  • Pharmaceutical Applications: Custom formulations available upon request

Consult your product development team or regulatory authority for region-specific usage limits.

(7) Specifications & COA Summary

Category Item Specification Test Method
General Appearance Brown-yellow fine powder Visual
Odor & Taste Characteristic Organoleptic
Assay Schisandrins ≥ 2.0% HPLC
Moisture Loss on Drying ≤ 5.0% USP <731>
Ash Total Ash ≤ 5.0% AOAC 942.05
Pesticide Residues 500+ multi-residue screening Complies GC-MS/MS
Heavy Metals Lead (Pb) ≤ 3.0 mg/kg ICP-MS
Arsenic (As) ≤ 2.0 mg/kg ICP-MS
Cadmium (Cd) ≤ 1.0 mg/kg ICP-MS
Mercury (Hg) ≤ 0.1 mg/kg ICP-MS
Microbiology Total Plate Count ≤ 1,000 cfu/g USP <2021>
Yeast & Mold ≤ 100 cfu/g USP <2021>
E. coli Negative USP <2022>
Salmonella Negative USP <2022>
Staphylococcus aureus Negative USP <2022>

(8) Storage & Shelf Life

  • Storage Conditions: Store in a cool, dry, well-ventilated area away from direct sunlight and moisture.

  • Shelf Life: 24 months in sealed packaging under recommended conditions.

  • Packaging: 1kg/aluminum foil bag; 25kg/drum (PE inner, fiber outer).

(9) Sample Policy, MOQ & Logistics

  • Samples: 20–50g free samples available upon request (shipping cost covered by buyer).

  • MOQ: 1kg (bulk order discounts for ≥25kg).

  • Lead Time: 3–7 working days after order confirmation.

  • Shipping: DHL, FedEx, air or sea freight (EXW, CIF, or DDP available).

(10) Applicable Industries & Applications

  • Nutraceuticals & Dietary Supplements – Liver health, energy, stress relief formulas.

  • Functional Foods & Beverages – Adaptogenic tonics, detox drinks, vitality beverages.

  • Pharmaceuticals – Hepatoprotective and cognitive-enhancing formulations.

  • Cosmetics & Personal Care – Anti-aging serums, skin brightening, antioxidant creams.

(11) Best Formulation Combinations

  • For Liver Health: Schisandra Extract + Milk Thistle Extract + Dandelion Root Extract

  • For Anti-Fatigue: Schisandra Extract + Ginseng Extract + Rhodiola Rosea Extract

  • For Skin Health: Schisandra Extract + Vitamin C + Ceramide NP + Hyaluronic Acid

(12) Safety & Precautions

  • Avoid use during pregnancy or breastfeeding unless supervised by a healthcare professional.

  • Not suitable for individuals with acute gastric or peptic ulcers.

  • Store out of reach of children.

(13) Certifications & Quality Assurance

  • GMP, ISO9001, ISO22000, HACCP Certified Factory

  • Third-Party Testing: SGS, Eurofins, Pony Testing

  • Compliance: USP, EP, and GB standards

  • Traceable Raw Material Supply Chain

(14) AIHerba® Factory Expertise & Capabilities

With 28+ years of R&D and manufacturing experience, Shaanxi Zhonghong Investment Technology Co., Ltd. (AIHerba®) is a leading Chinese factory specializing in natural plant extracts.
We utilize supercritical CO₂ extraction, membrane purification, and spray drying to produce high-potency, stable, and water-soluble extracts.
Our OEM & ODM services help global partners develop customized functional formulations for nutraceuticals, cosmetics, and beverages.

📧 Contact Us:
sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 Website: www.aiherba.com

(15) Frequently Asked Questions (FAQ)

Q1: What is the standard assay for Schisandra Extract?
A1: Typically standardized to 2.0%–9.0% total schisandrins by HPLC, depending on customer specification.

Q2: Can AIHerba provide custom extraction ratios or solvents?
A2: Yes, customized ratios (5:1, 10:1, etc.) and solvent profiles are available for OEM projects.

Q3: Is this extract water-soluble?
A3: Yes, AIHerba offers both water-soluble and ethanol-soluble forms for versatile formulations.

Q4: Do you provide documentation?
A4: COA, MSDS, TDS, and third-party test reports are available with every batch.

(16) References (Scientific & Regulatory)

  1. Panossian A, Wikman G. “Pharmacology of Schisandra chinensis: An overview of Russian research and uses.” J Ethnopharmacol. 2008;118(2):183–212. PubMed

  2. FDA Botanical Drug Development Guidance for Industry, 2016. FDA.gov

  3. National Institutes of Health (NIH): Schisandra chinensis Monograph

  4. Panossian, A., & Wikman, G. (2008). Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine. Journal of Ethnopharmacology, 118(2), 183-212. (Mechanisms, Adaptogenic Effects)

  5. Lu, Y., & Chen, D. F. (2009). Analysis of Schisandra chinensis and Schisandra sphenanthera. Journal of Chromatography A, 1216(11), 1980-1990. (Analytical Methods, Lignan Profiles)

  6. Nowak, A., Zakłos-Szyda, M., Błasiak, J., Nowak, A., Zhang, Z., & Zhang, B. (2019). Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review. Current Issues in Molecular Biology, 31(1), 1-24. (Comprehensive Health Benefits Review)

  7. EMA. (2016). Assessment report on Schisandra chinensis (Turcz.) Baill., fructus. European Medicines Agency. (Regulatory Perspective, Traditional Uses)

  8. USP-NF. (2023). United States Pharmacopeia and National Formulary. (General Quality Standards)

  9. ICH Q7. Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients. (GMP Standards)

  10. ICH Q1A(R2). Stability Testing of New Drug Substances and Products. (Stability Guidelines)

  11. Shaanxi Zhonghong Internal Research Data & Process Validation Reports. (Proprietary Extraction & QC Data – Available under NDA).

(17) Summary

AIHerba® Schisandra Extract combines ancient botanical wisdom with modern extraction technology to deliver a potent, traceable, and high-quality natural ingredient for global industries. Whether you are formulating a liver detox supplement, a stress-relief beverage, or an anti-aging skincare line, AIHerba provides the technical support, documentation, and manufacturing excellence you can trust.

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