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Dipotassium Glycyrrhizinate | High-Purity Cosmetic Ingredient by AIHerba®

What Is Dipotassium Glycyrrhizinate? Benefits, Uses & Formulation Guide

  1. Product Name: Dipotassium Glycyrrhizinate

  2. Specification: ≥98% (HPLC); water-soluble grade, cosmetic and pharmaceutical standards available

  3. Appearance: White to pale yellow crystalline powder with a mild characteristic odor

  4. CAS Number: 68797-35-3

  5. Lead Time: 3–7 working days

  6. Packaging: 25 kg/drum, 27 drums per tray

  7. Main Markets: Europe, North America, Asia

  8. Key Benefits: Licorice-derived active ingredient known for soothing, anti-irritation, and skin-conditioning properties, widely used to support barrier comfort and formulation stability

  9. Industry Applications:
    Cosmetics & Skincare: Sensitive-skin creams, serums, lotions, anti-redness and calming products
    Personal Care: Cleansers, masks, after-sun and oral-care formulations
    Pharmaceutical & Dermatological Raw Materials: Topical formulations and functional excipient use
    Contract Manufacturing / Private Label: Suitable for emulsions, gels, and customized cosmetic bases

1. Dipotassium Glycyrrhizinate

Cosmetic-Grade Soothing Active | Bulk Supply from GMP-Certified Manufacturer

Dipotassium Glycyrrhizinate is a highly refined, water-soluble derivative of glycyrrhizic acid extracted from Glycyrrhiza glabra (licorice root). Widely used as a soothing, anti-irritation cosmetic active, it is valued by formulators for its excellent skin compatibility, stability, and formulation flexibility.

AIHerba® supplies high-purity Dipotassium Glycyrrhizinate in bulk and wholesale quantities, produced under GMP, ISO, and HACCP-compliant systems. Each batch is supported by COA, MSDS, and third-party analytical testing, making it suitable for cosmetic, personal care, functional food, and nutraceutical applications where ingredient safety and consistency are critical.

As a long-term Dipotassium Glycyrrhizinate supplier, we support global buyers with stable pricing, fast lead times, and traceable raw material sourcing—helping brands reduce formulation risk and accelerate market launch.

👉 Free samples, technical documentation, and quotations available upon request.


2. What Is Dipotassium Glycyrrhizinate?

Dipotassium Glycyrrhizinate is the dipotassium salt of glycyrrhizic acid, a naturally occurring triterpenoid saponin found in licorice root. Through controlled extraction and neutralization, the compound becomes highly water-soluble, odor-light, and suitable for modern formulations.

Compared with crude licorice extract, Dipotassium Glycyrrhizinate offers:

  • More consistent active content

  • Better formulation stability

  • Lower color and odor impact

  • Improved compatibility with sensitive-skin products

This makes it a preferred choice in professional cosmetic and personal care formulations.


3. Product Source & Raw Material Traceability

  • Botanical source: Glycyrrhiza glabra L. (Licorice root)

  • Origin: Controlled cultivation zones in Northwest China

  • Traceability: Full batch traceability from raw root → extraction → finished ingredient

  • Adulteration control: No synthetic substitutes, no unauthorized additives

AIHerba® maintains long-term contracts with licensed raw material suppliers and applies incoming material identification before production.


4. Key Functional Benefits (Non-Medical, Formulation-Focused)

Benefits described below relate to cosmetic and ingredient functionality, not medical treatment.

  1. Soothing & Comforting Support
    Helps reduce visible redness and skin discomfort caused by environmental stressors.

  2. Skin Barrier Support
    Frequently used in formulations targeting sensitive, dry, or compromised skin conditions.

  3. Formulation Synergy
    Works well with niacinamide, panthenol, allantoin, hyaluronic acid, and ceramides.

  4. Excellent Water Solubility
    Easy to incorporate into aqueous systems without complex solubilization steps.


5. Health-Related Use Context (Regulatory-Neutral)

In functional foods and nutraceutical research contexts, Dipotassium Glycyrrhizinate has been studied for its interaction with inflammatory signaling pathways. However, AIHerba does not promote this ingredient for disease prevention or treatment, and applications must comply with local regulatory frameworks.


6. Traditional Background (Ingredient Context Only)

Licorice root has a long history of use in traditional herbal systems in Asia and Europe. Dipotassium Glycyrrhizinate represents a modern, standardized evolution of this traditional ingredient, designed for today’s regulated formulation environments.


7. Recommended Usage & Formulation Guide

Typical Use Levels (Cosmetic Formulations)

  • Leave-on products: 0.1% – 0.5%

  • Rinse-off products: 0.05% – 0.3%

Formulation Tips

  • Dissolve directly in water phase at room temperature

  • Add before emulsification

  • Stable across pH 5.0–7.5

  • Avoid prolonged exposure to strong acids


8. Product Specifications (COA Summary Table)

8.1 Basic Specifications

Item Specification
Appearance Yellowish-white to off-white powder
Assay (HPLC) ≥ 98.0%
Solubility Freely soluble in water
Loss on Drying ≤ 5.0%
pH (1% solution) 5.5 – 7.5

8.2 Pesticide Residues

Parameter Limit Test Method
Organophosphates Complies GC-MS
Organochlorines Complies GC-MS
Pyrethroids Complies GC-MS

8.3 Heavy Metals

Parameter Limit Test Method
Lead (Pb) ≤ 3 ppm ICP-MS
Arsenic (As) ≤ 2 ppm ICP-MS
Cadmium (Cd) ≤ 1 ppm ICP-MS
Mercury (Hg) ≤ 0.1 ppm ICP-MS

8.4 Microbiological Standards

Parameter Limit Test Method
Total Plate Count ≤ 1,000 CFU/g USP <61>
Yeast & Mold ≤ 100 CFU/g USP <61>
E. coli Negative USP <62>
Salmonella Negative USP <62>

9. Production Process & Technology

  1. Raw licorice root inspection & cleaning

  2. Water-ethanol extraction under controlled temperature

  3. Filtration & concentration

  4. Neutralization to dipotassium salt

  5. Purification & drying

  6. Milling & blending

  7. Final quality testing (HPLC / Microbial / Heavy metals)

  8. Packaging under clean conditions


10. Scientific Source & Quality Assurance

  • Analytical methods: HPLC, UV-Vis, ICP-MS, microbial assays

  • Third-party testing: Independent laboratories upon request

  • Standards referenced: USP, EP, internal enterprise standards

COA / MSDS / TDS available upon request.


11. Storage, Shelf Life & Packaging

  • Storage: Cool, dry place, tightly sealed, away from light

  • Shelf life: 24 months

  • Packaging: 25 kg fiber drum with double PE liner

  • Custom packaging: Available for OEM projects


12. Sample Policy, Shipping & MOQ

  • Samples: Available for qualified buyers

  • MOQ: 1 kg (trial) / 25 kg (bulk)

  • Lead time: 3–7 working days

  • Shipping: Air / Sea / Express courier


13. Applicable Industries & Use Scenarios

  • Cosmetic & personal care raw materials

  • Dermocosmetic & sensitive-skin lines

  • Functional food ingredients (region-dependent)

  • Nutraceutical formulation research


14. About AIHerba® – Manufacturer Credentials

AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.) is a GMP-certified manufacturer and exporter specializing in high-purity natural plant extracts.

With over 28 years of R&D and production experience, we integrate modern extraction technologies—including supercritical CO₂ extraction, water-ethanol extraction, and microbial fermentation—to ensure high potency, stability, and batch-to-batch consistency.

Our OEM & ODM services support customized herbal formulations, natural flavors, and food & beverage additives for global brands.

Contact:
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com


15. Frequently Asked Questions (FAQ)

1. What is Dipotassium Glycyrrhizinate mainly used for?
It is widely used as a soothing and comfort-support ingredient in cosmetic and personal care formulations.

2. Is it suitable for sensitive skin products?
Yes. It is commonly selected for sensitive-skin and post-procedure product lines.

3. What is the difference between Dipotassium Glycyrrhizinate and licorice extract?
Dipotassium Glycyrrhizinate is a purified, standardized derivative with better solubility and stability.

4. Can you provide COA and MSDS?
Yes. Full documentation is available upon request.

5. Do you support bulk and OEM supply?
Yes. We offer bulk, wholesale, and OEM/ODM services.

6. How long does delivery usually take?
Typically 3–7 working days after order confirmation.


16. References & Regulatory Context

  1. PubMed – Glycyrrhizic acid related research
    https://pubmed.ncbi.nlm.nih.gov

  2. NIH – Licorice root compound overview
    https://www.nih.gov

  3. FDA – Cosmetic ingredient regulatory framework
    https://www.fda.gov

  4. EU Cosmetic Regulation (EC) No 1223/2009

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