Hydroxybenzoates
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Hydroxybenzoates

Hydroxybenzoates | High-Purity Preservative Ingredients from China GMP-Certified Plant Extract Factory

  1. English Name: Hydroxybenzoates; Parabens
  1. Specification
    • Purity: ≥ 99.0% (HPLC)
    • Solubility: Varies by type; methylparaben is slightly soluble in water (0.22 g/100 mL at 25°C), while propylparaben is less soluble (0.05 g/100 mL at 25°C). More soluble in organic solvents like ethanol, propylene glycol (≥ 10 g/100 mL)
    • Appearance – related: Loss on drying ≤ 1.0%, Heavy metals ≤ 10 ppm, Residual solvents ≤ 0.5%
    • Melting Point: Methylparaben: 125 – 128°C; Propylparaben: 95 – 99°C
  1. Appearance
    • White crystalline powder or colorless crystals, odorless or with a faint, characteristic odor, not related to chocolate
  1. CAS NO.
    • Methylparaben: 99 – 76 – 3; Ethylparaben: 120 – 47 – 8; Propylparaben: 94 – 13 – 3; Butylparaben: 94 – 26 – 8 (different esters have separate CAS numbers)
  1. Lead time: 5 – 7 Working Days
  1. Package
    • 1 kg/aluminum foil bag, 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market
    • Global market, with significant demand in Europe, North America, Asia. Widely used in cosmetics, pharmaceuticals, food, and personal care industries
  1. Application Scenarios

Core Properties

  • Chemical Structure: Esters of p – hydroxybenzoic acid, with different alkyl chains (methyl, ethyl, propyl, butyl etc.). The general formula is C₇H₆O₃R, where R represents the alkyl group.
  • Key Features
    • Antimicrobial Activity: Effective against bacteria (e.g., Staphylococcus aureus, Escherichia coli), fungi (e.g., Candida albicans), and yeasts. They work by disrupting the cell membrane and inhibiting essential enzyme systems of microorganisms.
    • Broad – Spectrum Preservation: Can inhibit the growth of a wide range of microorganisms, providing long – term protection against spoilage.
    • Stability: Stable under a wide range of pH conditions (pH 4 – 8), heat – stable, and resistant to degradation during normal storage and processing.
    • Synergistic Effect: Often used in combination with other preservatives (such as sorbates, benzoates) to enhance the antimicrobial efficacy and extend the shelf – life of products more effectively.

Application Scenarios

1. Cosmetics & Personal Care

  • Skin – Care Products:
    • Added to moisturizers, creams, serums, and sunscreens (concentration typically 0.1 – 0.5%) to prevent microbial contamination, ensuring product safety and stability.
    • Used in facial cleansers, toners, and masks to maintain product integrity and prevent the growth of bacteria and fungi that could cause product spoilage or skin infections.
  • Hair Care:
    • Included in shampoos, conditioners, and hair treatments (0.05 – 0.3% concentration) to inhibit the growth of microorganisms that may thrive in the moist environment of these products.

2. Pharmaceuticals

  • Oral Medications:
    • Employed in liquid oral medications (syrups, suspensions) as preservatives to prevent microbial growth and ensure the safety and efficacy of the products during their shelf – life.
  • Topical Preparations:
    • Used in creams, ointments, and gels for topical application (0.1 – 0.5% concentration) to protect against microbial contamination, especially important for products applied to open wounds or damaged skin.

3. Food & Beverage Industry

  • Beverages:
    • Added to fruit juices, soft drinks, and iced teas (usually at ppm levels, e.g., 50 – 200 ppm) to prevent spoilage caused by bacteria and yeasts, extending the product’s shelf – life.
  • Processed Foods:
    • Used in processed meats, jams, jellies, and bakery products to inhibit the growth of mold and bacteria, maintaining product quality and safety. However, their use in food is more regulated in some regions due to consumer concerns.

4. Other Industries

  • Textile and Leather:
    • Applied as antimicrobial agents in textile finishing and leather treatment to prevent the growth of mold and bacteria that can cause fabric degradation or unpleasant odors.
  • Industrial Fluids:
    • Used in industrial lubricants, cooling fluids, and adhesives to prevent microbial contamination, which can affect the performance and lifespan of these products.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – 0.1% acetic acid (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 254 nm. This method allows for the accurate quantification of different hydroxybenzoate esters in various matrices.
  • Gas Chromatography – Mass Spectrometry (GC – MS):
    • Suitable for analyzing volatile and semi – volatile hydroxybenzoates after derivatization. It provides detailed information about the chemical structure and can detect trace amounts of these compounds in complex samples.
  • Fourier Transform Infrared Spectroscopy (FTIR):
    • Helps in identifying hydroxybenzoates by analyzing the characteristic absorption peaks of their functional groups, useful for quick screening and quality control during production.

Source & Advantages

  • Synthetic Production: Hydroxybenzoates are mainly produced synthetically through esterification reactions of p – hydroxybenzoic acid with corresponding alcohols. This ensures a consistent and reliable supply.
  • Cost – Effective Preservation: Offer an economical and effective solution for preventing microbial spoilage, reducing product waste and extending the shelf – life of various products.
  • Established Use: Have a long – history of use in multiple industries, with well – understood properties and application guidelines, making them a trusted choice for manufacturers. However, their use has been a subject of debate in recent years due to potential health concerns, leading to some regulatory restrictions in certain regions.
Categories: , , ,

Hydroxybenzoates Manufacturer | Wholesale Botanical Preservative & Customized Herbal Extract Solutions

Hydroxybenzoates Product Overview

Hydroxybenzoates, commonly known as parabens, are a class of organic compounds derived from p-hydroxybenzoic acid. They are widely used as natural and synthetic preservatives in cosmetics, pharmaceuticals, and food applications due to their exceptional antimicrobial stability, safety profile, and formulation flexibility.

At AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.), we produce high-purity hydroxybenzoate ingredients using GMP-certified extraction and purification processes. Our plant operates under ISO, HACCP, and Halal standards, ensuring every batch meets international safety and performance benchmarks.

1. Product Source & Production Process

Our hydroxybenzoates are derived from natural benzoic acid sources through controlled esterification with selected alcohols (e.g., methyl, ethyl, propyl, butyl).
Key Production Technologies:

  • Step 1: Natural benzoic acid extraction or synthesis verification

  • Step 2: Esterification reaction with target alcohols under controlled pH

  • Step 3: Purification via fractional distillation

  • Step 4: Crystallization & micronization

  • Step 5: GMP-grade packaging & COA batch testing

This ensures high purity (>99%), low impurity profile, and excellent batch consistency suitable for food-grade and cosmetic-grade formulations.

2. Health & Functional Benefits

While hydroxybenzoates are primarily used as preservatives, their benefits extend beyond antimicrobial function:

  • Broad-spectrum microbial inhibition against bacteria, molds, and yeasts

  • Synergistic preservation when combined with organic acids or phenolics

  • Formulation stability under wide pH (4–8) and temperature ranges

  • Reduced oxidation in emulsions and creams

  • Low toxicity & high biocompatibility, supported by global regulatory approvals (FDA, EFSA, WHO)

Expert Insight:

“Parabens remain one of the most effective and stable preservatives available for modern formulations when used within safe, regulated concentrations.”
— Dr. Mei Zhang, Senior Cosmetic Chemist, AIHerba® Technical Division

3. Applications & Recommended Usage

Main Application Industries:

  • Cosmetics: Lotions, creams, shampoos, conditioners

  • Pharmaceuticals: Topical ointments, oral suspensions, antiseptic solutions

  • Food & Beverage: Preservative systems for sauces, syrups, and baked goods

  • Dietary Supplements: Stability enhancer for herbal and vitamin blends

Recommended Dosage:

  • Cosmetics: 0.1–0.3% total formulation weight

  • Pharmaceuticals: 0.05–0.2%

  • Food use: ≤0.1%, compliant with Codex Alimentarius

Best Formulation Practice:
Combine with antioxidants (e.g., tocopherols) or mild acids (citric acid) to enhance synergistic preservation.

4. Specifications & COA Highlights

Category Item Specification / Limit Test Method
Appearance White crystalline powder Conforms Visual / USP
Purity ≥99.0% HPLC
Moisture ≤0.5% GB/T 6283
Residue on Ignition ≤0.1% USP 281

Pesticide Residue Test

Item Limit (ppm) Method
Organochlorine pesticides ≤0.1 GC-MS
Organophosphorus pesticides ≤0.1 GC-MS
Carbamates ≤0.05 LC-MS/MS

Heavy Metals

Item Limit (ppm) Method
Lead (Pb) ≤1.0 ICP-MS
Arsenic (As) ≤1.0 ICP-MS
Cadmium (Cd) ≤0.5 ICP-MS
Mercury (Hg) ≤0.1 ICP-MS

Microbiological Tests

Item Limit Method
Total Plate Count ≤1000 CFU/g GB 4789.2
Yeast & Mold ≤100 CFU/g GB 4789.15
E. coli Negative GB 4789.3
Salmonella Negative GB 4789.4

5. Packaging, Storage & Shelf Life

  • Packaging: 25kg fiber drums / 1kg aluminum foil bags

  • Storage: Store in a cool, dry place away from sunlight and moisture

  • Shelf Life: 24 months unopened under recommended conditions

6. Logistics, Samples & MOQ

  • Free sample herbal extract: Available (10–50g sample pack)

  • MOQ: 1kg for pilot testing / 25kg for bulk order

  • Shipping: Global air freight or sea shipment with export documentation

  • Lead Time: 7–10 working days after payment confirmation

7. Certifications & Quality Assurance

  • GMP, ISO 9001, HACCP, Halal, Kosher

  • Third-party testing by Eurofins and SGS

  • Full traceability with batch COA, MSDS, and chromatograms

8. Applications by Industry

Industry Use Case Form Example
Cosmetics Antimicrobial preservative Creams, masks, shampoos
Food & Beverage Shelf-life extender Bakery, sauces
Pharmaceuticals Stabilizing agent Topical ointments
Dietary Supplements Preservative for botanical blends Capsules, powders

9. Why Choose AIHerba® Hydroxybenzoates

✅ 28+ years of production experience
✅ GMP-certified factory with ISO & Halal systems
✅ Consistent bulk supply with competitive wholesale price
✅ Custom formulation support – customized herbal extract options
✅ Trusted by global food-grade botanical extract supplier networks
✅ Proven results across 1,200+ client formulations

10. Frequently Asked Questions (FAQ)

Q1: Are hydroxybenzoates safe for cosmetics?
A: Yes. When used within regulated limits, they’re approved by the FDA, EU SCCS, and WHO for cosmetic and food applications.

Q2: Can I request a small batch for testing?
A: Absolutely. We offer free sample herbal extract packs for formulation testing before you buy in bulk.

Q3: Do you provide OEM or customized blends?
A: Yes. As a GMP-certified plant extract manufacturer, we support customized herbal extract formulations for specific pH or product types.

Q4: What’s the best pH range for hydroxybenzoates?
A: Optimal performance occurs between pH 4–8. Below pH 4, hydrolysis may occur; above pH 8, activity decreases.

11. References

Contact & Verification

📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com
🏭 Shaanxi Zhonghong Investment Technology Co., Ltd.
— Trusted global manufacturer and bulk supplier of GMP-certified natural and synthetic plant extract ingredients.

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