Silybin
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Silybin

Premium Silybin for Supplements & Pharmaceuticals – Verified Quality from China’s Leading Plant Extract Factory

  1. English Name: Silybin
  1. Specification
Silybin has no relation with Cocoa Butter. It is a high – purity flavonolignan compound. While its water – solubility is relatively low, various pharmaceutical technologies can be applied to improve its dissolution, making it more suitable for different formulations in the medical field.
  1. Appearance
Typically appears as a white to off – white powder, with no characteristic chocolate aroma, ensuring its neutrality in applications where sensory interference should be minimized.
  1. CAS NO.
6905-67-7, a unique identifier for regulatory and identification purposes in global markets.
  1. Lead Time
3 – 7 working days, providing quick turnaround for customer orders and helping businesses manage their inventory efficiently.
  1. Package
Packed in 25kg/drum, with 27 drums/tray. This packaging method guarantees the stability and integrity of Silybin during transportation and storage, and also facilitates easy handling and distribution.
  1. Main Market
Widely distributed in European, North American, Asian markets, and other regions, meeting the global demand for liver – protecting substances and pharmaceutical raw materials.
  1. Application Scenarios
    • Pharmaceutical Industry: Silybin is a key ingredient in liver – protecting medications. It has strong antioxidant and anti – inflammatory properties, which can effectively protect liver cells from damage caused by toxins, drugs, and oxidative stress. It is used in the treatment of various liver diseases, such as hepatitis, cirrhosis, and fatty liver. Additionally, it can enhance liver function recovery and has potential applications in liver – related drug development.
    • Nutraceutical Industry: Due to its liver – protecting and health – promoting effects, Silybin is also used in the production of dietary supplements. It can help maintain overall liver health, especially for people with high – risk factors for liver problems, such as those with a high – fat diet, excessive alcohol consumption, or exposure to environmental pollutants.
Silybin, with its distinct chemical properties, specific applications, and efficient supply chain features, stands out as a valuable compound in the pharmaceutical and nutraceutical industries, continuously meeting the health – related needs of customers around the world.
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Buy Silybin Extract in Bulk – GMP Plant Extract Manufacturer for Nutraceutical, Cosmetic & Functional Food Brands

1. Product Overview: What Is Silybin?

Silybin (also called Silibinin) is the major active flavonolignan found in Silybum marianum (milk thistle) and is regarded as the most potent hepatoprotective component of the silymarin complex. At AIHerba®, we produce high-purity Silybin (≥ 98%) using pharmaceutical-grade extraction methods to ensure consistent potency, low solvent residues, and excellent stability.

As a GMP-certified plant extract manufacturer with more than 28 years of production experience, we specialize in bulk Silybin supply for dietary supplements, functional foods, liver-health formulations, and cosmetic anti-oxidation products. Global buyers choose us as their trusted supplier because of our traceable supply chain, clean raw material sourcing, and strong regulatory compliance.

2. Product Origin & Botanical Source

  • Botanical Name: Silybum marianum (L.) Gaertn.

  • Plant Part Used: Seeds

  • Active Compound: Silybin (Silibinin)

  • Specification Range:

    • Silybin ≥ 80%

    • Silybin ≥ 90%

    • Silybin ≥ 98% (HPLC) — flagship high-purity grade

  • Appearance: Light yellow to off-white powder

  • Quality Systems: GMP, ISO22000, HACCP, HALAL, Kosher (available)

3. Science-Backed Benefits & Mechanisms

Clinical and preclinical research suggests Silybin supports multiple health categories:

3.1 Liver Health & Detoxification

  • Helps protect hepatocytes from toxins (e.g., ethanol, acetaminophen)

  • Supports glutathione regeneration

  • Promotes healthy bile flow
    (NIH & PubMed references below)

3.2 Metabolic Health

  • May support blood sugar metabolism

  • Helps reduce oxidative stress and lipid peroxidation

3.3 Antioxidant & Anti-Inflammatory Effects

  • Strong free-radical scavenging

  • Supports cellular defense pathways (Nrf2 activation)

3.4 Skin & Cosmetic Applications

  • UV-protective antioxidant

  • Supports collagen integrity

  • Suitable for GMP certified plant extract for cosmetics formulations

4. Traditional Applications

Milk thistle has been used for centuries in Mediterranean and European herbal traditions for:

  • Liver cleansing

  • Digestive health

  • Protecting against herbs, alcohol, and environmental toxins

  • Promoting natural detox pathways

5. Recommended Usage & Dosage (B2B Formulation Guidance)

Formulators typically use:

  • 100–300 mg/day of high-purity Silybin

  • 200–600 mg/day of full silymarin blends

Formats Supported

  • Capsules

  • Tablets

  • Functional beverages

  • Effervescent granules

  • Liquid tinctures

  • Topical antioxidant serums

6. Best Formulation Guidelines (Expert Tips)

  1. Combine with phospholipids to improve bioavailability (Silybin-Phytosome® style complexes).

  2. Use in liver detox blends with taurine, NAC, and dandelion root.

  3. For cosmetics, pair with vitamin E and niacinamide.

  4. Avoid combining with strong acid environments—protect with enteric coating if needed.

7. Manufacturing Process (GMP Factory)

Extraction Technologies Used

  • Water–ethanol extraction

  • Supercritical CO₂ extraction

  • Macroporous resin purification

  • Low-temperature concentration

  • Vacuum drying

  • Fine milling & sterilization

Production Flow (Simplified)

  1. Raw Material Inspection

  2. Seed Cleaning & Crushing

  3. Ethanol Extraction

  4. Filtration

  5. Resin Purification

  6. Concentration

  7. Crystallization / High-Purity Isolation

  8. Drying

  9. Milling

  10. QC Testing (HPLC)

  11. Packaging

  12. Final Release

8. High-Detail COA Table (Pesticides / Heavy Metals / Microbiology)

8.1 Pesticide Residue Testing

Item Limit Method
500+ Pesticides Screen Complies (ND or < EU limits) GC-MS/MS, LC-MS/MS
Organochlorine Pesticides ND GC-MS
Organophosphorus Pesticides ND GC-MS
Pyrethroids < 0.1 mg/kg LC-MS

8.2 Heavy Metals

Item Limit Method
Lead (Pb) < 3 ppm ICP-MS
Arsenic (As) < 2 ppm ICP-MS
Cadmium (Cd) < 1 ppm ICP-MS
Mercury (Hg) < 0.1 ppm ICP-MS
Total Heavy Metals < 10 ppm ICP-MS

8.3 Microbiology

Item Limit Method
Total Plate Count < 1,000 cfu/g ISO 4833
Yeast & Mold < 100 cfu/g ISO 21527
E. coli Negative ISO 16649
Salmonella Negative ISO 6579
Staphylococcus aureus Negative ISO 6888
Coliforms < 10 cfu/g ISO standards

9. Storage, Shelf Life, Packaging, & Logistics

Storage:
Keep in a cool, dry place at < 25°C; protect from light and moisture.

Shelf Life:
24–36 months (sealed, under recommended storage).

Packaging Options:

  • 1 kg aluminum foil bag

  • 5 kg / 10 kg / 25 kg drum

  • Customized packaging available (for customized herbal extract projects)

MOQ:

  • 1 kg for R&D

  • 25 kg for bulk production

Transport:

  • Air freight, sea freight, DHL/FedEx/UPS

  • All shipments come with COA, MSDS, TDS, and photos

Free Sample Policy:
We offer free sample herbal extract (10–30 g), with shipping cost borne by the buyer.

10. Industries & Application Scenarios

Primary Industries

  • Dietary supplements

  • Pharmaceutical health products

  • Cosmetics (anti-oxidation, anti-aging)

  • Functional foods & beverages

  • Veterinary & pet nutrition

Application Forms

  • Liver health formulas

  • Detox blends

  • Alcohol recovery supplements

  • Beauty-from-within products

  • Sunscreen & anti-aging creams

11. Why Global Buyers Choose AIHerba®

✓ 28+ years manufacturer experience
✓ GMP, ISO22000, HACCP certified
✓ In-house laboratory (HPLC, GC-MS, ICP-MS)
✓ Verified raw material traceability
✓ Strong export experience (EU, US, Australia, Canada, Japan)
✓ Fast delivery + stable price
✓ Expertise in OEM, ODM, and customized herbal extract projects

12. Frequently Asked Questions (FAQ)

Q1: Can I buy Silybin in bulk for manufacturing?

Yes. We are a bulk supplier and manufacturer with stable year-round production.

Q2: Do you provide COA, MSDS, or third-party testing?

Yes. Every batch is tested with HPLC and optional SGS/Eurofins reports.

Q3: What is your typical lead time?

1–3 days for inventory; 7–15 days for customized specs.

Q4: Can you support OEM/ODM formulations?

Yes, our factory provides turnkey solutions for supplements and cosmetics.

Q5: Is Silybin safe for long-term use?

Studies show good safety at recommended doses. (See references)

13. Scientific References (PubMed, NIH, FDA)

  1. NIH LiverTox: Milk Thistle – https://www.ncbi.nlm.nih.gov/books/NBK548561/

  2. PubMed: Silibinin Pharmacology – https://pubmed.ncbi.nlm.nih.gov/

  3. FDA GRAS Notice: Milk Thistle Extract – https://www.fda.gov/food/generally-recognized-safe-gras

14. Contact Information (Verifiable)

AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd.
📧 sales@aiherba.com
📧 info@aiherba.com
📧 liaodaohai@gmail.com
🌐 www.aiherba.com

GMP-certified natural plant extract supplier, manufacturer, and factory for global nutraceutical brands.

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