Huperzine A

Bulk Huperzine A Powder – Trusted Plant Extract Manufacturer & Wholesale Supplier

English Name: Huperzine A

Specification

Purity: Huperzine A ≥ 99% (HPLC)

Water-soluble Form: Huperzine A ≥ 98% (HPLC), enhanced solubility via cyclodextrin complexation or nanoemulsion technology, solubility up to 1 mg/mL in water

Impurity Limits: Residual solvents ≤ 0.05%, heavy metals ≤ 10 ppm, related substances ≤ 1%

Appearance

Powder: White to off-white crystalline powder, odorless, tasteless

CAS NO.：102518-79-6

Lead time: 5 – 7 Working Days

Package

1 kg/bag (aluminum foil bag), 5 kg/drum (sterilized stainless steel drum with vacuum seal)

Main Market: Asia (China, Japan, South Korea), North America, Europe

Application Scenarios

Core Properties

Molecular Formula: C₁₅H₁₈N₂O

Solubility: Sparingly soluble in water; soluble in organic solvents like ethanol and chloroform. Water-soluble modifications improve bioavailability for pharmaceutical applications.

Key Features

Acetylcholinesterase Inhibitor: Potently inhibits acetylcholinesterase, increasing acetylcholine levels in the brain, which is crucial for memory and cognitive function.

Neuroprotective: Protects neurons from oxidative stress, apoptosis, and β-amyloid toxicity, showing potential in neurodegenerative disease treatment.

Low Toxicity: Generally well-tolerated compared to some synthetic cholinesterase inhibitors, allowing for long-term use.

High Selectivity: Selectively acts on the central nervous system, reducing peripheral side effects.

Application Scenarios

1. Pharmaceuticals

Alzheimer’s Disease Treatment:

Oral tablets (0.1 – 0.2 mg/day) used as a monotherapy or in combination with other drugs. Clinical trials show significant improvement in cognitive function scores, memory, and daily living activities in patients with mild to moderate Alzheimer’s.

Other Dementia and Cognitive Impairment:

Prescribed for vascular dementia and age-related memory decline, helping to slow down the progression of cognitive decline.

Myasthenia Gravis:

Investigated for its potential to enhance muscle strength by increasing acetylcholine levels at the neuromuscular junction, although its use in this area is still under research.

2. Dietary Supplements

Brain Health Supplements:

Capsules or softgels (50 – 100 μg per serving) marketed for cognitive enhancement, memory improvement, and focus in healthy individuals, especially students and professionals.

Anti-aging Formulas:

Included in multi-ingredient supplements targeting middle-aged and elderly consumers, aiming to maintain brain function and delay age-related cognitive decline.

3. Neurological Research

Research Reagent:

Widely used in in-vitro and in-vivo studies to investigate the mechanisms of neurodegenerative diseases and test the efficacy of new drug candidates. It serves as a reference compound for developing and validating acetylcholinesterase inhibition assays.

Detection Methods

High-Performance Liquid Chromatography (HPLC):

Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Methanol – 0.05 M phosphate buffer (pH 3.0) (60:40 v/v), Flow Rate: 1.0 mL/min, Detection Wavelength: 310 nm for accurate quantification.

Ultra-Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):

Confirms the molecular structure and detects trace impurities with high sensitivity, ensuring high-purity standards for pharmaceutical-grade products.

Nuclear Magnetic Resonance (NMR):

Used for structural elucidation and identification of Huperzine A, especially in research and development for new formulations.

Source & Advantages

Natural Source: Extracted from the Chinese club moss Huperzia serrata, a traditional Chinese medicinal plant.

Therapeutic Potential: Its unique mechanism of action as an acetylcholinesterase inhibitor provides a valuable option for treating neurodegenerative disorders.

Sustainable Extraction: Modern cultivation techniques for Huperzia serrata are being developed to ensure a sustainable supply, reducing pressure on wild plant populations.

Regulatory Compliance

China NMPA: Approved as a prescription drug for the treatment of Alzheimer’s disease and other cognitive impairments, subject to strict Good Manufacturing Practice (GMP) requirements.

US FDA: Regulated as a dietary ingredient when used in supplements under the Dietary Supplement Health and Education Act (DSHEA), but not approved as a drug for treating Alzheimer’s disease.

European Medicines Agency (EMA): In the process of evaluating its safety and efficacy for medicinal use, with ongoing clinical trials contributing to its regulatory status determination.

Categories: Dietary supplements, Dietary Supplement Ingredients, Life Science & Pharmaceutical Ingredients

Description

Huperzine A: The Gold Customary Cognitive Enhancer – Scientific & Industrial Profile| Supplier & Manufacturer

1. Product Overview

Huperzine A – High-Purity Cognitive Support Extract

Huperzine A, a natural alkaloid derived from Huperzia serrata, is renowned for its neuroprotective properties and cognitive enhancement benefits. As a GMP-certified plant extract, our Huperzine A is ideal for dietary supplements, functional foods, and pharmaceutical applications. AIHerba® offers this product in bulk, catering to suppliers and manufacturers seeking a reliable and traceable source of premium herbal extract.

Key Features:

Purity: ≥98% Huperzine A (HPLC)
Appearance: Yellow-brown fine powder
Form: Bulk powder suitable for capsules, tablets, and functional beverages
Certifications: GMP, ISO 9001, HACCP

2. Source and Extraction Process

Our Huperzine A is extracted from organically cultivated Huperzia serrata using modern water-ethanol extraction and refined chromatography. The process ensures:

Maximum potency retention
Free from synthetic additives
Consistent batch-to-batch quality

Production Highlights:

Plant material selection & cleaning
Drying and pulverization
Water-ethanol extraction
Purification via chromatography
Drying under low-temperature vacuum
Final milling and sieving for uniform powder

“High-quality extraction is key to retaining Huperzine A’s neuroprotective efficacy,” notes Dr. Li Zhang, AIHerba R&D Director. PubMed Reference

3. Health Benefits

Cognitive Enhancement – Supports memory, focus, and mental clarity
Neuroprotection – Helps mitigate oxidative stress and age-related cognitive decline
Cholinesterase Inhibition – Enhances acetylcholine levels, supporting neurotransmission
Traditional Use – Historically used in Chinese medicine to support mental alertness

Clinically studied for memory improvement and neuroprotection in mild cognitive impairment. NIH Reference

4. Recommended Dosage & Application

Typical Dosage: 50–200 µg per day, depending on formulation
Usage: Suitable for dietary supplements, functional beverages, and capsules
Best Formulation Practices:
- Combine with antioxidants like Bacopa or Ginkgo biloba for synergistic cognitive support
- Encapsulation or microencapsulation recommended for stability
- Avoid prolonged high-dose exposure without professional guidance

5. COA – Product Specification Table

Category	Parameter	Specification	Test Method
Active Compound	Huperzine A	≥98%	HPLC
Pesticide Residue	Total Pesticides	≤0.5 mg/kg	GC-MS / HPLC
	Organochlorine	ND	GC-MS
Heavy Metals	Lead (Pb)	≤1.0 mg/kg	ICP-MS
	Arsenic (As)	≤1.0 mg/kg	ICP-MS
	Mercury (Hg)	≤0.1 mg/kg	ICP-MS
	Cadmium (Cd)	≤0.3 mg/kg	ICP-MS
Microbial	Total Plate Count	≤1000 CFU/g	AOAC 990.12
	Yeast & Mold	≤100 CFU/g	AOAC 997.02
	E. coli	ND	AOAC 991.14
	Salmonella	ND	AOAC 2004.03

6. Storage, Shelf Life, and Packaging

Storage: Cool, dry place; avoid direct sunlight
Shelf Life: 24 months from production
Packaging Options:
- 1 kg foil bag
- 5 kg carton drum
- Customized packaging available upon request
Sample Policy: Free sample herbal extract available for testing

7. Shipping & MOQ

Shipping: Sea, air, or express courier worldwide
MOQ: 1 kg for standard packaging
Lead Time: 5–10 days for standard orders

8. Suitable Industries & Applications

Dietary Supplements: Capsules, tablets, powders
Functional Foods & Beverages: Cognitive support drinks, bars
Pharmaceuticals: Cognitive enhancers, memory-support formulations
Cosmetics: Formulations targeting mental alertness or stress reduction

Application Method: Mix into powders, encapsulate, or integrate into beverages with stabilizing agents.

9. Why AIHerba® Huperzine A

✅ Professional Expertise: Over 28 years in herbal extract manufacturing
✅ Authority: GMP-certified factory, ISO, HACCP, and rigorous COA testing
✅ Experience: Proven formulations for dietary supplements and functional foods
✅ Trustworthy: Full traceability, transparent lab reports, real production images
✅ Custom Solutions: OEM & ODM services for customized herbal extract, natural flavors, and functional beverage applications

10. FAQ

Q1: Can I buy Huperzine A in bulk?
A: Yes, we are a trusted supplier and manufacturer offering bulk and wholesale options.

Q2: Is this product safe for food and dietary supplement use?
A: Absolutely. It’s a food-grade botanical extract supplier product, GMP-certified for supplement and food applications.

Q3: Are free samples available?
A: Yes, we provide free sample herbal extract for testing and evaluation.

Q4: How long is the shelf life?
A: 24 months when stored under proper conditions.

11. References

12. Procurement Specs

MOQ: 1g (analysis), 100g (business)
Lead Time: 8 weeks
Contact: liaodaohai@gmail.com
Order Portal: aiherba.com/huperzine-a

Huperzine A

Bulk Huperzine A Powder – Trusted Plant Extract Manufacturer & Wholesale Supplier​