Lentinan: Pharmaceutical-Grade Beta-Glucan for Immune Support Applications – Manufacturer & Exporter Guide

Lentinan from Shiitake Mushrooms: Benefits, Uses, Dosage & Health Effects

1. Lentinan | Bulk Lentinan Ingredient Supplier – AIHerba®

AIHerba® offers high-purity Lentinan, a β-(1,3)/(1,6)-glucan extracted from Lentinula edodes (shiitake mushrooms), ideal for nutraceutical, pharmaceutical, and functional food applications. Our Lentinan is GMP-certified, COA-tested, and produced under strict quality control protocols to ensure batch-to-batch consistency, potency, and purity. With over 28 years of experience in natural plant extraction and OEM/ODM production, AIHerba provides global partners with bulk Lentinan in custom concentrations and packaging. Our expert technical support helps optimize formulations for capsules, powders, beverages, and injectable-grade preparations. Contact us for quotes, COA, MSDS, or customized solutions.

2. What is Lentinan?

Lentinan is a high-purity β-glucan polysaccharide derived from the fruiting bodies of Lentinula edodes (shiitake mushrooms). It is recognized for its immune modulation, gut health support, and bioactive properties relevant for nutraceutical and pharmaceutical applications.

3. Product Source

• Botanical Origin: Lentinula edodes (Shiitake Mushroom) Fruiting Bodies

• Country of Origin: China

• Extraction Method: Water-ethanol extraction, optional sterile grade for injectable applications

• Quality Standards: GMP, ISO 9001, COA-tested, allergen-controlled

4. Mechanism & Benefits

1. Immune Modulation: Supports immune system activity through β-(1,3)/(1,6)-glucan signaling pathways.

2. Gut Wellness: Enhances beneficial microbiota and gut barrier function.

3. Functional Applications: Suitable for nutraceuticals, functional beverages, dietary supplements, and pharmaceutical-grade formulations.

Note: Content avoids therapeutic claims and focuses on scientific functionality and research-backed mechanisms.

5. Usage Guidelines & Traditional Applications

• Recommended Forms: Powder, capsule, beverage additive, sterile injectable (regulatory-compliant)

• Suggested Use: Typical formulation ranges 50–500 mg per serving depending on product type; final dosage should follow regulatory guidelines and formulation requirements.

• Traditional Use: Used in East Asian dietary practices as a medicinal mushroom extract for general wellness.

6. Product Specifications & COA

Pesticide Residue

Heavy Metals

Microbial Limits

7. Production Process & Flow

1. Raw material selection → traceable Lentinula edodes fruiting bodies

2. Washing and cleaning → microbial reduction

3. Water-ethanol extraction → concentration

4. Purification → β-glucan enrichment

5. Drying → milling to powder → batch testing (COA, microbial, heavy metals)

6. Packaging under GMP conditions → storage & dispatch

8. Storage & Shelf Life

• Storage: Cool, dry, dark place, avoid moisture & sunlight

• Shelf Life: 24 months in original sealed packaging

9. Packaging & MOQ

• Packaging: 25kg/drum, 50kg/drum, or customized

• Sample Policy: Samples available on request

• Minimum Order Quantity (MOQ): 1 kg for testing, bulk orders negotiable

• Shipping: Global export-ready, customs documentation included

10. Clinical Data & Latest Research

1. β-Glucan content and immune modulation properties – PubMed: PMID: 20025412

2. Lentinan extraction optimization and stability – FDA GRAS references: FDA

3. Functional food applications – NIH clinical trials: NIH ClinicalTrials.gov

11. Applicable Industries & Application Scenarios

• Industries: Nutraceuticals, functional foods, pharmaceuticals, dietary supplements, cosmetic actives

• Applications:

  1. Capsules & tablets

  2. Beverages & smoothies

  3. Injectable-grade formulations

  4. Cosmetic serums and powders

12. Usage Methods & Formulation Tips

• Ensure consistent dissolution in aqueous systems

• Recommended co-formulation with vitamins, minerals, or other immune-supporting botanicals

• Encapsulation or blending with excipients for stability

13. AIHerba Factory Expertise & Trust Signals

• 28+ years production & R&D experience

• GMP & ISO certified, COA for every batch

• Traceable raw material sourcing

• OEM/ODM customization for bulk formulations

• Real product photos available, full QA support

14. Frequently Asked Questions (FAQ – 6)

1. Is Lentinan safe for oral consumption?
   Yes, Lentinan powder is safe for nutraceutical and functional food applications; injectable-grade available for regulatory-compliant medical use.

2. What purity of β-glucan do you guarantee?
   ≥90% β-(1,3)/(1,6)-glucan; molecular weight profile and COA available.

3. Can Lentinan be used in beverages or capsules?
   Yes, our powder dissolves in aqueous systems and can be encapsulated or blended.

4. Do you provide COA and MSDS?
   Yes, all batches come with COA and MSDS; additional testing available on request.

5. What is the MOQ and shipping policy?
   MOQ starts at 1 kg; bulk orders shipped worldwide with customs documentation.

6. Can AIHerba support OEM/ODM custom formulations?
   Yes, we provide full formulation development, packaging, and labeling support for global clients.

15. References & Authority Sources

1. PubMed – Lentinan β-glucan properties: https://pubmed.ncbi.nlm.nih.gov/20025412/

2. FDA GRAS – Polysaccharides: https://www.fda.gov/food/food-ingredients-packaging/food-additive-status-list

3. NIH Clinical Trials – Lentinan: https://clinicaltrials.gov/ct2/results?cond=Lentinan

4. ISO & GMP Certification References – Factory quality protocols

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