Piperine Benefits, Dosage, Uses & Health Research – Natural Bioenhancer from Trusted Supplier
(1) Piperine – High-Purity Natural Plant Extract for Nutraceuticals, Functional Foods & Cosmetics
Piperine is the primary bioactive compound naturally found in Piper nigrum (black pepper). Known for enhancing nutrient absorption and supporting metabolic health, Piperine has become a core ingredient for dietary supplement raw material manufacturers, functional food formulators, and cosmetic brands seeking high-performance botanical actives.
At AIHerba®, we supply GMP-certified Piperine extracted using supercritical CO₂ and refined purification steps to deliver high potency, excellent bioavailability, and consistent batch quality. As a long-established supplier and manufacturer, we support bulk procurement, OEM/ODM customization, and provide free sample herbal extract for formulation testing.
(2) Product Origin & Traceability
Our Piperine is sourced from non-GMO black pepper cultivated in Yunnan and Guangxi, China—regions known for stable alkaloid profiles. Each lot undergoes full traceability review, including farmer documentation, pesticide control records, and soil condition reports.
Extraction Methods Used:
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Supercritical CO₂ extraction (for high purity & solvent-free profile)
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Water-ethanol extraction (for standardized piperine content)
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Fine crystallization (for stability & color optimization)
(3) Key Benefits & Mechanisms
✔ Enhanced Nutrient Absorption
Piperine is widely recognized for boosting gastrointestinal bioavailability of nutrients such as curcumin, EGCG, and B-vitamins. Clinical trials show improved absorption via modulation of P-glycoprotein and CYP450 enzymes (NIH reference below).
✔ Supports Metabolic & Digestive Health
Traditionally used to support thermogenesis, digestion, and healthy lipid metabolism.
✔ Antioxidant & Anti-Inflammatory Support
Piperine exhibits strong free-radical scavenging activity, beneficial for healthy aging and cellular protection.
✔ Synergistic Ingredient
Often combined with curcumin, ginseng, resveratrol, berberine, and other actives in customized herbal extract formulas.
(4) Health Benefits Overview
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Supports healthy metabolism and thermogenesis
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Helps maintain digestive function
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Enhances bioavailability of vitamins and herbal extracts
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Provides antioxidant protection
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May support joint comfort and immune regulation
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Traditionally used for warming, activating circulation, and digestive tonicity
(5) Usage Guidelines
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Dietary Supplements: Capsules, tablets, tinctures, gummies
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Functional Foods: Healthy beverages, sports nutrition, metabolic blends
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Cosmetics: Skin-brightening serums, anti-aging formulas
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Phytopharmaceuticals: Synergistic bioavailability enhancer
(6) Recommended Dosage (Industry Guidance Only)
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Standardized Piperine 95%: 5–20 mg/day
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Synergistic blends (Curcumin + Piperine): 5–10 mg/day
Formulators may adjust dosage based on regulatory guidelines in target markets.
(7) Best Formulation Practices
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Pair with curcumin for maximum absorption
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Use microencapsulation for improved stability in beverages
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Combine with lipid-soluble actives for better uptake
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Ideal excipients: MCT, phospholipids, acacia fiber, plant protein carriers
(8) Safety & Precautions
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Not recommended during pregnancy
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Do not combine with high-dose medications without professional guidance
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Perform stability testing for liquid products due to piperine’s crystallization characteristics
(9) Product Specifications & COA (Sample Table)
Pesticide Residues
| Item | Specification | Testing Method |
|---|---|---|
| Organochlorine pesticides | ≤ 0.1 mg/kg | GC-MS |
| Organophosphorus pesticides | ≤ 0.1 mg/kg | GC-MS |
| Pyrethroid pesticides | ≤ 0.2 mg/kg | GC-MS |
| Carbamates | ≤ 0.1 mg/kg | LC-MS/MS |
Heavy Metals
| Item | Specification | Testing Method |
|---|---|---|
| Lead (Pb) | ≤ 3 ppm | ICP-MS |
| Arsenic (As) | ≤ 2 ppm | ICP-MS |
| Cadmium (Cd) | ≤ 1 ppm | ICP-MS |
| Mercury (Hg) | ≤ 0.1 ppm | ICP-MS |
Microbiological Tests
| Item | Specification | Testing Method |
|---|---|---|
| Total Plate Count | ≤ 1,000 CFU/g | USP <2021> |
| Yeast & Mold | ≤ 100 CFU/g | USP <2021> |
| E. coli | Negative | USP <2022> |
| Salmonella | Negative | USP <2022> |
| Staphylococcus aureus | Negative | USP <2022> |
(10) Manufacturing Process
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Raw material cleaning & sorting
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CO₂ supercritical extraction
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Ethanol precipitation & separation
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Purification & crystallization
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Vacuum drying
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Particle size adjustment
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Metal detection
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Final QC + COA generation
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Packaging in GMP-compliant cleanroom
(11) Production Flowchart
Black Pepper → Cleaning → Extraction → Filtration → Concentration → Crystallization → Drying → Milling → Testing → Packaging → Warehouse
(12) Storage & Shelf Life
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Store in a cool, dry, sealed environment
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Avoid direct light and moisture
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Shelf life: 24–36 months in original packaging
(13) Packaging Options
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1 kg / aluminum foil bag
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25 kg / fiber drum
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Custom packaging for bulk or wholesale buyers
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OEM/ODM packaging available for customized herbal extract formulations
(14) Samples, Shipping & MOQ
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Free sample herbal extract: 20–50 g
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MOQ: 1 kg
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Shipping options: DHL, FedEx, UPS, sea freight, air freight
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Lead time: 3–7 days for stock items; 10–20 days for custom batches
(15) Applicable Industries & Use Cases
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Dietary supplement brands
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Food & beverage manufacturers
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Cosmetic and skincare formulators
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Sports nutrition companies
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Pharmaceutical & herbal medicine manufacturers
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Functional food laboratories
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R&D centers requiring GMP certified plant extract for cosmetics
(16) How to Use Piperine in Formulation
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Add directly into powder premixes
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Disperse into oils for lipid-based products
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Encapsulate for targeted release
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Combine with curcumin, gingerols, and berberine for metabolic blends
(17) Why AIHerba® is a Trusted Supplier
Expertise (28+ years)
We have more than two decades of experience supplying botanical extracts to global partners.
Authority
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GMP, ISO, HALAL certified
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Full COA, MSDS, TDS, and third-party lab reports available
Credibility
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Traceable raw materials
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Real batch photos & factory QC images
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Transparent price quoting & procurement support
Experience
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3,000+ customer cases across supplements, cosmetics & functional foods
(18) Frequently Asked Questions (FAQ)
Q1: Can you provide a COA and MSDS?
Yes, every batch includes COA, MSDS, and full testing documentation.
Q2: Do you offer OEM/ODM?
Yes, we are a factory offering customized herbal extract formulas and private-label solutions.
Q3: What’s the MOQ?
MOQ is 1 kg, suitable for testing and pilot production.
Q4: Can I buy in bulk?
Yes, we support bulk and wholesale orders with competitive pricing.
Q5: Is your Piperine suitable for cosmetics?
Yes, we supply food-grade botanical extract and GMP certified plant extract for cosmetics.
(19) Scientific References
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PubMed – Piperine enhances nutrient absorption: https://pubmed.ncbi.nlm.nih.gov/9619120
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NIH – Piperine bioavailability studies: https://ods.od.nih.gov/
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FDA GRAS notice for black pepper constituents: https://www.fda.gov/
(20) Contact & Verification
AIHerba® | Shaanxi Zhonghong Investment Technology Co., Ltd.
📧 sales@aiherba.com | info@aiherba.com | liaodaohai@gmail.com
🌐 www.aiherba.com
Conclusion
Piperine transcends its function as a spice part—rising as a multitarget nutraceutical with clinically validated impacts on bioavailability, neurology, and metabolism. For innovators searching for licensed, research-backed piperine, Shaanxi Zhonghong delivers unmatched technical rigor: ISO 17025-accredited analytics, batch-specific chiral purity verification, and international cold-chain logistics.
Unlock Bioavailability—Request Your Certificates of Evaluation In the present day!
Piperine 95%, purchase piperine extract, bioavailability enhancer, black pepper alkaloid, high-purity piperine, Shaanxi Zhonghong.





