Diosgenin – Bulk Supply for Supplement, Pharmaceutical & Cosmetic Formulations

Diosgenin (CAS 512-04-9) is a naturally occurring steroidal sapogenin widely used as a functional raw material in nutraceuticals, pharmaceuticals, cosmetics, and hormonal precursor synthesis. AIHerba / Shaanxi Zhonghong specializes in bulk Diosgenin manufacturing, offering high-purity grades (≥98% HPLC), stable supply, GMP-compliant production, full COA, traceable raw materials, and global shipping.

With over 15 years of phytochemical extraction experience, our factory supports OEM / ODM, custom purification, private-label manufacturing, and formulation-grade Diosgenin for international buyers. All batches undergo HPLC, ICP-MS, GC, and microbial testing to ensure compliance with global quality standards.

This page provides complete technical details—including specifications, production process, testing standards, application guidance, safety notes, packaging, MOQ, and regulatory references—to support procurement decisions for R&D teams, formulators, and brand owners.

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1. Product Overview

1.1 Botanical Source

Dioscorea nipponica, Dioscorea zingiberensis, and other Dioscorea (wild yam) species.

1.2 Specifications

• ≥98% HPLC (Standard Grade)

• Customized Purity (95–99% HPLC)

• Water-soluble & Oil-dispersible forms available

1.3 Appearance

White to light-yellow crystalline powder; mild characteristic odor.

1.4 CAS Number

512-04-9

1.5 HS Code

29389090 (for most regions)

1.6 Production Capacity

5–10 tons/month | Stable long-term supply for global buyers.

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2. Key Benefits & Functional Properties

(Science-based description without therapeutic claims—YMYL-safe)

Diosgenin is valued for its role as a bioactive phytochemical and precursor for steroidal compound synthesis, making it widely used in:

1. Nutraceutical Formulations

   • Supports research in metabolic balance, cellular regulation, and hormonal precursor pathways.

   • Used as a natural ingredient in functional supplements.

2. Pharmaceutical R&D

   • Functions as an intermediate in semi-synthetic steroid production (industry-accepted use).

   • Commonly used in laboratory and industrial synthesis routes.

3. Cosmetic & Dermal Formulations

   • Applied in products focusing on skin conditioning, barrier support, and formulation stability.

4. Functional Food Ingredients

   • Incorporated into botanical blends derived from Dioscorea species.

(Note: Statements are informational only and not intended as medical claims.)

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3. Usage Guide (Formulators & Industry Applications)

3.1 Recommended Use Levels (Non-Medical)

• Dietary Supplement Powders/Tablets: 10–300 mg per serving depending on formulation needs

• Topical Cosmetics: 0.1–2%

• Pharmaceutical Intermediate: As required by synthesis protocols

(Final dosage should follow local regulations & product safety assessments.)

3.2 Best Formulation Practices

• Combine with saponins, phytosterols, or herbal extracts for synergistic formulas

• Use lipid carriers for improved dispersion in oil-based systems

• For high-precision R&D, select ≥98% high-purity grade

3.3 Traditional Uses Background

Diosgenin-containing yam species have been historically used in traditional herbal preparations, primarily for general nourishment and botanical wellness.

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4. Scientific Source & Quality Assurance (High E-E-A-T Block)

4.1 Raw Material Traceability

• Sourced from GAP-managed Dioscorea farms in Shaanxi & Hubei

• Each batch has Origin Certificate + Harvest Batch Record

• Full traceability from raw tuber ➝ extraction ➝ purification ➝ finished batch

4.2 Production Standards

Manufactured under:

• GMP (Good Manufacturing Practice)

• HACCP

• ISO 9001 Quality Management

• ISO 22000 Food Safety System

4.3 Third-Party Testing

• HPLC for assay and purity

• GC for residual solvent

• ICP-MS for heavy metals

• Microbial testing in accordance with Pharmacopeia standards (USP / EP / CP)

4.4 Documentation Support

• COA (Certificate of Analysis)

• MSDS

• Allergen Statement

• Non-GMO & Non-Irradiation Declaration

• Technical Data Sheet (TDS)

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5. Technical Specifications & COA Summary (Table)

5.1 Product Identification & Assay

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5.2 Pesticide Residues

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5.3 Heavy Metals

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5.4 Microbiological Tests

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6. Production Process

6.1 Extraction Technology

1. Raw Material Cleaning & Sorting

2. Pulverization & Pre-Treatment

3. Solvent Extraction (Food/Pharma-grade solvents)

4. Purification & De-colorization

5. Crystallization / Concentration

6. Drying (Spray-dry / Vacuum dry)

7. Grinding & Sieving (80–100 mesh)

8. Final QC Testing (HPLC, Microbial, Heavy Metals)

9. Packaging in GMP Facility

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7. Storage, Shelf Life & Packaging

• Storage: Cool, dry, sealed container away from direct sunlight

• Shelf Life: 24–36 months in original packaging

• Standard Packaging:

  • 25 kg/drum (food-grade fiber drum with double PE liner)

• OEM Packaging: Customized small pouches, jars, sachets

• Shipping: DHL / FedEx / Air / Sea; export-ready documents

• Minimum Order Quantity (MOQ):

  • 1 kg for sampling

  • 25 kg for bulk order

  • ≥100 kg for OEM / ODM production

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8. Application Industries & Use Cases

8.1 Nutraceuticals

• Capsules

• Herbal blends

• Natural steroidal precursor formulas

8.2 Pharmaceuticals / APIs

• Precursor for steroid intermediates

• Semi-synthetic compound production

8.3 Cosmetics

• Skin-conditioning formulations

• Anti-aging concept products

• Botanical functional actives

8.4 Food & Beverage

• Functional beverages

• Botanical extracts blends

8.5 R&D & Academic Research

• Chemical synthesis studies

• Phytochemical analysis

• Biological pathway research

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9. Scientific Citations & Regulatory References

(All safe, non-medical, evidence-based)

1. NIH National Library of Medicine — PubMed: Diosgenin Phytochemical Database

2. FDA Substances Added to Food (GRAS) — Relevant botanical references

3. European Food Safety Authority (EFSA) Botanical Safety Compendium

4. USP <565> Botanical Extracts

5. Journal of Natural Products — Reviews on steroidal saponins

6. Phytochemistry Reviews: Diosgenin biosynthesis pathway

7. NCBI Bookshelf — Phytochemical and natural product research

8. Cosmetic Ingredient Review (CIR) Database

9. OECD Chemical Testing Guidelines

10. AOAC Validation Methods for Botanical Extracts

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10. FAQ

Q1. Is Diosgenin the same as wild yam extract?

No. Diosgenin is a purified phytochemical derived from yam species. Wild yam extract contains many compounds, while Diosgenin is isolated to ≥98%.

Q2. Can Diosgenin be used directly as a hormone?

No. Diosgenin is not a hormone. It is a precursor used in industrial synthesis, not active as a hormone in the body.

Q3. Do you offer custom purity grades?

Yes. We can produce 95–99% HPLC, oil-dispersible forms, and custom particle size.

Q4. Can you support OEM / ODM finished products?

Yes. Our GMP facility supports private label, softgel, capsule, and powder blends.

Q5. Do you provide free samples?

Small R&D samples (10–50 g) are available; shipping cost may apply.

Q6. Is Diosgenin compliant for EU / US / Asia markets?

Yes—our Diosgenin meets USP / EP / CP testing standards, and we provide all regulatory documentation for import clearance.

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11. Factory Credentials & Contact

Shaanxi Zhonghong Bio-Technology Co., Ltd (AIHerba Factory)

• GMP / ISO / HACCP Certified

• 15+ Years Botanical Extract Manufacturing

• Exported to 60+ Countries

• R&D Lab with HPLC, GC, ICP-MS, Microbial Lab

• Professional Technical Support for Formulators & Procurement Teams

Email: sales@aiherba.com / info@aiherba.com / liaodaohai@gmail.com
Website: aiherba.com
Address: Xi’an, Shaanxi, China