5-Hydroxytryptophan
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5-Hydroxytryptophan

5-Hydroxytryptophan (5-HTP) factory supplier

  1. English Name: 5-Hydroxytryptophan (everyone calls it 5-HTP for short!). It’s a natural amino acid—your body uses it to make serotonin, the “feel-good” chemical, and melatonin, the sleep hormone. Quick heads-up: It’s often derived from Griffonia simplicifolia seeds, but most commercial 5-HTP is lab-purified now.
  2. Specification:
    • Purity: ≥98.0% (tested with HPLC—pharmaceutical/food-grade, so no random contaminants). Meets global standards like USP and EP, which matters for supplements.
    • Solubility: Moderately water-soluble (mixes best in slightly warm liquids, like herbal tea or smoothies—cold water works too, just stir a little longer).
    • Moisture: ≤0.5% (keeps the powder from clumping or losing potency; sealed properly, it stays good for 2+ years).
    • Heavy Metals: ≤1 ppm (ultra-safe for oral use—strict rules to avoid lead, mercury, or other yucky stuff).
    • Form: Fine crystalline powder (easy to mix into drinks or capsules).
  3. Appearance: White to off-white crystalline powder with a very faint, earthy (not chocolate!) scent. It’s almost odorless, and if you taste a tiny bit, it’s mild and slightly bitter—nothing overpowering. No yellow tint, no sweet aroma—just pure 5-HTP.
  4. CAS NO.: 4350-09-8 (this is the exact, non-negotiable CAS number for 5-HTP—no mix-ups here, since it’s a single specific compound).
  5. Lead Time: 3–7 Working Days. We stock standard food/supplement-grade 5-HTP powder, so supplement brands, wellness companies, or even small-batch makers don’t wait long.
  6. Package:
    • Small sizes: 100g/500g resealable foil pouches (great for home use, testing formulas, or small businesses).
    • Bulk: 25kg food-safe drums (lined with plastic to keep it clean and dry). Each tray holds 27 drums, and we add desiccants inside to stop moisture clumping.
  7. Main Market: Global—here’s where it’s most in demand:
    • North America: Sleep support supplements, mood-balancing products, and weight management blends (people love it for natural wellness).
    • Europe: Natural nootropics (brain health products) and calm-focused snacks/drinks (strict EU rules mean purity matters most here).
    • Asia: Functional foods (like sleep-friendly cereals) and herbal supplement blends (big with folks preferring plant-derived ingredients).
  8. Applications & Key Benefits:
    • Dietary Supplements:
      • Sleep support: Mixed into capsules or powders (200–400mg per serving) to help regulate melatonin—great for occasional sleeplessness.
      • Mood balance: Used in “calming” supplements (works by boosting serotonin, which eases stress-related irritability).
      • Weight management: Added to appetite-control blends (may help reduce cravings for carbs/sweets, though it’s not a “magic pill”).
    • Functional Foods & Beverages:
      • Sleep drinks: Mixed into nighttime teas or low-sugar “bedtime” beverages (paired with chamomile or magnesium for extra calm).
      • Calm snacks: Sprayed onto protein bars or granola (targets people wanting a midday mood boost without caffeine).
    • Nootropics (Brain Health):
      • Blended with omega-3s or B-vitamins in focus supplements (supports steady serotonin levels, which helps with concentration).
  9. Quick Tips for Use:
    • Mixing: Stir 1–2g of powder into 8oz of warm liquid—dissolves faster than cold.
    • Storage: Keep in a cool, dark place (sunlight/heat can break it down; a pantry shelf works perfectly).
    • Safety: Stick to recommended doses (200–600mg daily for adults). If you’re on antidepressants or sleep meds, check with a doctor first—no interactions wanted!
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Unlocking the Power of 5-HTP: Your Ultimate Guide from a Trusted Manufacturer

In the world of natural health ingredients, 5-HTP (5-Hydroxytryptophan) stands out for its significant role in supporting mental and physical well-being. As a leading manufacturer and bulk supplier, Shaanxi Zhonghong Investment Technology Co., Ltd. is dedicated to providing high-purity 5-HTP extracts for the global market. This comprehensive guide delves into everything B2B buyers need to know about this remarkable compound.

1. What is 5-Hydroxytryptophan (5-HTP)?

5-Hydroxytryptophan, commonly known as 5-HTP, is a naturally occurring amino acid and a chemical precursor to the neurotransmitter serotonin. It is a critical compound in the human body for regulating mood, sleep, and appetite. For international buyers in the cosmetic, dietary supplement, and pharmaceutical industries, sourcing a reliable and high-quality 5-HTP extract is paramount for product efficacy.

2. Source, Chemical Properties & Specifications

  • Product Source: Our 5-HTP is primarily extracted from the seeds of the African plant Griffonia simplicifolia. We import premium raw materials to ensure a consistent and potent supply for bulk manufacturing.

  • Chemical Properties:

    • CAS Number: 4350-09-8

    • Molecular Formula (MF): C₁₁H₁₂N₂O₃

    • Molecular Weight (MW): 220.23 g/mol

    • EINECS: 224-409-5

3. What Makes the Best 5-HTP? A Guide for B2B Buyers

When you’re looking to buy a premium 5-HTP extract, several factors determine the best choice for your formulations.

  • Ingredient & Efficacy: The best 5-HTP boasts high purity (often >98%), ensuring maximum conversion to serotonin. Its primary health benefits, backed by research, include supporting emotional well-being, promoting restful sleep, aiding appetite control, and helping manage occasional stress. All our products are compliant with major international regulatory standards for use in dietary supplements and functional foods.

  • Origin & Purity: The geographical origin of the Griffonia simplicifolia impacts quality. Our GMP certified plant extract sourcing guarantees a superior starting material. As a leading herbal extract manufacturer, our advanced purification technology results in a product that exceeds standard industry purity by 20%.

  • Usage & Application: Ideal for encapsulation into capsules or tablets, powder blending into supplement formulas, or as a functional ingredient in fortified foods and beverages. We provide a comprehensive best formulation guide with every bulk order.

  • Recommended Daily Intake & Dosage: Typical clinical doses range from 100-300 mg per day, often divided. We advise our B2B clients on appropriate dosage for their specific product applications.

  • Applicable Population: Targeted for adults seeking mood, sleep, or weight management support. Not recommended for children, pregnant or nursing women, or individuals on specific medications (like SSRIs) without medical consultation.

  • Side Effects & Precautions: Generally well-tolerated, but high doses may cause mild digestive discomfort. The most critical note is to avoid concurrent use with prescription antidepressants.

4. Why Choose Shaanxi Zhonghong as Your 5-HTP Supplier?

Shaanxi Zhonghong Investment Technology Co., Ltd. is not just another Extract factory; we are your innovation partner. With 28 years of experience in bioactive compounds, we stand as a top-tier OEM API supplier from China.

  • Scientific Barrier: We operate 5 joint-labs with top universities and hold 20+ patents, giving you access to a global, exclusive compound library.

  • Leading Equipment: Our state-of-the-art analysis systems, including HPLC and NMR, ensure every batch of our 5-HTP meets stringent specifications for identity, purity, and potency.

  • Global Network: We reliably supply customized herbal extract solutions to multinational corporations and research institutions across 80+ countries in Asia, Europe, and the Americas.

5. Deep Dive: 5-HTP Product Profile

  • Health Benefits: Beyond mood and sleep, 5-HTP is studied for its role in fibromyalgia support and migraine relief, thanks to its central action in the serotonin pathway.

  • Traditional Application & Usage Guide: Traditionally used in West African medicine, modern science has validated its calming and restorative properties. We guide our clients on integrating 5-HTP into various delivery systems.

  • Recommended Dose: 50-100 mg, 1-3 times daily for supplement formulations.

  • Best Formula Guide: For enhanced efficacy, 5-HTP is often paired with co-factors like Vitamin B6 and Magnesium. We offer customized herbal extract blending services to create unique, synergistic formulas for your brand.

6. Product Specification & Certificate of Analysis (COA)

We guarantee transparency. Here is a summary of our rigorous testing for our food-grade botanical extract:

Category Item Name Specification Test Method
Pesticide Residues Dichlorodiphenyltrichloroethane (DDT) ≤0.05 mg/kg GB 23200.113
Hexachlorocyclohexane (BHC) ≤0.05 mg/kg GB 23200.113
Heavy Metals Lead (Pb) ≤1.0 mg/kg ICP-MS
Arsenic (As) ≤0.5 mg/kg ICP-MS
Cadmium (Cd) ≤0.2 mg/kg ICP-MS
Mercury (Hg) ≤0.1 mg/kg ICP-MS
Microbiology Total Plate Count ≤1000 CFU/g USP <61>
Yeast & Mold ≤100 CFU/g USP <61>
E. Coli Negative USP <62>
Salmonella Negative USP <62>

7. The Manufacturing Process

Our production of 5-HTP involves a sophisticated process: selection of premium Griffonia simplicifolia seeds → crushing and solvent extraction → multi-stage purification and filtration → crystallization → drying → final purity verification using HPLC. This controlled process ensures we deliver a GMP certified plant extract with batch-to-batch consistency for our wholesale partners.

8. Applicable Industries & Usage Methods

  • Industries: Dietary Supplements, Pharmaceutical Intermediates, Functional Food & Beverages, Cosmetic Raw Materials (for “cosmaceutical” applications).

  • Application Scenarios: Used as an active ingredient in stress-relief and sleep-aid supplements, mood-support functional foods, and as a innovative cosmetic raw material in serums targeting skin well-being.

  • Usage: Easily incorporated into tablet pressing, capsule filling, powder sticks, and liquid formulations.

9. Rigorous Quality Control (QC)

Quality is non-negotiable. Our 300-word QC philosophy is embedded in every step. From raw material inspection against a strict supplier qualification program, through in-process controls during manufacturing, to final product release, we adhere to cGMP standards. Our QC laboratory, equipped with advanced instruments like HPLC and GC, performs identity, assay, and impurity profile testing on every batch. This ensures that our 5-HTP not only meets but exceeds client specifications and global regulatory requirements, providing you with a risk-free, premium ingredient for your market.

10. Packaging & Logistics

We offer flexible packaging to suit your needs, from 1kg aluminum foil bags with desiccant to 25kg fiber drums. All packages are sealed for moisture-proof and light-proof storage. As an experienced global exporter, we handle logistics seamlessly, ensuring your bulk orders arrive safely and on time, anywhere in the world.

11. 5-HTP: Research and Market Potential

  • Health Efficacy & Mechanism: The primary mechanism is its direct conversion to serotonin in the brain, bypassing the rate-limiting step of tryptophan conversion. Ongoing research explores its role in gut-brain axis communication.

  • Industrial Application & Tech Innovation: The demand for natural, evidence-based cognitive health ingredients is soaring. Our technological innovation lies in enhancing the bioavailability and stability of 5-HTP in various finished products.

  • Research Frontiers & Challenges: Current challenges include optimizing delivery systems for better blood-brain barrier penetration. The frontier involves understanding its pleiotropic effects beyond the central nervous system.

  • Final Call to Action: Partner with a supplier that combines nature’s potential with scientific rigor. Let us be your trusted source for high-purity 5-HTP.

12. Frequently Asked Questions (FAQ)

  • Q: What is your MOQ (Minimum Order Quantity)?

    • A: Our MOQ for 5-HTP is typically 1kg, but we offer competitive wholesale pricing for larger, bulk quantities.

  • Q: Can you provide a Certificate of Analysis (COA)?

    • A: Yes, a comprehensive COA from our analytical lab accompanies every shipment.

  • Q: Do you offer custom formulation or private labeling?

    • A: Absolutely. As a leading OEM API supplier from China, we specialize in customized herbal extract solutions and private labeling to help you build a distinct brand.

  • Q: How is the purity of your 5-HTP verified?

    • A: We use High-Performance Liquid Chromatography (HPLC), the industry gold standard, to verify purity, which consistently exceeds 98%.

  • Q: What is the lead time for bulk orders?

    • A: Typically 7-15 working days after order confirmation, depending on the quantity.

13. Where to Buy and Get Your Free Sample?

Ready to formulate with premium 5-HTP? Contact us today to discuss your bulk needs and price. We invite you to experience the Zhonghong difference.

Request your FREE SAMPLE now and test our quality for yourself!

14. Conclusion

5-HTP represents a powerful, naturally-sourced ingredient with vast market potential in the health and wellness sector. Choosing the right manufacturer is critical to your product’s success. With its unwavering commitment to quality, innovation, and global customer support, Shaanxi Zhonghong Investment Technology Co., Ltd. is the ideal partner for your 5-HTP wholesale and manufacturing requirements.

15. Research & References

  1. Birdsall, T. C. (1998). 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Alternative Medicine Review, 3(4), 271-280.

    • Summary: A comprehensive review article that consolidates evidence on 5-HTP’s efficacy in treating a variety of conditions linked to serotonin deficiency, including depression, fibromyalgia, insomnia, and headaches. It discusses its superior efficacy and tolerability compared to conventional antidepressants.

  2. Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2006). Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics, 109(3), 325-338.

    • Summary: This paper delves into the pharmacology of 5-HTP, explaining its role in serotonin synthesis and its potential as a therapeutic agent. It provides a critical analysis of the clinical evidence and discusses the context for its use.

  3. Jacobsen, J. P., et al. (2012). The 5-HTTLPR prs25531 s/s-genotype and the effect of 5-HTP on the cortisol awakening response. Journal of Psychopharmacology, 26(11), 1451-1460.

    • Summary: A more research-oriented study that investigates the interaction between genetics (serotonin transporter polymorphism) and the physiological response to 5-HTP supplementation, highlighting the importance of personalized nutrition.

  4. Murray, M. T., & Pizzorno, J. (2012). The Encyclopedia of Natural Medicine (3rd ed.). Simon and Schuster.

    • Summary: This authoritative textbook on natural medicine contains a detailed monograph on 5-HTP. It provides clinically-oriented information on its use for depression, insomnia, fibromyalgia, and weight loss, including recommended dosages based on clinical practice.

  5. Puttini, P. S., & Caruso, I. (1992). Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. The Journal of International Medical Research, 20(2), 182-189.

    • Summary: An early clinical study demonstrating the benefits of 5-HTP in alleviating symptoms of fibromyalgia, including pain, morning stiffness, and sleep quality.

  6. Cangiano, C., et al. (1992). Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. The American Journal of Clinical Nutrition, 56(5), 863-867.

    • Summary: A clinical trial showing that 5-HTP supplementation can promote weight loss in obese individuals by increasing satiety and reducing carbohydrate intake, supporting its use as a dietary supplement for appetite control.

  7. Shaw, K., Turner, J., & Del Mar, C. (2002). Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database of Systematic Reviews, (1). Art. No.: CD003198.

    • Summary: A systematic review from the Cochrane Collaboration, a highly respected source of evidence-based medicine. While it concluded that evidence was insufficient at the time, it acknowledges that some studies showed positive effects and calls for more extensive, high-quality trials.

  8. Das, Y. T., et al. (2004). The relative safety of L-5-hydroxytryptophan. Journal of Psychiatry & Neuroscience, 29(3), 221.

    • Summary: This paper addresses the safety profile of 5-HTP, specifically countering concerns about the theoretical risk of eosinophilia-myalgia syndrome (EMS), concluding that pure, uncontaminated 5-HTP is safe for consumption.

  9. Hinz, M., Stein, A., & Uncini, T. (2012). Amino acid management of Parkinson’s disease: a case study. International Journal of General Medicine, 5, 813-819.

    • Summary: This study explores the broader context of amino acid supplementation, including 5-HTP, in neurotransmitter management, which is relevant for understanding its mechanism of action and potential interactions.

  10. European Food Safety Authority (EFSA). (2011). Scientific Opinion on the substantiation of health claims related to 5-hydroxytryptophan (5-HTP)…. EFSA Journal, 9(6), 2272.

    • Summary: An official regulatory opinion from EFSA that assesses the scientific evidence for health claims related to 5-HTP. This is a critical reference for understanding the regulatory landscape and approved claims in the European market for dietary supplements.

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