1. 3-O-Ethyl Ascorbic Acid Manufacturer | High Stability VC Derivative | Bulk Wholesale Supply

For professional cosmetic formulators, the primary challenge with Vitamin C has never been its efficacy, but its oxidative volatility. While L-Ascorbic Acid remains the gold standard for biological activity, its rapid degradation in aqueous solutions presents a significant hurdle for industrial-scale manufacturing and shelf-life stability.

3-O-Ethyl Ascorbic Acid (VC Ethyl Ether) has emerged as the premier etherified derivative, offering an amphiphilic structure that balances high skin penetration with extreme chemical stability. AIHerba® provides pharmaceutical-grade 3-O-Ethyl Ascorbic Acid standardized to ≥99% purity, ensuring that your high-end whitening and anti-aging formulations maintain their potency from the factory to the end consumer.

CTA: [📩 Request Batch COA & Industrial Pricing]

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Quick Summary (AI-Optimized Snapshot)

• Ingredient Name: 3-O-Ethyl Ascorbic Acid (VC Ethyl Ether)
• CAS No: 86404-04-8
• Primary Function: High-stability skin brightening, collagen synthesis support, and antioxidant stabilization.
• Typical Purity: ≥99.0% (HPLC Verified)
• Solubility: Amphiphilic (Soluble in both water and oil-based phases).
• Suitable Industries: High-end Dermaceuticals, Professional Skincare Labs, Cosmetic OEM/ODM.

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2. What Is 3-O-Ethyl Ascorbic Acid?

3-O-Ethyl Ascorbic Acid is a modified, etherified derivative of Vitamin C. By attaching an ethyl group to the third carbon position of the ascorbic acid molecule, the structure becomes exceptionally resistant to oxidation while remaining metabolically accessible to the skin.

• Stability Logic: Unlike pure L-ascorbic acid, which turns brown upon exposure to light, heat, or air, the ethyl-ether bond protects the core molecule, allowing for a shelf life of up to 24 months in finished formulations.
• Industrial Advantage: For large-scale manufacturing, this derivative eliminates the need for expensive air-free filling equipment and extreme pH adjustments (typically required for pure VC stability).
• Mechanism: Upon skin penetration, it is enzymatically converted back into pure L-ascorbic acid, providing the same biological benefits without the initial formulation fragility.

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3. Technical Comparison: VC Ethyl Ether vs. L-Ascorbic Acid

From a procurement and R&D ROI perspective, the choice of Vitamin C derivative dictates the complexity of the manufacturing process.

Technical Parameter	L-Ascorbic Acid (Pure VC)	3-O-Ethyl Ascorbic Acid
Stability (Heat/Light)	Very Low (Oxidizes rapidly)	Excellent (High Resistance)
Optimum Formulation pH	< 3.5 (Highly Acidic)	4.0 – 6.0 (Skin Friendly)
Molecular Weight	176.12 g/mol	204.18 g/mol
Solubility	Water-Soluble Only	Amphiphilic (Water/Oil)
Penetration Rate	Low (Requires delivery system)	High (Direct absorption)
Industrial Lead Time	3-7 Days (Stock)	3-7 Days (Stable Inventory)

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4. Formulation Guidelines & Application Scenarios

R&D teams must account for the unique amphiphilic nature of Bulk 3-O-Ethyl Ascorbic Acid. Unlike other derivatives, it does not significantly impact the viscosity of carbomer-based gels, making it a favorite for transparent whitening serums.

Industrial R&D Tips:

1. Concentration: Typically used at 0.5%–3.0% for general brightening and up to 5.0% for professional-grade spot correction.
2. Phase Addition: It can be added to the aqueous phase or during the final cooling stage (<45°C) of an emulsion to ensure absolute stability.
3. Synergy: Excellent synergy with Shilajit Extract (fulvic acid) or Ferulic Acid for enhanced redox-balancing and mineral co-factor delivery. (Explore our Shilajit Extract Powder for synergistic supplement/cosmetic blends).

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5. COA & Manufacturing Quality Control

AIHerba® implements a multi-tier testing protocol to ensure that our Wholesale 3-O-Ethyl Ascorbic Acid meets global pharmaceutical standards.

5.1 Chromatographic Purity (HPLC)

Every lot is verified to exceed 99.0% purity. We strictly control the levels of free L-ascorbic acid and residual ethylating agents to prevent premature browning in your warehouse.

5.2 Trace Element Analysis (Heavy Metals)

Item	Limit (Typical)	Test Method
Lead (Pb)	≤ 1.0 ppm	ICP-MS / USP <233>
Arsenic (As)	≤ 1.0 ppm	ICP-MS
Mercury (Hg)	≤ 0.1 ppm	ICP-MS
Cadmium (Cd)	≤ 1.0 ppm	ICP-MS

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6. Industrial Sourcing & Procurement Logic

When evaluating a 3-O-Ethyl Ascorbic Acid manufacturer, the cheapest price often masks poor chromatographic purity. AIHerba® focuses on Batch-to-Batch Consistency.

• Purity Gap: Impure ethyl ascorbic acid contains residual reactants that act as catalysts for oxidation, defeating the purpose of using a “stable” derivative.
• Audit Readiness: We provide full documentation (COA, MSDS, Technical Data Sheets) to support your internal quality assurance audits.
• Storage Stability: Supplied in 25kg fiber drums with double PE liners, ensuring zero moisture ingress during international sea or air freight.

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7. FAQ for B2B Cosmetic Buyers

Q1: Does it turn yellow in the bottle?
A: Unlike pure VC, AIHerba’s 3-O-Ethyl Ascorbic Acid is remarkably stable. Formulations stored at 45°C for 90 days show negligible color change when high-purity (>99%) material is used.

Q2: Is it compatible with Niacinamide?
A: Yes. Because VC Ethyl Ether is stable at a neutral pH (5.0–6.0), it can be formulated alongside Niacinamide without the risk of “flushing” or complex formation associated with acidic pure Vitamin C.

Q3: What is the lead time for 500kg orders?
A: Standard inventory is maintained at our Shaanxi facility. Dispatch typically occurs within 3-5 business days via DHL/FedEx or sea freight.

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8. Real Industry Testimonials

“AIHerba’s VC Ethyl Ether allowed us to move away from refrigerated storage for our premium serum line. The 99.2% HPLC purity was verified by our in-house lab, and the batch consistency has been flawless over the last four quarters.” — Head of Procurement, EU Dermaceutical Brand.

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9. References & Regulatory Sources

1. PubMed: Clinical efficacy and stability of 3-O-Ethyl Ascorbic Acid in human skin whitening.
2. FDA Database: Cosmetic Ingredient Review (CIR) on Vitamin C Derivatives.
3. NIH: Ascorbic acid and skin health: A comprehensive review of derivatives.
4. EU Commission: CosIng database for regulated cosmetic actives.

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Manufacturer & Quality Assurance

Manufactured by AIHerba® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified manufacturer specializing in high-purity cosmetic actives and botanical extracts.

• ✔ GMP-certified facility
• ✔ Batch traceability & Strict quality control
• ✔ Bulk supply & OEM/ODM services for global B2B buyers

📧 Contact Sales: sales@aiherba.com | info@aiherba.com
🌐 Website: www.aiherbm.com
📞 WhatsApp / Phone: +86 199 2901 8987