Bulk Provitamin B5 Manufacturer: D-Panthenol 98% | CAS 81-13-0
, ,

D-Panthenol (Provitamin B5) Bulk Supplier | USP Grade | AIHerba®

  1. Product Name: D-Panthenol (Provitamin B5) | Industrial Bulk Supply

  2. Assay (GC/HPLC): ≥ 98.0% (Certified D-Isomer High Chiral Purity)

  3. Appearance: Colorless to Pale Yellow Viscous Liquid (High Clarity)

  4. CAS No.: 81-13-0

  5. Solubility: Highly Water-Soluble & Soluble in Ethanol (Miscible)

  6. Stability: High Thermal Stability; Optimal between pH 4.0 – 7.0

  7. Lead Time: 3–7 Working Days (Global Bulk Stock)

  8. Packaging: 25kg Standard Drum / 1kg R&D Sample Available

  9. Compliance: GMP Certified / USP & EP Grade / Batch-Specific COA Provided

  10. Application: Professional Haircare & Follicle Conditioning / Barrier Repair Skincare / OEM/ODM

Bulk Supply & Technical Advisory
🛡️
GMP Certified
🔬
HPLC Lab Tested
🌍
Global Logistics
📦
Free Samples

01. D-Panthenol Bulk Supplier — Procurement Summary

Manufacturer: AIHerba® (Direct Factory)
Grade: USP / EP / Cosmetic Grade
Form: Colorless to Pale Yellow Viscous Liquid
Assay: ≥ 98.0% (D-Form Purity)
MOQ: 25kg Standard Drum
Lead Time: 3–7 Working Days
COA: Full USP Monograph Available
Logistics: Global DDP/CIF Ready

02. Manufacturer & Quality Assurance Platform

AIHerba® Industrial Infrastructure

As a strategic B2B partner for hair care giants and premium cosmeceutical brands, AIHerba® operates a cGMP facility specializing in the precision synthesis of Provitamin B5. Our D-Panthenol is optimized for consistent viscosity and high chiral purity, ensuring peak efficacy in skin barrier repair and follicle protection.

GMP Certified
USP/EP Compliant
Chiral Verified
Audit Ready

03. D-Panthenol Identity Profile

Chemical Name D-Panthenol / Dextropanthenol
CAS Number 81-13-0
Molecular Weight 205.25 g/mol
Molecular Formula C9H19NO4
Standard Grade USP / EP / Ph. Eur. / JP

04. Technical Specification & Release Standard

ASSAY (GC/HPLC)

98.0% – 102.0%

SPECIFIC ROTATION

+29.0° to +31.5°
Ensures 100% Chiral D-Form

HEAVY METALS

≤ 10 ppm

REFRACTIVE INDEX

1.495 – 1.502

05. Analytical Verification Hub

AIHerba® provides absolute verification of Provitamin B5 bio-activity. Every commercial lot is tested for chiral purity, ensuring zero contamination with the inactive L-Panthenol isomer.

HPLC-RI
Purity Verification
FT-IR
Identity Confirmation
Optical Rotation
Chiral Integrity

06. Batch Release & Quality Control System

01 Raw Material Audit
02 Chiral Synthesis
03 Thin-Film Evaporation
04 Laboratory Release

07. Manufacturing Process & Chiral Control

The production of AIHerba® D-Panthenol utilizes Resolution-Free Chiral Synthesis. By using D-Pantolactone as the core precursor, we bypass the need for racemic separation, resulting in a product with consistently high optical rotation. Our purification process uses High-Vacuum Distillation to remove traces of aminopropanol, satisfying the low-odor requirements of premium fragrance-free cosmetic lines.

08. Molecular Structure & Functional Characteristics

As the alcohol analogue of pantothenic acid (Vitamin B5), D-Panthenol is rapidly converted into Vitamin B5 within the skin. Its small molecular weight allows for deep follicular penetration, making it the gold standard for hair shaft conditioning and epidermal barrier hydration.

09. Industrial Application Compatibility

Professional Hair Care

Improves hair elasticity, moisture retention, and shine in shampoos and conditioners.

Medical Dermaceuticals

Functional property in wound-healing ointments and post-procedure barrier creams.

Sun Care Formulations

Soothing support for after-sun lotions and UV-stress recovery systems.

10. Formulation Development Guide

Solubility & Mixing

Highly soluble in water and ethanol. Insoluble in oils and fats. To preserve bio-activity, D-Panthenol should be added to the aqueous phase at temperatures below 70°C.

pH Optimization

Optimally stable in aqueous solutions at pH 4.0 – 7.0. At pH levels outside this range, hydrolysis to pantoic acid may occur, reducing efficacy.

11. Stability & Transport Engineering

Risk: Hygroscopicity
D-Panthenol is highly hygroscopic, absorbing water from air, which can lower the assay over time.
Solution: Shipped in moisture-proof, induction-sealed PE drums with secondary foil protection.
Engineering: Viscosity Control
High viscosity at room temp can slow down industrial pumping systems.
Impact: Standardized viscosity (approx. 50,000 mPa.s) for predictable processing.

12. Regulatory & Compliance Documentation

USP COA
MSDS (GHS)
TDS / SPEC
HALAL/KOSHER

13. Packaging Storage & Global Shipping

Packaging: 25kg net fiber or plastic drums. 1kg vacuum packs for R&D. Logistics: Validated DDP (Duty Paid) shipping to USA/EU/UK. We own the customs risk to ensure production continuity.

14. Custom Specification & OEM Support

AIHerba® provides Panthenol 75% Aqueous Solutions and custom-diluted blends for manufacturers without high-viscosity liquid handling equipment. Private labeling and premixing with Hyaluronic Acid are available.

15. Provitamin B5 Market & Industry Insights

The global D-Panthenol market is projected to grow by 5.8% CAGR through 2030, driven by the clean-beauty trend in hair restoration. AIHerba is leading this shift by providing Non-GMO, Solvent-Minimized grades that meet the compliance hurdles of Tier-1 cosmetic brands.

16. Market Benchmark: AIHerba vs. Generic Trades

Criterion Generic Grade AIHerba® Industrial Grade
Chiral Purity DL-Panthenol (50% Active) Pure D-Panthenol (100% Active)
Documentation Basic SDS Full USP/EP Dossier Support
Lead Time 4-6 Weeks 3-7 Days (In-Stock)

17. Technical Procurement FAQ

Q1: What is the difference between D-Panthenol and DL-Panthenol for procurement?
D-Panthenol is the biologically active isomer. DL-Panthenol is a racemic mixture where only 50% is active. AIHerba provides pure D-form to ensure maximum efficacy and lower usage rates in high-end formulations.
Q2: Can AIHerba provide D-Panthenol in powder form?
Pure D-Panthenol is a viscous liquid. For solid dosage forms (tablets), we recommend Calcium Pantothenate or our custom spray-dried D-Panthenol on a silica carrier.
Q3: How do you ensure the product doesn’t crystallize during shipping?
D-Panthenol may crystallize if stored below 15°C. We ship in temperature-stabilized containers and provide a Redissolution Protocol (gentle heating to 40°C) for winter logistics.
Q4: Is the material compliant with EU REACH and US FSMA?
Yes, AIHerba provides all necessary REACH registration data for EU importers and full cGMP/FSMA compliance for the US food and cosmetic markets.
Q5: What is the typical shelf life of an opened bulk drum?
We recommend using the drum within 3-6 months after opening to prevent moisture absorption. Ensure the nitrogen blanket is maintained or the drum is tightly resealed after sampling.

18. AIHerba Industrial Quality Commitment

✓ GMP Manufacturing
✓ USP/EP Grade
✓ 100% Chiral D-Form
✓ DDP Logistics
📧 sales@aiherba.com | info@aiherba.com | 🌐 www.aiherba.com


Bulk Supply & Technical Advisory
🛡️
GMP Certified
🔬
HPLC Lab Tested
🌍
Global Logistics
📦
Free Samples
Scroll to Top

Request Factory-Direct Quote & Lab Samples

Access our 29-year R&D database. Batch-specific HPLC Fingerprints, COA & MSDS included. Standard samples dispatched via FedEx/DHL within 48h.

Request Factory-Direct Quote & Lab Samples