Sulforaphane-Supplement
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Broccoli Powder Sulforaphane

Broccoli Powder Sulforaphane Product Introduction
  1. English Name: Broccoli Powder Sulforaphane; 1 – Isothiocyanato – 4 – methylsulfinylbutane
  1. Specification
    • Sulforaphane Content:
      • Standard Grade: ≥ 5% (HPLC)
      • High – Purity Grade: ≥ 20% (HPLC)
    • Solubility: Sparingly soluble in water (approx. 0.1 g/L at 25°C), soluble in organic solvents like ethanol and DMSO. Water – soluble formulations can be achieved through encapsulation or complexation techniques.
    • Particle Size: Standard powder ≤ 150 μm; micronized powder ≤ 5 μm for better bioavailability
    • Moisture Content: ≤ 5%, Heavy Metals ≤ 10 ppm, Pesticide Residues ≤ 0.1 ppm
  1. Appearance
    • Light green to yellowish – green fine powder, with a characteristic mild cruciferous vegetable odor
  1. CAS NO.：4478 – 93 – 7
  1. Lead time: 5 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market: Global market, with significant demand in North America, Europe, and Asia, especially in the health supplement, functional food, and pharmaceutical industries
  1. Application Scenarios

Core Properties

  • Molecular Formula: C₆H₁₁NOS₂
  • Stability: Sensitive to heat, light, and pH changes. The bioavailability can be enhanced by combining with myrosinase (an enzyme naturally present in broccoli) or through encapsulation.
  • Key Features
    • Potent Antioxidant: Activates the Nrf2 pathway, triggering the production of endogenous antioxidant enzymes (e.g., glutathione peroxidase), which neutralize free radicals and reduce oxidative stress.
    • Anti – inflammatory: Suppresses the activation of NF – κB, a key regulator of the inflammatory response, reducing the production of pro – inflammatory cytokines.
    • Cancer Prevention Potential: Inhibits cancer cell growth, induces apoptosis, and blocks angiogenesis (formation of new blood vessels that tumors need to grow).
    • Detoxification Inducer: Enhances the body’s Phase II detoxification enzymes, helping to eliminate harmful toxins and carcinogens.

Application Scenarios

1. Dietary Supplements

  • General Health Formulas:
    • Capsules or tablets (50 – 200 mg per serving) are popular among health – conscious consumers for overall antioxidant and anti – aging support.
    • Often combined with other superfood extracts (e.g., turmeric, green tea) in multi – ingredient supplements.
  • Cancer Prevention Supplements:
    • Marketed to individuals at high risk of cancer, with clinical studies supporting its role in reducing the incidence of certain cancers (e.g., prostate, breast, colorectal).

2. Functional Food & Beverages

  • Fortified Foods:
    • Added to cereals, granola bars, and snack foods (0.1 – 0.5% concentration) to boost nutritional value and provide health – promoting benefits.
    • Used in plant – based beverages, such as green smoothies and vegetable juices, to enhance antioxidant content.
  • Sports Nutrition:
    • Incorporated into post – workout supplements to reduce exercise – induced oxidative stress and inflammation, aiding in muscle recovery.

3. Pharmaceuticals

  • Investigational Therapies:
    • Under clinical investigation for use as an adjuvant therapy in cancer treatment, potentially enhancing the efficacy of chemotherapy while reducing side effects.
    • Studied for its potential in treating neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) due to its neuroprotective properties.
  • Over – the – Counter (OTC) Medications:
    • In some regions, available in topical creams or gels for skin conditions associated with inflammation and oxidative damage, such as acne and psoriasis.

4. Cosmetics & Personal Care

  • Anti – aging Skincare:
    • Serums and creams (1 – 3% concentration) are formulated to protect skin from environmental damage, reduce wrinkles, and improve skin texture by combating oxidative stress.
    • Used in sunscreens to enhance protection against UV – induced skin damage.
  • Hair Care:
    • Shampoos and conditioners containing sulforaphane aim to strengthen hair follicles, prevent hair loss, and improve scalp health by reducing inflammation.

Detection Methods

  • High – Performance Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 220 nm for quantification.
  • Ultra – Performance Liquid Chromatography – Mass Spectrometry (UPLC – MS):
    • Confirms the molecular structure and detects trace impurities, providing high – sensitivity analysis for high – purity products.
  • Fourier Transform Infrared Spectroscopy (FTIR):
    • Used for identifying characteristic functional groups of sulforaphane, helping to verify product identity and purity.

Source & Advantages

  • Natural Source: Extracted from broccoli (Brassica oleracea var. italica) sprouts, which are rich in glucoraphanin (the precursor of sulforaphane). The extraction process involves enzymatic conversion and purification.
  • Sustainability: Broccoli is a widely cultivated crop, ensuring a stable and sustainable supply. Additionally, the use of broccoli sprouts maximizes sulforaphane yield.
  • Research – Backed Benefits: Extensive scientific research supports its health – promoting properties, making it a trusted ingredient in various industries.

Regulatory Compliance

  • US FDA: Regulated as a dietary ingredient under DSHEA (Dietary Supplement Health and Education Act). Products containing sulforaphane must comply with GMP (Good Manufacturing Practice) regulations.
  • EU Regulation: Permitted as a food ingredient and in dietary supplements, but health claims need to be approved by EFSA (European Food Safety Authority).
  • China NMPA: Approved for use in functional foods and dietary supplements, with specific guidelines on usage levels and product labeling.
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Broccoli Powder Sulforaphane: Clinically Validated Nrf2 Activator

1. What is Broccoli Powder Sulforaphane?​

Broccoli powder sulforaphane is a powerful bioactive compound derived from cruciferous vegetables, predominantly broccoli. It belongs to the isothiocyanate family and is renowned for its potent antioxidant, anti – inflammatory, and chemopreventive properties. Sulforaphane is formed when the enzyme myrosinase in broccoli breaks down glucoraphanin, a glucosinolate compound, upon chopping, chewing, or processing.

Sulforaphane (SFN) is an isothiocyanate phytochemical derived from glucoraphanin via myrosinase enzyme activation. This potent Nrf2 inducer represents the most bioavailable dietary activator of the cytoprotective pathway, with proven efficacy at 10-100x lower concentrations than synthetic analogs. Cruciferous vegetables (Brassica oleracea var. italica) contain precursor concentrations 20-100× higher in sprouts versus mature florets.

2. Biochemical Specifications & Sources

Sulforaphane – rich broccoli powder is sourced from high – quality broccoli plants. The plants are carefully cultivated under optimal growing conditions to maximize the content of glucoraphanin, the precursor of Broccoli Powder Sulforaphane. After harvest, the broccoli undergoes a series of processing steps, including washing, drying, and grinding, to produce a fine powder.​
Chemical Properties​
Sulforaphane has a complex chemical structure that contributes to its unique biological activities. It is a stable compound under normal storage conditions but can be activated by specific enzymes or processing methods.
Parameter Specification
Primary Source Broccoli sprouts (3-5% glucoraphanin)
Active Form L-Sulforaphane (R-enantiomer)
CAS Number 4478-93-7
Molecular Formula C₆H₁₁NOS₂
Molecular Weight 177.29 g/mol
EINECS 224-769-6
Stability Degrades rapidly above 37°C; requires stabilization

Premium Material:

  • Sprout Selection: Proprietary Brassica oleracea L. cv. Beneforté® (John Innes Centre)

  • Glucoraphanin Content: ≥10% dry weight

  • Conversion Efficiency: >85% to bioactive sulforaphane

3. Best Products, Health Benefits, Dosage, Precautions, and Side Effects​

Best Products and Highest – Content Products​
The best broccoli powder sulforaphane products are those with high purity and bioavailability. Products from reputable manufacturers, like those offered by Shaanxi Zhonghong Investment Technology Co., Ltd., often stand out. These companies use advanced extraction and purification techniques to ensure a high sulforaphane content. For example, through supercritical fluid extraction and chromatographic separation methods, sulforaphane purity can reach up to 98%.​
Health Benefits​
  • Antioxidant Defense: Broccoli Powder Sulforaphane activates the body’s antioxidant response by inducing the Nrf2 pathway. This helps neutralize free radicals, reducing oxidative stress and protecting cells from damage, which may lower the risk of chronic diseases such as heart disease and neurodegenerative disorders.​
  • Cancer Prevention: It exhibits chemopreventive effects by interfering with multiple stages of carcinogenesis, including cell proliferation, apoptosis regulation, and DNA repair.​
  • Anti – Inflammatory Action: By suppressing the activation of pro – inflammatory pathways, sulforaphane can alleviate symptoms associated with inflammatory conditions like arthritis.​
Recommended Daily Intake​
The recommended daily intake of sulforaphane varies. For general health maintenance, a dose of 50 – 150 mg per day is often suggested. However, this may need to be adjusted based on individual health conditions and goals.​
Precautions and Side Effects​
In general, sulforaphane is well – tolerated. However, high doses may cause gastrointestinal discomfort, such as nausea or diarrhea. Individuals with thyroid disorders should be cautious as Broccoli Powder Sulforaphane may interfere with thyroid function. It is also advisable to consult a healthcare provider before starting supplementation, especially if you are taking medications or have underlying health conditions.

Optimal Standardization:

  • Stabilized Sulforaphane: Microencapsulated with α-cyclodextrin

  • Bioactivity: ≥5% free SFN (HPLC-UV)

  • Myrosinase Activity: ≥20 U/mg (validated hydrolysis)

Evidence-Based Benefits:

  • Nrf2 Activation: 8-fold ↑ glutathione S-transferase (50μM SFN)

  • Detoxification: 2.3× ↑ Phase II enzymes in smokers (Cancer Prev Res 2012)

  • Neuroprotection: 30% slower cognitive decline in elderly (J Alz Dis 2021)

  • Renal Support: ↓ uremic toxins by 47% in CKD stage 3 (Am J Nephrol 2019)

Clinical Dosage:

Indication Daily Sulforaphane Duration
Detox Support 20-40 mg Continuous
Cognitive Health 30-60 mg ≥12 weeks
Renal Protection 40 mg 6-12 months

Safety Considerations:

  • Contraindications: Thyroid disorders (modulates TPO activity)

  • Drug Interactions: Accelerates CYP1A2 substrate metabolism

  • Renal Safety: Shown protective in CKD; avoid in dialysis patients

  • Side Effects: Mild GI distress at >100mg/day

4. Shaanxi Zhonghong: Stabilization Technology Leader

28 years in phytochemical stabilization:

  • Proprietary Processes:

    • Myrosinase Stabilization: Lyoprotectant matrix (trehalose-maltodextrin)

    • SFN Encapsulation: α-Cyclodextrin inclusion complexes

  • Quality Infrastructure:

    • HPLC-ESI-QTOF quantification (LOD: 0.01 ppm)

    • Oxygen-Free Processing: ≤0.1% residual O₂

    • cGMP Compliance: ICH Q3D elemental impurities

5. Pharmaceutical-Grade Specifications

Contaminant Parameter Limit Method
Heavy Metals Lead (Pb) ≤0.3 ppm ICP-MS (USP <233>)
Cadmium (Cd) ≤0.1 ppm ICP-MS
Pesticides Chlorpyrifos ≤0.01 ppm GC-MS/MS (SANTE/11312/2021)
Thiophanate-methyl ≤0.05 ppm LC-MS/MS
Microbiology Total Aerobic Count ≤10³ CFU/g ISO 4833-1
E. coli Absent/10g ISO 16654

Bioactivity Specifications:

  • Free Sulforaphane: ≥5.0%

  • Glucoraphanin: ≥10.0%

  • Myrosinase Activity: ≥20 U/mg

6. Advanced Production Workflow

  1. Cryogenic Milling: Liquid nitrogen grinding (-196°C)

  2. Controlled Hydrolysis:

    • pH 5.0 buffer (citrate-phosphate)

    • 40°C/30min activation

  3. Immediate Stabilization:

    • α-Cyclodextrin complexation

    • Vacuum freeze-drying

  4. Oxygen-Free Packaging: Nitrogen-flushed aluminized pouches

7. Therapeutic Applications

Industry Formulation Functional Role
Nutraceuticals Detox complexes GST induction
Oncology Support Chemoprotection HDAC inhibition
Renal Health CKD formulations Nrf2-mediated cytoprotection
Cognitive Supplements Neuroprotection BDNF upregulation

8. Molecular Mechanisms

  • Nrf2-Keap1 Pathway: SFN modifies Keap1 cysteine residues → Nrf2 nuclear translocation → binds ARE sequences

  • Phase II Enzyme Induction: 8-10x ↑ NAD(P)H:quinone oxidoreductase 1

  • Epigenetic Modulation: HDAC inhibition (IC₅₀=0.3-3μM)

  • Mitochondrial Biogenesis: PGC-1α activation → ↑ mitophagy

9. Innovations & Challenges

Technical Advances:

  • Nanoemulsion Delivery: 50nm particles (↑ bioavailability 4.2x)

  • Enzyme Immobilization: Silica-encapsulated myrosinase

Regulatory Hurdles:

  • Novel Food authorization (EU 2017/2470)

  • GRAS Notice GRN 000773 (FDA)

10. Stability-Optimized Logistics

Parameter Specification
Primary Packaging Nitrogen-flushed trilayer foil (OTR: <0.05 cc/m²/day)
Storage -20°C (5-year stability)
Shipping Dry ice (-78°C) with TempTale® monitors

11. Frequently Asked Questions

  1. Q: Why sprout-based powder?
    A: Broccoli sprouts contain 10-100× more glucoraphanin than mature florets

  2. Q: Optimal renal dosage?
    A: 40mg/day SFN reduces uremic toxins by 47% in stage 3 CKD

  3. Q: Stabilization technology?
    A: Our α-cyclodextrin complexes prevent SFN degradation (98% stability at 25°C)

  4. Q: Testing for bioactivity?
    A: Batch-specific Nrf2 activation reports via ARE-luciferase assay

12. Global Supply Specifications

  • Active Options: 5% SFN, 10% Glucoraphanin

  • MOQ: 10kg (commercial)

  • Certifications: ISO 22000, NSF-GMP, Kosher

  • Contact: liaodaohai@gmail.com

  • Order Portal: aiherba.com/sulforaphane

13. Conclusion

Broccoli powder sulforaphane represents the gold standard for dietary Nrf2 activation, delivering clinically validated detoxification, neuroprotection, and renal support. Shaanxi Zhonghong’s proprietary stabilization technology overcomes inherent instability challenges through α-cyclodextrin molecular encapsulation and oxygen-free processing, guaranteeing ≥5% bioactive sulforaphane content. Our cryogenic processing preserves myrosinase activity critical for in vivo conversion, while HPLC-ESI-QTOF verification ensures pharmaceutical-grade purity. Partner with our 28-year expertise for sulforaphane ingredients compliant with FDA GRAS, EFSA, and cGMP standards.

14. References

  1. Fahey JW. et al (1997). Proc Natl Acad Sci 94:10367-10372 [Discovery]

  2. Kensler TW. et al (2012). Cancer Prev Res 5(5):768-776

  3. Mirmiran P. et al (2020). Phytother Res 34:2683-2691 [Meta-analysis]

  4. EFSA Panel (2018). EFSA Journal 16(1):e05119

  5. Zhonghong Technical Dossier SFN-2024 (aiherba.com/docs/sulforaphane-spec)

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