Cosmetics and Personal Care, Functional Foods, Healthcare & Pharmaceutical Ingredients, Natural plant extracts

Triterpenoids

Product Overview
English Name: Triterpenoids
Source: Triterpenoids are a large class of natural compounds found in various plants, fungi, and some animals. They are synthesized through the mevalonate pathway in living organisms. Common sources include plants like ginseng, licorice, and fungi such as Poria cocos.
Specification:Purity: Total Triterpenoids ≥ 95% (HPLC – tested). The extraction process depends on the source material. For plant – derived triterpenoids, methods like solvent extraction (using ethanol, methanol, etc.) are often employed, followed by purification through chromatography techniques (e.g., silica gel column chromatography, high – performance liquid chromatography). Stringent quality control measures are in place to limit heavy metals, pesticides, and microbial contaminants, ensuring compliance with international standards for different applications.
Appearance:Triterpenoids typically appear as white to off – white powders or colorless to pale – yellow crystals. They may have a faint, characteristic odor depending on the source. The powder or crystals are free – flowing, making them suitable for incorporation into different products.
CAS Number:Since triterpenoids are a class of compounds, there is no single CAS number. Each individual triterpenoid, such as betulinic acid (CAS NO.: 472 – 15 – 1) or oleanolic acid (CAS NO.: 508 – 02 – 1), has its own unique CAS number for chemical identification, research, and regulatory compliance.
Lead Time:Lead time: 3 – 7 Working Days. Minor adjustments may occur based on order volume and production capacity. Our efficient production and logistics systems are designed to ensure timely delivery. However, factors such as the availability of raw materials (seasonal for some plants) or any production – related issues may slightly impact the lead time.
Package: Usually packaged in 25kg food – grade drums, with 27 drums per tray for convenient transportation. The drums are made of materials that protect the product from moisture, light, and physical damage during storage and transportation. Custom packaging options, such as smaller containers for laboratory use or larger bulk containers for industrial applications, are available upon request.
Main Market: European, North America, Asia etc. In Asia, especially in countries with a strong traditional medicine background, triterpenoids from plants like ginseng have been used for centuries. In Europe and North America, with the growing interest in natural health products, triterpenoids are gaining popularity.
Applications
- Health Supplements:
  - Anti – inflammatory: Many triterpenoids exhibit anti – inflammatory properties. They can inhibit the production of inflammatory mediators like cytokines and prostaglandins in the body. This is beneficial for conditions such as arthritis, where they can reduce joint inflammation and pain, and inflammatory bowel disease, by soothing the inflamed intestinal lining.
  - Antioxidant: Acting as antioxidants, triterpenoids can scavenge free radicals, protecting cells from oxidative damage. This can contribute to overall health and potentially reduce the risk of chronic diseases like heart disease, cancer, and neurodegenerative disorders.
  - Immune System Modulation: Some triterpenoids can modulate the immune system. They may enhance the activity of immune cells such as macrophages, T – lymphocytes, and B – lymphocytes, strengthening the body\’s defense against infections and diseases.
- Cosmetics:
  - Skin Soothing: Their anti – inflammatory nature makes them effective in calming irritated skin. They can reduce redness, itching, and inflammation associated with skin conditions like acne, eczema, and psoriasis.
  - Anti – aging: By protecting skin cells from oxidative stress, triterpenoids help reduce the appearance of fine lines, wrinkles, and age spots. They may also enhance skin elasticity.
- Food Industry:
  - Functional Foods: Triterpenoids can be added to functional foods such as health drinks, energy bars, and fortified snacks. These products can provide consumers with the added health benefits of triterpenoids. However, their use in the food industry is subject to strict regulatory approvals to ensure safety and proper dosage.
  - Natural Preservative: Some triterpenoids may have antibacterial and antifungal properties, which could potentially be used to extend the shelf – life of certain food products. But this application requires further research and regulatory clearance.

Categories: Cosmetics and Personal Care, Functional Foods, Healthcare & Pharmaceutical Ingredients, Natural plant extracts Tags: anti-aging, Anti-inflammatory, Antioxidant, Immune System Boost, Skin soothing

Premium Triterpenoids: Nature’s Bioactive Powerhouses for Health & Innovation

1. Product Introduction

Triterpenoids represent a class of cyclic organic compounds comprising 30 carbon atoms with diverse pharmacological activities. As secondary metabolites predominantly found in medicinal plants and fungi, these compounds exhibit:

Structural diversity: Over 20,000 identified variants including oleanane, ursane, and lupane skeletons
Bioactivity spectrum:
- Cytotoxic (IC50 values as low as 0.8μM against cancer cell lines)
- Anti-inflammatory (COX-2 inhibition up to 92% at 50μg/mL)
- Hypoglycemic (PPARγ activation at EC50 3.2nM)

Our GMP-certified triterpenoid portfolio includes:

Betulinic acid (≥98.5%, White powder)
Oleanolic acid (≥99%, USP grade)
Ursolic acid (≥98%, Kosher certified)
Specialty blends: Custom ratios for synergistic formulations

2. Company Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

Core Differentiators

Competitive Edge	Technical Specification
Academic Network	Joint R&D with CAS, MIT, and ETH Zurich
IP Portfolio	27 patents including nano-encapsulation technologies
Analytical Capability	800MHz NMR with cryoprobe, UPLC-QTOF-MS/MS
Regulatory Compliance	DMF filings for US/EU/JP markets

Production Capacity:

200+ metric tons/year across 15 triterpenoid compounds
Purity benchmarks: Consistently 15-25% above USP/EP monographs

3. Botanical Sources & Sustainable Sourcing

Primary Plant Sources

Triterpenoid	Botanical Source	Yield Optimization
Betulinic acid	Betula platyphylla bark	Supercritical CO₂ extraction (92% recovery)
Asiatic acid	Centella asiatica leaves	Enzyme-assisted extraction (45% yield boost)
Ganoderic acids	Ganoderma lucidum mycelium	Submerged fermentation technology

Sustainability Practices:

Wild-simulated cultivation: 3-year rotation cycles
Blockchain traceability: From soil to final product

4. Clinically Validated Health Benefits

Mechanistic Pharmacodynamics

Compound	Target Pathway	Therapeutic Application
Corosolic acid	GLUT4 translocation	Type II diabetes management
Madecassic acid	TGF-β/Smad signaling	Anti-fibrotic therapy
Glycyrrhetinic acid	11β-HSD2 inhibition	Dermatological formulations

Dosing Guidelines:

Nutraceuticals: 50-500mg/day in divided doses
Topicals: 0.1-5% w/w depending on indication
IV formulations: Strictly for clinical use under supervision

5. Pharmaceutical-Grade Specifications

Comprehensive QC Parameters

Table 1: Triple-Verification Quality Standards

Category	Parameter	Specification	Method
Pesticides	Chlorpyrifos	≤0.01 ppm	GC-MS/MS (EU 396/2005)
	Pyrethroids	≤0.05 ppm	EPA 8081B
Heavy Metals	Pb	≤0.5 ppm	ICP-MS (USP <232>)
	Cd	≤0.2 ppm	GF-AAS
Microbiology	Total aerobic count	≤1000 CFU/g	USP <61>
	Salmonella	Absent in 25g	ISO 6579

6. Advanced Production Workflow

Plant Material Authentication:
- DNA barcoding (ITS2/rbcL markers)
- Microscopic identification
Green Extraction Technologies:
- Subcritical water extraction: 120-180°C, 50 bar
- Ionic liquid-assisted extraction: [BMIM]BF4 system
Purification Cascade:
- Macroporous resin chromatography (HPD-826 resin)
- Preparative HPLC (C30 columns for isomer separation)
Crystallization Control:
- Polymorph screening (Forms I-V characterization)
- Controlled nucleation technology

7. Cutting-Edge Applications

Emerging Market Utilization

Oncology: Betulinic acid-PLGA nanoparticles (Phase II trials)
Cosmeceuticals: Ursolic acid liposomes for transdermal delivery
Veterinary: Oleanolic acid as hepatoprotective in livestock

Formulation Technologies:

Nanoemulsions: 50-200nm particle size for enhanced bioavailability
Cocrystals: With nicotinamide for solubility enhancement

8. Quality Management Ecosystem

Our 360° quality assurance incorporates:

Stability Indicating Methods: Forced degradation per ICH Q1A(R2)
Elemental Impurities: Full suite USP <232>/<233> compliance
Chiral Purity: ≥99% ee by chiral HPLC (Chiralpak IC column)
Residual Solvents: Class 1-3 monitoring per ICH Q3C

Stability Data:

Accelerated conditions: 40°C/75% RH, 6-month stability confirmed
Long-term: 36-month shelf life at -20°C

9. Intelligent Packaging Systems

Format	Packaging Solution	Special Features
Bulk (>10kg)	Nitrogen-flushed aluminum foil bags	Oxygen ingress <0.1% over 24 months
Clinical samples	Amber glass vials with Teflon septa	USP Class VI certified
Transport	Vacuum-insulated shippers	2-8°C maintenance for 120h

10. Research Frontiers & Technical Challenges

Innovation Pipeline

Biocatalytic Modification: P450 engineering for novel derivatives
AI-assisted Discovery: Predicting structure-activity relationships

Technical Hurdles

Oral Bioavailability: Typically <15% for most triterpenoids
Metabolite Identification: Phase II conjugation patterns

11. Expert FAQ

Q: What\’s your MOQ for research samples?
A: 100mg available for academic institutions with COA.

Q: Can you provide customized glycosylation profiles?
A: Yes, we offer β-glucuronidase treated variants upon request.

12. Conclusion

Our GMP-certified triterpenoid platform combines centuries of traditional use with 21st century analytical rigor, delivering standardized bioactive compounds for next-generation therapeutics.

13. Authoritative References

Journal of Natural Products (2023) – Structural diversity review
USP Monographs for Triterpenes (2024)
EMA Assessment Reports on Herbal Substances

Pharmaceutical triterpenoids supplier, GMP-certified plant extracts, bioactive pentacyclic compounds, natural anti-inflammatory ingredients, high-purity ursolic acid

Weight	1000 克
Dimensions	20 × 10 × 10 厘米

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