Beverage addition, Cosmetics and Personal Care, Dietary supplements, Food additives, Healthcare & Pharmaceutical Ingredients

Silybin B

English Name: Silybin B

Specification

Silybin B is a flavonolignan, unrelated to Cocoa Butter. High – quality Silybin B usually has a purity of ≥ 98% (determined by HPLC). It has poor water – solubility, but through modern pharmaceutical technologies like micronization or formulation with cyclodextrins, its solubility can be enhanced, facilitating better bioavailability in various applications.

Appearance

Typically appears as a white to off – white powder, odorless, which makes it suitable for use in a wide range of products without affecting their sensory characteristics.

CAS NO.

64432 – 86 – 0, a unique identification number crucial for regulatory approval, product classification, and scientific studies across different regions.

Lead Time

3 – 7 working days, ensuring fast order processing. This short lead time helps businesses maintain efficient inventory management and promptly meet market demands.

Package

Packaged in 25kg/drum, with 27 drums/tray. This packaging provides excellent protection against moisture, light, and air during transportation and storage, preserving the product’s quality and stability. It also enables easy handling and distribution for large – scale orders.

Main Market

Widely sold in European, North American, Asian markets, and other regions. Its global presence is attributed to its significant therapeutic properties and increasing demand in the pharmaceutical and nutraceutical industries.

Application Scenarios

- Pharmaceutical Industry: Silybin B is a vital component in liver – protecting drugs. It demonstrates strong antioxidant and anti – inflammatory capabilities, effectively protecting liver cells from damage caused by various factors such as chemical toxins, drugs, and oxidative stress. It is used in the treatment of liver diseases including hepatitis, cirrhosis, and liver fibrosis. Moreover, it contributes to the restoration of liver function and is actively involved in research for new liver – targeted medications.

- Nutraceutical Industry: Owing to its liver – health – promoting effects, Silybin B is incorporated into dietary supplements. It helps individuals with risk factors for liver problems, like those with unhealthy diets, excessive alcohol intake, or exposure to environmental pollutants, maintain optimal liver function. Supplements containing Silybin B also support overall health and the body’s natural detoxification processes.

Silybin B, with its specific chemical properties, wide – ranging applications, and efficient supply chain, plays a crucial role in promoting human health and meets the diverse needs of customers globally in the pharmaceutical and nutraceutical sectors.

Categories: Beverage addition, Cosmetics and Personal Care, Dietary supplements, Food additives, Healthcare & Pharmaceutical Ingredients

Describe
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Silybin B: Unveiling the Powerhouse Compound for Health and Wellness

1. What is Silybin B?

Silybin B is a pivotal flavonolignan compound extracted from the seeds of the milk thistle plant (Silybum marianum). As a key constituent of silymarin, a mixture of flavonolignans, Silybin B has drawn significant attention in the scientific and medical communities due to its remarkable bioactive properties. Its intricate chemical structure, characterized by multiple chiral centers and functional groups such as hydroxyls and carbonyls, endows it with potent antioxidant, anti – inflammatory, and hepatoprotective capabilities. These attributes make Silybin B a cornerstone in natural health remedies, particularly in supporting liver function and combatting oxidative stress – related conditions.

2. Product Source, Chemical Properties, and Identification Details

2.1 Product Source

The primary source of Silybin B is the seeds of the milk thistle plant, which has a long – standing history of use in traditional medicine. Modern extraction processes, including solvent extraction, supercritical fluid extraction, and counter – current chromatography, are employed to isolate Silybin B with high purity. These advanced techniques ensure the preservation of the compound’s bioactive properties while minimizing impurities.

2.2 Chemical Properties

CAS Number: [Insert the specific CAS number]. This unique identifier serves as a digital fingerprint, enabling precise identification of Silybin B across various chemical databases and regulatory platforms.

Molecular Formula (MF): [Provide the molecular formula]. The formula elucidates the elemental composition of Silybin B, indicating the types and quantities of atoms within each molecule, which is fundamental for understanding its chemical behavior and reactivity.

Molecular Weight (MW): [Specify the molecular weight]. Calculated by summing the atomic weights of all constituent atoms, the molecular weight influences critical properties such as solubility, bioavailability, and metabolic pathways.

EINECS Number: [Include the EINECS number]. This European Inventory of Existing Commercial Chemical Substances number is crucial for regulatory compliance and classification within the European market, ensuring proper handling and safety protocols are in place.

Silybin B is slightly soluble in water but exhibits better solubility in organic solvents, a characteristic that impacts its formulation in various dietary supplements and pharmaceutical products. Its chemical stability can be affected by factors such as temperature, pH, and exposure to light, necessitating careful storage and handling during production and distribution.

3. Optimal Products, Health Benefits, Dosage, Precautions, and Side Effects

3.1 Best Products and Highest – Content Offerings

Determining the “best” Silybin B product depends on several factors, including purity, bioavailability, and manufacturing standards. Products with a high Silybin B content, typically above 95% purity, are often considered superior as they deliver a more concentrated and potent dose of the active compound. Look for supplements that are standardized to contain a specific amount of Silybin B per serving, ensuring consistent and reliable therapeutic effects. Brands that adhere to Good Manufacturing Practices (GMP) and undergo third – party testing for quality and purity are also preferable.

3.2 Health Benefits

Hepatoprotection: Silybin B is renowned for its exceptional liver – protective properties. It acts by preventing toxins, such as alcohol, drugs, and environmental pollutants, from entering liver cells and by promoting the regeneration of damaged liver tissue. Clinical studies have demonstrated its efficacy in treating liver diseases, including alcoholic liver disease, non – alcoholic fatty liver disease, and viral hepatitis.

Antioxidant Defense: As a powerful antioxidant, Silybin B scavenges free radicals in the body, reducing oxidative stress. This helps protect cells from damage caused by reactive oxygen species, which are implicated in the development of chronic diseases such as cancer, cardiovascular diseases, and neurodegenerative disorders.

Anti – Inflammatory Action: Silybin B modulates the body’s inflammatory response by inhibiting the production of pro – inflammatory cytokines. This property makes it beneficial in managing conditions characterized by chronic inflammation, including autoimmune diseases and certain types of arthritis.

3.3 Dosage

The appropriate daily intake of Silybin B varies depending on individual health status and the intended use. For general liver support, a common dosage range is 100 – 400 mg per day, divided into 2 – 3 doses. In cases of more severe liver conditions, higher dosages may be prescribed under medical supervision. It is advisable to start with a lower dose and gradually increase as needed, while closely monitoring any potential side effects.

3.4 Precautions

Allergic Reactions: Although rare, some individuals may be allergic to Silybin B or components of the milk thistle plant. Symptoms of an allergic reaction may include itching, swelling, rash, or difficulty breathing. If any of these symptoms occur, discontinue use immediately and seek medical attention.

Drug Interactions: Silybin B may interact with certain medications, including anticoagulants, immunosuppressants, and drugs metabolized by the liver’s cytochrome P450 enzyme system. Individuals taking prescription medications should consult their healthcare provider before starting Silybin B supplements to avoid potential interactions.

3.5 Side Effects

Silybin B is generally well – tolerated, but some individuals may experience mild side effects, such as gastrointestinal discomfort (nausea, diarrhea, or bloating), headache, or dizziness. These side effects are usually transient and resolve on their own. If side effects persist or worsen, it is recommended to reduce the dosage or discontinue use.

4. Company Introduction – Shaanxi Zhonghong Investment Technology Co., Ltd.

Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a paragon in the field of natural product research and development. As a high – tech enterprise, it seamlessly integrates agile research and development, collaborative innovation, integrated manufacturing, and global marketing strategies, catering to diverse sectors such as chemistry, materials, and life sciences. The company’s core focus lies in the extraction, separation, purification, and market application of plant – derived active ingredients.

With a commitment to excellence, Shaanxi Zhonghong imports top – quality raw materials from around the globe. Its extensive product portfolio encompasses a wide range of offerings, including natural plant extracts, cosmetic raw materials, medical and health – care ingredients, natural plant pigments, and natural plant sweeteners.

4.1 Scientific Research Prowess

The company has established strategic partnerships with five prestigious universities, jointly operating advanced research laboratories. Boasting over 20 patented technologies and a globally exclusive compound library, Shaanxi Zhonghong remains at the forefront of innovation, continuously developing cutting – edge products with enhanced efficacy and quality.

4.2 State – of – the – Art Equipment

Equipped with international – class detection systems, such as high – performance liquid chromatography (HPLC), ultra – performance liquid chromatography (UPLC), and superconducting nuclear magnetic resonance (NMR) spectrometers, the company’s quality control standards surpass industry averages by 20%. This advanced equipment ensures meticulous analysis and stringent quality assurance at every stage of production.

4.3 Global Reach

With a far – reaching global network spanning more than 80 countries across Asia, Europe, and the Americas, Shaanxi Zhonghong provides customized raw material solutions to multinational pharmaceutical companies and research institutions. Leveraging 28 years of invaluable experience in the bioactive compound industry, the company has earned a reputation for reliability, quality, and innovation.

5. Product Source (Revisited)

As previously mentioned, Silybin B is sourced from the seeds of the milk thistle plant. Shaanxi Zhonghong Investment Technology Co., Ltd. carefully selects premium – quality raw materials and employs state – of – the – art extraction and purification techniques. The company’s rigorous supply chain management system ensures full traceability, from the raw material source to the final product, guaranteeing consistent quality and purity.

6. Health Benefits and Side Effects, Is Nattokinase Good for Kidneys?

6.1 Health Benefits and Side Effects (Recap)

The health benefits of Silybin B, including hepatoprotection, antioxidant activity, and anti – inflammatory effects, have been extensively studied and validated. While side effects are generally mild and infrequent, it is essential to follow recommended dosages and take necessary precautions, especially when combining with other medications.

6.2 Is Nattokinase Good for Kidneys?

Nattokinase, an enzyme derived from natto, a traditional Japanese fermented soybean food, has shown promise in promoting kidney health. Studies suggest that nattokinase may help improve blood circulation, reduce blood pressure, and prevent blood clot formation, all of which are crucial for maintaining optimal kidney function. However, more research is needed to fully understand its long – term effects and potential benefits for kidney health. Individuals with kidney conditions should consult their healthcare provider before taking nattokinase supplements.

7. Usage Guidelines

Recommended Usage: Silybin B supplements are typically taken orally with food to enhance absorption. Follow the dosage instructions provided on the product label or as prescribed by a healthcare professional.

Storage: Store Silybin B products in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children and pets.

8. Precautions (Expanded)

Pregnancy and Lactation: The safety of Silybin B during pregnancy and lactation has not been fully established. Pregnant or breastfeeding women should consult their healthcare provider before using Silybin B supplements.

Medical Conditions: Individuals with pre – existing medical conditions, especially liver or kidney disorders, should seek medical advice before starting Silybin B supplementation.

Alcohol and Drug Use: Avoid consuming alcohol while taking Silybin B, as it may counteract the compound’s liver – protective effects. Additionally, be cautious when combining Silybin B with other drugs, as interactions may occur.

9. Product Specifications

Category	Item Name	指标 (Standard)	检测方法 (Detection Method)
Pesticide Residues	Chlorpyrifos	≤0.01 mg/kg	HPLC – MS/MS
	Dichlorvos	≤0.01 mg/kg	HPLC – MS/MS
	Malathion	≤0.01 mg/kg	HPLC – MS/MS
Heavy Metals	Lead (Pb)	≤1.0 mg/kg	Inductively Coupled Plasma – Mass Spectrometry (ICP – MS)
	Arsenic (As)	≤0.5 mg/kg	ICP – MS
	Cadmium (Cd)	≤0.3 mg/kg	ICP – MS
	Mercury (Hg)	≤0.1 mg/kg	Cold Vapor Atomic Absorption Spectrometry (CV – AAS)
Microorganisms	Total Aerobic Microbial Count	≤1000 CFU/g	Plate Count Method
	Yeast and Mold Count	≤100 CFU/g	Plate Count Method
	Escherichia coli	Negative/25 g	Cultural Method
	Salmonella	Negative/25 g	Cultural Method

10. Production Process

The production of Silybin B involves several intricate steps:

Raw Material Selection: High – quality milk thistle seeds are carefully sourced and undergo strict quality inspection to ensure they meet the company’s high standards.

Extraction: The seeds are subjected to extraction using suitable solvents or supercritical fluid extraction methods to isolate the silymarin mixture, which contains Silybin B.

Separation and Purification: Advanced chromatography techniques, such as column chromatography and preparative HPLC, are employed to separate and purify Silybin B from the silymarin mixture, achieving high – purity levels.

Formulation: The purified Silybin B is formulated into various products, such as capsules, tablets, or powders, depending on the intended application.

Quality Control: Each batch of products undergoes rigorous quality testing, including analysis of purity, potency, and the absence of contaminants, to ensure compliance with international standards.

11. Application Scenarios

Dietary Supplements: Silybin B is widely used in dietary supplements aimed at supporting liver health, enhancing antioxidant status, and reducing inflammation.

Pharmaceutical Products: In the pharmaceutical industry, Silybin B – based formulations are being investigated for the treatment of liver diseases and other conditions related to oxidative stress and inflammation.

Cosmetics: Due to its antioxidant and anti – inflammatory properties, Silybin B is incorporated into cosmetics to protect the skin from environmental damage, reduce signs of aging, and soothe irritated skin.

12. Quality Control

Quality control is the cornerstone of Shaanxi Zhonghong Investment Technology Co., Ltd.’s manufacturing processes. From the moment raw materials enter the facility, they are subjected to stringent testing to verify their identity, purity, and quality. The company’s state – of – the – art detection systems, including HPLC, UPLC, and NMR, enable precise analysis of Silybin B content, ensuring that each product meets or exceeds the specified purity standards.

During the production process, in – process quality checks are conducted at multiple stages to monitor critical parameters such as extraction efficiency, purification yield, and formulation consistency. After production, every batch of products undergoes comprehensive testing for purity, potency, heavy metals, pesticide residues, and microbial contamination. Only products that pass all quality control tests are released for distribution.

The company also adheres to strict quality management systems, such as ISO 9001 and GMP, to ensure consistency and reliability in its manufacturing operations. Regular internal audits and external certifications further reinforce the company’s commitment to delivering high – quality Silybin B products to customers worldwide.

13. Packaging and Logistics

Silybin B products are packaged in high – quality, air – tight containers to protect the integrity of the compound and prevent degradation. The packaging materials are selected for their barrier properties against moisture, light, and oxygen, ensuring product stability during storage and transportation.

For logistics, Shaanxi Zhonghong Investment Technology Co., Ltd. partners with reliable international shipping carriers to ensure timely and secure delivery of products. Orders are carefully processed and shipped using appropriate shipping methods, depending on the destination, order size, and customer requirements. The company also provides tracking information to customers, allowing them to monitor the progress of their shipments.

14. Health Efficacy and Mechanism Research, Industrial Applications and Technological Innovations, Research Frontiers and Challenges

14.1 Health Efficacy and Mechanism Research

Ongoing research is delving deeper into the molecular mechanisms underlying Silybin B’s health benefits. Scientists are exploring how Silybin B interacts with specific cellular pathways, such as the nuclear factor – erythroid 2 – related factor 2 (Nrf2) pathway, to activate antioxidant and detoxification enzymes. Understanding these mechanisms can lead to the development of more targeted and effective Silybin B – based therapies.

14.2 Industrial Applications and Technological Innovations

In the industrial realm, continuous technological advancements are being made to improve the extraction, purification, and formulation of Silybin B. Novel extraction techniques, such as microwave – assisted extraction and enzyme – assisted extraction, are being explored to enhance extraction efficiency and product quality. Additionally, innovative formulation strategies, such as nanoencapsulation and solid – dispersion technologies, are being developed to improve the bioavailability of Silybin B.

14.3 Research Frontiers and Challenges

One of the major frontiers in Silybin B research is the development of more bioavailable formulations. Despite its numerous health benefits, Silybin B has limited solubility and oral bioavailability, which restricts its therapeutic potential. Overcoming this challenge requires interdisciplinary research efforts, combining knowledge from chemistry, pharmacology, and materials science. Another challenge is the standardization of Silybin B products across different manufacturers to ensure consistent quality and efficacy.

15. FAQ

Q: Can I take Silybin B with other supplements?

A: It is advisable to consult a healthcare provider before combining Silybin B with other supplements, as potential interactions may occur.

Q: How long does it take to see the effects of Silybin B?

A: The time to experience the effects of Silybin B varies depending on individual factors and the condition being treated. Some people may notice improvements within a few weeks, while others may require longer – term use.

Q: Is Silybin B suitable for vegetarians and vegans?

A: Most Silybin B supplements are derived from plant sources and are suitable for vegetarians and vegans. However, it is always best to check the product label for specific information.

16. Where to Purchase?

Interested in purchasing high – quality Silybin B products? You can contact us at liaodaohai@gmail.com or visit our website at aiherba.com. Our team is ready to assist you with product inquiries, orders, and any other questions you may have.

17. Conclusion

Silybin B is a remarkable compound with a wide range of health benefits, particularly in liver protection, antioxidant defense, and anti – inflammation. Shaanxi Zhonghong Investment Technology Co., Ltd., with its extensive research capabilities, advanced manufacturing facilities, and global reach, is a trusted provider of high – quality Silybin B products. Whether you are looking to support your liver health, boost your antioxidant status, or explore the potential of natural remedies, Silybin B offers a promising solution. As research continues to uncover new insights into its properties and applications, the future of Silybin B in health and wellness looks bright.

18. Reference Materials

1.Kim, N. C., et al. (2003). Journal of Natural Products, 66(9), 1171–1174.

2.Abenavoli, L., et al. (2010). Phytotherapy Research, 24(10), 1423–1432.

3.Křen, V., et al. (2000). Journal of Chromatography B, 739(1), 187–197.

4.European Pharmacopoeia (EP 11.0): The content of Silybin A+B in silymarin extract is ≥ 40% (calculated as isomer mixture).

5.United States Pharmacopoeia (USP-NF): Silymarin standard contains Silybin A/B, Isosilybin A/B and other ingredients.

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