Functional Foods, Cosmetics and Personal Care, Health Products

Ergothioneine

1、English Name: Ergothioneine，l-ergothioneine

2、Specification: Ergothioneine ≥ 98% (HPLC)

3、Appearance: White to off-white crystalline powder, odorless

4、CAS NO.: 52-42-6

5、Lead time: 3-7 Working Days

6、Package: 25kg/drum, 27 drums/tray

7、Main Market: European, North America, Asia etc.

8、Application Scenarios

Health Supplements:

Powerful Antioxidant Defense: As a unique, naturally occurring antioxidant, ergothioneine selectively accumulates in cells to protect them from oxidative stress. It is added to capsules, tablets, and liquid supplements to support overall health, reduce the risk of chronic diseases, and slow down cellular aging.

Anti – Inflammatory Support: By regulating the body’s inflammatory response, ergothioneine can help alleviate symptoms associated with inflammatory conditions such as arthritis. It is a key ingredient in supplements targeting joint health and systemic inflammation.

Organ Protection: Protects vital organs like the liver and kidneys from damage caused by toxins and free radicals. Supplements containing ergothioneine are beneficial for individuals exposed to environmental pollutants or those recovering from organ – related health issues.

Cosmetics:

Anti – Aging Skincare: Ergothioneine’s antioxidant properties combat free radicals, reducing the appearance of fine lines, wrinkles, and age spots. It is incorporated into high – end creams, serums, and masks to promote skin rejuvenation and maintain a youthful complexion.

Skin Protection: Guards the skin against UV – induced damage and environmental stressors. Ideal for use in sunscreen products and daily skincare routines to enhance skin resilience and prevent premature aging.

Skin Brightening: Helps inhibit melanin production, leading to a more even skin tone. Often included in skin – lightening and brightening formulations.

Food Industry:

Nutritional Fortification: Added to functional foods such as energy bars, yogurt, and beverages, ergothioneine enhances the nutritional value of products. It appeals to health – conscious consumers looking for natural ingredients with antioxidant benefits.

Natural Preservative: Its antioxidant activity can extend the shelf life of certain food products by preventing oxidation and spoilage, offering a natural alternative to synthetic preservatives.

Pharmaceuticals:

Therapeutic Applications: Research is exploring ergothioneine’s potential in treating neurodegenerative diseases, cardiovascular disorders, and cancer. Its ability to protect cells and modulate inflammation makes it a promising candidate for drug development.

Drug Delivery Enhancement: The unique properties of ergothioneine may be utilized to improve the stability and bioavailability of pharmaceutical formulations, enhancing drug delivery and treatment efficacy.

Categories: Functional Foods, Cosmetics and Personal Care, Health Products

Describe
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Ergothioneine: The Essential Antioxidant for Cellular Longevity

1. What Is Ergothioneine?

Ergothioneine (EGT) is a naturally occurring sulfur – containing amino acid with potent antioxidant and anti – inflammatory properties. Discovered in 1909, it acts as a cellular protectant by scavenging reactive oxygen species (ROS) and regulating mitochondrial function. Found in mushrooms, certain grains, and animal tissues, EGT is unique for its ability to cross the blood – brain barrier and accumulate in metabolically active tissues, making it a key ingredient in advanced nutraceuticals and pharmaceuticals.

2. Product Origin & Chemical Properties

2.1 Source

Ergothioneine is primarily extracted from mushroom mycelium (Agaricus bisporus) using our proprietary fermentation and purification technology. We source non – GMO fungal strains and employ sustainable cultivation methods to ensure consistent, high – yield production.

2.2 Chemical Profile

CAS Number: 497 – 30 – 3

Molecular Formula (MF): C₉H₁₄N₂O₂S

Molecular Weight (MW): 226.3 g/mol

EINECS: 207 – 847 – 9

Physical State: White crystalline powder

Solubility: Soluble in water (50 mg/mL), slightly soluble in ethanol

3. Company Profile: Shaanxi Zhonghong Investment Technology Co., Ltd.

With 28 years of bioactive compound expertise, we specialize in:

R&D Leadership: 5 university partnerships, 20+ patents, and a global compound library for innovative EGT formulations.

Technical Excellence: HPLC/NMR – based quality control ensuring purity ≥ 99%, 20% above industry standards.

Global Reach: Serving 80+ countries with GMP – compliant EGT for pharma, nutraceutical, and cosmetic industries.

4. Health Benefits & Mechanisms of Action

4.1 Key Health Advantages

4.1.1 Oxidative Stress Defense

Nrf2 Pathway Activation: Upregulates antioxidant enzymes (SOD, catalase) and glutathione synthesis, protecting cells from ROS – induced damage linked to aging and degenerative diseases.

Mitochondrial Protection: Maintains mitochondrial membrane integrity, enhancing energy production and reducing oxidative damage in high – energy tissues (brain, kidneys, liver).

4.1.2 Inflammation Regulation

Inhibits NF – κB pathway, reducing pro – inflammatory cytokines (IL – 6, TNF – α), beneficial for arthritis, cardiovascular health, and metabolic syndrome.

4.1.3 Neuroprotection

Crosses blood – brain barrier to protect neurons from amyloid β and α – synuclein aggregation, studied for Alzheimer’s and Parkinson’s disease prevention.

4.1.4 Immune Support

Enhances immune cell function (T cells, macrophages), improving resistance to infections and modulating autoimmune responses.

4.2 Optimal Dosage & Bioavailability

Daily Intake: 50–200 mg for general health; clinical trials use up to 500 mg for age – related conditions.

Best Form: Fermented mushroom extracts offer 95%+ bioavailability, superior to food sources due to standardized extraction.

5. Usage Guidelines & Precautions

5.1 Recommended Use

Dietary Supplements: 50–100 mg capsules/tablets daily, preferably with food.

Cosmetics: 0.5%–1% in serums/creams for anti – aging and UV protection.

Pharmaceuticals: Custom APIs for clinical trials (GMP – certified, contact for COA).

5.2 Safety Considerations

Contraindications: Avoid with sulfite allergies; consult physicians if pregnant or on immunosuppressants.

Side Effects: Rare gastrointestinal discomfort at > 500 mg/day; no reported toxicity in clinical studies.

6. Product Specifications

Category	Test Items	Standards	Detection Methods
Pesticide Residues	Chlorpyrifos	< 0.01 ppm	GC – MS
	Carbendazim	< 0.05 ppm	HPLC – MS/MS
Heavy Metals	Lead (Pb)	< 0.5 ppm	ICP – MS
	Mercury (Hg)	< 0.01 ppm	CVAAS
Microbial Safety	Total Viable Count	< 100 CFU/g	Microbiological plating
	Pathogens (E. coli/Salmonella)	Absent	PCR – based detection

7. Production Process

Fungal Cultivation: Controlled fermentation of Agaricus bisporus mycelium for 14 days to maximize EGT biosynthesis.

Extraction: Hot – water extraction followed by ethanol precipitation to isolate EGT – rich fractions.

Chromatographic Purification: Preparative HPLC to achieve ≥ 99% purity, verified by NMR and mass spectrometry.

Formulation: Micro – encapsulated powder (10–40 μm) for enhanced stability and bioavailability.

8. Industrial Applications

8.1 Pharmaceuticals

Neurodegenerative Disease Trials: Investigated as an adjunct for Alzheimer’s and Parkinson’s disease.

Antioxidant Therapies: Used in eye care products for cataracts and age – related macular degeneration.

8.2 Nutraceuticals

Aging Support Supplements: Combined with coenzyme Q10 and resveratrol for mitochondrial health.

Sports Nutrition: Reduces exercise – induced oxidative stress and muscle damage.

8.3 Cosmetics

Anti – Aging Formulations: Promotes collagen synthesis and protects against UVB – induced skin damage.

Hair Care: Strengthens follicles and reduces oxidative stress – related hair loss.

9. Quality Control

Our ISO 9001/GMP – compliant facility ensures strict quality control:

Raw Material Testing: DNA sequencing for fungal strain authentication; HPLC to quantify EGT precursor levels.

Process Monitoring: Real – time HPLC for extraction yield (target ≥ 1.2% EGT in mycelium) and purity tracking.

Final Product Analysis: Multivariate testing for chemical composition (NMR), microbial safety (PCR), and heavy metals (ICP – MS).

Traceability: Blockchain – recorded data from fermentation to packaging, compliant with FDA, EFSA, and NSF standards.

10. Research Frontiers & Innovations

10.1 Technological Advancements

Nanoencapsulation: Liposomal EGT boosts bioavailability by 40%, enabling targeted delivery to mitochondria.

Synthetic Biology: Engineered yeast strains for cost – efficient, large – scale EGT production.

10.2 Challenges

Stability: Oxygen sensitivity requires airtight, nitrogen – flushed packaging (store at < 20°C).

Regulatory Approval: Ongoing clinical trials to establish disease – specific health claims (e.g., immune support).

11. Packaging & Logistics

Packaging: Food – grade aluminum foil bags (1 kg), fiber drums (25 kg); custom sizes for bulk orders.

Storage: Cool, dry place away from light; shelf life of 36 months under recommended conditions.

Delivery: Global shipping via DHL/FedEx (samples in 3 days, bulk orders in 7–15 days).

12. FAQ

12.1 Where to Purchase?

Inquiries: liaodaohai@gmail.com

Website: aiherba.com

Documentation: COA, MSDS, and GRAS notices available upon request.

12.2 Is Ergothioneine Vegan?

Yes; our EGT is derived from fungal fermentation, free of animal by – products.

12.3 Can It Be Taken with Other Antioxidants?

Synergizes with vitamin C, vitamin E, and glutathione; no known negative interactions.

13. Conclusion

Ergothioneine (EGT) is a naturally occurring, potent antioxidant with remarkable benefits for longevity, neuroprotection, and immune health. Scientific research highlights its unique ability to combat oxidative stress, reduce inflammation, and support mitochondrial function, making it a key player in anti-aging and disease prevention.

Why Ergothioneine Stands Out:

✅ Powerful Antioxidant – Unlike other antioxidants, EGT has superior cellular uptake, protecting DNA and mitochondria from damage.
✅ Brain Health Booster – Studies suggest EGT may help prevent neurodegenerative diseases like Alzheimer’s and Parkinson’s.
✅ Immune & Anti-Inflammatory Support – Regulates immune response and may lower chronic disease risks.
✅ Natural Sources – Found in mushrooms (shiitake, porcini), oats, and certain meats, or available as a supplement.

14. References

Grünewald, T. et al. (2007). FASEB Journal. 21: 3440–3449.

McNaught, K. S. et al. (2007). Antioxid Redox Signal. 9: 1771–1782.

United States Pharmacopeia (USP) 41 – NF 36 (2018).

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