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イソステビオール

Isosteviol Product Introduction

  1. 英語名: Isosteviol
  1. 仕様
    • 純度: Isosteviol ≥ 98% (HPLC); High – purity grade: ≥ 99% (HPLC)
    • 溶解度: Sparingly soluble in water (approx. 0.1 g/L at 25°C), soluble in organic solvents such as ethanol, acetone, and chloroform
    • 融点: 198 – 202°C
    • 残留溶媒: Ethanol ≤ 0.5%, Acetone ≤ 0.5%
    • 重金属: ≤ 10 ppm
    • 粒子サイズ: Standard powder ≤ 100 μm; micronized powder ≤ 5 μm for better reactivity
  1. 外観
    • White to off – white crystalline powder, odorless
  1. CAS番号：7979-62-4
  1. リードタイム: 5～7営業日
  1. パッケージ
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. メインマーケット: Global market, with significant demand in Asia (China, Japan, South Korea), North America, and Europe, especially in the food, pharmaceutical, and chemical industries
  1. アプリケーションシナリオ

コアプロパティ

  • 分子式: C₂₀H₂₈O₃
  • 化学構造: A diterpenoid compound, derived from the hydrolysis and isomerization of steviol, featuring a complex ring structure with a carboxylic acid group and hydroxyl groups
  • 主な特徴
    • Versatile Chemical Intermediate: Serves as a crucial building block for the synthesis of various bioactive compounds and industrial chemicals.
    • 安定性: Stable under normal storage conditions away from heat, light, and strong oxidizing agents.
    • 生体適合性: Generally low toxicity, making it suitable for applications in the food and pharmaceutical sectors with proper processing.
    • Modifiable Structure: Functional groups can be easily modified through chemical reactions, enabling the creation of derivatives with tailored properties.

アプリケーションシナリオ

1. 食品・飲料業界

  • Sweetener Synthesis:
    • As a precursor for the production of high – intensity sweeteners. Isosteviol can be chemically modified to create sweeter derivatives with improved taste profiles, aiming to replace or supplement traditional stevia – based sweeteners.
  • Flavor and Fragrance Enhancement:
    • Some of its derivatives are used to enhance the flavor and aroma of food products, providing unique sensory experiences. For example, certain esters of isosteviol can impart pleasant, natural – like flavors.

2. 製薬業界

  • Drug Synthesis:
    • Serves as an intermediate in the synthesis of anti – inflammatory, antioxidant, and antidiabetic drugs. Its chemical structure can be modified to create compounds with specific pharmacological activities. For instance, isosteviol – based derivatives are being investigated for their potential in treating metabolic disorders.
  • Biomedical Research:
    • Used in research laboratories as a reference compound or starting material for the development of new drug delivery systems. Its biocompatibility allows for the exploration of novel carrier molecules for targeted drug delivery.

3. 化粧品・パーソナルケア

  • Anti – aging Formulations:
    • Incorporated into creams, serums, and lotions (0.5 – 2% concentration) due to its potential antioxidant and anti – inflammatory properties. It may help protect the skin from oxidative stress and reduce the signs of aging, such as wrinkles and fine lines.
  • Hair Care Products:
    • Added to shampoos and conditioners to improve hair texture, strength, and manageability. Some derivatives of isosteviol can act as conditioning agents, reducing static and enhancing shine.

4. Chemical Industry

  • Polymer Synthesis:
    • Utilized as a monomer or cross – linking agent in the production of biodegradable polymers. Isosteviol – based polymers have potential applications in packaging materials, where their biodegradability offers an environmentally friendly alternative.
  • Surfactant Production:
    • Its derivatives can be used to create surfactants with unique surface – active properties. These surfactants find applications in various industries, including detergents, emulsifiers, and wetting agents.

検出方法

  • 高速液体クロマトグラフィー（HPLC）:
    • Column: C18 (250 × 4.6 mm, 5 μm), Mobile Phase: Acetonitrile – water (gradient elution), Flow Rate: 1.0 mL/min, Detection Wavelength: 210 nm for quantification.
  • ガスクロマトグラフィー – 質量分析法（GC – MS）:
    • Used for the identification and quantification of isosteviol in complex mixtures, especially when analyzing volatile derivatives. GC – MS provides detailed information about the molecular structure and impurities.
  • フーリエ変換赤外分光法（FTIR）:
    • Helps in confirming the chemical structure of isosteviol by analyzing the characteristic absorption peaks of its functional groups. It is a quick and effective method for quality control and product identification.

出典と利点

  • 天然源: Derived from stevia leaves, a renewable plant resource. The extraction process involves isolation from steviol, which is further processed to obtain isosteviol.
  • Sustainable Chemistry: Enables the development of green and sustainable chemical processes, especially in the production of biodegradable materials and natural – based products.
  • Economic Potential: As a valuable intermediate, it offers opportunities for the creation of high – value – added products, driving innovation in multiple industries.

規制コンプライアンス

  • 米国FDA: For food and pharmaceutical applications, products containing isosteviol must comply with relevant regulations. As a food additive precursor, it needs to meet safety standards set by the FDA.
  • EU Regulation: Regulated under REACH (Registration, Evaluation, Authorization, and Restriction of Chemicals) for industrial applications. In the food and cosmetic sectors, it must adhere to specific EU directives regarding safety and labeling.
  • 中国NMPA: Approved for use in certain industrial and consumer products, with strict quality control and safety requirements in place to ensure compliance with national standards.
カテゴリ： , , , ,

Unlocking the Potential of Isosteviol: Nature’s Zero-Calorie Sweetener Powerhouse

1. What is Isosteviol?

Isosteviol is a diterpenoid carboxylic acid derived from its precursor, steviol glycosides, the intensely sweet compounds found in the leaves of the ステビア・レバウディアナ Bertoni plant. Through a specific acid hydrolysis process, the glucose moieties of stevioside are cleaved off, yielding isosteviol. Unlike its parent glycosides, isosteviol itself is non-caloric but possesses only mild sweetness. Its significance lies primarily in its role as a key metabolic intermediate and, increasingly, in its own distinct and promising bioactive properties, making it a compound of significant interest in food science, nutraceuticals, and pharmaceutical research.

2. 製品の供給元、化学的性質および識別情報

  • ソース： Synthesized via chemical modification (hydrolysis) of steviol glycosides extracted from ステビア・レバウディアナ leaves.

  • 化学的性質:

    • Chemical Name: ent-16-Ketobeyeran-19-oic acid or 13-Hydroxyent-kaur-16-en-19-oic acid

    • 分子式: C₂₀H₃₀O₃

    • 分子量: 318.45 g/mol

    • 外観： Typically a fine, white to off-white crystalline powder.

    • 溶解度: Exhibits lipophilic characteristics, soluble in organic solvents like ethanol, methanol, chloroform, and dimethyl sulfoxide (DMSO), but exhibits low solubility in water.

    • 安定性： Chemically stable under typical storage conditions. Resistant to heat and pH changes encountered in food processing.

  • Key Identifiers:

    • CAS登録番号: 471-80-7

    • EC番号（EINECS）： 207-442-5

    • MF: C₂₀H₃₀O₃

    • MW: 318.45

3. Benefits, Purity, Dosage & Safety Considerations

  • “Best” & Highest Purity: The “best” isosteviol prioritizes exceptional purity (>98%), rigorous absence of residual solvents、 そして undetectable levels of contaminants (heavy metals, pesticides, microbes). Reputable suppliers like Shaanxi Zhonghong Investment Technology Co., Ltd. achieve this through proprietary purification techniques (e.g., multi-stage crystallization, preparative HPLC) exceeding standard industry purity benchmarks.

  • Health Benefits (Emerging Research):

    • Cardiometabolic Health: Shows potential in modulating glucose homeostasis (improving insulin sensitivity), managing 脂質異常症 (reducing triglycerides, LDL), and supporting healthy blood pressure via effects on vascular tone and endothelial function. Acts partly through AMPK活性化 そして PPARγ調節.

    • Anti-inflammatory & Antioxidant: Exhibits significant reactive oxygen species (ROS) scavenging ability and modulates key inflammatory pathways (e.g., NF-κB, MAPK signaling).

    • Renal Protection: Research suggests protective effects against renal fibrosis そして glomerular damage in experimental models, potentially via TGF-β/Smad pathway inhibition そして oxidative stress reduction. (Note: While nattokinase is researched for cardiovascular benefits, its direct impact on kidney health is less established compared to the emerging renal protective data for isosteviol).

    • Neuroprotective Potential: Preliminary studies indicate possible benefits in neurodegenerative conditions by reducing neuroinflammation and oxidative damage.

  • Daily Intake & Usage Guidelines: Currently, no established ADI (Acceptable Daily Intake) exists specifically for isosteviol. Dosing in research varies significantly. Crucially consult a healthcare professional before supplementation. Usage depends heavily on the application (food additive, supplement, research chemical). Follow specific product labeling or research protocols meticulously.

  • 注意事項と副作用:

    • Limited Human Safety Data: Comprehensive long-term human studies are still needed.

    • Potential Drug Interactions: Theoretical interactions exist due to effects on CYP450 enzymes and blood pressure/glucose; caution with antihypertensives, antidiabetics, and anticoagulants.

    • Pregnancy & Lactation: Avoid use due to insufficient safety data.

    • Reported Side Effects: Generally well-tolerated in research, but high doses could potentially cause gastrointestinal discomfort. Allergic reactions are rare but possible.

    • 品質は最優先です: Underscores the necessity of sourcing ultra-pure isosteviol from GMP-compliant manufacturers to minimize contaminant risks.

4. Introducing Shaanxi Zhonghong Investment Technology Co., Ltd.: Your Trusted Isosteviol Partner

Shaanxi Zhonghong Investment Technology Co., Ltd. stands as a premier ハイテク企業 dedicated to excellence in 生理活性化合物 research, development, and manufacturing. We specialize in the advanced 抽出、分離、精製 of potent phytochemicals, serving global markets in nutraceuticals, pharmaceuticals, cosmeceuticals, food additives (natural sweeteners, colors), and research chemicals.

  • Core Competencies & Differentiation:

    • Unmatched Scientific Prowess (The Research Barrier): Strategic academic-industry partnerships with 5 elite universities underpin our innovation. We possess a formidable IP portfolio exceeding 20 patents and maintain a 世界限定の化合物ライブラリ, driving cutting-edge discovery.

    • Analytical Leadership (Equipment Dominance): 私たちの state-of-the-art QC infrastructure features High-Performance Liquid Chromatography (HPLC/UHPLC), Gas Chromatography-Mass Spectrometry (GC-MS), Superconducting Fourier Transform Nuclear Magnetic Resonance (FT-NMR)、 そして 誘導結合プラズマ質量分析法（ICP-MS）. This enables stringent purity verification (>98% standard, exceeding industry norms by 20%) and comprehensive contaminant profiling.

    • Global Supply Chain Excellence: We reliably serve a diverse clientele across 80か国以上 throughout Asia, Europe, and the Americas, providing custom synthesis そして オーダーメイドの原料ソリューション to multinational pharmaceutical corporations, research institutions, and supplement brands.

    • Legacy of Expertise: 活用 28 years of specialized experience in the isolation and application of bioactive natural compounds.

5. Product Specifications: Rigorous Quality Assurance

Contaminant Category パラメータ 仕様限界 試験方法
残留農薬 グリホサート ≤ 0.05 mg/kg LC-MS/MS
クロルピリホス ≤ 0.01 mg/kg GC-MS/MS
シペルメトリン ≤ 0.05 mg/kg GC-ECD
Total Other Pesticides ≤ 0.1 mg/kg (each) Multi-residue Methods (GC/LC)
重金属 鉛（Pb） ≤ 1.0 mg/kg ICP-MS / AAS
ヒ素（As） ≤ 0.5 mg/kg ICP-MS / HG-AAS
カドミウム（Cd） ≤ 0.5 mg/kg ICP-MS / GFAAS
水銀（Hg） ≤ 0.1 mg/kg ICP-MS / CVAAS
微生物学的 総皿数 ≤ 1000 CFU/g USP <61>
酵母とカビ ≤ 100 CFU/g USP <61>
大腸菌 10gで陰性 USP <62>
サルモネラ 属 Negative in 375g USP <62>
黄色ブドウ球菌 1gで陰性 USP <62>
一般的な Isosteviol Purity ≥ 98.0% (HPLC) HPLC-ELSD/UV
乾燥減量 ≤ 2.0% USP <731>
強熱残留物 ≤ 0.2% USP <281>
残留溶媒 Meets ICH Q3C Guidelines GC-FID/HS-GC

6. Advanced Production Process
Our isosteviol production employs a vertically integrated, GMP-compliant workflow:

  1. Sourcing & Authentication: プレミアム ステビア・レバウディアナ leaves undergo botanical verification (macroscopic/microscopic, DNA barcoding).

  2. Primary Extraction: Supercritical CO2 extraction または food-grade solvent extraction yields crude steviol glycosides.

  3. Hydrolysis: Controlled acid-catalyzed hydrolysis selectively cleaves glycosidic bonds, converting stevioside/rebaudioside A to isosteviol.

  4. 精製： Multi-stage liquid-liquid extraction、 に続く activated carbon decolorization そして multi-step fractional crystallization under precise temperature control. Preparative HPLC is employed for ultra-high purity (>99%) batches.

  5. Drying & Milling: Lyophilization (freeze-drying) または vacuum belt drying ensures stability, followed by micronization to desired particle size distribution.

  6. 厳格な品質管理： すべてのバッチは comprehensive analytical profiling against stringent specifications before release.

7. 多様な応用シナリオ

  • 栄養補助食品および栄養補助食品: Formulated in capsules, tablets, softgels, and powders targeting metabolic health, cardiovascular support, antioxidant defense, and anti-aging.

  • 機能性食品・飲料： Incorporated as a non-caloric functional ingredient in health-focused drinks, snacks, and meal replacements, leveraging its bioactivity beyond sweetness.

  • 医薬品研究: A crucial 参照標準, pharmacophore、 そして 鉛化合物 in drug discovery for diabetes, hypertension, inflammation, and neurodegeneration.

  • 化粧品: Explored in topical formulations for アンチエイジング (combating oxidative stress/inflammation) and skin-brightening 効果。

  • Sweetener Intermediate: Key precursor in the synthesis of next-generation steviol glycosides with improved taste profiles.

8. 厳格な品質管理（QC）
Quality is embedded at every stage. Our ISO 9001 and cGMP-aligned QC system mandates:

  • 本人確認: FT-NMR そして HPLC-UV/ELSD fingerprint matching against reference standards.

  • Purity & Potency: HPLC-ELSD/UV quantification of isosteviol content (≥98%), monitoring for related compounds (steviol, steviol glycosides).

  • 汚染物質管理: GC-MS/MS/LC-MS/MS screens for >500 pesticide residues. ICP-MS ensures heavy metals compliance. Microbiological testing (aerobic count, pathogens) follows validated USP/EP methods.

  • 残留溶媒: GC-FID/HS-GC analysis per ICH Q3C guidelines.

  • Physical & Chemical Tests: 乾燥減量（LOD）, Residue on Ignition (Sulfated Ash), pH, 比回転.

  • 安定性研究: Ongoing ICH Q1A(R2) compliant 加速した そして long-term stability studies to define shelf life and storage conditions. ドキュメントとトレーサビリティ: 満杯 Certificate of Analysis (CoA) per batch, adhering to ALCOA+ principles for data integrity.

9. 安全な梱包とグローバル物流

  • パッケージ: 食品グレード double HDPE bags と integrity liners, sealed inside robust, tamper-evident fiber drums (25kg standard). Smaller R&D quantities use glass bottles. Custom packaging (vacuum-sealed, nitrogen-flushed) available.

  • ストレージ： 保管場所 cool, dry place (<25°C), protected from light and moisture. Maintain original sealed packaging.

  • ロジスティクス： Efficient global shipping via air freight, sea freight, or express couriers. Expertise in handling customs clearance そして regulatory documentation for international markets. Cold chain options available.

10. Health Efficacy, Mechanism & Research

  • Mechanism Insights: Isosteviol exerts effects via multiple pathways:

    • AMPK Activation: Enhances glucose uptake, fatty acid oxidation.

    • PPARγ Modulation: Influences adipogenesis, insulin sensitivity, inflammation.

    • K+ Channel Activation (Vascular): Promotes vasodilation, lowering blood pressure.

    • TGF-β1/Smad Pathway Inhibition: Key mechanism in reducing renal fibrosis.

    • NF-κB & MAPK Suppression: Reduces pro-inflammatory cytokine production (TNF-α, IL-6).

    • ROS Scavenging: Direct antioxidant activity and upregulation of endogenous antioxidants (SOD, GSH).

  • 産業応用とイノベーション: Driving innovation in functional sweeteners, metabolic syndrome therapeutics, natural preservatives、 そして cosmeceutical actives. Zhonghong’s patented enzymatic bioconversion そして continuous chromatography technologies enhance yield and purity.

  • 研究の最前線と課題:

    • フロンティア: Exploring isosteviol derivatives for enhanced bioavailability/activity; clinical translation of preclinical benefits; 併用療法.

    • 課題: Establishing human-specific ADI; definitive large-scale human clinical trials; optimizing delivery systems for poor water solubility; navigating complex 世界的な規制環境 (GRAS, Novel Food, etc.).

11. よくある質問（FAQ）

  • Q1: Is Isosteviol the same as Stevia?

    • 答え: No. Stevia refers to the plant or its sweet leaf extracts (steviol glycosides like stevioside, rebaudioside A). Isosteviol is a specific metabolite/derivative produced by chemically modifying those glycosides. It has different properties (mildly sweet/non-sweet, distinct bioactivity).

  • Q2: Is Isosteviol safe?

    • 答え: Existing preclinical and limited human data suggest a good safety profile at researched doses. However, long-term, large-scale human studies are ongoing. Always choose high-purity (>98%) isosteviol from reputable suppliers adhering to GMP and consult your healthcare provider before use, especially if pregnant, breastfeeding, taking medication, or have underlying conditions.

  • Q3: What are the main health benefits of Isosteviol?

    • 答え: Research highlights potential for supporting healthy blood sugar metabolism, cardiovascular function (blood pressure, lipids), reducing inflammation and oxidative stress, and protecting kidney health. More human trials are needed to confirm efficacy for specific conditions.

  • Q4: What is the recommended daily dosage of Isosteviol?

    • 答え: There is no universally established daily intake (ADI). Dosages used in research vary widely. Crucially, consult your doctor or a qualified healthcare practitioner for personalized advice based on your health goals and circumstances. Follow product-specific labeling.

  • Q5: How does Isosteviol compare to Nattokinase for kidney health?

    • 答え: While both are researched for health benefits, their mechanisms differ. Isosteviol shows direct anti-fibrotic and antioxidant effects in kidney tissue in preclinical models, primarily via TGF-β inhibition. Nattokinase is a fibrinolytic enzyme primarily studied for cardiovascular benefits (blood flow, clot prevention); its direct impact on kidney structure/function is less established. Neither replaces medical treatment for kidney disease.

  • Q6: Why choose Zhonghong’s Isosteviol?

    • 答え: Zhonghong delivers ultra-high purity (>98%), industry-leading contaminant control, batch-to-batch consistency, backed by 20+ patents, cutting-edge analytical capabilities (HPLC, NMR, ICP-MS), GMP compliance、 そして 28年間の生理活性化合物の専門知識. We offer customization そして global regulatory support.

12. Where to Buy High-Purity Isosteviol?
Source premium Isosteviol directly from the manufacturer:

  • Webサイト： Explore products and specifications at aiherba.com

  • 接触： Reach our sales team via email: liaodaohai@gmail.com

  • Inquiry: Request a detailed Certificate of Analysis (CoA), MSDS、 そして competitive quotation for your specific needs (bulk, research samples).

13. Conclusion: Isosteviol – A Versatile Bioactive with Significant Promise
Isosteviol, derived from the natural sweetener stevia, transcends its origins as a metabolic intermediate. Its compelling portfolio of bioactivities – spanning cardiometabolic regulation, renoprotection, anti-inflammation, and antioxidant defense – positions it as a highly promising compound for the nutraceutical, functional food, and pharmaceutical industries. While further robust human clinical validation is essential, the existing scientific foundation is strong. The critical factor for efficacy and safety lies in sourcing ultra-pure, meticulously characterized isosteviol. Shaanxi Zhonghong Investment Technology Co., Ltd., with its scientific rigor, advanced purification technology, and unwavering commitment to quality, stands as the premier global partner for unlocking the full potential of this remarkable diterpenoid. Contact us today to discuss your isosteviol requirements.

14. 参考文献

  1. Wang, J., et al. (2014). Isosteviol reduces plasma glucose levels in diabetic Goto-Kakizaki rats by enhancing insulin sensitivity and improving glucose metabolism. European Journal of Pharmacology, 734, 50-55. DOI: 10.1016/j.ejphar.2014.03.036

  2. Liu, J. C., et al. (2010). Antihypertensive effects of isosteviol in spontaneously hypertensive rats. Molecular and Cellular Biochemistry, 340(1-2), 55-60. DOI: 10.1007/s11010-010-0401-1

  3. Mizushina, Y., et al. (2005). Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors. ライフサイエンス, 77(17), 2127-2140. DOI: 10.1016/j.lfs.2005.03.022

  4. Chen, T. H., et al. (2016). Isosteviol protects against endotoxin-induced acute kidney injury by inhibiting NF-κB and MAPK signaling pathways. 農業および食品化学ジャーナル, 64(34), 6669-6677. DOI: 10.1021/acs.jafc.6b02895

  5. International Stevia Council. (2023). Stevia Production & Science. https://internationalsteviacouncil.org/

  6. EFSA Panel on Food Additives and Flavourings (FAF). (2021). Safety of use of steviol glycosides. EFSAジャーナル, 19(1), e06336. DOI: 10.2903/j.efsa.2021.6336

  7. FDA GRAS Notices: GRN No. 252 (Steviol Glycosides), GRN No. 667 (Reb M). https://www.fda.gov/food/gras-notice-inventory

  8. JECFA (Joint FAO/WHO Expert Committee on Food Additives). (2016). Steviol glycosides. WHO Food Additives Series 71. https://apps.who.int/food-additives-contaminants-jecfa-database/

  9. ICH Quality Guidelines (Q1A(R2), Q2(R1), Q3C). https://www.ich.org/page/quality-guidelines

  10. USP-NF General Chapters: <61> Microbiological Examination, <62> Microbiological Procedures, <731> Loss on Drying, <281> Residue on Ignition. https://www.usp.org/

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