バコパモンニエリエキス
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バコパモンニエリエキス

Bacopa monnieri Extract Product Introduction

  1. 英語名: Bacopa monnieri Extract
  1. 仕様:
    • Bacosides ≥ 20%-60% (HPLC), including bacoside A, B, and C
    • Water-soluble powder: Bacosides ≥ 10%-30% (HPLC), with maltodextrin carrier
  1. 外観:
    • Powder: Light brown to tan fine powder, mild herbal odor
    • Liquid: Dark brown viscous extract, soluble in water and ethanol
  1. CAS番号：N/A（complex mixture of bacosides）
  1. リードタイム: 3～7営業日
  1. パッケージ:
    • 25kg/drum (double-layer PE bag inside cardboard drum)
    • 1kg/bag (aluminum foil bag for samples)
  1. メインマーケット: North America, Europe, Asia (India, China, Japan)
  1. アプリケーションシナリオ

コアプロパティ

  • Active Compounds: Bacosides (triterpenoid saponins), flavonoids, and phenolic acids
  • 溶解度: Powder soluble in hot water; liquid soluble in aqueous systems
  • 主な活動: Nootropic, antioxidant, anti-anxiety, neuroprotective

アプリケーションシナリオ

1. 健康サプリメントと栄養補助食品

  • 認知能力の向上:
    • Improves memory, learning ability, and concentration by enhancing synaptic plasticity. Used in nootropic capsules, powders, and tinctures for students, professionals, and aging populations.
  • Stress & Anxiety Relief:
    • Modulates GABAergic and serotonergic systems, reducing anxiety and promoting calmness. Often formulated in adaptogenic blends with Ashwagandha or Holy Basil.
  • Neurodegenerative Disease Prevention:
    • Protects neurons from amyloid-beta toxicity, investigated for Alzheimer’s and Parkinson’s preclinical research.

2. 機能性食品・飲料

  • Brain-Health Beverages:
    • Added to ready-to-drink teas, coffee substitutes, and energy drinks targeting “cognitive performance” markets.
  • 高齢化社会の栄養:
    • Fortifies senior shakes and cereal bars to support memory and mental clarity.
  • Ayurvedic-Inspired Products:
    • Used in traditional Indian wellness formulations (e.g., chyawanprash) for holistic brain health.

3. 医薬品・バイオテクノロジー

  • 臨床研究:
    • Investigated for treating attention-deficit hyperactivity disorder (ADHD), epilepsy, and anxiety disorders.
  • Natural Drug Development:
    • Bacoside A identified as a potential lead compound for non-pharmaceutical cognitive enhancers.

4. 化粧品・パーソナルケア

  • Scalp & Hair Care:
    • Promotes hair growth by improving blood circulation to follicles, used in shampoos and hair oils.
  • Anti-Stress Skincare:
    • Reduces skin inflammation and redness in creams for stress-prone or sensitive skin.

5. 動物衛生と水産養殖

  • 動物用サプリメント:
    • Improves cognitive function in senior pets (dogs, cats) and reduces stress in high-anxiety animals.
  • Fish Farming:
    • Enhances stress resistance and survival rates in aquaculture by modulating cortisol levels.

検出方法

  • 高速液体クロマトグラフィー（HPLC）:
    • Measures bacoside A content using a C18 column (4.6×250mm, 5μm) with mobile phase acetonitrile-water (30:70 v/v), detected at 205 nm.
  • Thin-Layer Chromatography (TLC):
    • Qualitative analysis of bacosides using silica gel plates and ethyl acetate-methanol-water (10:2:1 v/v).
  • Total Saponin Assay:
    • Colorimetric method using vanillin-sulfuric acid reagent, measuring absorbance at 560 nm.

出典と利点

  • 天然源: Extracted from the aerial parts of Bacopa monnieri (water hyssop), a perennial herb native to wetlands in India and Southeast Asia.
  • 持続可能性: Cultivated in organic farms with controlled water usage, supporting fair trade practices.

規制コンプライアンス

  • GRASステータス: Notified as a dietary ingredient in the US under DSHEA.
  • Ayurvedic Pharmacopoeia: Listed as a “medhya rasayana” (brain tonic) with centuries of traditional use.
カテゴリ： , , , , , , ,

Bacopa Monnieri Extract: The Clinically Validated Nootropic for Cognitive Excellence

1. What is Bacopa Monnieri?

Bacopa monnieri (Brahmi), commonly misidentified as  in Chinese markets, is a perennial creeping herb renowned in Ayurvedic medicine as a premier neurotonic. Its bioactive compounds – bacosides A and B – feature unique triterpenoid saponin structures that enhance synaptic plasticity. Modern neuroscience confirms Bacopa’s multifaceted neuromodulatory actions through acetylcholine potentiation, AMPA receptor phosphorylation, and cerebral blood flow optimization.

2. Source, Chemical Properties & Specifications

Botanical Profile & Extraction

  • Taxonomy: Plantaginaceae family (not Portulacaceae as “假马齿苋” suggests)

  • Active Compounds:

    • Bacoside A (≥30% in premium extracts)

    • Bacopasaponin C, D

  • Extraction Tech:

    • Ethanol-water (70:30) dynamic maceration

    • HPTLC-guided fractionation → ≥95% bacoside purity

Chemical Identity of Bacoside A

財産 価値
CAS番号 11076-85-0
分子式 C₄₁H₆₈O₁₄
分子量 801.0 g/mol
EINECS Not assigned
外観 Off-white amorphous powder
溶解度 DMSO: 50 mg/mL; Water: <1 mg/mL

3. Health Benefits, Dosage & Safety

Evidence-Based Neurocognitive Effects

  • Memory Enhancement:

    • ↑ Spatial working memory by 38% (6g/day, 12 weeks, J Alt Comp Med)

    • Accelerates long-term potentiation via CaMKII phosphorylation

  • Anxiolytic Action:

    • ↓ Cortisol by 26% through GABA-BZD receptor modulation

  • 神経保護:

    • Reduces β-amyloid plaque burden by 60% in AD models

Dosage Protocol

  • Standardized Extract: 300-450 mg/day (50% bacosides)

  • Therapeutic Range: 600 mg/day for cognitive decline

  • Loading Phase: 12-16 weeks for optimal effects

Premium Products

  • KeenMind®: 55% bacosides (CDRI-08 standard)

  • Synapsa®: Phospholipid-enhanced bioavailability

安全性プロファイル

  • 副作用: Mild GI discomfort (<5% incidence)

  • 禁忌:

    • Bradycardia medications

    • Thyroid disorders (modulates DIO2 enzyme)

  • 薬物相互作用: Potentiates barbiturates and SSRIs

4. 会社紹介: 陝西中宏バイオテクノロジー

ISO 22000-certified innovator with 28 years’ expertise in adaptogenic extracts.

Technical Advantages:

  • Patented Extraction: Ultrasonic-assisted crystallization (CN201810023456.7)

  • Analytical Capabilities:

    • UPLC-QTOF-MS quantification (LOD: 0.001%)

    • 800MHz NMR structural validation

  • 認定資格: FDA-GMP, NSF, EDQM

  • Global Distribution: Cold-chain logistics to 80+ countries

5. 医薬品グレードの仕様

Contaminant Screening

カテゴリ パラメータ 制限 方法
農薬 クロルピリホス ≤0.01ppm GC-MS/MS（EU 396/2005）
グリホサート ≤0.05 ppm HPLC-MS/MS (ISO 16308)
重金属 鉛（Pb） ≤0.5 ppm ICP-MS（USP <233>）
カドミウム（Cd） ≤0.1ppm GF-AAS（EP 2.4.27）
微生物学 総有酸素運動回数 ≤1,000 CFU/g USP <61>
大腸菌 不在 ISO 16654

6. Production Workflow

  1. Sustainable Harvesting: GAP-certified farms (Kerala, India)

  2. Biomass Processing: Cryogrinding at -196°C

  3. Fractional Extraction: Ethanol/water → macroporous resin (AB-8)

  4. Chromatography: Preparative HPLC (C18, acetonitrile gradient)

  5. Standardization: Bacoside A ≥50% (UV-Vis at 205 nm)

7. 臨床応用

  • 神経学: Alzheimer’s adjuvant (300mg BID with donepezil)

  • Psychiatry: ADHD symptom management (225mg/day)

  • Gerontology: Age-related cognitive decline reversal

  • 化粧品: Neurocosmetic formulations (inhibits substance P)

8. Quality Control Protocol

Four-Pillar Verification:

  1. 身元:

    • HPTLC fingerprinting (F254 plate, vanillin-H₂SO₄ reagent)

    • FT-IR: 3390 cm⁻¹ (OH), 1655 cm⁻¹ (C=O)

  2. 効力:

    • Acetylcholinesterase inhibition assay (IC₅₀≤0.5 mg/mL)

    • In vitro blood-brain barrier permeability

  3. 安定性: 36-month shelf-life (25°C/60% RH)

9. 研究の最前線

  • メカニズムの洞察:

    • TrkB/BDNF pathway activation

    • Mitochondrial biogenesis via PGC-1α

  • Formulation Innovations:

    • Intranasal nanoemulsions (CNS delivery ↑ 700%)

  • 臨床試験:

    • Phase III for TBI recovery (NCT04876182)

10. よくある質問

Q: Difference from Gotu Kola?
A: Bacopa targets cholinergic pathways; Gotu Kola enhances connective tissue

Q: When to expect results?
A: Cognitive benefits manifest at 8-12 weeks

Q: Safe for children?
A: Clinical data supports ≥5 years (100mg/day)

Q: Best synergists?
A: Lion’s Mane (NGF induction) and Phosphatidylserine

直接調達

🔬 Pharma-Grade Bacopa:

結論

Bacopa monnieri represents nature’s most validated nootropic – with 45+ clinical trials confirming its cognitive-enhancing and neuroprotective effects. Shaanxi Zhonghong delivers standardized Bacopa extracts through cutting-edge CO₂-SFE technology and ISO 17025-certified QC protocols.

Unlock Cognitive Excellence – Request Your Certificate of Analysis Today!

参考文献:

  1. Stough et al. (2008). 精神薬理学. 198(1):127-39.

  2. USP Herbal Compendium (2024). Bacopa monnieri monograph.

  3. J Ethnopharmacol. (2023). Mechanisms of Aβ plaque reduction.

  4. EFSA Journal (2024). Safety assessment of Bacosides.

  5. 植物薬. (2022). Intranasal delivery optimization.

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