Genistein
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Genistein

Genistein 98% (Soy Isoflavone Extract) – Premium Bulk Supplier

  1. English Name: Genistein
  1. Specification
    • Purity: Genistein ≥ 98% (HPLC); high-purity grade: ≥ 99.5% (HPLC)
    • Water-soluble Type: Genistein – 7 – O – glucoside (a water-soluble by-product) or nanoemulsion – primarily based formulations, solubility improved as much as 5 g/L by means of cyclodextrin complexation
    • Particle Measurement: Commonplace powder ≤ 100 μm; micronized powder ≤ 5 μm for enhanced bioavailability
  1. Appearance
    • Powder: Off – white to pale yellow crystalline powder, odorless
  1. CAS NO.：446-72-0
  1. Lead time: 3 – 7 Working Days
  1. Package
    • 1 kg/bag (aluminum foil bag), 25 kg/drum (double – layer PE bag inside cardboard drum)
  1. Main Market: North America, Europe, Asia, particularly within the well being and wellness, pharmaceutical, and beauty sectors
  1. Application Scenarios

Core Properties

  • Molecular Formulation: C₁₅H₁₀O₅
  • Solubility: Sparingly soluble in water (27.7 mg/L at 25°C), soluble in DMSO, ethanol, and alkaline options
  • Key Options
    • Phytoestrogenic Exercise: Structurally much like estrogen, binds to estrogen receptors (ERα and ERβ), modulating hormonal stability. It could act as an agonist or antagonist relying on tissue sort and estrogen ranges.
    • Anticancer Potential: Inhibits tyrosine kinases, angiogenesis, and induces apoptosis in most cancers cells. Research present efficacy in opposition to breast, prostate, and ovarian cancers.
    • Antioxidant and Anti – inflammatory: Scavenges free radicals and suppresses professional – inflammatory cytokines, decreasing oxidative stress and persistent irritation.
    • Cardioprotective: Lowers levels of cholesterol, improves endothelial perform, and reduces the danger of cardiovascular illnesses.

Application Scenarios

1. Prescribed drugs

  • Most cancers Remedy and Prevention:
    • Investigated as an adjuvant remedy for breast most cancers. In pre – medical research, genistein has been proven to reinforce the efficacy of chemotherapy medication whereas decreasing their toxicity.
    • Medical trials are exploring its use in stopping prostate most cancers recurrence in sufferers after surgical procedure or radiation.
  • Hormone – Associated Issues:
    • Thought of for menopausal symptom administration, corresponding to sizzling flashes and osteoporosis, because of its phytoestrogenic properties. Though not a alternative for hormone alternative remedy, it gives a pure various with fewer negative effects.

2. Dietary Dietary supplements

  • Common Well being Formulation:
    • Capsules or tablets containing 50 – 200 mg of genistein are widespread amongst shoppers seeking to assist general well being, particularly for girls in perimenopause or menopause.
    • Typically mixed with different isoflavones (like daidzein) in soy – primarily based dietary supplements, marketed for antioxidant and hormonal stability advantages.
  • Sports activities Diet:
    • Added to dietary supplements for athletes because of its potential to scale back muscle irritation and oxidative stress after intense train.

3. Cosmetics & Private Care

  • Anti – growing old Skincare:
    • Serums and lotions (0.5 – 2% focus) are formulated with genistein to stimulate collagen manufacturing, cut back wrinkles, and enhance pores and skin elasticity.
    • Its antioxidant properties defend pores and skin from UV – induced harm and environmental pollution.
  • Hair Care:
    • Shampoos and conditioners with genistein can promote hair progress by bettering blood circulation within the scalp and decreasing DHT (dihydrotestosterone) – associated hair loss.

4. Useful Meals & Drinks

  • Soy – primarily based Merchandise:
    • Naturally current in soybeans, genistein is a key element in soy milk, tofu, and soy protein isolates, contributing to their well being – selling fame.
  • Fortified Meals:
    • Added to cereals, power bars, and drinks at 10 – 50 mg/serving, marketed as merchandise that assist coronary heart well being and hormonal stability.

5. Animal Well being

  • Livestock Feed Components:
    • In poultry and swine feed (50 – 200 ppm), genistein can enhance progress efficiency, improve meat high quality, and increase immune perform.
  • Pet Dietary supplements:
    • Formulated in pet meals or dietary supplements for canine and cats, particularly for senior pets, to assist joint well being and cut back the danger of age – associated illnesses.

Detection Strategies

  • Excessive – Efficiency Liquid Chromatography (HPLC):
    • Column: C18 (250 × 4.6 mm, 5 μm), Cell Section: Methanol – 0.1% phosphoric acid (55:45 v/v), Circulation Charge: 1.0 mL/min, Detection Wavelength: 260 nm for correct quantification.
  • Mass Spectrometry (MS):
    • Utilized in mixture with HPLC (HPLC – MS) to verify the molecular construction and detect hint impurities, making certain excessive – high quality requirements.
  • Nuclear Magnetic Resonance (NMR):
    • Offers detailed structural data for analysis and improvement, particularly for brand spanking new genistein – primarily based formulations.

Supply & Benefits

  • Natural Supply: Plentiful in soybeans (Glycine max), in addition to different legumes like chickpeas and lentils. Extracted from soybean germ or hulls by means of solvent extraction and purification processes.
  • Sustainable Sourcing: With the widespread cultivation of soybeans, there’s a dependable and sustainable provide. Moreover, extraction could be a part of the soybean processing trade‘s by – product utilization, decreasing waste.
  • Multi – useful Benefits: Its various organic actions make it helpful throughout a number of industries, from medication to client merchandise.

Regulatory Compliance

  • US FDA: Regulated as a dietary ingredient beneath DSHEA. Merchandise containing genistein should adjust to GMP rules. Well being claims associated to genistein’s advantages have to be substantiated.
  • EU Regulation: Permitted as a meals ingredient and in dietary dietary supplements, however topic to strict security evaluations and labeling necessities.
  • China NMPA: Permitted to be used in useful meals and dietary dietary supplements, with particular tips on utilization ranges and product claims.
Categories: , , , , , ,

Genistein: The Premier Soy Isoflavone for Well being & Innovation| Supplier & Manufacturer

1. Product Overview

Genistein 98% is a high-purity soy isoflavone extract derived from non-GMO Glycine max (soybeans). As a bioactive phytoestrogen, it offers targeted health benefits for hormonal balance, cardiovascular support, bone health, and antioxidant protection. AIHerba® delivers this extract in bulk, designed for cosmetics, nutraceuticals, functional foods, and dietary supplements.

Our Genistein 98% is manufactured in a GMP-certified facility using advanced extraction and purification methods to ensure consistent potency, high stability, and superior bioavailability.

Keywords naturally included: supplier, bulk, factory, buy, wholesale, price, manufacturer, free sample herbal extract, customized herbal extract, GMP certified plant extract for cosmetics, food-grade botanical extract supplier, dietary supplement raw material manufacturer.

2. Product Highlights & Benefits

  1. High Purity & Bioactivity: ≥98% Genistein (HPLC).

  2. Supports Hormonal Balance: Promotes healthy estrogenic activity in women’s health formulations.

  3. Cardiovascular & Bone Health: Antioxidant and phytoestrogenic effects help maintain bone density and heart function.

  4. Functional Food & Cosmetic Applications: Suitable for anti-aging formulations, nutraceuticals, and functional beverages.

  5. GMP-Certified Quality: Traceable production and verified COA for consistent results.

3. Health Benefits (Evidence-Based)

  • Menopause Support: Clinical studies show genistein helps relieve hot flashes and supports hormonal balance. [PubMed]

  • Bone Health: Supports osteoblast activity and bone mineral density. [NIH Osteoporosis Guidelines]

  • Cardiovascular Function: Isoflavones contribute to vascular flexibility and antioxidant protection. [FDA GRAS Summary]

  • Antioxidant & Anti-Inflammatory: Reduces oxidative stress, improving cellular resilience. [PubMed]

4. Recommended Dosage & Formulation Guidance

Application Suggested Dosage Notes
Dietary supplements 30–60 mg/day Encapsulated or powder form
Functional foods/beverages 0.05–0.2% w/w Stable in pH 4–7; avoid high heat
Cosmetic formulations 0.1–0.5% Anti-aging creams, serums; add during cooling phase
OEM/ODM customized formulations As requested Contact factory for customized blends

Formulation Tips: Genistein is compatible with polyphenols, collagen peptides, and vitamins for synergistic effects. Avoid prolonged exposure to high temperatures or strong acids to preserve potency.

5. Production Process

  1. Raw Material Selection: Non-GMO soybeans sourced from trusted suppliers.

  2. Cleaning & Dehulling: Remove impurities and hulls.

  3. Extraction: Water-ethanol extraction under controlled temperature.

  4. Purification: Multi-step column chromatography to achieve ≥98% purity.

  5. Drying: Spray-drying to produce stable powder.

  6. Quality Control: Full COA verification including HPLC, heavy metals, pesticide residues, and microbial limits.

  7. Packaging & Storage: Sealed, moisture-proof containers; stored at room temperature in a dry environment.

6. COA & Specification Table

A. Assay & Physical-Chemical

Item Specification Test Method
Genistein (HPLC) ≥98% HPLC
Appearance Yellow to light brown fine powder Visual
Odor Characteristic Sensory
Loss on Drying ≤5% USP <731>
Ash Content ≤1% USP <281>

B. Heavy Metals

Item Limit Test Method
Lead (Pb) ≤2 mg/kg ICP-MS
Arsenic (As) ≤1 mg/kg ICP-MS
Mercury (Hg) ≤0.1 mg/kg ICP-MS
Cadmium (Cd) ≤1 mg/kg ICP-MS

C. Pesticide Residues

Item Limit Test Method
Organochlorine ND GC-MS
Organophosphate ND GC-MS
Pyrethroids ND GC-MS

D. Microbiological Limits

Item Limit Test Method
Total Plate Count ≤1000 CFU/g USP <61>
Yeast & Mold ≤100 CFU/g USP <61>
E. coli Negative USP <62>
Salmonella Negative USP <62>
Staphylococcus aureus Negative USP <62>

7. Storage & Shelf Life

  • Storage: Keep in a cool, dry place away from light and moisture.

  • Shelf Life: 24 months in original sealed packaging.

8. Packaging & MOQ

  • Packaging Options: 1 kg/5 kg/10 kg vacuum-sealed aluminum foil bags, or customized OEM packaging.

  • Minimum Order Quantity (MOQ): 1 kg for bulk, free sample available on request.

  • Transportation: Air freight, sea freight, and express courier available globally.

9. Applicable Industries & Use Cases

Industry Application
Dietary Supplements Capsules, tablets, powders
Functional Foods Soy-based beverages, bars, snacks
Cosmetics Anti-aging creams, serums, lotions
Pharmaceuticals Women’s health & bone support formulations

Usage Guidance:

  • Blend with excipients for capsule/tablet production.

  • Incorporate into beverages or functional foods at recommended concentrations.

  • Stable in pH 4–7; avoid prolonged heat to prevent degradation.

10. Safety & Precautions

  • Avoid exceeding recommended dosages.

  • Not recommended for individuals with soy allergies.

  • Pregnant or nursing women should consult a healthcare professional.

  • Keep out of reach of children.

11. Free Sample & OEM/ODM Services

AIHerba® offers free sample herbal extract for quality evaluation and supports customized herbal extract formulation services. Our GMP-certified plant extract for cosmetics and food-grade botanical extract supplier capabilities ensure consistent bulk supply and fast delivery.

12. FAQ

Q1: Can I buy Genistein 98% in bulk for functional foods?
Yes, we are a direct supplier and manufacturer offering wholesale, bulk, and customized Genistein 98% for functional foods, dietary supplements, and cosmetics.

Q2: Is your Genistein non-GMO?
Absolutely, sourced from certified non-GMO soy.

Q3: Do you provide COA and stability reports?
Yes, all products come with a full COA, heavy metals, microbial, and pesticide residue reports.

Q4: What is the MOQ?
MOQ starts at 1 kg; free samples are available.

Q5: Can you support OEM formulations?
Yes, our factory provides full OEM & ODM services for bulk orders and custom blends.

13. References & Literature

  1. PubMed: Genistein effects on menopause

  2. NIH: Osteoporosis and phytoestrogens

  3. FDA GRAS Summary: Isoflavones

  4. PubMed: Genistein antioxidant properties

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